Eyebright ( Euphrasia) Processes Anti-Oxidative Stress Activity

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also is caused the long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.


Long-term oxidative stress presented in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.

The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".

In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruits and vegetable consumption accompanied by moderate exercise and reducing intake of saturated and trans fat and processed foods.


On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined the potential protective effects of a commercial eye drop (Dacriovis™) containing Matricaria chamomilla and Euphrasia officinalis extracts on human corneal epithelial cells (HCEC-12).

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe.


The plant has been used in traditional and herbal medicine to treat eye infections and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

According to the tested analysis of human corneal epithelial cells (HCEC-12) exposed to UVB radiation followed by the treatment of the eye drops at a various concentration to induce oxidative stress,* The eye drops were able to protect corneal epithelial cells from UVB-induced cell death and ameliorated the wound healing; the eye drops exhibited a strong antioxidant activity.

* The eye drops exerted a strong antioxidant activity by decreasing ROS levels and protein and lipid oxidative damage.

* The eye drops also exerted anti-inflammatory activities by decreasing COX-2, IL-1β, iNOS expression that promote inflammation and counteracted UVB-induced GSS and SOD-2 expression induce oxidative stress and restored HO-1 expression to control levels.

Based on the results, researchers suggest, "...an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts exerts positive effects against UVB induced oxidative stress and inflammation and may be useful in protecting corneal epithelial cells from UVB exposure".

Taken altogether, Eyebright (Euphrasia) may be considered a remedy for the treatment of diseases involving oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells by Bigagli E1, Cinci L1, D'Ambrosio M1, Luceri C2. (PubMed)

Lycopene Improves the Lung Function Against Allergic Airways Disease (AAD)

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove the carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.


In 2017, 28,600 Canadians were diagnosed with lung cancer, represented 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, smoking are some of the most prevalent factors associated with the onset of the disease.

Most common lung diseases in North America including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Allergic airways disease (AAD) is an inflammatory disease associated with the immune response to allergies.

In other words, allergic airway inflammation is an abnormal reaction of the immune system towards unharmfully common and environmental factors, such as pollen grains or dust mites.

Inflammation is a natural reaction of the immune system which protects our body against the stimuli of invasive pathogens.

Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines during the acute phase of infection.

The most common diseases associated with allergic airway inflammation are asthma and allergic rhinitis.

* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.
*Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose associated with the overreaction of the immune system against allergens in the air.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of allergic asthma, researchers examined the effects of lycopene, on allergic inflammation in a mouse model of AAD.

The study included BALB/c mice who received lycopene supplement or control induced AAD. by ovalbumin (OVA).

Based on the tested differentiation, lycopene supplementation reduced eosinophilic infiltrates associated with an inflammatory response in the bronchoalveolar lavage fluid, lung tissue, and blood, and mucus-secreting cell numbers in the airways.

The T helper cells (Th2) associated with the immune response in the production of pro0inflamamtory cytokines such as cytokines IL-4 and IL-5 were also significantly reduced by the administration of lycopene.

In other words, lycopene protects the airway cell integrity against the onset of allergic airway inflammation, particularly in allergic airways disease (AAD).

Based on the findings, researchers said, " Supplementation with lycopene reduces allergic inflammation both in the lungs and systemically, by decreasing Th2 cytokine responses. T" and " lycopene supplementation may have a protective effect against asthma".

Taken altogether, lycopene found in tomato may be considered a remedy for the prevention of allergic airways disease (AAD), pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma by Hazlewood LC1, Wood LG, Hansbro PM, Foster PS. (PubMed)

Tocopherols Exhibits Cardioprotective Activity in Vivo

Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including the heart, blood vessels(arteries and veins).

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.

Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.

According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting for 1 in 4 deaths.

The most common symptoms of heart disease are poor appetite, weight loss, shortness of breath, sudden collapse, blood clots and stunted growth found in children.

Stroke is a medical condition caused by poor blood flow to the brain, leading to brain cell death in the affected region.

