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Thursday, December 14, 2017

All About Vitamins: Antiepileptic Drugs in Vitamin B6 Metabolism

By Kyle J. Norton.

Antiepileptic drugs are class of anticonvulsants used in the treatment of epileptic seizures.

Epilepsy is a neuro disease characterized by abnormal electrical activity in the brain with condition of sudden recurrent episodes of sensory disturbance.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Although vitamin B6 and its derivative have shown a strong impact in treatment of all groups of epilepsy, intake of antiepileptic drugs do not influence to the expression of plasma levels of vitamin B6, according to the University Hospital Zurich, in the study of analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n=385), untreated (n=15) and healthy controls (n=233).

But further differentiation of the interaction of vitamin B6 in patient with epilepsy underdone treatment of antiepileptic drugs (AEDs) including phenytoin or carbamazepine) and non-inducing AED (levetiracetam, lamotrigine, or topiramate), researcher found that
1. Contrast to general belief that intake of antiepileptic drugs did not lower either levels of folate nor vitamin B12, observed by blood test.
2. Vitamin B6 deficiency was found in 16/33 patients (48%) in compared to 1/11 controls (9%; p=0.031)
3. Patients in antiepileptic drugs group showed a significant in vitamin B6 deficiency of only 7 patients (21%) .after switching to non inducers.

After taking into account of con founders, Dr. Mintzer S, the lead author said, "The incidence of deficiency was similar regardless of which inducing or non-inducing AED was being taken" and "treatment with inducing AEDs commonly causes pyridoxine deficiency, often severe".

Intrusively, the study also address that other health conditions in patients with epilepsy also must be taken into consideration before injection of older AED as the medicine may induced neuro damage and chronic heath difficulties.

More importantly, in the study to determine the means of determination of activity of EGOT in 30 and of serum pyridoxal phosphate in 27 epileptic children under antiepileptic treatment with various antiepileptic drugs and with hydantoin and succinimide alone, 25 healthy infants and children were controls, researchers indicated that
1. Application of antiepileptic drugs, especially with hydantoin and succinimide depressed the level of pyridoxal-phosphate in serum
2. Injection of various antiepileptic drugs may disturb the vitamin B6 metabolism through inhibition of activity of pyridoxalkinase.

Therefore, vitamin B6 testing in patients treated with hydantoin and succinimide may be necessary to prevent risk of reduced vitamin b6 metabolism cause of toxic effects in several neurological pathologies.

Taking altogether, injection of antiepileptic drugs  may have a complicative effect in reduced vitamin B6 metabolism in induction of neuro damage and chronic heath difficulties.



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Sources
(1) Antiepileptic drugs and vitamin B6 plasma levels in adult patients by Linnebank M1, Moskau S, Semmler A, Widman G, Weller M, Kallweit U, Elger CE.(PubMed)
(2) B-vitamin deficiency in patients treated with antiepileptic drugs by Mintzer S1, Skidmore CT, Sperling MR.(PubMed)
(3) The influence of antiepileptic drugs on vitamin B6 metabolism by Reinken L.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, December 11, 2017

All About Vitamins: Vitamin B6 and Treatment of Pyridoxine-Dependent Epilepsy

By Kyle J. Norton.

Epilepsy is a neuro disease characterized by abnormal electrical activity in the brain with condition of sudden recurrent episodes of sensory disturbance.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions in stimulation of carbohydrate metabolism, brain health, and liver detoxification, etc.

The effect of vitamin B6 in treatment of pyridoxine-dependent epilepsy was under microscopic investigations extensively through many aspects, particularly in vitamin B6 application.

In inborn errors of autosomal recessive inheritance that lead to vitamin B6-dependent seizures, after taking account of other con founders, researchers suggested that a vitamin B6 withdrawal for diagnose should also be considered as an therapy for resistant neonatal seizures as early consideration of a vitamin B6 trial over 3 consecutive days is crucial in order to prevent irreversible brain damage, instead of only for patients with a clear vitamin B6 response.

Neonatal seizures, a medical condition of occurrence of seizures due to neurologic dysfunction in the neonatal period.

Pyridoxine, an the active form of vitamin B6 would be effective commonly in treatment of vitamin B6-dependent seizures, but pyridoxine showed no signs of potency in patients with neonatal seizures due to PNPO deficiency.

