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Focal segmental glomerulosclerosis is scar tissues in the filtering unit of the kidney due to primary glomerular diseases in children and adolescents inducing edema and the loss of protein from the plasma into the urine. The syndrome may result of kidney failure when affected children and adolescents grow into adulthood. According to Dr. Fogo AB, Focal segmental glomerulosclerosis (FSGS) has a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury(*).
Recent studies back by well known institutions proposed, Vitamin D fortified whole milk, Lipoic acid (LA) and Orange Juice may be the next generation of natural ingredients for prevention and treatment of podocyte injury due to Focal segmental glomerulosclerosis.
According to the Tokai University School of Medicine, the primary insult of podocyte injury may be short-lived. but the transmission of podocyte injury may form a vicious cycle leading to accelerated pother odocyte deterioration and glomerulosclerosis(1). Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including mushroom may benefit patients of focal segmental glomerulosclerosis caused by podocyte injury(2). According to the Southeast University School of Medicine, vitamin D ameliorated podocyte injury in STZ-induced diabetic rats through down regulated over expression of TRPC6 involved the developed focal segmental glomerulosclerosis (FSGS)(3).
Dr. Lin H and colleagues in the investigation of anti-inflammation of alpha-lipoic acid in type 2 diabetics, suggested that ALA exhibited protection against glomerular podocyte injury in type 2 diabetics through alleviating enhanced OS and strengthening antioxidant ability in vivo(5).
Ascorbic acid also known as vitamin C found abundantly in orange may also exhibit renal podocytes protection effects by increasing antioxidative capacity and ameliorating the renal oxidative stress(6).
(5) The alpha-lipoic acid decreases urinary podocalyxin excretion in type 2 diabetics by inhibiting oxidative stress in vivo by Lin H1, Ye S2, Xu J3, Wang W3.(PubMed)
(6) [Study on the effect and mechanism of ascorbic acid on renal podocytes in diabetes].[Article in Chinese] by Qin QJ1, Deng HC, Zhao TF, Cao WF, Liu DF, Lan LZ.(PubMed)
(7) Effect of vitamin E and vitamin C supplementation on antioxidative state and renal glomerular basement membrane thickness in diabetic kidney by Kedziora-Kornatowska K1, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora J, Bartosz G.(PubMed)