The most common types of stroke are ischemic stroke associated with the obstruction of a blood vessel supplying blood to the brain and hemorrhagic stroke associated with small blood vessel ruptures. The most common cause of stroke is unmanaged high blood pressure.

Cardiac toxicity is a condition in which the heart has been damage to some extent caused by harmful chemicals, including toxins induced by the treatment of chemotherapy, leading to reduced heart muscle function to pump blood and heart failure.

Long-term intake of certain medications and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.

Cardioprotection is an action that contributes to the protection of heart and blood vessels integrity against damage or injury, including heart diseases, and stroke.

In other words, cardioprotection is a process in which substances or medicines are used including an herbal remedy to protect heart muscle tissues against ischemic insult and deoxygenation injury.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effect of alpha-tocopheryl phosphate, a phosphoric acid ester of alpha-tocopherol cardioprotective activity.

According to the analysis of rats treated by 5 mg/kg body wt for a period of thirty days compared to control rats which were given water only, after thirty days before both control and experimental hearts were subjected to 30-min global ischemia followed by 2 h of reperfusion.* The tocopheryl phosphate-fed rats exhibited significant cardioprotection by improved ventricular performance and reduced myocardial infarct size and cardiomyocyte apoptosis compared to control.

* Supplementation with alpha-tocopheryl phosphate converted the pathway-induced death signal into a survival signal by enhancing anti-apoptotic pathways by inhibiting the expression of pro-apoptotic proteins.

* These results lead to the reduction of phosphorylation of pro-apoptotic c-Src that has been found to promote cardio functioning.

* Moreover, the application of tocopheryl phosphate also increased the DNA binding of the redox-sensitive transcription factor NFkappaB associated with proinflammatory activation with and potentiated the activation of anti-death protein Bcl-2 and survival signaling protein.

After talking about other factors into account, researchers said, "tocopheryl phosphate could ameliorate myocardial ischemia-reperfusion injury by converting ischemia/reperfusion-mediated death signal into a survival signal by modulating MAP kinase signaling".

Taken altogether, tocopherols may be considered an adjunct therapy that promotes cardioprotection, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cardioprotection with alpha-tocopheryl phosphate: amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation by Mukherjee S1, Lekli I, Das M, Azzi A, Das DK. (PubMed)

Herbal Elder (Sambucus), A Natural and Potential Anti-Glycation Remedy

Advanced glycation end is a by-product formed by protein or fat combine with sugar caused by cooking meat at high temperatures.

The products have been found to affect metabolic health.

The most common causes of AGEs are from the diet, particularly in people who follow the Western diet with high saturated and trans fat, a lot of red meats, and processed foods.

Low levels of AGEs may not be a problem, however, overexpression of AGEs can induce oxidative stress, leading to inflammation and damage proteins, lipid, and sometimes alternation of cells DNA.

In other words, AGEs initiate the production and free radicals and free radical's chain reaction that can not be stopped until all electrons in the outer ring paired or inhibited by antioxidants.

Diabetes mellitus, chronic renal failure, neurodegenerative diseases, osteoarthritis and also non-diabetic atherosclerosis and chronic heart failure are some of the most common forms of chronic diseases associated with oxidative stress-induced by AGEs.


Some researchers suggested that modern life byproducts AGEs are the results of the promotion of the processed food diet.


Dr. Chetan Sharma, Amarjeet Kaur, the lead scientist in the assessment of AGEs, wrote, "As modern diets are largely heat-processed, they are more prone to contain high levels of advanced glycation end products (AGEs)".

Elder or Common Elder, is a shrub or small tree of the genus Sambucus of 30 species, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere.


The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

On findings a natural compound for the treatment of cancer, researchers analyzed the anti-glycation activity of chemical compounds found in Sambucus formosana (Elder)

According to chemical analysis,
* Chlorogenic acid, rutin, isoquercetrin, nictoflorin, astragalin, and quercetin were quantified in a linearity range of 10-100 (μg/mL) with a correlation coefficient of greater than 0.996.

* Furthermore, six phenolics with the relative standard deviation ranging from 1.7-3.1%.showed a high recovery (86.5-93.1%) and good reproducibility.