Pyridoxal 5'-phosphate-dependent epilepsy(PNPO) is a condition with failure response to vitamin B6 treatment in seizures patients.

The use of PLP in patients with resistant neonatal seizures should be taken with care with resuscitation equipment at hand during a first pyridoxine/PLP administration, as severe apnea has been occurred in patients, researcher continued.

Unfortunately, due to PLP is unlicensed within Europe and North America, pyridoxine is widely used as the first line drug, therefore for patient do not response to the treatment of PLP, some researchers suggested that PLP injection may be necessary and should be followed by a trial, especially in neonates.

Furthermore, caregivers, including parents with children with epilepsy should be inform about the lifelong dependency and recurrence risks in forthcoming pregnancies.

Further analysis of  the resistant conventional antiepileptic medications of early-onset epilepsy in children with neonates caused by hypophosphatasia and congenital rickets and in compared to patients of hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency of epilepsy, also indicated that although many patients with epilepsy are response to treatment of vitamin B6 injection but PLP treatment was more effective than pyridoxine, through some unknown mechanisms.

Dr. Wang HS, the lead author said, "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Additionally, Pyridoxine-dependent epilepsy (PDE) may also be caused by genetic mutation of certain genes, such as c.1597_1597delG mutations in ALDH7A1 gene.

Observation of patients data in 3 groups with complete seizure control with pyridoxine and normal development (group 1), complete seizure control with pyridoxine and development delay (group 2), and patients with persistent seizures despite pyridoxine treatment and with development delay (group 3) researchers at the Çukurova University Faculty of Medicine found that early diagnosis and treatment of these patients is vital. Patients with persistent seizure despite pyridoxine treatment and with development delay should be diagnosed in condition of any neonate with signs of encephalopathy and refractory seizures.

Taken together, if patients with epilepsy do not response to treatment of application of vitamin B6, PLP injection may be considered but substantial care must be taken  to reduce risk of complications of severe apnea.
 

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Sources
(1) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(2) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(3) Pyridoxine-dependent epilepsy in two Turkish patients in Turkey and review of the literature by Gül-Mert G1, İncecik F, Hergüner MÖ, Ceylaner S, Altunbaşak Ş.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thursday, December 7, 2017

All About Vitamins: Vitamin B6 in Reduced Risk and Treatment of non-small cell lung cancer (NSCLC)

By Kyle J. Norton.

Vitamin B6 may have a profound effect in reduced non-small cell lung cancer (NSCLC), some scietists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Non-small cell lung cancer is the most common type of lung cancer with characteristic to grow and spread methodically and predictably.

In the study to examine the clinical outcomes of the sodium cantharidinate/vitamin B6/GP regimen in the treatment of middle-late stage Non-small-cell lung carcinoma (NSCLC) with
86 cases of NSCLC selected and randomized into two groups; 45 cases in the treatment group were given 30 ml cantharidinate/vitamin B6+ GP regimen, for four 21-day cycles and 41 cases in the control group were subject to regular GP regimen, for four 21-day cycles, at the end of experiment, researchers found
1. Treatment group showed a significant improvement with effectiveness rate of 57.8% in compared to 36.6% in the control group,
2. Patients in group demonstrated an improvement of quality of life
3. Treatment group also displayed a lower toxic/adverse effects in compared with that in the control group.

After taking into account of other risk factors, Dr. Wang B, the lead author said, "odium cantharidinate/vitamin B6/GP regimen had fair effectiveness and synergistically improved the clinical outcomes. It lowered the toxic/adverse effects and its application is worth further investigation and promotion".

Other, in the study to examine the effect vitamin B6 for treatment of non-small cell lung cancer, after observation of vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo, researchers at the INSERM showed that
1. Vitamin B6 sensitized lung cancer cells to apoptosis induction by distinct types of physical and chemical stress.
2. Pyridoxal kinase (PDXK), the enzyme played an important role in generated the bioactive form of vitamin B6 and deficiency of PDXK expression levels were associated with poor disease outcome in two independent cohorts of patients with NSCLC.

The result of the study demonstrated the important role of pyridoxal kinase (PDXK) in exhibited vitamin B6 in reduced risk and treatment of NSCLC.
In fact, most patients with NSCLC are found to correlation with low levels of pyridoxal kinase (PDXK).

