The Curable Smoothies: March 2018

Monday, March 26, 2018

All About Calcium: The dosage of calcium and life style risks

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: The dosage of calcium and life style risks

According to the study by Aarhus University, secondary hyperparathyroidism caused bycalcium and vitamin D insufficiency may reduce bone mass and strength and increase fracture risk and should be avoided. Since calcium supplementation has been associated with an increased risk of cardiovascular complications and renal stones, the dose should be tailored to the habitual daily calcium intake. Lifestyle-related risk factors (smoking, alcohol consumption, lack of physical activity and low body weight) should be addressed. The antifracture efficacy of antiresorptive and anabolic treatment for osteoporosis has not been documented in larger randomized controlled studies(5).

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Wednesday, March 21, 2018

All About Calcium: Ca(2+) waves regulate blood vessel tone and vasomotion

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: Ca(2+) waves regulate blood vessel tone and vasomotion

Agonist-stimulated smooth muscle Ca(2+) waves regulate blood vessel tone and vasomotion.The Pharmacology, and Therapeutics, University of British Columbia, present a first report of endothelin-1 stimulated waves of Ca(2+) depletion from the sarcoplasmic reticulum of vascular smooth muscle cells using a calsequestrin-targeted Ca(2+) indicator and confirmed that these waves are due to regenerative Ca(2+)-induced Ca(2+) release by the receptors for inositol 1,4,5-trisphosphate(14).

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Monday, March 19, 2018

All About Calcium: BK Channels in Cardiovascular Diseases and Aging

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: BK Channels in Cardiovascular Diseases and Aging

Aging is a major risk factor for cardiovascular diseases, one of the main world-wide causes of death. Several structural and functional changes occur in the cardiovascular system during the aging process and the mechanisms. BK channels are transmembrane proteins that play a key role in many physiological processes, including regulation of vascular tone.In vascular smooth muscle cells, BK opening and the consequent efflux of potassium (K(+)) leads to membrane hyperpolarization, which is followed by the closure of voltage-dependent Ca(2+) channels, reduction of Ca(2+) entry and vasodilatation. BK regulates nitric oxide-mediated vasodilatation and thus is crucial for normal endothelial function(13).
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Sunday, March 18, 2018

All About Calcium: Disruption of calcium homeostasis and Alzheimer's disease (AD)

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: Disruption of calcium homeostasis and Alzheimer's disease (AD)

Oligomerization, conformational changes, and the consequent neurodegeneration of Alzheimer's β-amyloid protein (AβP) play crucial roles in the pathogenesis of Alzheimer's disease (AD). Mounting evidence suggests that oligomeric AβPs cause the disruption of calcium homeostasis, eventually leading to neuronal death, according to the School of Pharmaceutical Sciences, Kyushu University of Health and Welfare(12).

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Thursday, March 15, 2018

All About Calcium: Neuronal calcium homeostasis in the aging nervous system

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: Neuronal calcium homeostasis in the aging nervous system

Numerous studies indicate various disturbances of the Ca2+ homeostasis on different levels like Ca2+ channel properties, 45Ca2+ uptake, or Ca2+ binding proteins. Investigations on alterations of the free intracellular calciumconcentration ([Ca2+]i) in presynaptic synaptosomal preparations led to inconsistent results reporting increased or unchanged [Ca2+]i in aged animals, according to the Central Institute of Mental Health, Dept. Psychopharmacology(11).

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Wednesday, March 14, 2018

All About Calcium: Calcium and aluminum in Neurodegenerative disorders

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: Calcium and aluminum in Neurodegenerative disorders

Both calcium and aluminum have been implicated in the cell damage and death that occurs in several neurodegenerative disorders including Alzheimer's disease (AD). In the study to examine the effects of experimentally elevated intraneuronal levels of aluminum ([Al]i) and/or calcium ([Ca2+]i) on neuronal degeneration and antigenic alterations in the microtubule-associated protein tau in cell cultures of rat hippocampus and human cerebral cortex, showed that Exposure of cultures to Al3+ alone (200 microM) for up to 6 d did not result in neuronal degeneration. Neurons exposed to the divalent cation ionophore A23187 degenerated within 4 h when Ca2+ was present in the culture medium whether or not Al3+ was present. Measurements of [Ca2+]i using the calcium indicator dye fura-2 demonstrated a direct relationship between increased [Ca2+]i and neuronal degeneration. In contrast, neurons did not degenerate when exposed to A23187 in the presence of Al3+ and the absence of Ca2+, despite a 10-fold elevation in [Al]i as measured by laser microprobe mass spectrometry. Calcium influx, but not aluminum influx, elicited antigenic changes in tau similar to those seen in AD neurofibrillary tangles. Neurons exposed to glutamate in the presence of Al3+ but in the absence of Ca2+ were not vulnerable to injury. Finally, increased [Al]i occurred in neurons that degenerated as the result of exposure to glutamate indicating that aluminum associates with degenerating neurons(10).