* Methanol extract showed the greatest values of total phenolic content (93.1 mg gallic acid equivalent/g).

* Additionally, the methanol extract revealed the best antioxidant capacity based on the DPPH scavenging activity and anti-glycation activity (IC50 was observed at 97.1 and 77.9 μg/mL, respectively).

Taken altogether, Elder processes a number of antioxidants that may be considered an anti-glycation activity, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) HPLC-DAD-ESI-MS Analysis for Simultaneous Quantitation of Phenolics in Taiwan Elderberry and Its Anti-Glycation Activity by Huang HS1, Yu HS2, Yen CH3, Liaw ET. (PubMed)
(2) Advanced glycation End-products (AGEs): an emerging concern for processed food industries by Chetan Sharma, Amarjeet Kaur, and Shiveta Raina. (PMC)

Ashwagandha, the Potential Anti Neuro-Inflammatory Herbal Remedy

The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.

Inflammation is a natural response of the immune system in which the macrophages of the first defense stimulates the production of blood palette to cover the wound in case of injury and production of proinflammatory cytokines to the site of infection to fence off the foreign pathogens.

Inflammation also can be triggered by the immune mistakenly attacked the body tissues in cases of autoimmune disease.

Neuroinflammation is a process of the immune system that responds to harmful pathogens that induced oxidative stress to the brain.

A nerve cell is a brain cell specialized in transmitting nerve impulses.

Neuroinflammation is a medical condition characterized by the inflammation of the central nervous tissues, including the brain and spinal cord.

There many risk factors associated with the onset of neuroinflammation similar to other tissues inflammation, including infection, traumatic brain injury, toxic metabolites, or autoimmunity.


In other words, neuroinflammation is a complex response to brain injury involving the activation of inflammatory cytokines and chemokines, and the generation of reactive oxygen and nitrogen species.

Overnutrition in the Western world may be one of the main culprits associated with the widespread neuroinflammation in the aging population.

The neuroinflammatory disease can be acute or chronic. Chronic neuroinflammation that leads to the activation of glial cells and the recruitment of inflammatory cytokines into the brain is found to associate with neurodegenerative diseases.

Most cases of neuroinflammatory disease associated with the loss of neuronal structure and function can be measured by the typical inflammatory markers, including CSF Aβ1-42, tau and p-tau181, and a panel of 37 neuroinflammatory markers in patients with Alzheimer's disease.


Aswagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.


In the urgency to discover a natural ingredient for the prevention of chronic inflammatory diseases, researchers examined the neuroprotective activity of Ashwagandha (Withania somnifera) against the inflammation associated with neurodegeneration and cognitive impairments induced by systemic LPS administration using in vivo rat model system.

The study included young adult Wistar strain male albino rats randomized into four groups: (i) Control, (ii) LPS alone, (iii) LPS + ASH-WEX, (iv) ASH-WEX alone.

According to the tested analysis, orally administered ASH-WEX not only significantly suppressed the cognitive and motor-coordination impairments in rats, but also regulated the expression of various proteins involved in synaptic plasticity and neuronal cell survival.

In LPS-mediated microglial activation induced damage to neurons via direct cell-to-cell contact or through secretion of inflammatory mediators, the application of ASH-WEX and FIV pretreatment restored neurite outgrowth and protect neurons from apoptotic cell death.

In other words, LPS-induced neuroinflammation activated in microglial conditioned medium-treated neuronal cultures and microglial-neuronal co-culture were significantly demolished by the application of ASH-WEX.

Collectively, researchers said, "ASH-WEX can be used as a promising natural therapeutic remedial for the prevention of neurodegeneration and cognitive impairments associated with peripheral inflammation and neuroinflammation".

Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of neuroinflammation, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation by Gupta M1, Kaur G. (PubMed)

Herbal Dandelion(Taraxacum officinale) Inhibits the Diseases Associated with Dengue Virus Serotype 2

Infection is a condition that caused the invasion of stimuli and micro pathogens, including viral infection.

Similar to bacterial infection, both infections shared common characteristics by spreading through coughing and sneezing by and contact with infected people, especially through kissing and sex.

