The most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunctional, dementia can be Parkinson's, Alzheimer's,... or Huntington's disease.
Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant cause of stroke and vascular dementia.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
Dementia is a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.
There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition and medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.
The most common form of neurodegenerative disease in North America is Alzheimer's disease (AD).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas through the destruction of brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of neurodegenerative diseases, researchers elucidated the effects of sterol β-Sitosterol on the production of platelet Aβ in Alzheimer's disease (AD).
According to the results in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice which were treated with β-Sitosterol for four weeks, * β-Sitosterol treatment improved spatial learning and recognition memory ability, and reduced plaque load in APP/PS1 mice.
* β-Sitosterol treatment reversed dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency.
In other words, β-Sitosterol demonstrated a neuroprotective effect that may offer a novel pharmaceutical agent for the treatment of AD.
Based on the findings, researchers said, " these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition".
Beta-Sitosterol may be considered a remedy for the prevention and treatment of AD, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice by Ye JY1, Li L1, Hao QM1, Qin Y1, Ma CS. (PubMed)
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