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Monday, September 25, 2017

All About Vitamins: Niacin Overload in increased Risk of Obesity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Chronic niacin excessive intake may be associated to risk of obesity a study by the Medical College, Dalian University suggested.

Obesity is a medical condition of excess body fat has accumulated overtime with a BMI of over 30.
 According to the statistic, 68% of American population are either overweight or obese.

According to the examine between the niacin consumption and the obesity prevalence among US children using the data from the Economic Research Service of the US Department of Agriculture and from US Centers for Disease Control and Prevention, respectively, increased consumption of grain niacin-fortification and fortified ready-to-eat cereal consumption, with a 10-year lag increased per capita niacin consumption among Us children may be one of the risk factor in elevated obese risk.

Dr. Li D, the lead author said, " The regression analyses showed that the obesity prevalence in the US children of all age groups was determined by niacin consumption (R(2) = 0.814, 0.961 and 0.94 for 2-5 years, 6-11 years and 12-19 years age groups, respectively)".

In deed, the appetite-stimulating effect of nicotinamide involved oxidative stress may be directly induced excess niacin consumption and considered as a major factor in the increased obesity prevalence in US children.

Additionally, in the study to determine whether and how long-term treatment with nicotinamide) NAM at lower dose would affect insulin sensitivity in mice fed chow diet with NAM (100 mg/kg/day) and normal chow for 8 weeks, researchers found that NAM (100 mg/kg/day) injection group induced obesity and expressed a significant in increased glucose intolerance and skeletal muscle lipid accumulation through impaired mitochondrial respiration capacity and energy production in skeletal muscle.

The excessive niacin overload also showed a persistent rate of oxidative stress in compared to high-fat diet (HFD) and resveratrol (RSV; 100 mg/kg/day) group.

Taking together, there is no doubt that niacin overload may have a direct influence to increased risk of obesity through expression of oxidative stress induced increased glucose intolerance and skeletal muscle lipid accumulation


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Sources
(1) Chronic niacin overload may be involved in the increased prevalence of obesity in US children by Li D1, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M.(PubMed)
(2) Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity by Qi Z1, Xia J2, Xue X2, He Q2, Ji L2, Ding S3.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, September 22, 2017

All About Vitamins: Niacin Lowers Hypercholesterol and risk of CVD in Diabetic patients

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may have a potential in reduced risk of hypercholesterol and cardiovascular disease in patients with diabetes, a Medical institute suggested.

According to the School of Medicine and Pharmacology, niacin exhibited HDL metabolism in reduced all forms of bad cholesterol and increased good cholesterol level in patients with type 2 diabetes.

In a total of 12 men with type 2 diabetes mellitus recruited for a randomized, crossover design trial, patients randomized to rosuvastatin or rosuvastatin plus ER niacin for 12 weeks and then crossed over to the alternate therapy after a 3-week washout period, metabolic assay showed that extended-release (ER) niacin treatment significantly decreased plasma triglyceride, plasma cholesterol, non-HDL cholesterol, low-density lipoprotein cholesterol, articular in HDL cholesterol in compared to other groups.

Dr. the lead researcher said, " ER niacin increases HDL apoA-I concentration in statin-treated subjects with type 2 diabetes mellitus by lowering apoA-I(in measurement of cardiovascular risk) fractional catabolic rate".

In the same same group of patients with type 2 diabestes, in compared the effective of rosuvastatin or rosuvastatin plus ER niacin, extended-release (ER) niacin on apolipoprotein B-48 (apoB-48) kinetics in statin-treated treatment also showed a reduction of level of apoB-48 concentration, but significant lower than group treated with conventional treatment.

The study also emphasized that the ER niacin exhibition of reduced cardiovascular risk showed independent to the levels of triglyceride, according to testing assay.

In fact, the efficacy of ER in reduced risk of CVD may be resulted of reduction of apoB-48 concentration through lowering fasting and postprandial apoB-48 secretion rate.

Taking together, niacin injection may have a profound effect in treating diabetic patients in ameliorated risk of CVD through expression of lower level of total blood cholesterol.




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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of niacin on high-density lipoprotein apolipoprotein A-I kinetics in statin-treated patients with type 2 diabetes mellitus by Pang J1, Chan DC, Hamilton SJ, Tenneti VS, Watts GF, Barrett PH.(PubMed)
(2) Effect of niacin on triglyceride-rich lipoprotein apolipoprotein B-48 kinetics in statin-treated patients with type 2 diabetes by Pang J1, Chan DC1, Hamilton SJ1,2, Tenneti VS1, Watts GF1, Barrett PH1,3.(PubMed)

Thursday, September 21, 2017

All About Vitamins: Niacin in reduced Risk of High Levels of Phosphorus in Kidney Diseases

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered a dietary supplement in reduced risk and progression of kidney diseases, a renowned institute study suggested.

