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Friday, August 18, 2017

All About Vitamins: Vitamin B2 In Reduced Risk of Postnatal Depression

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Dietary intake of vitamin B2 and other B vitamin member are associated to the reduced risk of postpartum depression, a Japanese study suggested.

The prevalence of antenatal depression are found as high as 20%, while approximately 12% to 16% of women experience postpartum depression.

Women who consume a typical western diet often expressed an inadequate intakes of n-3, folate, B vitamins including vitamin B2, iron, and calcium in pregnant women inducing depletion of nutrient reserves and increasing risk for maternal depression.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Postpartum depression is depression of a mother following childbirth due to hormone change and other psychological factors, including fatigue.

According to the dietary data obtained during pregnancy from a validated self-administered diet history questionnaire in 865 Japanese women, women with postpartum depression developed found in 121 subjects (14.0%) 2 to 9 months postpartum are associated to lower plasma levels of vitamin B2.

Dr. Miyake Y, the lead researcher said, "Compared with riboflavin intake in the first quartile, only riboflavin consumption in the third quartile was independently related to a decreased risk of postpartum depression (multivariate odds ratio: 0.53, 95% CI: 0.29-0.95, P for trend=0.55)".

Other researchers in the study of longitudinal relationships between maternal red-cell folate status and dietary intakes of vitamins B(6), B(12) and folate before and during pregnancy and subsequent postpartum depressive symptoms, also supported the role of vitamin B2 in reduced risk of symptoms of postnatal depression.

There is no doubt that oral injection of vitamin B2 may have a direct role in reduced risk postnatal depression in women when used conjunction with other micro nutrients or alone, but intake of large amount should be taken with care.


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Sources
(1) Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study by Miyake Y1, Sasaki S, Tanaka K, Yokoyama T, Ohya Y, Fukushima W, Saito K, Ohfuji S, Kiyohara C, Hirota Y; Osaka Maternal and Child Health Study Group(PubMed)
(2) Perinatal depression: prevalence, risks, and the nutrition link--a review of the literature by Leung BM1, Kaplan BJ.(PubMed)

Thursday, August 17, 2017

All About Vitamins: Vitamin B2 Reduced Risk outflow tract defects (OTD) and congenital heart defects (CHDs) in New Born

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Low levels of vitamin B2 during pregnancy may be associated to reproductive outcomes and heart development in new born, a renowned institute study suggested.

According to the McGill University pregnant women with low dietary choline and riboflavin daily are associated to increased new born complications and abnormal heart development.

In a study with female Mthfr(+/+) and Mthfr(+/-) mice fed a control diet (CD), a choline-deficient diet (ChDD), or a riboflavin-deficient diet (RbDD) and then mated with male Mthfr(+/-) mice, RbDD fed mice with diet of riboflavin-deficient diet (RbDD, expressed a higher percentage of delayed embryos and smaller embryos in compared control.

Heart defects,in terms of all ventricular septal defects was also found more in embryos from the ChDD- and RbDD than from the CD- fed females.

Dr. Chan J, the lead author said, " Low dietary choline and riboflavin affects embryonic growth and cardiac development in mice. Adequate choline and riboflavin may also play a role in the prevention of these pregnancy complications in women".

Furthermore, in the study of maternal intake of fat, riboflavin and nicotinamide against risk of having offspring with congenital heart defects, researchers found that riboflavin and nicotinamide are co-enzymes in lipid metabolism in enhancing the embryonic development.

In a case-control family study conducted in 276 mothers of a child with a CHD comprising of 190 outflow tract defects (OTD) and 86 non-outflow tract defects (non-OTD) and 324 control mothers of a non-malformed child, mothers filled out general and food frequency questionnaires at 16 months after the index-pregnancy indicated dietary intakes of riboflavin and nicotinamide were lower in mothers of a child with an OTD than in controls

In fact, low dietary intakes of both riboflavin (<1.20 mg/d) and nicotinamide (<13.5 mg/d) increased more than two-fold the risk of a child with an OTD, particular pregnant women with maternal diet high in saturated fats and low in riboflavin and nicotinamide.

Taking together, women, who reduced in take of saturated fat and increased intake of riboflavin and nicotinamide during pregnancy may have a better outcome in reduced risk of new born with outflow tract defects (OTD) and congenital heart defects (CHDs).


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Sources
(1) Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice by Chan J1, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R.(PubMed)
(2) Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects by Smedts HP1, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, Steegers-Theunissen RP.(PubMed)

Wednesday, August 16, 2017

All About Vitamins: Vitamin B2 Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 as photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation may have a potential efficacy for treatment of breast cancer.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone.

According to the joint study lead by the Moscow Technological University, vitanin B2 induced phototoxicity on human breast adenocarcinoma cells SK-BR-3 with 30 and 60 μM-μM and irradiated with ultraviolet light.

