Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Friday, August 18, 2017

All About Vitamins: Vitamin B2 In Reduced Risk of Postnatal Depression

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Dietary intake of vitamin B2 and other B vitamin member are associated to the reduced risk of postpartum depression, a Japanese study suggested.

The prevalence of antenatal depression are found as high as 20%, while approximately 12% to 16% of women experience postpartum depression.

Women who consume a typical western diet often expressed an inadequate intakes of n-3, folate, B vitamins including vitamin B2, iron, and calcium in pregnant women inducing depletion of nutrient reserves and increasing risk for maternal depression.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Postpartum depression is depression of a mother following childbirth due to hormone change and other psychological factors, including fatigue.

According to the dietary data obtained during pregnancy from a validated self-administered diet history questionnaire in 865 Japanese women, women with postpartum depression developed found in 121 subjects (14.0%) 2 to 9 months postpartum are associated to lower plasma levels of vitamin B2.

Dr. Miyake Y, the lead researcher said, "Compared with riboflavin intake in the first quartile, only riboflavin consumption in the third quartile was independently related to a decreased risk of postpartum depression (multivariate odds ratio: 0.53, 95% CI: 0.29-0.95, P for trend=0.55)".

Other researchers in the study of longitudinal relationships between maternal red-cell folate status and dietary intakes of vitamins B(6), B(12) and folate before and during pregnancy and subsequent postpartum depressive symptoms, also supported the role of vitamin B2 in reduced risk of symptoms of postnatal depression.

There is no doubt that oral injection of vitamin B2 may have a direct role in reduced risk postnatal depression in women when used conjunction with other micro nutrients or alone, but intake of large amount should be taken with care.


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Sources
(1) Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study by Miyake Y1, Sasaki S, Tanaka K, Yokoyama T, Ohya Y, Fukushima W, Saito K, Ohfuji S, Kiyohara C, Hirota Y; Osaka Maternal and Child Health Study Group(PubMed)
(2) Perinatal depression: prevalence, risks, and the nutrition link--a review of the literature by Leung BM1, Kaplan BJ.(PubMed)

Thursday, August 17, 2017

All About Vitamins: Vitamin B2 Reduced Risk outflow tract defects (OTD) and congenital heart defects (CHDs) in New Born

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Low levels of vitamin B2 during pregnancy may be associated to reproductive outcomes and heart development in new born, a renowned institute study suggested.

According to the McGill University pregnant women with low dietary choline and riboflavin daily are associated to increased new born complications and abnormal heart development.

In a study with female Mthfr(+/+) and Mthfr(+/-) mice fed a control diet (CD), a choline-deficient diet (ChDD), or a riboflavin-deficient diet (RbDD) and then mated with male Mthfr(+/-) mice, RbDD fed mice with diet of riboflavin-deficient diet (RbDD, expressed a higher percentage of delayed embryos and smaller embryos in compared control.

Heart defects,in terms of all ventricular septal defects was also found more in embryos from the ChDD- and RbDD than from the CD- fed females.

Dr. Chan J, the lead author said, " Low dietary choline and riboflavin affects embryonic growth and cardiac development in mice. Adequate choline and riboflavin may also play a role in the prevention of these pregnancy complications in women".

Furthermore, in the study of maternal intake of fat, riboflavin and nicotinamide against risk of having offspring with congenital heart defects, researchers found that riboflavin and nicotinamide are co-enzymes in lipid metabolism in enhancing the embryonic development.

In a case-control family study conducted in 276 mothers of a child with a CHD comprising of 190 outflow tract defects (OTD) and 86 non-outflow tract defects (non-OTD) and 324 control mothers of a non-malformed child, mothers filled out general and food frequency questionnaires at 16 months after the index-pregnancy indicated dietary intakes of riboflavin and nicotinamide were lower in mothers of a child with an OTD than in controls

In fact, low dietary intakes of both riboflavin (<1.20 mg/d) and nicotinamide (<13.5 mg/d) increased more than two-fold the risk of a child with an OTD, particular pregnant women with maternal diet high in saturated fats and low in riboflavin and nicotinamide.

