Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Sunday, May 8, 2016

All About #CurableVitamins: The effect of Vitamin K on Cervical Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamins are organic compounds and vital nutrients needed by your body to grow and develop in a profound way.

Vitamin K
Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble vitamin, found abundantly in leafy green vegetables, broccoli, and Brussels sprouts, etc. It is best known for promotion of coagulation and bone health.


    The Effect of Vitamin K on Cervical Cancer

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(1).
Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble vitamin, found abundantly in leafy green vegetables, broccoli, and Brussels sprouts, etc. It is best known for promotion of coagulation and bone health.

Vitamin K3 (2-methyl-1,4-naphthoquinone), also known as menadione, was found effectively in inhibition of the proliferation of human cervical epithelial cancer cells (HeLa), through binding of tubulin, a small family of globular proteins, including α-tubulin and β-tubulin possible with function of cell division and the movement of materials within cells(1)(2). Other synthetic vitamin K analogue, 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone or compound 5 (Cpd 5) also was found effectively inhibited tumors through arrested cell cycle progression at both G1 and G2-M(3). In cervical carcinoma SiHa cells, Vitamin K3 (VK3)exerted its anti proliferative effects through inhibited cyclin expression via cell cycle arrest and transition of the aphidicolin-synchronised SiHa cells(4)and induced cytotoxicity in human cervical-carcinoma tsgh8302 cells, through exhibited chromatin condensation and DNA fragmentation(5).

Taken altogether, synthetic Vitamin K and its analogue have shown to reduced risk of and treatment of cervical cancer through cell cycle arrest and regulation of cancer cell proliferation. Further studies with large sample size and multi center studies to validate the effectiveness are necessary. Overdoses can induce symptoms of Skin rash, Diarrhea, Nausea, Vomiting, Anemia, etc. Please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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References
(1)Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity by Acharya BR1, Choudhury D, Das A, Chakrabarti G.(PubMed)
(2) Mystery of Vital Cell Protein Solved After 30 Years. Receive News Releases Immediately Via E-mail By Lynn Yarris, lcyarris@lbl.gov (Berkeley Lab)
(3) Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue by Tamura K1, Southwick EC, Kerns J, Rosi K, Carr BI, Wilcox C, Lazo JS.(PubMed)

(3) Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase by Wu FY1, Sun TP.(PubMed)
(4) Vitamin-k-3 induces cell-death via apoptosis in human cervical-carcinoma tsgh8302 cells by Wu F, Chang W, Sun T.(PubMed)

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