However, unlike bacteria, a virus replicates only inside the living cells of an organism. Viruses can infect all types of life forms, including humans and microorganisms, such as bacteria and archaea.

Anti-viral effects are the process that certain substances are used to cause the destruction of a virus.

In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,

The viral infection has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.

The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.

The battle between the immune white blood cell and viral invaders in most cases an in the flavor of the side of the immune system, the invaders are killed and the infection is healed.

However, if the immune system can not kill off the invaders with 3 - 8 weeks, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.

Dengue virus (DENV) belongs to the Flavivirus genus and is transmitted by Aedes aegypti and Ae. Albopictus mosquitoes, found in tropical and subtropical regions of the world. In severe cases, dengue virus serotype 2 has been found to induce symptoms of severe plasma leakage, severe hemorrhage, and/or severe organ impairment.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the cytotoxic concentration and the inhibitory effect of extracts or fractions from Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima on the dengue virus serotype 2 (DENV2 replication on the BHK-21 cell line.
According to the tested differentiation,
* The methanolic extracts at 60 °C of T. officinale and U. dioica showed the higher inhibitory effects on DENV2 replication.

* The chemical analysis suggested that the higher activity fraction is found for U. dioica and T. officinale, at the IC50 values of 165.7 ± 3.85 and 126.1 ± 2.80 μg/ml, respectively.

The compounds which exhibited the efficacy of T. officinale were luteolin and caffeoylquinic acid derivatives and quercetin diclycosides compared to the compounds in the active fraction chlorogenic acid, quercetin derivatives, and flavonol glycosides (quercetin and kaempferol) in the U. dioica.

Based on the results, researchers suggest, "Two fractions from U. dioica and T. officinale methanolic extracts with anti-dengue activity were found. The compounds present in both fractions were identified, several recognized molecules have demonstrated activity against other viral species".


Taken altogether, dandelion may be considered an antioxidant remedy for the treatment of dengue virus serotype 2, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro by María R. Flores-Ocelotl,1,2,3 Nora H. Rosas-Murrieta,4 Diego A. Moreno,5 Verónica Vallejo-Ruiz,1 Julio Reyes-Leyva,1 Fabiola Domínguez,2 and Gerardo Santos-López. (PMC)

Angelica Sinensis Shows to Destroy the Glioma Cells in Vitro and in Vivo

A glioma is a type of brain and spinal cord tumor characterized by the alternation of DNA of the glial cells.

Believe it or not, gliomas have been found to account for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.

Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.

* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.

* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.

Primary glioblastoma is considered the most aggressive cancer that begins within the brain. Cancer may arise de novo, meaning they begin as a Grade IV tumor with no evidence.

According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.

Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches, and localized symptoms depending on the location of the tumor.

Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.


On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the inhibitory effects of Angelica polysaccharides (APs), bioactive constituents of Angelica on a glioma cell line.

Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis both in vitro and in vivo models,
* APs exerted a significant inhibition of the growth and proliferation of U251 cells and induced their apoptosis.

* APs effectively reduced the expression of several cell cycle regulators such as cyclins D1, B, and E in the induction of cell cycle division of the tested cell line.

* APs also inhibited the anti-apoptotic protein Bcl-2 and increased the expression of pro-apoptotic proteins Bax and cleaved-caspase-3.

* Most importantly, APs inhibited the transforming growth factor (TGF)-β signaling pathway and stimulated the expression of E-cadherin, associated with the inhibition of cell growth.

Based on the results, researchers suggest, " the results indicate that APs attenuate the tumorigenicity of glioma cells and promote their apoptosis by suppressing the TGF-β signaling pathway".


Taken altogether, Dandelion may be considered a neuroprotective remedy, pending the confirmation of the larger sample size and multicenter human study. 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo by Zhang WF1, Yang Y1, Li X1, Xu DY1, Yan YL1, Gao Q1, Jia AL1, Duan MH. (PubMed)

Herbal Coltsfoot May Process Antitussive Activity Against Coughing

Coughing is a natural reflex that clears the throat of mucus or foreign pathogens. Frequent coughing may be a condition of infection caused by inflammation of the airway.

