All About Vitamins: Vitamin A deficiency increased risk of Bilateral corneal ulceration

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Vitamin A, a bi-polar molecule formed by bonds between carbon and hydrogen, is a fat soluble vitamin which can not be stored in the liver but it can be converted from beta-carotene, a powerful antioxidant. The vitamin is best known fir its strong effects in improving vision and enhancing bone growth.

A corneal ulcer is an open sore on the cornea caused most by infection and in some cases are the result of vitamin A deficiency.

Bilateral corneal ulceration may be caused by vitamin a deficiency in patients with eosinophilic gastroenteropathy, an uncommon inflammatory gastrointestinal (GI).

Furthermore, vitamin A deficiency is found to induce a bilateral corneal affection in alcoholic patients or in patients with gastrointestinal, pancreatic or biliary pathology(2),due to caloric-protein malnutrition and vitamin A deficit.

Dr. Lange AP, and the research team at the University of British Columbia said, A 29-year-old male with known eosinophilic gastroenteropathy was treated with oral steroids for peripheral ulcerative keratitis. Two weeks after resolution, the patient suffered from peripheral ulcerative keratitis in his other eye, with a self-sealing perforation. Vitamin A deficiency was confirmed and successfully treated, leading to subsequent resolution of signs and symptoms".

In support of the above, serum vitamin A level below 0.01 microg/dL (normal, 0.30-0.75). is found to be associated to with with bilateral corneal ulcerations and severe visual loss, according to the West Virginia University School of Medicine(3).


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Sources
(1) Bilateral corneal ulceration caused by vitamin a deficiency in eosinophilic gastroenteropathy. by Lange AP1, Moloney G, Sheldon CA, Sasaki S, Holland SP.(PubMed)
(2) [Severe bilateral ocular affection caused by vitamin A deficiency].[Article in Spanish] by Ruiz-Martín MM1, Boto-de-los-Bueis A, Romero-Martín R.(PubMed)
(3) Bilateral corneal ulcers in primary vitamin A deficiency by Macsai MS1, Agarwal S, Gamponia E.(PubMed)