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All About Calcium: Calcium, dairy products, and bone health in children and young adults

Sunday, March 11, 2018

All About Calcium: Vitamin D, calcium and the importance of other vitamins

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: Vitamin D, calcium and the importance of other vitamins in Osteoporosis

Osteoporosis is a major health disorder associated with an increased risk of fracture. Nutrition is among the modifiable factors that influence the risk of osteoporosis and fracture. Calcium and vitamin D play important roles in improving bone mineral density and reducing the risk of fracture. According to the study by American University of Beirut,deficiencies in vitamins C, E, and K are also associated with compromised bonehealth; this effect may be modified by smoking, estrogen use or hormonal therapy after menopause, calcium intake, and vitamin D(3).

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Saturday, March 10, 2018

All About Calcium: Vitamin D3, calcium and reduced risk of fractures and falls

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: Vitamin D3, calcium and reduced risk of fractures and falls

According to the study by the research team of Dr. Cranney A, in most trials, the effects of vitamin D and calcium could not be separated. Vitamin D(3) (>700 IU/day) with calciumsupplementation compared to placebo has a small beneficial effect on BMD, and reduces the risk of fractures and falls although benefit may be confined to specific subgroups. Vitamin D intake above current dietary reference intakes was not reported to be associated with an increased risk of adverse events. However, most trials of higher doses of vitamin D were not adequately designed to assess long-term harms(2).

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Thursday, March 8, 2018

All About Calcium: The effects of Vitamin D and Calcium on Osteoporosis

By Kyle J. Norton.

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

Calcium: The effects of Vitamin D and Calcium on Osteoporosis

Osteoporosis is a bone disease that predisposes to fractures. Sufficient intake of calciumand vitamin D is recommended for prevention and treatment. According to the study of 28,406 respondents aged 50 or older to the 2009 Canadian Community Health Survey (CCHS)--Healthy Aging, found that
In 2009, 19.2% of women and 3.4% of men aged 50 or older reported having been diagnosed with osteoporosis; the 2004 rates were similar. Age, sex and household income were associated with the probability of reporting osteoporosis. In 2004, based on dietary and supplement intake, 45% to 69% of the population aged 50 or older had inadequate intake of calcium, and 54% to 66% had inadequate intake of vitamin D(1).

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Tuesday, March 6, 2018

All About Minerals: Potassium - The Effect on Leptospirosis

By Kyle J. Norton.

Potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

Potassium: The Effect on Leptospirosis

The Normal serum potassium is 3.5 to 5.5 mEq/L. The total body potassium is lower in females and in older patients, serum potassium concentration is independent of sex and age.
Leptospirosis is disease caused by bacteria as a result of contact with water, soil or food contaminated by urine from infected animals.

The benefits
Patient infected by bacteria cause of Leptospirosisis susceptible to hypokalemic acute renal failure characterized with low level of serum of potassium and sodium may be associated to increased risk of mortality. In the study to measure the levels of serum potassium and serum creatinine andduration of symptoms at admission, showed the death rate increased with serum potassium: 11.1% in the hypoK, 14.7% in the normoK and 47.1% in the hyperK group (p = 0.002). the result suggested that hypoK is an positive and independent risk correlated with the risk of in-hospital death and hyperK are directly associated to increase risk of mortality in patient with Leptospirosis. Other in the study of the same also indicated that older age was also strongly and independently associated with higher risk of death.

