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Wednesday, June 28, 2017

All About Vitamins: Vitamin A in Treatment of Skin Diseases

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Skin diseases is defined as a condition of skin damage and classified according to each pathogenic causes of diseases, including Moles, rashes, hives, and eczema, affecting over 14 millions people alone in US.

Recent study suggested that epidermal vitamin A deficiency may effect the protective effect against these deleterious conditions, such as increased antioxidant to potentiate their beneficial effects in the skin.

In photodamaged skin of 31 subjects, application of hydroquinone skincare regimen designed for melasma treatment combined with a cosmetic retinol cream, signicantly improve melasma disease severity assessment, tactile roughness, wrinkles, crepiness, actinic lentigines, and laxity.

In fact, retinoids, the compounds chemically related to vitamin A used in retinoid therapy exhibited immunomodulatory and anti-inflammatory effects against related diseases, but induced adverse effects such as ocular side effects.

According tje Dermatologii Slaskiej Akademii Medycznej w Katowicach, The use of retinoids in dermatology may be beneficiary with skin disorder, such as severe forms of psoriasis, ance evenmore with biological function and mechanisms of retinoid receptors.

Dr. Fritsch P. said, " At the present time, two synthetic retinoids are commercially available: etretinate (Tigason) and isotretinoin (Accutane),...... The broadest indications for the use of these retinoids are psoriasis (etretinate) and cystic acne (isotretinoin), whereas the most dramatic effects are encountered in a number of severe ichthyosiform disorders".

Taken together, Vitamin A and its derivatives may be effective for treatment of various skin diseases. The quantity intake should only be taken with care in prevention of toxicity.

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(1) Topical retinoids in skin ageing: a focused update with reference to sun-induced epidermal vitamin A deficiency by Sorg O1, Saurat JH.(PubMed)
(2) Clinical Evaluation of a 4% Hydroquinone + 1% Retinol Treatment Regimen for Improving Melasma and Photodamage in Fitzpatrick Skin Types III-VI by Rendon MI, Barkovic S.(PubMed)
(3) Side effects of retinoid therapy on the quality of vision by Bergler-Czop B, Bilewicz-Stebel M, Stańkowska A, Bilewicz-Wyrozumska T.(PubMed)
(4) [The use of retinoids in dermatology].[Article in Polish] by Brzezińska-Wcisło L1, Pierzchała E, Kamińska-Budzińska G, Bergler-Czop B, Trzmiel D.(PubMed)
(5) [Use of systemic retinoids in dermatology].[Article in German] by Fritsch P.(PubMed)

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