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Thursday, October 19, 2017

All About Vitamins: Vitamin B5 Deficiency and Risk of Auto immunity

Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid deficiency may have an implicated effect on promoted immune system in production of proinflammatroy status, a renowned institute study suggested.

In the study of vitamin D replacement slowly induced a secondary pantothenic acid deficiency with oral administration of vitamin D + B100 (100mg of all B vitamins except 100mcg of B12 and biotin and 400mcg of folate) to over 1000 neurology patients, researchers found that the vitamin D supplement reduced expression of pro inflammatry cytokins in improved sleep, reduced pain and unexpected resolution of bowel symptoms.

Vitamin D-supplement ameliorated vitamin B5 deficiency also created an intestinal environment that favors the return of the four specific species, Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria through regulating inflammation of intestinal system.

Dr. Gominak SC, also said, "... Improved sleep and more cellular repairs eventually depletes body stores of pantothenic acid, causing reduced cortisol production, increased arthritic pain and widespread "pro-inflammatory" effects on the immune system" and "Pantothenic acid deficiency also decreases available acetylcholine, the neurotransmitter used by the parasympathetic nervous system".

According to Dr. Tautt J. in the experiments carried out to test the length of time necessary to induced vitamin deficiency by removing vitamins from the diet or by giving the rabbits antibiotics of different activity spectrum when the animals kept on a diet without vitamins, said, "(observation by microbiological assay) the time after which changes in vitamin levels developed as well as the intensity of changes differ, depending on the experimental model used, but the sequence of vitamin disappearance from the organism is always the same. The first to disappear were vitamins B1, followed by vitamin B6 and pantothenic acid"

Taking altogether, vitamin B5 deficiency induced by diet deficiency or antibiotics stimulated Immune expression of pro inflammatory cytokins in various types of disease.



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Sources
(1) Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity by Gominak SC1.(PubMed)



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, October 18, 2017

All About Vitamins: Vitamin B5 Improved Intestinal Bacterial Expression

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.


Vitamin B5 deficiecy may have a negative effect in balancing the gut bacterial expression, a recent study suggested.

And, long term PA deficiency may induced weight loss or reduced growth, hair loss and exudation around the eyes, then diarrhea and hindleg paralysis and splenomegaly, and finally death.

According to Dr. Tautt J. in the experiments carried out to test the length of time necessary to induce vitamin deficiency by removing vitamins from the diet or by giving the rabbits antibiotics of different activity spectrum when the animals kept on a diet without vitamins, said, "(observation by microbiological assay) the time after which changes in vitamin levels developed as well as the intensity of changes differ, depending on the experimental model used, but the sequence of vitamin disappearance from the organism is always the same. The first to disappear were vitamins B1, followed by vitamin B6 and pantothenic acid".

Truly, in the evaluated intestinal pantothenic acid (PA) uptake in mice fed diets with high, normal and deficient PA levels researchers found that
1, Treatment of antibitics have a positive effect to reduced intestinal pantothenic acid (PA)
2. Dietary PA levels had no effect on intestinal PA uptake at 5 microM

There fore, the study postulated, " intestinal transporters may be regulated only for vitamins absorbed predominantly by carrier-mediated transport and subject to natural deficiency states."

Taking altogether, there is no doubt that vitamin B5 deficiency caused by environment ethanol and intake of antibiotics may have a significant effect in over exhibition of bacterial expression in  inducing intestinal disorder,


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Sources
(1) Changes in the levels of certain vitamins from B group under conditions of vitamin deficiency by Tautt J.(PubMed)
(2) Do dietary levels of pantothenic acid regulate its intestinal uptake in mice?by Stein ED1, Diamond JM.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, October 17, 2017

All About Vitamins: Vitamin B5 on implication of Brain Acetylcholine

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid may have a profound effect in improved brain activities through influencing function of acetylcholine, neurotransmitter.

Acetylcholine as a neurotransmitter, is a chemical released by nerve cells to send signals to other cells.

In a study to measure brain acetylcholine (ACh) synthesis from precursor [14C]-pyruvate, pantothenic acid (PA) concentration in the brain of rats treated with either ethanol (5-6 g kg-1 body wt daily) alone or ethanol with PA supplementation (100-200 mg kg-1 body wt daily), researchers found that chronic ethanol exposure in rats showed a significant decreased ACh synthesis caused by depleting PA, in negated function of neurotransmitters induced by acetylcholine (ACh).