An acute cough is a condition that lasts for less than three weeks. Chronic coughing that lasts more than 3 weeks may be a condition of respiratory diseases, including asthma, allergies, gastroesophageal reflux disease (GERD), or bronchitis.


Phlegm produced in the lungs and lower respiratory tract is a type of mucus found mostly in acutely sick or longstanding health conditions patients.

Chronic mucus collected in the lungs has been associated with patients with tuberculosis (TB), pneumonia, a fungal infection, whooping cough early in life, and measles.

Seriously, chronic mucus collected in the lungs increases a significant risk of further infections and more damage.

Antitussive is a type of substance used to prevent or relieve a cough.

The most common type of antitussive drugs used for the treatment of cough is dextromethorphan

Another expectorant available in OTC products is guaifenesin.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of chronic cough, researchers examined the anti-antitussive effect of Tussilagone (TSL) chemical constituents, chlorogenic acid (1), 3,5-dicaffeoylquinic acid (2), 3,4-dicaffeoylquinic acid (3), and 4,5-dicaffeoylquinic acid (4).isolated from the flower of buds of Tussilago farfara (Compositae).

The study included selected mice orally treated with these compounds and their mixture (in a ratio of 5:28:41:26 as in EtE) at doses of 10 and 20 mg/kg once daily for 3 days.

According to the tested analysis, chemical compounds 4,5-dicaffeoylquinic acid (4) exerted a significant anti-inflammatory activity by 49.7%.observed by the leukocyte count in the bronchoalveolar lavage fluid associated with acute airway inflammation compared to the other compounds.


Moreover, 4,5-dicaffeoylquinic acid (4) also inhibited 58.0% in cough frequency.

Based on the findings, researchers said, "The caffeoylquinic acids and their mixture, exhibiting significant antitussive,...and anti-inflammatory effects, could be considered as the main effective ingredients of FTF, and they may act in a collective and synergistic way.".

Taken altogether, coltsfoot may be considered an antitussive remedy, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara by Wu QZ1, Zhao DX1, Xiang J1, Zhang M1, Zhang CF1, Xu XH. (PubMed)

Pinto Beans, A Potential Antifungal Health Food

Infectious diseases are medical conditions caused by pathogenic microorganisms, including bacteria, viruses, parasites, or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

Conventionally, most cases of infectious diseases except those caused by viruses are treated by antibiotics.

A fungus is a primitive organism, including mushrooms, mold, and mildew.found in the air, in the soil, on plants, and in water.

Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin.

People with a weakened immune system are more likely to infected by fungi, including the fungus Aspergillus which causes lung infection.

Similar to other bacterias, there are millions of different fungal species on Earth, but only about 300 are known to infect people.

Conventionally, a fungal infection also is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the effects of Chinese pinto bean lectin (CPBL), a 58-kDa dimeric glucosamine-binding protein anti-fungal activity.


Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to the tested analysis of the purified lectin on six fungal species including Phyllosticta citriasiana, Magnaporthe grisea, Bipolans maydis, Valsa mali, Mycosphaerella arachidicola, and Setosphaeria turcica,
* Only the mycelial growth of V. mali was reduced by 30.6 % by the lectin at 30 μM.

* The lectin was able to suppress the proliferation of nasopharyngeal carcinoma HONE-1 cells, with an IC50 of 17.3 μM.

Additional analysis of the lectin activity, researchers wrote, " A few plant lectins demonstrate antifungal activity against V. mali, and not many others have inhibitory effects on HONE-1 cells, CPBL is a distinctive lectin which may be exploited for development into an agent against V. mali and HONE-1 cells".



Taken altogether, Pinto beans may process antioxidant and cytotoxic properties against diseases associated with a fungal and viral infection, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Purification and characterization of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans with antiproliferative activity towards nasopharyngeal carcinoma cells by Ang AS1, Cheung RC, Dan X, Chan YS, Pan W, Ng TB. (PubMed)

Ashwagandha, the Potential Post Stroke Management Herbal Medicine

Stroke is a condition in which the brain function is interrupted rapidly due to the loss of blood supply as a result of the blockage of blood such as thrombosis and arterial embolism, or leakage of blood causes of the death of brain cells, according to the article of Mitochondria, oxidative metabolism and cell death in stroke by Sims NR, Muyderman H (September 2009).