Taking together, women, who reduced in take of saturated fat and increased intake of riboflavin and nicotinamide during pregnancy may have a better outcome in reduced risk of new born with outflow tract defects (OTD) and congenital heart defects (CHDs).


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Sources
(1) Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice by Chan J1, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R.(PubMed)
(2) Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects by Smedts HP1, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, Steegers-Theunissen RP.(PubMed)

Wednesday, August 16, 2017

All About Vitamins: Vitamin B2 Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 as photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation may have a potential efficacy for treatment of breast cancer.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone.

According to the joint study lead by the Moscow Technological University, vitanin B2 induced phototoxicity on human breast adenocarcinoma cells SK-BR-3 with 30 and 60 μM-μM and irradiated with ultraviolet light.

In deed, beside treating breast cancer through photo synthesis, Vitamin B2 and other B vitamin metabolism-important for DNA stability and integrity-may play a role in breast carcinogenesis as breast cancer is associated to levels of plasma folate, riboflavin, vitamin B-6, vitamin B-12, and homocysteine in women.

In a nested case-control study on women aged 35-65 y recruited with a median body mass index of 25.3 kg/m(2) who gave blood samples in 1987-1992 and again in 1993-1998 with breast cancer cases identified by 31 December 2009 individually matched to controls, indicated that breast caner patients is correlated to lower plasma vitamin B-6 and riboflavin.

Dr. Agnoli C, the lead author said, " High plasma riboflavin was associated with significantly lower risk in premenopausal women (RR: 0.45; 95% CI: 0.21, 0.94; highest compared with the lowest quartile, P trend = 0.021). Plasma homocysteine, folate, and vitamin B-12 were not associated with breast cancer risk".

Taking all together, vitamin B2 not only reduced risk of early onset of breast cancer and  can be used as supplement for treatment of breast cancer.


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Sources
(1) Riboflavin photoactivation by upconversion nanoparticles for cancer treatment by Khaydukov EV1, Mironova KE1,2, Semchishen VA1, Generalova AN1,2, Nechaev AV1,3, Khochenkov DA1,4, Stepanova EV4, Lebedev OI5, Zvyagin AV1,6, Deyev SM2, Panchenko VY1.(PubMed)
(2) Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese Cohort by Agnoli C1, Grioni S1, Krogh V2, Pala V1, Allione A3, Matullo G3, Di Gaetano C3, Tagliabue G4, Pedraglio S1, Garrone G1, Cancarini I1, Cavalleri A1, Sieri S1.(PubMed)

Tuesday, August 15, 2017

All About Vitamins: Vitamin B2 Reduced Risk and Symptoms of Depression

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Status of Riboflavin in the blood stream may associate to risk of depression, a renowned study by the  institute proposed.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

According to Jondi-Shapour University of Medical Sciences, patients with depressive symptoms are found to process a elevated levels of serum concentrations of high-sensitive C-reactive protein (hs-CRP) of that indicated lower levels of Riboflavin.

In a cross-sectional study on 98 female clinical nurses, including 45 depressed and 53 nondepressed subjects) using the Beck Depression Inventory in assessed dietary intake of riboflavin using 3-day 24-hour recalls, riboflavin deficiency marginal was more prevalent in depressed subjects.

Dr. Naghashpour M, the lead author said, "(although) higher prevalence of marginal riboflavin deficiency in depressed subjects.... both nondepressed and depressed subjects (addressed) no significant difference between hs-CRP tertiles in dietary intakes of riboflavin, EGRAC, or riboflavin deficiencies".

The promising of the supplement in reduced risk of depression with low cost, prompted a further study of Vitamin B2 in other subjects. 

A cohort of HIV-infected patients conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 y with 26 percent depressed participants (men: 23%; women: 29%), residing in the Kathmandu, Nepal, low intake of riboflavin was associated with an increased risk of depression in women but not in men.

Dr. Poudel-Tandukar K, the lone researcher in the study said, "No clear associations were seen between other B vitamins and depressive symptoms in either sex. Low intake of riboflavin was independently associated with an increased risk of depressive symptoms in all participants and in HIV-infected women".

There is no doubt that intake of vitamin B2 supplement is associated to reduced risk and symptoms of depression but large amount intake should be taken with care.

