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Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.
Cerebellar hypoplasia is a prenatally neurological condition of smaller than usual or not completely developed. cerebellum.
Vitamin A deficiency in pregnant women may induce Cerebellar hypoplasia. In a group presented the case of an infant diagnosed with pontocerebellar hypoplasia and vitamin A deficiency, researchers at the University of Alberta, Edmonton, suggested, mother with vitamin A deficiency accompanied with
a mutation in the gene coding for cytoplasmic retinol-binding protein II may be the cause of Cerebellar hypoplasia. children tested with hypovitaminosis A.
Dr. Jacob FD, the lead researcher at the University of Alberta,insisted that vitamin A screening should be considered in maternal and newborn metabolic screening, as children with pontocerebellar hypoplasia type 3 are found to associate to severe vitamin A deficiency.
a mutation in the gene coding for cytoplasmic retinol-binding protein II may be the cause of Cerebellar hypoplasia. children tested with hypovitaminosis A.
In fact, Physical therapy to promote ambulation, occupational therapy to help with fine-motor skill development, and educational support. may be the best approach for children with Cerebellar hypoplasia, but administrated high dose of vitamin A for vitamin A deficient women may be necessary.
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Sources
(1) Three cases of cerebellar hypoplasia and vitamin a deficiency: a case report and a possible pathophysiology. by Scott O1, Goez HR.(PubMed)
(2) Pontocerebellar hypoplasia type 3 with severe vitamin A deficiency by Jacob FD1, Hasal S, Goez HR.(PubMed)
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