Taking altogether, vitamin B6 may be considered as a secondary and therapeutic treatment of NSCLC.


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Sources
(1) Treatment of mid-late stage NSCLC using sodium cantharidinate/vitamin B6/GP regimen in clinic by Wang B, Cui J1.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, December 4, 2017

All About Vitamins: Vitamin B6 in Reduced Risk of Depression

By Kyle J. Norton.

Vitamin B6 may have a intrinsic effect in reduced symptoms of depression, some scientists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

In the study to investigate whether different intake levels of folate, vitamin B6 and B12 were associated with a 3-year depression incidence among generally healthy, community-dwelling older men and women conducted by the joint study lead by the St Francis Xavier University, researchers showed that
1. Vitamin B6 intake from foods were associated to 43% less likely to become depressed when adjusting for demographic and health factors in women.
2. Risk of depression also decreased in men who took dietary vitamin B6 during the study.


The results indicated that dietary vitamin B6 may be the choice for both men and women to reduced risk of depression.

Other in the study to investigate whether adolescent pregnant women were on greater risk of nutritional deficits in stress, and depression than their adult counterparts, and these risk factors associated to adverse pregnancy outcomes, researchers at the joint study lead by the Columbia University Medical Center, suggested that vitamin B6 was one of many micro nutrients found in deficient status in these group of women.

After taking into account of other risk factors, Dr. Singh A, the lead author postulated, "mood and dietary factors are associated and should be considered together for health interventions during adolescent pregnancy for the young woman and her future child".

Taking altogether, vitamin B6 may be considered as an adjunct supplement with standard therapy for reducing risk of depression in general population.
 
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Sources
(1) Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging by Gougeon L1,2, Payette H3,4, Morais JA5, Gaudreau P6,7, Shatenstein B8,9, Gray-Donald K2.(PubMed)
(2) Micronutrient Dietary Intake in Latina Pregnant Adolescents and Its Association with Level of Depression, Stress, and Social Support by Singh A1,2,3, Trumpff C4, Genkinger J5,6, Davis A7, Spann M8,9, Werner E10,11, Monk C12,13,14.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, December 1, 2017

All About Vitamins: Vitamin B6 in Reduced Psychological symptoms of Schizophrenia

By Kyle J. Norton.

Vitamin B6 may have a potential effect in reduced psychological symptoms in chronic schizophrenic and schizoaffective patients, some researchers suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Schizophrenia is a severe mental disorder characterized with inability to interpret reality normally and Schizoaffective disorder is also a chronic mental health condition characterized primarily by symptoms of schizophrenia.

In a study to examine the effects of vitamin B6 reduced psychotic symptoms of psychopharmacologic treatment of patients suffering from schizophrenia or organic mental disorder, of spanning 9 weeks with all patients with stable psychopathology for at least 1 month before entry and randomly received placebo or vitamin B6, starting at 100 mg/day in the first week and increasing to 400 mg/day in the fourth week by 100-mg increments each week, researchers found that there are no differences between vitamin B6- and placebo-treated patients in amelioration of mental state of attendees.

Dr. Lerner V, after taking into account of other confounders, said, "Further studies with larger populations and shorter duration of illness are needed to clarify the question of the possible efficacy of vitamin B6 in treatment of psychotic symptoms in schizophrenia".

Other researchers in the confirmation of vitamin B6 great progress in the treatment of positive symptoms in schizophrenic patients and movement disorders induced by neuroleptics,at the Ben Gurion University of the Negev, launched a a double-blind crossover controlled during 9 weeks with patient treated with up to 400 mg/day vitamin B6 versus placebo, after reviewing the result taken from Positive and Negative Symptoms Scale (PANSS), Extrapyramidal Symptoms Rating Scale (ESRS) and a blood sample of level pyridoxal showed that vitamin B6 treated group demostrated a significant improvement in tardive dyskinesia and parkinsonian symptoms. but failed to express therapeutic effect of psychotic symptoms from vitamin B6 added to antipsychotic agents.

The contradictory findings suggested that further studies with larger samples and higher doses of vitamin B6 are necessary before clarifying the possibility of a positive therapeutic effect of vitamin B6 as an augmentation agent for the treatment of psychotic symptoms.