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Sources
(1) Riboflavin status and its association with serum hs-CRP levels among clinical nurses with depression by Naghashpour M1, Amani R, Nutr R, Nematpour S, Haghighizadeh MH.(PubMed)
(2) Dietary B Vitamins and Depression in Persons with Human Immunodeficiency Virus Infection: The Positive Living with HIV (POLH) Study by Poudel-Tandukar K1.(PubMed)

Monday, August 14, 2017

All About Vitamins: Vitamin B2 Improved Metabolism by Reduced Urinary Dicarboxylic Acids in Autism

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Riboflavin may have a potential effect in children with autism used conjunction with other B vitamin, a recent study suggested by a renowned institute.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Autism is one of the most common forms of brain development disorder and one in 166 child is diagnosed with some forms of autism with weak immune system and auto immune problems.

Children with autism is found to associate to dietary intake of deficiency micronutrients (traditional Mediterranean diet) of dairy and cereal products, and less iodine, sodium, and calcium than their typically developing peers.

According to the University of Valencia, children with autism tended to eating selectively with dietary failed to meet dietary recommendations for thiamin, riboflavin, vitamin C, or calcium... as well as fiber, vitamin E, and sodium.

Dr. Marí-Bauset S, the lead author said, " Results suggest that (1) risk of inadequate intake of some micronutrients in children with autism spectrum disorder and (2) cultural patterns and environment may influence food intake and anthropometric characteristics in autism spectrum disorder".

In the investigation of the potential problems especially connected with energy production, intestinal dysbiosis, and nutritional individuality in autistic children, researchers found that increased urinary dicarboxylic acids showed an important role in reduced nutritional metabolism.
And oral administration of supplements including vitamin B2 ameliorated the production of level of dicarboxylic acids in the urine of autistic children.

The study also indicated before treatment with vitamin B2, levels of succinic, adipic, and suberic acids in the urine of autistic children were 41.47 ± 50.40 μmol/mmol creatinine, 15.61 ± 15.31 μmol/mmol creatinine, 8.02 ± 6.08 μmol/mmol creatinine, but after supplementation, the levels were 9.90 ± 8.26 μmol/mmol creatinine, 2.92 ± 2.41 μmol/mmol creatinine, and 2.57 ± 3.53 μmol/mmol creatinine,

This result demonstrated the efficacy of vitamin B2 in attenuated the levels of urinary dicarboxylic acids in induced symptoms of autism.

Taking together, intake Vitamin B2 combined with other micro nutrients are effective to improve dietary metabolism through ettentiating the levels of Dicarboxylic Acids in Autism.


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Sources
(1) Comparison of nutritional status between children with autism spectrum disorder and typically developing children in the Mediterranean Region (Valencia, Spain) nu Marí-Bauset S1,2, Llopis-González A1,2,3, Zazpe I4,5, Marí-Sanchis A6, Morales Suárez-Varela M1,2,3.(PubMed)
(2) B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children by Kałużna-Czaplińska J1, Socha E, Rynkowski J.(PubMed)

Saturday, August 12, 2017

All About Vitamins: Vitamin B2 in Inflammatory Response

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 may process a potency in reducing obesity-related inflammation, the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Inflammation is a natural expression by immune system in induction of while blood cells for protection our body against infection with foreign organisms and injure.

According to the joint study lead by the Jagiellonian University Medical College, pretreatment with a low dose of riboflavin (10.4-1000 nM) following with lipopolysaccharide stimulation (LPS; 100 ng/mL) affected the pro-inflammatory activity through reduced obesity-related inflammation.

Dr. Mazur-Bialy AI, the lead author said, " riboflavin effectively inhibits the pro-inflammatory activity of adipocyte, the lipocytes and fat cells in stored fat and macrophage in induced against imuune abnormal response to allergens.

Furthermore, riboflavin deficiency is also shown to associate to obese subject induced over expression of pathological pro-inflammatory response of macrophages, the main component of adipose tissues.

In the study of mouse 3T3 L1 preadipocytes differentiated to adipocyte and culture in the state of riboflavindeficiency (3.1nM) or control condition (10.4nM), treatment of riboflavin. reduced a significant elevation in adipocyte lipolysis and obesity-related apoptosis of adipocytes.