Kidney diseases are medical condition characterized by impairment of kidney function in filter metabolic wastes from the blood.

According to the University of Karachi, niancin treatment over 4 months, showed a significant effect in reduced risk dyslipidemia and phosphorus level, in compared to control group treated with statin.
in a study of chronic kidney disease patients fulfilling the pre-defined criteria and randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or NER 500 mg/day with the same dose of statin.

In compared to conventional medicine atorvastatin, niacin extended release (NER) scored a significant result in decreased levels of phosphorus than atorvastatin, used as lone treatment.

Dr. Yasmeen G, the lead researcher said," its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction.".

Instantly, in the post hoc data analysis of serum phosphorus concentrations among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268). only one of daily treatment of ERN-L  expressed a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline in compared to other groups.

Further more, the testing of extended release niacin (ERN) alone and ERN combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (ERN-L), treatment of extended release niacin (ERN) also showed a same effect in reduced serum FGF23 concentration in compared to 2 other groups, with equivalent declines in serum phosphorus in (ERN-L) group but not in placebo group.

Taking altogether, there is no doubt that niacin under the form extended release niacin (ERN) may have a potential used conjunction of with conventional medicine in reduced complications of kidney diseases caused high levels of phosphorus.


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Sources
(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)
(3) Effect of niacin on FGF23 concentration in chronic kidney disease by Rao M1, Steffes M, Bostom A, Ix JH.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, September 20, 2017

All About Vitamins: Niacin in reduced Risk Oxidative Stress

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered as dietary supplement in reduced risk of oxidative stress in induction of various diseases, a respectable institute study opinionated.

In a total of 127 men and women aged 48-77 yr with brachial artery flow-mediated dilation (FMD), patients, above-average dietary niacin intake showed a significant greater function in compared to those below-average intake (P < 0.05).

The study also found that above-average dietary niacin intake patients showed a lower levels of oxidative stress through expression of plasma oxidized low-density lipoprotein.

Further more, levels of antioxidants also has linearly association to amount intake of niacin as shown in this participants.

Dr. Kaplon RE, the lead author said, " higher dietary niacin intake is associated with greater vascular endothelial function related to lower systemic and vascular oxidative stress among healthy middle-aged and older adults."

In support of the above analysis, the study of 17 patients with hypercholesterolemia and low HDL-C and 8 healthy control subjects, 12 weeks.of niacin treatment showed a strong improvement of lipid profile, oxidative stress and C-reactive protein (CRP) levels, through increase in HDL-C and apolipoprotein A1 levels involving transferred to HDL in the bloodstream and a decrease in triglyceride levels.

More promisingly, Niacin treatment in these patients with low HDL levels showed a significant in reduced oxidative stress through improved activities in regulated C-reactive protein (CRP) levels and lipid profiles.

Taking altogether, There is no doubt that niacin may be considered as a dietary treatment in reduced risk of diseases caused by oxidative stress.



(2) Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol by Hamoud S1, Kaplan M, Meilin E, Hassan A, Torgovicky R, Cohen R, Hayek T.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, September 19, 2017

All about Vitamins: Niacin, A dietary Supplement for Enhanced Immunity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be a potential agent in promoted immune response against invasion of micro bacterial invasion. a renowned institute suggested.

Immune responses is a normal reaction of immune system in prevented infection and inflammation caused by foreign invasion, and further injure and damage due to wound of body tissues and organs.

According to the study of 30% of HIV-1-infected patients receiving antiretroviral therapy in reduced elevated risk for clinical progression to AIDS and non-AIDS events, involving CD4+ T-cell depletion, extended-release form of niacin (Niaspan FCT™) in combination with antiretroviral therapy, showed a significant effect in improved immune activation, thus increasing CD4 recovery in compared to deferred use of Niaspan patients after 24 week periods.

Apparently, niacin expressed a strong expression pf suboptimal immune responses, through its impact of on neurocognitive function in HIV-infected individuals.

Dr. Lebouché B, the lead author said, " Niacin (vitamin B3) is able to control the excess tryptophan oxidation, correcting tryptophan depletion, and therefore represents an interesting strategy to improve CD4 recovery".

Niacin, in other study, with direct action in regulation of inflammatory responses or disordered immune mechanisms may be considered as a supplementary therapy in rheumatic diseases, atopic disorders and chronic infections. 