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Sources
(1) Vitamin B6 as add-on treatment in chronic schizophrenic and schizoaffective patients: a double-blind, placebo-controlled study by Lerner V1, Miodownik C, Kaptsan A, Cohen H, Loewenthal U, Kotler M.(PubMed)
(2) [Vitamin B6 add-on therapy in treatment of schizophrenic patients with psychotic symptoms and movement disorders].[Article in Hebrew] by Miodownik C1, Cohen H, Kotler M, Lerner V.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 29, 2017

All About Vitamins: Vitamin B6 for Treatment of Anxiety

By Kyle J. Norton.

Vitamin B6 may have an positive effect in reduced levels of anxiety, some scientists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Anxiety, a psychological symptom caused by a feeling of worry, nervousness, or unease, particularly about an imminent event or something with an uncertain outcome.

According a randomized, double-blind, placebo-controlled and crossover design study to investigate single and combined effects of daily dietary supplementation with 50 mg of vitamin B6 and 200 mg magnesium (as MgO) for one cycle for the relief of mild premenstrual symptoms, among 44 assigned to treatments daily for one menstrual cycle: (1) 200 mg Mg, (2) 50 mg vitamin B6, (3) 200 mg Mg + 50 mg vitamin B6 and (4) placebo, after taking into account of other risk factors, researchers showed that treatment with 200 mg/day Mg + 50 mg/day vitamin B6 expressed a significant reduction of anxiety-related premenstrual symptoms (nervous tension, mood swings, irritability, or anxiety) in compared to other treated groups, specially in mild premenstrual anxiety-related symptoms.

Other in the study to evaluate the effect of combination of Magne-B6 used, in the treatment of 25 patients with different forms of epilepsy with psychiatric status of patients featured by depression, anxiety and some psychotic sighs researchers indicated that according to the results of self-rating scales for Zung anxiety and depression scale, SCL-90 and Global clinical impression (CGI) scale, the combination display a strong effect in non-specific influence on patient's mental state at between the 14 - 28 days of treatment without inducing serious side effects.

Taking altogethers, Vitamin B6 may be used alone or conjunction with other minerals supplement for treatment of anxiety.
 

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Sources
(1) A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study by De Souza MC1, Walker AF, Robinson PA, Bolland K.(PubMed)
(2) [A use of Magne-B6 in the treatment of anxiety-depressive states in patients with epilepsy].[Article in Russian] by Kalinin VV, Zheleznova EV, Rogacheva TA, Sokolova LV, Polianskiĭ DA, Zemlianaia AA, Nazmetdinova DM.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, November 27, 2017

All Above Vitamins: The Effect of Vitamin B6 on Central Nervous System

By Kyle J. Norton.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Central nervous system is a part of nervous system, including the brain and spinal cord.

Vitamin B6 may have a profound and positive effect in reduced neuro toxicity used conjunction with other herbal medicine, some scientists suggested

In a study to investigate the neuroprotective role of grape seed extract and/or vitamin B6 against Triton WR-1339 -induced neurotoxicity, with 35 adult male albino rats of the Sprague-Dawley strain, weighing 140-145 g, divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + tritonresearchers at the Alexandria University found that application of grape seed extract and/or vitamin B6 demonstrated a significant effect in attentuated disturbances in the hematological parameters, the neurological functions, and the antioxidant profile, caused py injection of the above product.

Further analysis suggested that grape seed extract and/or vitamin B6 protect against neuro damage caused by Triton WR-1339 through over expression of antioxidative and antiapoptotic capacities.

In support to the above study, researchers at the Laboratori di Ricerca della FIDIA S.p.A, launched a study to examine the effect of a brain cortex phospholipids (BC-PL) and vit. B6 association on animal behaviour and enzymatic activities specific for CNS postulated that although vitamin B6 showed a strong positive influence to BC-PL and  activities, the results obtained are very different in compared to  methamphetamine used for treatment of CNS.

The result suggests a different mechanism of action at CNS level, according to the motility and avoidance tests and cerebral L-amino acid aromatic decarboxylase assays.

Taking together, there is no doubt that vitmain B6 has a intrigue effect in improved and protective central nervous system activities.


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Sources
(1) Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity by Abdou HM1, Wahby MM2.(PubMed)
(2) [Neurochemical and behavioural alterations in animals due to a neurohomologous phospholipids and vitamin B6 association at CNS level].[Article in Italian] by Aporti F1, Toffano G, Castellani A.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.