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Sources
(1) The association between serum potassium at hospital admission and the case-fatality rate of leptospirosis in men by Lopes AA, Costa E, Costa YA, Bina JC, Sacramento E.(PubMed)
(2) Comparative study of the in-hospital case-fatality rate of leptospirosis between pediatric and adult patients of different age groups by Lopes AA, Costa E, Costa YA, Sacramento E, de Oliveira Junior AR, Lopes MB, Lopes GB.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, March 5, 2018

All About Minerals: Potassium - The Effect of Lower serum potassium in hemodialysis patients

By Kyle J. Norton.

Potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

Potassium: The Effect of Lower serum potassium in hemodialysis patients

The Normal serum potassium is 3.5 to 5.5 mEq/L. The total body potassium is lower in females and in older patients, serum potassium concentration is independent of sex and age.

Hemodialysis is the most common method to remove waste products for treatment in advanced and permanent kidney failure.

The benefits
Albumin is a protein made by the liver and found in your blood with function to help your body maintain fluid balance. Hypoalbuminemia, a medical condition where levels of albumin in blood serum are abnormally low characterized by with lower Serum potassium and lower Serum sodium. In a study of Lower serum potassium combined with lower sodium concentrations predict long-term mortality risk in hemodialysis patients, suggested that hemodialysis patients with hypoalbuminemia combined with lower normalized protein catabolism rate (nPCR) are associated with is associated with worse health outcomes, more complex clinical management, and increased health care costs and those patients with higher levels of serum potassium and serum sodium tended to have better clinical outcomes. Other in the study of the same in chronic. indicated that hypoalbuminemia patients also had a lower cumulative survival rate than hyperkalemia (hyperK) patients.

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Sources
(1) Lower serum potassium combined with lower sodium concentrations predict long-termmortality risk in hemodialysis patients by Hwang JC, Jiang MY, Wang CT.(PubMed)
(2) Hypokalemia is associated with increased mortality rate in chronic hemodialysis patients, by Hwang JC, Wang CT, Chen CA, Chen HC.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sunday, March 4, 2018

All About Minerals: Potassium - The Effect on Diabetic Nephropathy

By Kyle J. Norton.

Potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

Potassium: The Effect on Diabetic Nephropathy

The Normal serum potassium is 3.5 to 5.5 mEq/L. The total body potassium is lower in females and in older patients, serum potassium concentration is independent of sex and age.
Diabetic Nephropathy is a progressive kidney disease caused by disease of the blood vessels in the kidney glomeruli in diabetics.

The benefits
Angiotensin, a peptide hormone with function to cause vasoconstriction and a subsequent increase in blood pressure. Its inhibitors and angiotensin receptor blockers such as lisinopril (80 mg) were randomized to spironolactone (25 mg daily), losartan (100 mg daily) prescibed in conventional medicine for treating diabetic nephropathy may be distribute more safe depending to the levels of serum potassium after intake of the medicine. In a blinded, randomized, three-arm placebo-controlled clinical trial, 80 participants with diabetic nephropathy taking lisinopril (80 mg) were randomized to spironolactone (25 mg daily), losartan (100 mg daily), or placebo (trial dates from July of 2003 to December of 2006), researcher suggested that a better understanding of extrarenal potassium homeostasis will provide an opportunity to use this drug more safely in patients with diabetic nephropathy as well as other patient populations.

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Sources
(1) Potassium Handling with Dual Renin-Angiotensin System Inhibition in Diabetic Nephropathy by Van Buren PN, Adams-Huet B, Nguyen M, Molina C, Toto RD.(PubMed)
(2) Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.Chapter 195, Serum Potassium by Asghar Rastegar.

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Saturday, March 3, 2018

All About Minerals: Potassium - The Effect on Chronic kidney disease

Chronic kidney disease is a progression of degeneration of kidney function over a prolonged period of time, most often in years.

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Sources
(1) Higher serum potassium level associated with late stage chronic kidney disease by Hsieh MF, Wu IW, Lee CC, Wang SY, Wu MS.(PubMed)
(2) Correction of hyperkalemia in dogs with chronic kidney disease consuming commercial renal therapeutic diets by a potassium-reduced home-prepared diet by Segev G, Fascetti AJ, Weeth LP, Cowgill LD.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, March 2, 2018

All About Minerals: Potassium - The Effect on nonalcoholic fatty liver disease

By Kyle J. Norton.

Potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

Potassium: The Effect on nonalcoholic fatty liver disease

Fatty liver disease is defined as a condition of accumulation of fat in the liver, including people who drink little or no alcohol (Non alcohol fatty disease) or who are excessive alcohol drinking (Alcohol fatty liver disease). The disease can even occur after a short period of heavy drinking (acute alcoholic liver disease). More than 15 million people in the U.S. either abuse or overuse alcohol with fatty liver diseases with fat makes up 5-10 percent of liver weight.
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of clinical conditions, actually representing an emerging disease of great clinical interest(4).

The benefits
Nonalcoholic fatty liver disease (NAFLD) are associated to increased risk of metabolic syndrome. In the study of in 8592 subjects with NAFLD (30·3%) and gradually decreased across serum potassium quartiles, to investigate the association of serum potassium with the risk of prevalent NAFLD. The result showed a significant relation between serumpotassium level and NAFLD in women, younger subjects, those with insulin resistance and central obesity. Other in the study to investigate the association between NAFLD and primary aldosteronism (PA), and to identify determinants of NAFLD in this condition, showed that Serum potassium was lower in primary aldosteronism (PA) than in LREH patients with NAFLD (P < 0.001), while it was similar in PA and LREH patients without NAFLD.

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Sources
(1) Low serum potassium level is associated with nonalcoholic fatty liver disease and its related metabolic disorders by Sun K, Lu J, Jiang Y, Xu M, Xu Y, Zhang J, Xu B, Sun J, Sun W, Ren C, Liu J, Wang W, Bi Y, Ning G.(PubMed)
(2) Nonalcoholic fatty liver disease in primary aldosteronism: a pilot study by Fallo F, Dalla Pozza A, Tecchio M, Tona F, Sonino N, Ermani M, Catena C, Bertello C, Mulatero P, Sabato N, Fabris B, Sechi LA.(PubMed)
(3) Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods by Festi D, Schiumerini R, Marzi L, Di Biase AR, Mandolesi D, Montrone L, Scaioli E, Bonato G, Marchesini-Reggiani G, Colecchia A.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thursday, March 1, 2018

All About Minerals: Potassium - The Effect on Metabolic Syndrome

By Kyle J. Norton.

Potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.

Potassium: The Effect on Metabolic Syndrome

According to the American Academy of Family Physicians, insulin resistance often goes along with other health problems, such as diabetes, high cholesterol and high blood pressure. These problems are all risk factors for heart disease. When a person has many of these problems at the same time, doctors commonly call it “metabolic syndrome.” It is sometimes called “insulin resistance syndrome” or “syndrome X.” Many people who have type 2 diabetes also have metabolic syndrome
Other defined it as a disorder of energy utilization and storage, diagnosed by a co-occurrence of 3 out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density cholesterol (HDL) levels. The metabolic syndrome increases the risk of developing cardiovascular disease, particularly heart failure, and diabetes.

The benefits
Lower potassium intake may be associated to increased risk of diabetes. The Korean National Health and Nutritional Examination Survey (2008-2010, The incidence was more prominent in postmenopausal women, but not among men. Diet higher potassium is significantly associated with reduced risk of Metabolic syndrome in women, as well as insulin resistance (IR). In a cross-sectional study in 10,341 participants aged 40 years or older also supported the prevalence of metabolic syndrome in middle-aged and elderly Chinese with low serum potassium level. Nordic diet containing important potassium sources with intake in potatoes, fruit and berries, vegetables and milk products, is found to decreased diastolic ambulatory BP and mean arterial pressure as well as metabolic syndrome, may be attributed to higher intake of potassium products.

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A Simple Cooking Technique That Cuts The Calories & Glycemic
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Sources
1. Metabolic syndrome (Wikipedia)
2. Metabolic syndrome, (American Academy of Family Physicians)
3. Potassium intake and the prevalence of metabolic syndrome: the Korean National Health and Nutrition Examination Survey 2008-2010 by Lee H, Lee J, Hwang SS, Kim S, Chin HJ, Han JS, Heo NJ.(PubMed)
4. Effects of an isocaloric healthy Nordic diet on ambulatory blood pressure in metabolicsyndrome: a randomized SYSDIET sub-study by Brader L , Uusitupa M, Dragsted LO, Hermansen K.(PubMed)
5. Serum potassium level is associated with metabolic syndrome: A population-based study by Sun K, Su T, Li M, Xu B, Xu M, Lu J, Liu J, Bi Y, Ning G.(PubMed)
Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Curable Smoothies