The study also found that riboflavin treatment not only decreased the generation of reactive oxygen species by 43% but also inhibited the production of inflammatory cytokins, in riboflavin-deficient subject.

Taking together, obese patients with induction of chronic systemic inflammation accompanied by pro-inflammatory cytokines and fatty acid elevation probably involved many mechanisms, including vitamin B2 deficiency.


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Sources
(1) Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development by Mazur-Bialy AI1, Pocheć E2.(PubMed)
(2) Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development by Mazur-Bialy AI1, Pocheć E2.(PubMed)

Friday, August 11, 2017

All About Vitamins: Vitamin B2 in Physical Activity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Intake of riboflavin supplement accompanied with other nutrients may improve physical function in athletes and active individuals, a renowned institute study suggested.

According to the Arizona State University, on the basis of metabolic studies, young and older women in exercise moderately (2.5-5 h/wk) appears to be poorer of the riboflavin status in periods of exercise, dieting, and dieting plus exercise than during control periods.

Dr. said, Manore MM " Exercise appears to decrease nutrient status even further in active individuals with preexisting marginal vitamin intakes or marginal body stores" and " active individuals who restrict their energy intake or make poor dietary choices are at greatest risk for poor thiamine, riboflavin, and vitamin B-6 status".

Importantly. active individuals should be more careful with body nutritional status for B-vitamin, as decrease of this nutrients not only may reduce the ability to perform exercise but also lower higher levels of exercise intensities.

The study also suggested that examining dietary intakes and nutritional status in active individuals must be related to to physical activity requirement for promoted energy metabolism and cell regeneration.

Dt. Woolf K, the lead author also found, " exercise may increase the requirements for riboflavin and vitamin B-6, while data for folate and vitamin B-12 are limited. Athletes who have poor diets, especially those restricting energy intakes or eliminating food groups from the diet, should consider supplementing with a multivitamin/mineral supplement".

Taking together, there is no doubt that vitamin B2 is important for ensuring the performance of people with moderate and  high levels of physical exercises, but intake of the vitamin should be taken with care.

Thursday, August 10, 2017

All About Vitamins: Vitamin B2 and Psychomotor function

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Intake of supplement Riboflavin accompanied other nutrients may contribute to improve mental performance, a study suggested.

In a study of 290 children in six classroom sections from a public school in Manila examined by measurement of urinary iodine excretion (UIE) and thyroid palpation showed that levels of energy, protein, thiamin, and riboflavin, iodized salt intake correlated to the variance in deficient and adequate mental performance.

According to the Food and Nutrition Research Institute, higher class median of non-iodine deficient was associated to the better psychomotor and cognitive performance in children.

Dr. Amarra MS, the lead author said, "Longer-term factors that can contribute to improved performance are achievement of normal iodine status and elimination of protein-energy malnutrition".

More importantly, riboflavin treatment of 100 mg/d not only increased residual activity but also promoted his cognitive and motor performance partially in a patient with L-2-hydroxyglutaric aciduria (LHGuria), a rare neurometabolic disorder.

Additionally, the study also intake of higher levels ofriboflavin 200mg/d, provided further The improvement but not higher.

Taking together, riboflavin could be considered as a potential therapeutic approach in patient of in LHGuria to improved psychomotor and cognitive performance used alone or combination with other nutrients for children with iodine deficiency.

Wednesday, August 9, 2017

All About Vitamins: High Dose of Vitamin B2 for Treatment of Defective Gene ACAD9

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

High dose of supplement of riboflavin may have a beneficiary effect for patients with gene ACAD9 defected, a renowned institute reported.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Gene ACAD9 provides function of making enzyme in the mitochondria, by converting oxygen and nutrients to energy involved structures inside cells.

In a reported study, high dose of  riboflavin treatment of a 13-year-old boy reduced symptoms of exercise intolerance, weakness, and mild psychomotor delay and muscle histochemistry with severe complex I deficiency due to mitochondrial proliferation caused by ACAD9 defected

According to the Clinical Genomics Unit, Maastricht University, oxidative phosphorylation defect due to ACAD9 defected, decreased function in production and modification of the enzymes, including arginine-532 into tryptophan, induced mitochondrial complex I deficiency.

