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Monday, November 13, 2017

All About Vitamins: Vitamin B6 In decreased Symptoms Severity In Premenstrual Syndrome

By Kyle J. Norton.

Vitamin B6 may have a strong impact in reduced symptoms in women with premenstrual syndrome, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts, effecting over 70% to 90% of women in the US.

In the study of 84 female students lived at the university dorm, randomly selected and allocated into two groups of 42 with the first group received auriculotherapy (10 sessions) for two menstrual cycles and the second group consumed 40 mg of vitamin B6 daily from a week before their menstruation for two menstrual cycles, after examining the returned questionnaire, researchers filed the following results
1. Both groups showed a significant difference compared to before the intervention
2. Vitamin B6 treated group displayed a mean score of 22.60 (10.87) and 24.17 (14.15), in the first and second cycles in compared to the auriculotherapy group of 26.70 (19.49) and 24.76 (17.07)
3. After considering other risk factors, in comparing the total score of symptoms in the first and second cycles after the intervention, both groups showed no significant difference.

In other word, both vitamin B6 and  auriculotherapic treatment expressed an decreased symptoms of  premenstrual syndrome.

Additionally, in a two-stage double-blind clinical trial conducted on 126 women and randomly allocated into 3 groups to receive magnesium, vitamin B6, or placebo performed in 10 selected health centers in Isfahan and lasted for 4 months, researchers reported that all groups showed a significantly decreased the mean scores of premenstrual syndrome after the intervention.

However, in compared to magnesium treatment group, vitamin B6 and placebo had the most and least efficiency in improving the mean premenstrual syndrome score.

Interestingly, in a double blind randomized controlled carried out on 76 students of Hamadan University of Medical Sciences and randomly allocated to two groups, 38 people in each group either received calcium tablet (500mg) and vitamin B6 (40 mg) or only vitamin B6 twice a day for two consecutive months, researchers indicated that although vitamin B6 alone treatment group expressed some improvement of symptoms pf PMS, but combination of calcium and vitamin B6 are far more better in controlling of the premenstrual syndrome symptoms.

Taking altogether, There is no doubt that vitamin B6 may be recommended as a potential and therapeutic supplement in reduced the severity of symptoms of PMS.




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Sources
(1) Comparing the Effect of Auriculotherapy and Vitamin B6 on the Symptoms of Premenstrual Syndrome among the Students who Lived in the Dorm of Isfahan University of Medical Sciences by Koleini S1, Valiani M2.(PubMed)
(2) Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms by Ebrahimi E1, Khayati Motlagh S1, Nemati S1, Tavakoli Z1(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 8, 2017

All About Vitamins: Vitamin B6 in Improved Infant childhood Neuromotor Activities

By Kyle J. Norton.

Vitamin B6 deficiency may have a strong impact in behavioral effects in child neuro development, a renowned study suggested.
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In animal study to investigate behavioral effects of preweaning pyridoxine deficiency, researchers filed the following results
1. Rat with vitamin B6 deficiency expressed less the body weight in compared to control
2. The vitamin B6 deficiency rat also displayed a delay of supported standing and eye opening
3. Reduced open-field activity reflected by the exploratory score was also observed in vitamin-deficient rats

Dr. Krishna AP, after taking account of other co founders said, "considerable effects of prenatal pyridoxine deficiency were observed in the neonatal pups as stunting of growth and in the delayed onset of neuromotor coordination as well as a low level of open-field activity".

These results reflected the important role of of maternal pyridoxine supplementation during pregnancy in reduced risk of child neuro development abnormality, particularly in neuromotor coordinations.

Other, in the support of the above analysis, researchers at the A.B. Shetty Memorial Institute of Dental Sciences, conducted a review of the effect of preweaning pyridoxine deficiency in induced lower the body weight and brain weight in compared to control found that
1. Vitamin B6 deficiency rat showed a delay of stabilisation of reflex reactions
2. Reaction of these group of rat expressed in maturation of neuromotor coordination also significantly slow

Dr. Krishna AP, the led author said, "This suggests that the importance of maternal pyridoxine supplementation cannot be overlooked in pregnant women especially after prolonged use of anovulatory steroids".

