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The smoothie for prevention and treatment of Malarial nephropathy
Yield: 2 servings (about 8 ounces each)
1/ 2 cup peanut
1 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding of a natural source for treatment of Malarial nephropathy has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Malarial nephropathy is a condition of renal and renal-related disorders commonly occur in infection with Plasmodium falciparum and P. malariae. Falciparum malaria causes fluid and electrolyte disorders, affecting mostly people in tropics. The disease may cause chronic glomerulopathy, leading to end stage of renal failure. Most case of Malarial nephropathy is a result of Plasmodium falciparum cause of kidney infection(1).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study led by the Chiang Mai University, green tea extract (GTE) used conjunction with 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) inhibited the growth of malaria parasite Plasmodium falciparum(2).
Furthermore, EGCG also inhibited the formation of MSP2 fibrils, one of the most abundant proteins on the surface of Plasmodium falciparum merozoites(4).
furthermore, resveratrol isolated from the leaves of Parthenocissus tricuspidata (Vitaceae) expressed significant antiplasmodial activity(7).
The combination of Green Tea, Peanut and Grape smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Malarial nephropathy and Malaria induced by Malaria Parasite without inducing adverse effects.
People who are at increased risk of Malarial nephropathy and Malaria induced by Malaria Parasite due to weaken immunity, family history .....should drink at least one cup daily and people with Malarial nephropathy and Malaria induced by Malaria Parasite should drink the juices at least 4 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.
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(1) A female patient with malarial nephropathy by Kanda E1, Kida Y, Suzuki H, Ando M, Negishi M, Sasaki S, Saito H.(PubMed)
(2) Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) andgreen tea extract on growth of Plasmodium falciparum by Thipubon P1, Uthaipibull C2, Kamchonwongpaisan S3, Tipsuwan W4, Srichairatanakool S5.(PubMed)
(3) Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate by Patil PR1, Gemma S, Campiani G, Craig AG.(PubMed)
(4) EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2 by Chandrashekaran IR1, Adda CG, Macraild CA, Anders RF, Norton RS.(PubMed)
(5) Antimalarial activity in mice of resveratrol derivative from Pleuropterus ciliinervis by Moon HI1, Sim J.(PubMed)
(6) Inhibition by flavonoids of amyloid-like fibril formation by Plasmodium falciparum merozoite surface protein 2 by Chandrashekaran IR1, Adda CG, MacRaild CA, Anders RF, Norton RS.(PubMed)
(7) Antiplasmodial activity of novel stilbene derivatives isolated from Parthenocissus tricuspidata from South Korea by Son IH1, Chung IM, Lee SJ, Moon HI.(PubMed)