In order to achieve a optimal effect of niacin as immunostimulating therapy, other micro and marco nutrients such as suboptimal levels of EFAs, vitamins and trace elements should always be taken into account, the study also suggested.

More importantly, NAD in synthesis of mono ADP-ribose, expressed a significant involvement in signal transduction. as the vitamin showed to important function in mediation of two intracellular calcium signaling pathways to enhance immunity against cancer cell division through improved genomic stability.

Dr. Kirkland JB, said, " niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations".

Taking together, niacin as a dietary supplement may have a potential effect in reduced risk of any form disease involving action of  immune system.


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Sources
(1) The role of extended-release niacin on immune activation and neurocognition in HIV-infected patients treated with antiretroviral therapy - CTN PT006: study protocol for a randomized controlled trial by Lebouché B1, Jenabian MA, Singer J, Graziani GM, Engler K, Trottier B, Thomas R, Brouillette MJ, Routy JP.(PubMed)
(2) Specific application of single nutrients as a basic treatment in immunostimulating therapy by Reinhold U.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, September 18, 2017

All About Vitamins: Niacin Reduced Risk and Treatment Glaucoma?

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin supplement may have a potential effect in reduced risk and treatment glaucoma, a Pennsylvania study suggested.

Intake of 500 mg of oral niacin(also known as vitamin B3 or nicotinic acid) daily is shown to increased intraocular pressure to 37 and 27 mm Hg, according to the the Jefferson Medical College. study.

In the exam of 73-year-old man with a history of primary open-angle glaucoma, intake of niacin have a significant effect on the eye pressure which may be increased or decreased depending to amount of niacin intake.

The increased abnormal eye pressure also reduced to normal once niacin intake was stopped.

The finding is contrasted to the investigation of mice treated with nicotinamide adenine dinucleotide (NAD), in genetically predisposed to developing glaucoma with healthy mice acted as control, in indication of niacin effect in treatment of glaucoma through anti oxidative stress by Dr. John and colleagues. 

According to Dr. John and colleagues study, the depletion of NAD weakens the metabolism of the brain cells, and intraocular pressure may have a direct influence on the onset of glaucoma. And  in glaucoma-predisposed mice, adding niacin to the drinking water showed to improve aging retinal ganglion cells and modify the neuro change associated with advancing age and prevent the early onset of glaucoma.

Taking altogether, intake of niacin supplement to reduced risk and treatment of glaucoma may need further studies by larger human trial and involvement of multi centers before confirming.


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Sources
(1) Oral niacin can increase intraocular pressure by Tittler EH1, de Barros DS, Navarro JB, Freitas DG, Gheith ME, Siam GA, Spaeth GL.(PubMed)
(2) http://dailyhealthalerts.com/new-study-vitamin-b3-may-help-glaucoma-and-macular-degeneration/
(3) Vitamin B-3 successfully prevents glaucoma in mice by By Ana Sandoiu
Published Friday 17 February 2017(Medical News Today)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, September 15, 2017

All About Vitamins: Niacin reduced risk of co-morbidities in patient with chronic kidney disease.

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Kidney disease is a medical condition of kidney impairment, characterized by adequately filter metabolic wastes from the blood.

Niacin may have a potential effect as phosphorus lowering agents in patient with ischemic nephropathy, inducingvarious types of syndromes and diseases,  a joint study suggested.

According to the University of Karachi, Karachi, niacin may be one of low cost supplement used management effectively in attenuated elevated serum phosphorus in patient population with compromised kidney performance. Thus reducing co-morbidities especially cardiovascular disease risk and derangement in calcium-phosphorus homeostasis in advancing to onset of chronic kidney disease.

In the study of 170 chronic kidney disease patients and 50 healthy control, fulfilling the pre-defined criteria, randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or extended release niacin(NER) 500 mg/day with the same dose of statin for four months, injection of atorvastatin alone and NER showed a significantly reduced phosphorus level.

In compared to the adverse effect in both treatments, the university also said, "NER, at its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction".

Furthermore, in data analysis of serum phosphorus concentrations, among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268), repeated measurement of ERN-L treatment resulted in lowering serum phosphorus change comparing ERN-L with placebo.


Dr. Maccubbin D, the lead author siaid, "once-daily ERN-L treatment causes a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline".

Taking together, niacin may be effective for enhanced kidney function by reduced level of phosphorus in both healthy and chronic kidney disease patients. intake of large amount should be taken with care under close observation by medical professional.


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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)