Taking altogether, Oral administrated of vitamin B6 may have a profound effect in reduced risk of 
childhood neuromotor abnormality if taken with recommended dose during pregnancy, particularly in women with prolonged use of anovulatory steroids'.


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Sources
(1) Effect of pyridoxine deficiency on the exploratory behavior of rats by Krishna AP, Ramakrishna T.(PubMed)
(2) Effect of pyridoxine deficiency on maturation of neuromotor coordinations by Krishna AP1, Ramakrishna T.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, November 6, 2017

All About Vitamins" Vitamin B6 in Improved Cognitive Function?

By Kyle J. Norton.

Vitamin B6 may have a therapeutic effect in improved cognitive development of offsring, a Johns Hopkins University School of Hygiene and Public Health study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In the study the effect of vitamin B6 in pregnant and lactating women,  researchers found that recommended dietary allowance of vitamin B6 may have a strong effect in improved cognitive and brain development as the nutrient is an essential cofactor in the developing central nervous system of fetus.

Dr. Guilarte TR, at the study said, " Recent work in animal models suggests that vitamin B6 deficiency during gestation and lactation alters the function of N-methyl-D-aspartate receptors, a subtype of receptors of the glutamatergic neurotransmitter system thought to play an important role in learning and memory".

Other, in the study of nutrient effect on cognitive impairment, patients with AD expressed a 50% deficits of various nutrients, including folic acid, vitamin B12, B6, C, E, A, D, K, beta carotene and omega 3 fatty acids.

Interestingly, In the investigation of whether baseline folate, vitamin B-6, and/or vitamin B-12 intake, alone or in combination, are associated with incident MCI/probable dementia among older women containing 7030 Postmenopausal women free of MCI/probable dementia at baseline in the Women's Health Initiative Memory Study, after carefully examine the returned questionnaire, researchers indicated that vitamin B6 showed no effect in improved symptoms of dementia in this group of women.

Taking together, vitamin B6 may have a profound effect in reduced risk of brain and cognitive abnormality in infant if taken according to recommended doses during pregnant. However, the vitamin does not reduce symptoms in patient with dementia.

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Sources
(1) Vitamin B6 and cognitive development: recent research findings from human and animal studies by Guilarte TR1(PubMed)
(2) Nutrition and cognitive impairment by [Article in Spanish; Abstract available in Spanish from the publisher] by Hernando-Requejo V1.(PubMed)
(3) Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study by Agnew-Blais JC, Wassertheil-Smoller S, Kang JH, Hogan PE, Coker LH, Snetselaar LG, Smoller JW.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thursday, November 2, 2017

All About Vitamins: Vitamin B6 for Treatment of Symptoms of Carpal Tunnel Syndrome?

By Kyle J. Norton.

Vitamin B6  may have a profound effect in reduced symptoms of  Carpal Tunnel Syndrome, an Iran study suggested

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Carpal Tunnel Syndrome is a condition, characterized by numbness, tingling, weakness, or muscle damage in the hand and fingers, as a result of the pressure on the median nerve.

In the study of Forty patients (67 hands) with mild-moderate CTS initially selected and randomly assigned into two groups as follows: 1) Case group with 20 subjects (32 affected hands) receiving vitamin B6 (120 mg/day for 3 months) and splinting. 2) Control group with 19 subjects (35 affected hands) only received splinting, researchers filed the following reports
1. Vitamin B6 treatment group expressed a strong improvement of nocturnal awakening frequency due to pain, daily pain, daily pain frequency, daily pain persistence, hand numbness, hand weakness, hand tingling, severity of nocturnal numbness and tingling, nocturnal awakening frequency owing to hand numbness and tingling, and clumsiness in handling objects. in compared to other groups
2. However, oral administrated vitamin B6 group displayed insignificant result in opening a jam bottle and handling phone in compared to control
3. Vitamin B6 groups also demonstrated an improvement of median nerve sensory latency mean decreased and the median nerve sensory amplitude mean and sensory conduction velocity mean increased.

Dr. Talebi M, the led author said, "vitamin B6 treatment improves clinical symptoms and sensory electrodiagnostic results in CTS patients" and "(it) is recommended for CTS treatment".