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

There is a general belief that stroke is an accumulation over a long period of the unhealthy diet with red meat and processed meats in the induction of artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrots accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow, and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

In the US, according to statistics, approximately 800,000 people suffer a stroke of which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

Stroke is also the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or its complications.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention of disease associated with plaque accumulated on the arterial wall, researchers examined the effects of Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in an experimental model of ischemic stroke.


According to the tested analysis, before treatment with WS, tested mice showed an ischemia-reperfusion injury, leading to the increase of the oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels, and low levels of antioxidant enzymes.

The untreated mice also exerted decreased antioxidant enzymes superoxide dismutase and catalase activity, along with a reduction in GSH levels and the redox ratio, impaired mitochondrial functions, and enhanced expression of apoptosis markers.

Ischemia-reperfusion injury in the tested mice also induced mitochondrial dysfunctions.

Moreover, the levels of pro-inflammatory and apoptotic proteins were also increased in the untreated mice. The Y maze test also indicated a significant impairment in cognitive functions in the tested animal.


However, WS pre-supplementation ameliorated all parameters associated with the induction of MCAO such as oxidative stress, mitochondrial dysfunctions, apoptosis, and cognitive impairments.

Based on the evidence, researchers said, "WS pre-supplementation in ischemic stroke and are suggestive of its potential application in stroke management".

Taken altogether, Ashwagandha may be considered a supplement for stroke management, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke by Sood A1, Mehrotra A1,2, Dhawan DK3, Sandhir R. (PubMed)

Tocopherols Protects the Liver Against Hepatotoxicity in Vivo

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reduced partly or completely the function of the liver, including liver failure.

There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.

Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.

Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.

Sadly, according to the statistic, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.

Symptoms of liver diseases include persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankles swelling, itching, and pale color of stool.

The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.

Liver toxicity is a condition caused by the accumulation of toxins in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long-term use of certain medicines.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.


On finding a potential phytochemical for the treatment of liver diseases, researchers examined the protective role of curcumin and α-tocopherol against oxidative stress-induced hepatotoxicity in rats upon cisplatin treatment.

The study included male Wistar rats that were divided into five groups (n = 5),
* Pre-treated with a single dose of α-tocopherol (250 mg/kg b.w.), curcumin (200 mg/kg b.w.), and combined α-tocopherol with curcumin, respectively, for 24 h prior to the administration of cisplatin.

* The Saline and Cis groups, injected with normal saline and cisplatin [20 mg/kg body weight (b.w.)],
* Cis + α-tocopherol group,

* Cis + Cur group, and

* Cis + α-tocopherol + Cur group.

According to the analysis after 72 h of the first injection, * Cisplatin revealed a significant increase of hepatic malondialdehyde (MDA) levels and a significant reduction of hepatic superoxide dismutase (SOD) and catalase activities compared to the saline group.

* Cis elicited a marked increase of the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, the liver stress markers, and demonstrated the liver pathologies including liver congestion.

* Cis demonstrated a significant increase of NADPH oxidase gene expression compared to the saline group.

* Pre-treatment with combined curcumin and α-tocopherol improved the liver enzymes, lipid peroxidation biomarker, liver histopathology, and gene expression of liver NADPH oxidase in cisplatin-treated rats.

In other words, pretreatment with curcumin and α-tocopherol inhibited the adverse effects induced by the treatment of Cis.

After talking about other factors into account, researchers said, "pre-treatment with combined curcumin and α-tocopherol can protect cisplatin-induced hepatotoxicity including the biochemical, histological and molecular aspects".

Taken altogether, tocopherols may be considered an adjunct therapy in the prevention of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress by Palipoch S1, Punsawad C, Koomhin P, Suwannalert P. (PubMed)