All About Vitamins: Vitamin A Deficiency in increased risk of Chronic liver disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

Liver disease is defined as a broad term describing any single number of diseases affecting the liver, leading to liver inflammation or tissue damage and affects liver function. Beside forming part of immune system, it also converts nutrients into essential blood components, stores vitamins and minerals, etc.

According to the University Hospital of Heidelberg, Vitamin A deficiency is associated to chronic cholestatic liver disease as retinoids nolonger attenuate or even prevent hepatic fibrosis, and to regulate hepatic immunological response to cholestatic injury in different rodent models of chronic cholestasis.

In patients with liver cirrhosis, vitamin A deficiency (VAD) showed to alter thyroid function in induction of central hyperthyroidism. A total of 120 patients with clinically stable HCV-related cirrhosis and 56 healthy controls matched for age, sex, and socioeconomic status, researchers found that patients with VAD had significantly lower vitamin A intake and serum albumin and higher serum bilirubin, FT4, FT3, and TSH than patients with normal vitamin A status.

Dr. van Stuijvenberg ME the lead author at the joint study lead by South African Medical Research Council, said, " In the newborns, the low serum retinol is likely to increase rapidly, as liver is frequently eaten by mothers and practically all of them intended to breastfeed"...."(Therefore, there is) a need for better indicators of vitamin A status or alternative cut-off values during this period" in an impoverished South African community.

The use of vitamin A supplement to prevent risk of chronic liver diseases may be helpful but the quality of supplement should be prescribed by qualified dietitian, as Vitamin A toxicity is found in patients taking large doses of vitamin A and in patients with type I hyperlipidemias and alcoholic liver disease.

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Sources
(1) Vitamin A deficiency in chronic cholestatic liver disease -is vitamin A therapy beneficial ? by Freund C1, Gotthardt DN1.(PubMed)
(2) Relationship between vitamin A deficiency and the thyroid axis in clinically stable patients with liver cirrhosis related to hepatitis C virus by El-Eshmawy MM1, Arafa MM2, Elzehery RR3, Elhelaly RM3, Elrakhawy MM4, El-Baiomy AA3.(PubMed)
(3) Serum retinol in post-partum mothers and newborns from an impoverished South African community where liver is frequently eaten and vitamin A deficiency is absent by van Stuijvenberg ME1,2, Schoeman SE1, Nel J3, Lombard CJ4, Dhansay MA1,5,6,7.(PubMed)
(4) The vitamin A spectrum: from deficiency to toxicity by Russell RM1(PubMed).