Other, in the study of a 42-year-old woman with carpal tunnel syndrome started taking vitamin B6 supplement to relieve her symptoms, researchers indicated that vitamin B6 is often used as a conservative and adjunct therapy for patients with carpal tunnel syndrome, but patients attempted to treat their symptoms with vitamin B6 on their own should be aware that Vitamin B6 at more than 200 mg daily may induce some unpredictable adverse effects.

Dr. Ryan-Harshman M, the led authorsaid, " Vitamin B6 at less than 200 mg daily is not likely to cause any adverse effects, but patients should be monitored for changes in symptoms, particularly when high doses are taken over long periods".

Contrastively, in the Electroencephalogram (EEG) studies to evaluate the role of vitamin B6 as a therapeutic agent in the treatment of carpal tunnel syndrome by monitoring both the standard clinical and electrophysiological parameters for entrapment neuropathy at the wrist, researchers disagreed that vitamin B6 may be sued for treatment of carpal tunnel syndrome, as patients in the tested showed no changes occurred during the treatment period. Motor latency, while the most common screening test for carpal tunnel syndrome, was not significantly changed during the course of treatment.

Taking altogether, Vitamin B6  may have a profound effect in reduced symptoms of  Carpal Tunnel Syndrome, but large sample size and cohost studies are necessary to prove this validity.


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Sources
(1) Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome by Talebi M1, Andalib S, Bakhti S, Ayromlou H, Aghili A, Talebi A.(PubMed)
(2) Carpal tunnel syndrome and vitamin B6 by Ryan-Harshman M1, Aldoori W.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 1, 2017

All About Vitamins: Vitamin B6 for Treatment of inborn errors Epilepsy

By Kyle J. Norton.

Vitamin B6  supplement may have a profound effect in reduced risk of childhood epilepsy, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In concern of inborn errors of metabolism in affecting vitamin B6 concentrations in the brain in induced early-onset epilepsy, without showing hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency researchers at the Chang Gung University found that pyridoxal phosphate (PLP), the active form of vitamin B6 displayed a significant effect in treating patients without the above four disorders.

The study also indicated that patients with pyridoxine phosphate oxidase deficiency also responded to pyridoxal phosphate (PLP) instead of pyridoxine.

DR. Wang HS, the led author said, "patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known" and "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Others, in the support of the about differentiation also postulated that PLP therapy also found to be effective in treatment of all four disorders, but pyridoxine oral intake failed to improved seizures in PNPO deficiency.

However, PLP treatment in epilepsy expressed some adverse effect in severe apnea, therefore  resuscitation equipment should be at hand during a first pyridoxine/PLP administration. 

Interestingly, in he study of four genetic epilepsies with vitamin B6 dependent seizures, particularly, to pyridoxine therapy resistant seizures in the neonatal period with PNPO patients researchers found these patients may need PLP substitution and therapy resistant seizures diagnosed early can prevent irreversible neurologic damage.

Taking altogether, there is no doubt that vitamin B6 in form of pyridoxine and PLP may have a therapeutic effect in treatment childhood epilepsy. But in case of therapy of resistant seizures, substitution of pyridoxine by PLP are always necessary.


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Sources
(1) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(2) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(3) Vitamin B6 dependent seizures by Plecko B1, Stöckler S.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, October 31, 2017

All About Vitamins: Vitamin B6(pyridoxine), the Best in Prevented Hair Loss

By Kyle J. Norton.

Administrated vitamin B6 may have a strong impact in prevented hair loss, a respectable institute study suggested

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Androgenic alopecia hair loss are caused by shrieked the follicles in inducing hair thins and hair receding at the forehead, crown and temple for men and thins over the entire scalp for women.

According to the joint study led by the University of Genova, injection of vitamin B6 (pyridoxine) of 160 or 80 mg/kg body weight/day) used conjunction with chemopreventive treatment against adverse effect caused by doxorubicin in treatment of various types of cancer expressed a significant reduced hair loss in C57BL/6 mice.

In the study of C57BL/6 mice exposed whole-body to environmental cigarette smoke in a smoking machine, assigned to groups received in the diet, at three dose levels, a mixture of L-cystine with vitamin B6 after 6 months of experiment, researchers found that L-Cystine/vitamin B6 treated group displayed a strong effect in inhibited alopecia in a dose-dependent manner.