Other, in the compared 3 studies of rats fed Lieber-DeCarli formula diet with either 5% ethanol or maltose-dextrin (controls) for 19-36 d, researchers filed the following reports
1. The heart pantothenate levels of ethanol-fed rats were 51-78% in compared to control
2. The heart total CoA levels, the precursor of vitamin B5 of ethanol-fed rats were 78-90% in compared to  controls.
3. Liver total CoA and pantothenate levels were lower in ethanol-fed rats than in controls in one and two studies,
4. Rats fed with 0.5-2.5 g ethanol/kg body weight, showed an acute effect of ethanol on pantothenate conversion to CoA in liver.

The result implicated an important result of environment ethanol in reduced levels of brain acetylcholine (ACh) and Total coenzyme A (CoA), thus attenuating brain function in regulating in arousal, attention, memory and motivation.
Taking altogether, there is no doubt that exposure to environment ethanol may have a negative effect the function of motor neurons release  in order to activate muscles in nervous system

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Sources
(1) Effects of acute and chronic ethanol ingestion on pantothenate and CoA status of rats by Israel BC, Smith CM.(PubMed)
(2) Effects of ethanol and pantothenic acid on brain acetylcholine synthesis by Rivera-Calimlim L1, Hartley D, Osterhout D.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, October 16, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) in Reduced Risk Of Non Alcoholic Liver Disease?

By Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5

Vitamin B5 deficiency may have a significant effect in Risk Of Non Alcoholic Liver Disease, a respectable institute study suggested.

In the evaluated methionine-choline deficient (MCD) and Western diet mouse models of NASH, with MCD diet-fed mice treated with pantothenate and N-acetylcysteine or placebo, researcher at the joint study lead by the Duke University Medical Center, suggested that treatment with pantothenate and N-acetylcysteine did not inhibit caspase-2 activation, improve NASH, normalize PANK expression, or restore free CoA levels in MCD diet-fed mice evn though antothenic acid (PaA) is a vitamin fromed an integral part of coenzyme A (CoA).

The result indicated that Pantothenic acid have a insignificant effect in reduced risk and treatment of Nonalcoholic fatty liver disease (NAFLD).

Contrast to the above differentiation, the university of Shiga Prefecture study of PaA deficiency in increased risk of accumulation of tissue fats, with Weaning rats fed the PaA-free diet for 30 d. Rats, then divided into two groups. One group was continuously fed the PaA-free diet, and the other was fed the PaA-containing diet for an additional 13 d, reported the following results
1. Fat accumulated by consuming the PaA-free diet for 30 d was decreased by consuming the PaA-containing diet for an additional 13 d.
2. PaA-free diet feeding elicited much greater accumulation of liver, perinephric, and plasma fats.
3.. Administration of PaA expressed a strong effect in decreased accumulated fat.

Dr. Shibata K, the lead author said, "PaA deficiency causes fat accumulation, and re administration of PaA decreases the tissue fat in rats fed the pantothenic acid-free diet".

Furthermore, in the evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine the role of ketogenesis in preventing diet-induced steatohepatitis, researchers showd that intake of supplementation of the CoASH precursors pantothenic acid and cysteine normalized TCA intermediates and gluconeogenesis in the liver, resulting in ameliorately hepatocyte injury and inflammation, decreased glycemia,.......

In regard to the information collected, further cohost and large sample size studies are necessary to confirm either ways.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model by Machado MV1,2, Kruger L1, Jewell ML1, Michelotti GA1, Pereira Tde A1, Xie G1, Moylan CA1, Diehl AM3.(PubMed)
(2) Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption by Shibata K1, Fukuwatari T, Higashiyama S, Sugita C, Azumano I, Onda M.(PubMed)
(3) Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia by Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA.(PubMed)

Friday, October 13, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) Deficiency in Risk Of Osteoarthritis

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid deficiency may be associated to risk of osteoarthritis, a study by renowned institute suggested.

In the study of 77 osteoarthritis patients assessed biweekly for 12 weeks as part of a multidisciplinary approach to the management of osteoarthritis, nutrient information and food frequency questionnaire returned by patients, showed a significantly correlated between obesity pain from osteoarthritis and vitamins deficiency, particularly vitamin B5.

According to the study, obese osteoarthritis patients may benefit from weight loss if meal were chosen with care to include nutrients in which they are deficient.