In deed, beside treating breast cancer through photo synthesis, Vitamin B2 and other B vitamin metabolism-important for DNA stability and integrity-may play a role in breast carcinogenesis as breast cancer is associated to levels of plasma folate, riboflavin, vitamin B-6, vitamin B-12, and homocysteine in women.

In a nested case-control study on women aged 35-65 y recruited with a median body mass index of 25.3 kg/m(2) who gave blood samples in 1987-1992 and again in 1993-1998 with breast cancer cases identified by 31 December 2009 individually matched to controls, indicated that breast caner patients is correlated to lower plasma vitamin B-6 and riboflavin.

Dr. Agnoli C, the lead author said, " High plasma riboflavin was associated with significantly lower risk in premenopausal women (RR: 0.45; 95% CI: 0.21, 0.94; highest compared with the lowest quartile, P trend = 0.021). Plasma homocysteine, folate, and vitamin B-12 were not associated with breast cancer risk".

Taking all together, vitamin B2 not only reduced risk of early onset of breast cancer and  can be used as supplement for treatment of breast cancer.


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Sources
(1) Riboflavin photoactivation by upconversion nanoparticles for cancer treatment by Khaydukov EV1, Mironova KE1,2, Semchishen VA1, Generalova AN1,2, Nechaev AV1,3, Khochenkov DA1,4, Stepanova EV4, Lebedev OI5, Zvyagin AV1,6, Deyev SM2, Panchenko VY1.(PubMed)
(2) Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese Cohort by Agnoli C1, Grioni S1, Krogh V2, Pala V1, Allione A3, Matullo G3, Di Gaetano C3, Tagliabue G4, Pedraglio S1, Garrone G1, Cancarini I1, Cavalleri A1, Sieri S1.(PubMed)

Tuesday, August 15, 2017

All About Vitamins: Vitamin B2 Reduced Risk and Symptoms of Depression

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Status of Riboflavin in the blood stream may associate to risk of depression, a renowned study by the  institute proposed.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

According to Jondi-Shapour University of Medical Sciences, patients with depressive symptoms are found to process a elevated levels of serum concentrations of high-sensitive C-reactive protein (hs-CRP) of that indicated lower levels of Riboflavin.

In a cross-sectional study on 98 female clinical nurses, including 45 depressed and 53 nondepressed subjects) using the Beck Depression Inventory in assessed dietary intake of riboflavin using 3-day 24-hour recalls, riboflavin deficiency marginal was more prevalent in depressed subjects.

Dr. Naghashpour M, the lead author said, "(although) higher prevalence of marginal riboflavin deficiency in depressed subjects.... both nondepressed and depressed subjects (addressed) no significant difference between hs-CRP tertiles in dietary intakes of riboflavin, EGRAC, or riboflavin deficiencies".

The promising of the supplement in reduced risk of depression with low cost, prompted a further study of Vitamin B2 in other subjects. 

A cohort of HIV-infected patients conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 y with 26 percent depressed participants (men: 23%; women: 29%), residing in the Kathmandu, Nepal, low intake of riboflavin was associated with an increased risk of depression in women but not in men.

Dr. Poudel-Tandukar K, the lone researcher in the study said, "No clear associations were seen between other B vitamins and depressive symptoms in either sex. Low intake of riboflavin was independently associated with an increased risk of depressive symptoms in all participants and in HIV-infected women".

There is no doubt that intake of vitamin B2 supplement is associated to reduced risk and symptoms of depression but large amount intake should be taken with care.

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Sources
(1) Riboflavin status and its association with serum hs-CRP levels among clinical nurses with depression by Naghashpour M1, Amani R, Nutr R, Nematpour S, Haghighizadeh MH.(PubMed)
(2) Dietary B Vitamins and Depression in Persons with Human Immunodeficiency Virus Infection: The Positive Living with HIV (POLH) Study by Poudel-Tandukar K1.(PubMed)

Monday, August 14, 2017

All About Vitamins: Vitamin B2 Improved Metabolism by Reduced Urinary Dicarboxylic Acids in Autism

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Riboflavin may have a potential effect in children with autism used conjunction with other B vitamin, a recent study suggested by a renowned institute.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Autism is one of the most common forms of brain development disorder and one in 166 child is diagnosed with some forms of autism with weak immune system and auto immune problems.

Children with autism is found to associate to dietary intake of deficiency micronutrients (traditional Mediterranean diet) of dairy and cereal products, and less iodine, sodium, and calcium than their typically developing peers.

According to the University of Valencia, children with autism tended to eating selectively with dietary failed to meet dietary recommendations for thiamin, riboflavin, vitamin C, or calcium... as well as fiber, vitamin E, and sodium.

Dr. Marí-Bauset S, the lead author said, " Results suggest that (1) risk of inadequate intake of some micronutrients in children with autism spectrum disorder and (2) cultural patterns and environment may influence food intake and anthropometric characteristics in autism spectrum disorder".

