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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.
Recent study suggested that patients with hepatitis C virus-related chronic liver disease
are associated to vitamin A deficiency.
According to the Federal University of Rio de Janeiro, "Vitamin A deficiency was detected in 54·3 % of all patients, and there was a progressive drop in serum retinol levels from chronic hepatitis C patients towards cirrhosis and HCC patients"
Hepatitis is characterized by the destruction of a number of liver cells and the presence of inflammatory cells in the liver tissue caused by excessive alcohol drinking, disorders of the gall bladder or pancreas, including medication side effects, and infections.
In a total of One hundred forty-four patients (age 55.34 ± 9.38 years) with chronic liver diseases evaluated in a cross-sectional study, Dr. Arantes Ferreira Peres W, the lead author suggested that Vitamin A deficiency (VAD) was detected in 51.4% of all patients.
In fact, vitamin A deficiency may also induce the progression of chronic liver diseases, probaly due to drop of drop in serum retinol (P < 0.001) and RBP (P = 0.002) depending to the severity of the liver disease,
In children with chronic liver disease, according to the The Children's Hospital, Denver, vitamin A deficiency is relatively common in children who have chronic cholestatic liver disease and suggest that metho; of checking serum retinol level followed by confirmation with a modified oral RDR test to identify vitamin A deficiency in these children may be necessary.
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(1) Vitamin A deficiency in patients with hepatitis C virus-related chronic liver disease by Peres WA1, Chaves GV, Gonçalves JC, Ramalho A, Coelho HS.(PubMed)
(2) Assessment of the relative dose-response test as indicators of hepatic vitamin A stores in various stages of chronic liver disease by Arantes Ferreira Peres W1, Villaça Chaves G, Saraiva Gonçalves JC, Ramalho A, Moraes Coelho HS.(PubMed)
(3) Vitamin A and retinol-binding protein deficiency among chronic liver disease patients by Chaves GV1, Peres WA2, Gonçalves JC3, Ramalho A4.(PubMed)
(4) Comparison of indices of vitamin A status in children with chronic liver disease by Feranchak AP1, Gralla J, King R, Ramirez RO, Corkill M, Narkewicz MR, Sokol RJ.(PubMed)