Dr. White-O'Connor B, the lead author said, " In addition to providing nutritional recommendations to avoid dietary deficiencies, a registered dietitian can assist in the multidisciplinary treatment of osteoarthritis by providing weight-control counseling and follow-up".

In deed, further differentiation showed that  dietary intake of these group of patients were below 80% of pantothenic acid, the recommended dietary allowance daily. 

Other, in the study of vitamin therapy in the absence of obvious deficiency opinionated that deficiency of vitamin may lead to a specific deficiency syndrome, which may be primary (due to inadequate diet) or secondary (due to malabsorption or to increased metabolic need), and it is rational to use high-dose vitamin supplementation in situations where these clinical conditions exist and vitamin B5 deficiency is associated to increased risk and progression of osteoarthritis.

Dr. Ovesen L. said, "Most of the vitamins have been reported to cause adverse effects when ingested in excessive doses" and "therefore worthwhile to consider the risk-benefit ratio before embarking upon the use of high-dose vitamin supplementation for disorders were proof of efficacy is lacking".

Taking altogether, vitamin B5 deficiency may be one of major factor in increased incidence and progression of osteoarthritis, therefore intake of supplement may be necessary but please consult with your doctor before applying in large doses.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Nutrient intake and obesity in a multidisciplinary assessment of osteoarthritis by White-O'Connor B, Sobal J.(PubMed)

Thursday, October 12, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) Deficiency in Risk Of Hypertension

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Vitamin B5 deficiency may have a profound and positive effect in promoted hypertension, an Asian study postulated.

In the study of endemic pantothenic acid deficiency of some Japanese populations and risk of increased occurrence of hypertension suggested that pantothenic acid deficiency is a factor in the experimental origin of hypertension due to adrenal regeneration, but in most cases, blood samples observations of vitamin B5 expression have largely been ignored.

Dr. Schwabedal PE, ignorance of vitamin B5 deficiency may put many patient of these group at risk of cardiovascular disease due to undiscovered of high blood pressure, one of risk factors of CVD incidence.

Other, in the examined 171 patients with hypertension and coronary heart disease, researchers found that there are association between vitamin decreased as the disease progressed and heart failure supervened.

More interestingly, in the study of Vitamin D and B100 oral administration to 1000 neurology patients with sleep characteristics, pain levels, neurologic symptoms, and bowel complaints were recorded by the author at routine appointments, researchers indicated that oral administrated group showed to improve sleep and more cellular repairs eventually depletes body stores of pantothenic acid, causing reduced cortisol production, and increased sympathetic tone in produced hypertension  and a "hyper-adrenergic" state known to predispose to heart disease and stroke.

Taking together, vitamin B5 deficiency may have a profound effect in increased risk of hypertension, a major risk factor of CVD development.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pantothenic acid deficiency as a factor contributing to the development of hypertension by Schwabedal PE, Pietrzik K, Wittkowski W.(PubMed)
(2) [Pantothenic acid metabolic disorder and its relation to the change in energy processes in patients with ischemic heart disease and hypertension].[Article in Russian] by Borets VM, Ovchinnikov VA, Mironchik VV, Moĭseenok AG, Lis MA.(PubMed)

Wednesday, October 11, 2017

All About Vitamins: Vitamin B5(pantothenic acid) and Oral Contraceptive

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Women, using oral contraceptives agents may have a profound effect in reduced pantothenic acid levels during menstrual cycle, a study by renowned institute suggested.

In a total of 13 young women, ages 19-25, at the beginning and end of a 12-day confined study. 9 women using (+OCA) oral contraceptives and the other 4 were not (-OCA), entered the metabolic unit during the 1st week of their menstrual cycle and fed a constant formula diet containing 2.0 mg thiamin, 3.0 mg riboflavin, and 10 mg pantothenic acid then from 3-day dietary records, subjects were fed with 1/2 of the thiamin, riboflavin, and pantothenic acid levels, researchers found that in compared to the blood urine collected at the beginning, groups treated with +OCA group showed a significantly lower than the -OCA group.

Dr. Lewis CM, the lead author said, "At the beginning of the study, blood and urine pantothenic acid levels were significantly lower in the +OCA group than the -OCA group. These differences were no longer evident by the end of the study".

The expression showed some effects of oral contraceptive in influence to levels of pantothenic acid, but this effect can be controllable through intake of vitamin B5 rich diet during menstrual cycle.


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A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of oral contraceptives agents on thiamin, riboflavin, and pantothenic acid status in young women by Lewis CM, King JC.(PubMed)