In the investigation of the potential problems especially connected with energy production, intestinal dysbiosis, and nutritional individuality in autistic children, researchers found that increased urinary dicarboxylic acids showed an important role in reduced nutritional metabolism.
And oral administration of supplements including vitamin B2 ameliorated the production of level of dicarboxylic acids in the urine of autistic children.

The study also indicated before treatment with vitamin B2, levels of succinic, adipic, and suberic acids in the urine of autistic children were 41.47 ± 50.40 μmol/mmol creatinine, 15.61 ± 15.31 μmol/mmol creatinine, 8.02 ± 6.08 μmol/mmol creatinine, but after supplementation, the levels were 9.90 ± 8.26 μmol/mmol creatinine, 2.92 ± 2.41 μmol/mmol creatinine, and 2.57 ± 3.53 μmol/mmol creatinine,

This result demonstrated the efficacy of vitamin B2 in attenuated the levels of urinary dicarboxylic acids in induced symptoms of autism.

Taking together, intake Vitamin B2 combined with other micro nutrients are effective to improve dietary metabolism through ettentiating the levels of Dicarboxylic Acids in Autism.


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Sources
(1) Comparison of nutritional status between children with autism spectrum disorder and typically developing children in the Mediterranean Region (Valencia, Spain) nu Marí-Bauset S1,2, Llopis-González A1,2,3, Zazpe I4,5, Marí-Sanchis A6, Morales Suárez-Varela M1,2,3.(PubMed)
(2) B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children by Kałużna-Czaplińska J1, Socha E, Rynkowski J.(PubMed)

Saturday, August 12, 2017

All About Vitamins: Vitamin B2 in Inflammatory Response

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 may process a potency in reducing obesity-related inflammation, the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Inflammation is a natural expression by immune system in induction of while blood cells for protection our body against infection with foreign organisms and injure.

According to the joint study lead by the Jagiellonian University Medical College, pretreatment with a low dose of riboflavin (10.4-1000 nM) following with lipopolysaccharide stimulation (LPS; 100 ng/mL) affected the pro-inflammatory activity through reduced obesity-related inflammation.

Dr. Mazur-Bialy AI, the lead author said, " riboflavin effectively inhibits the pro-inflammatory activity of adipocyte, the lipocytes and fat cells in stored fat and macrophage in induced against imuune abnormal response to allergens.

Furthermore, riboflavin deficiency is also shown to associate to obese subject induced over expression of pathological pro-inflammatory response of macrophages, the main component of adipose tissues.

In the study of mouse 3T3 L1 preadipocytes differentiated to adipocyte and culture in the state of riboflavindeficiency (3.1nM) or control condition (10.4nM), treatment of riboflavin. reduced a significant elevation in adipocyte lipolysis and obesity-related apoptosis of adipocytes.

The study also found that riboflavin treatment not only decreased the generation of reactive oxygen species by 43% but also inhibited the production of inflammatory cytokins, in riboflavin-deficient subject.

Taking together, obese patients with induction of chronic systemic inflammation accompanied by pro-inflammatory cytokines and fatty acid elevation probably involved many mechanisms, including vitamin B2 deficiency.


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Sources
(1) Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development by Mazur-Bialy AI1, Pocheć E2.(PubMed)
(2) Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development by Mazur-Bialy AI1, Pocheć E2.(PubMed)

Friday, August 11, 2017

All About Vitamins: Vitamin B2 in Physical Activity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Intake of riboflavin supplement accompanied with other nutrients may improve physical function in athletes and active individuals, a renowned institute study suggested.

According to the Arizona State University, on the basis of metabolic studies, young and older women in exercise moderately (2.5-5 h/wk) appears to be poorer of the riboflavin status in periods of exercise, dieting, and dieting plus exercise than during control periods.

Dr. said, Manore MM " Exercise appears to decrease nutrient status even further in active individuals with preexisting marginal vitamin intakes or marginal body stores" and " active individuals who restrict their energy intake or make poor dietary choices are at greatest risk for poor thiamine, riboflavin, and vitamin B-6 status".

Importantly. active individuals should be more careful with body nutritional status for B-vitamin, as decrease of this nutrients not only may reduce the ability to perform exercise but also lower higher levels of exercise intensities.

The study also suggested that examining dietary intakes and nutritional status in active individuals must be related to to physical activity requirement for promoted energy metabolism and cell regeneration.

Dt. Woolf K, the lead author also found, " exercise may increase the requirements for riboflavin and vitamin B-6, while data for folate and vitamin B-12 are limited. Athletes who have poor diets, especially those restricting energy intakes or eliminating food groups from the diet, should consider supplementing with a multivitamin/mineral supplement".

Taking together, there is no doubt that vitamin B2 is important for ensuring the performance of people with moderate and  high levels of physical exercises, but intake of the vitamin should be taken with care.