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Sunday, June 18, 2017

All About Vitamins: Vitamin A deficiency and and Cirrhosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Cirrhosis is defined as a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis.

Vitamin A deficiency (VAD) is associated to patients with liver cirrhosis. According to the joint study lead by University of Illinois at Chicago, early diagnosis and treatment with vitamin A supplementation of these patients can reverse the signs of complication, leading to symptoms of xerophthalmia(1).

In alcoholic cirrhosis patients, vitamin A deficiency is associated with disease severity as a result of a participate in the pathophysiology of the disease by priming immune cells, vitamin A supplementation could downregulate the excessive inflammatory monocyte response(2).

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(1) Vitamin A deficiency and xerophthalmic fundus in autoimmune hepatitis and cirrhosis by Chow CC1, Mieler WF.(PubMed)
(2) Correction of all-trans retinoic acid deficiency in alcoholic
cirrhosis lessens the excessive inflammatory monocyte response: a translational study by Ouziel R1, Trépo E, Cremer A, Moreno C, Degré D, Chaouni M, Vercruysse V, Quertinmont E, Devière J, Lemmers A, Gustot T.(PubMed)

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