However, the study also indicated that micronucleated erythrocytes as an Index of Cytogenetic Damage if frequently increased due to continuous exposure ECS may negate treatment with L-cystine/vitamin B6. ECS-induced alopecia and promoted apoptosis of hair bulb cells.

Additionally, in a clinical and trichological examination (trichogram and hair loss evaluation) conducted comparatively before and after the treatment in 46 women between pubescence and 30 years of age with symptoms of diffuse alopecia, given the following adminitration
1. Calcium pantothenate twice a day orally in doses 100 mg for 4-5 months.
2. Vitamin B6 was injected every day (i ampoule intramusculary) for the period of 20 to 30 days and repeated again after 6 month.
researchers at the Katedry i Kliniki Dermatologii Slaskiej Akademii Medycznej w Katowicach reported the results as follows
1. Vitamin B6 administered parenterally expressed a significant improvement in the hair condition in a number of women for a period of several weeks.
2. Vitamin B6 group also reduced the hair loss especially in alopecia of telogenic patomechanism in compared to calcium group

Taking together, there is no doubt that vitamin B6 is effective in reduced hair loss used in conjunction of chemo medicine and alone. high dose of intake should only prescribed by professional doctors.


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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of L-cystine and vitamin B6  by D'Agostini F1, Fiallo P2, Ghio M3, De Flora S4.(PubMed)
(2) Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6 by D'Agostini F1, Fiallo P, Pennisi TM, De Flora S.(PubMed)
(3) [Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women].[Article in Polish]by Brzezińska-Wcisło L1.(PubMed)

Monday, October 30, 2017

All About Vitamins: Vitamin B6 in Reduced Risk and Treatment of Gestational Diabetes?

By Kyle J. Norton.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Vitamin B6 may have a potential effect in controlling blood glucose and plasma insulin in pregnancy with gestational diabetes mellitus, a renowned institute study suggested.

In the study of 13 woman with gestational diabetes mellitus treated with 100 mg. of vitamin B6 per day for 2 weeks than tested with an intravenous glucose tolerance for both blood glucose and plasma insulin levels, researchers filed the following results
1. Vitamin B6 treatment induced a statistically significant improvement in the glucose tolerance in all aspects
2. Vitamin B6 group also enhanced glucose effect with unchanged or lowered plasma insulin level.

After taking into account of other factors, researchers insisted that women with a relative deficiency in vitamin B6 associated with some cases of gestational diabetes mellitus are most beneficial with replacement of this vitamin in improved the metabolic state.

Dr. Spellacy WN, the led author said, "The low vitamin B6levels appear to alter metabolic pathways which result in a lowering of the biologic activity of endogenous insulin".

More interestingly, in a study of 14 pregnant women with gestational diabetes caused by increased xanthurenic-acid synthesis during pregnancy treated with vitamin B6 (pyridoxine) 100 mg/day for 14 days by mouth resaerchers found that
1. Treatment of vitamin B6 not only reduced the deficiency but also improved glucose tolerance considerably.
2. Treatment with vitamin B6 normalized the production of xanthurenic-acid by restoring tryptophan metabolism.

Contrastively, in the investigate the potential simplicity and far-reaching benefits of the amelioration or prevention of gestational diabetes mellitus by pyridoxine, researcher showed that vitamin B6 showed no beneficial effects on abnormal glucose tolerance in pregnancy in 4 cases studied and These studies failed to confirm their results statistically significant in compared to previous studies.

Dr, Perkins RP said, the reason behind these failure may be a result of "the dietary alterations made during pyridoxine therapy in the previous report had a greater effect on outcome than the authors had suspected".

Taking altogether, vitamin B6 administration may have positive effect in reduced symptoms and treatment of gestational diabetes only to vitamin B6 deficient pregnant women. For other use of vitamin B6, particularly in gestational diabetes women without expressing vitamin B6 deficiency,  may require further confirmation of large sample sizes and cohost studies.

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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Vitamin B6 treatment of gestational diabetes mellitus: studies of blood glucose and plasma insulin by Spellacy WN, Buhi WC, Birk SA(PubMed)
(2) Failure of pyridoxine to improve glucose tolerance in gestational diabetes mellitus by Perkins RP.(PubMed)
(3) Improvement of oral glucose tolerance in gestational diabetes by pyridoxine by Bennink HJ, Schreurs WH.(PubMed)