More importantly, the study also found that mutation of gene to activate protein in production of enzymes is found to be absent in 188 ethnically matched healthy controls.

Dr. Gerards M, the lead author said,"Protein modelling suggested a functional effect due to the loss of a stabilizing hydrogen bond in an α-helix and a local flexibility change. " and
"fibroblasts of patients with wild-type and mutant ACAD9. Wild-type, but not mutant, ACAD9 restored complex I activity".

The astonished findings suggested that gene expression may become important for further studies as ACAD9 defected in complex I function can be improved by intake of high dose of Vitamin B2.


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Sources
(1) Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defectiveACAD9: new function for an old gene by Gerards M1, van den Bosch BJ, Danhauser K, Serre V, van Weeghel M, Wanders RJ, Nicolaes GA, Sluiter W, Schoonderwoerd K, Scholte HR, Prokisch H, Rötig A, de Coo IF, Smeets HJ.(PubMed)
(2) Garone C, Donati MA, Sacchini M, et al. Mitochondrial encephalomyopathy due to a novel mutation in ACAD9. JAMA Neurol. 2013;70(9):1177–1179. [PubMed]

Tuesday, August 8, 2017

All About Vitamins: Vitamin B2 reduced Risk of in Insulin Resistance in Obesity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 deficiency may be associate to the development.of insulin resistance induced by the expression of pro-inflammatory activity of adipocyte the lipocytes and fat cells in obesity, the respectable institute study suggested.

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Insulin resistance is the early stage of diabetes, affecting the levels of blood glucose in induced risk of developing heart disease.

In the study of the mouse 3T3 L1 preadipocytes differentiated to adipocyte and culture in the state of riboflavin deficiency (3.1nM) or control condition (10.4nM), treatment with vitamin B2 supplement improved mRNA expression in ameliorated pro-inflammatory cytokines (TNFα, IL-6) and adipokines functions in increased insulin resistance.

Dr. Mazur-Bialy AI, the lead author said, "in an obesity state, it participates in the induction of chronic systemic inflammation accompanied by pro-inflammatory cytokines and fatty acid elevation..... involved in, e.g., insulin resistance, type 2 diabetes or hyperlipidemia development".

Furthermore, in obese patients, a low dose of riboflavin (10.4-1000 nM) treatment attenuated the pro-inflammatory activity of adipocyte-macrophage expression in promoted obesity-related inflammation, the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis, according to the joint study lead by the Jagiellonian University Medical College.

Additionally, in animals induced hyperglycaemia by injection of streptozotocin, riboflavin supplementation improved the activity pancreas islet FAD-glycerophosphate dehydrogenase in glucose utilization as well as inhibited B-cell dysfunction in text subjects.

The study also found that the efficacy of vitamin B12 in reduced blood glucose with out affected the enzymic defect of the syndrome.
Taking together, there is no doubt that vitamin B2 has played an important role in reduced risk of insulin resistance in the early onset of metabolic syndrome, including diabetes, heart disease.



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Sources
(1) Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development by Mazur-Bialy AI1, Pocheć E2.(PubMed)
(2) Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development by Mazur-Bialy AI1, Pocheć E2.(PubMed)
(3)  Streptozotocin-induced FAD-glycerophosphate dehydrogenase suppression in pancreatic islets. Relationship with the severity and duration of hyperglycaemia and resistance to insulin or riboflavin treatment by Rasschaert J1, Malaisse WJ.(PubMed)

Friday, August 4, 2017

All About Vitamins: The Effects of Vitamin B2 In Migraine Headache

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recent study suggested that intake of Riboflavin may be an effective prophylactic therapy for the prevention of migraines.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.
Migraine headache is one most common headaches defined as condition of chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes and affected over 15% of the population in US alone, as a result of the change in the brain and its surrounding blood vessels.

According to the Southwestern Oklahoma State University, in the review of all data dates 1966-2016 using the search terms: riboflavin and migraine disorders, 5 clinical trials show a consistent positive therapeutic effect in adults and  four clinical trials show a mixed effect in paediatric and adolescent patients.

Dr. Thompson DF, the lead author said, "Riboflavin is well tolerated, inexpensive and has demonstrated efficacy in the reduction of adult patient's migraine headache frequency"

Other study revealed that Low serum of vitamin B2 is associated mitochondrial dysfunction and have a serious effect in induced migraine pathogenesis.

Supplementation vitamin B2 administrated in adults exhibited a strong properties in reducing the frequency and duration of migraine attacks with no serious side effects.

Furthermore, although riboflavin is a safe and well-tolerated supplement in preventing migraine symptoms, such as nausea, photophobia, vomiting, and sensitivity to light in adults, further studies are necessary to recommend vitamin B2 as an adjunct therapy in adults and children with migraine.


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Sources
(1) Prophylaxis of migraine headaches with riboflavin: A systematic review by Thompson DF1, Saluja HS1.(PubMed)
(2) Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review by Namazi N1, Heshmati J2, Tarighat-Esfanjani A3.(PubMed)

Thursday, August 3, 2017

All About Vitamins: The Effects of Vitamin B2 in Inflammatory Diseases

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B2 (Riboflavin), in a murine model. showed to reduced risk of development of gastrointestinal inflammatory diseases, a renowned institute suggested.

According to the joint study lead by the Universidad Nacional de Tucumán, vitamin B2 produced by strains of lactic acid bacteria (LAB) enhance the function of the gastrointestinal tract in reduced risk of inflammatory diseases, such as colitis and inflammatory bowel diseases (IBD).

Dr. Levit R, the lead researcher said, " Mice that received soymilk fermented by (Stimulating production of Riboflavin) Produced L. plantarum CRL 2130, showed a decrease in weight loss, lower damage scores in their large intestines, lower microbial translocation to liver and decreased cytokines levels in their intestinal fluids"..."in a trinitrobenzene sulfonic induced colitis mouse model".

Other study in the probiotic ability of riboflavin-overproducing Lactobacillus strains, Lactobacillus plantarum and Lactobacillus fermentum strains, have a potential in induced overproducing riboflavin, in simulating gastrointestinal system in exhibited the probiotic ability in ameliorated the growth of pathogenic microbial strains.

The study also reveals that these Lactobacillus stains may consist a promising probiotic properties which can be development of novel functional food which would be both enriched in riboflavin and induce additional health benefits.

With all information collected above, Vitamin B2, no doubt is a good candidate for use as therapeutic
agent for enhancing gastrointestine function against early forming of inflammatory diseases.


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Sources
(1) Evaluation of the effect of soymilk fermented by a riboflavin-producing Lactobacillus plantarum strain in a murine model of colitis by Levit R1, de Giori GS1,2, de Moreno de LeBlanc A1, LeBlanc JG1.(PubMed)
(2) Probiotic abilities of riboflavin-overproducing Lactobacillus strains: a novel promising application of probiotics by Arena MP1, Russo P, Capozzi V, López P, Fiocco D, Spano G.(PubMed)

Wednesday, August 2, 2017

All about Vitamins: Vitamin B2, A Neuroprotective Vitamin

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Vitamin B2 may process an neuroprotective effect against neurological disability in the early stage of dementia

In the study of C57BL/6 female mice (n=56) dived into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), healthy mice receiving PBS and riboflavin; sham treatment 1 (ST1), EAE mice receiving water; sham treatment 2 (ST2), EAE mice receiving sodium acetate buffer; treatment 1 (T1), EAE mice receiving interferon beta-1a (INFβ-1a); treatment 2 (T2), EAE mice receiving riboflavin; treatment 3 (T3), EAE mice receiving INFβ-1a and riboflavin, mice treated with vitamin B2 showed an increased the expression and protein levels in brain-derived neurotrophic factor (BDNF), involved canonical nerve growth compared with the other groups.

The study also found that in daily clinical score, neurological disability was reduced significantly by riboflavinneurological disability compared with that of the controls (P<0.05), through mediation of involved immune response.

In support of the above analysis, Dr. Tripathi AK in the study of "attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro" said," RF pretreatment significantly inhibited cell death and reduced (Lactate Dehydrogenase/secretion) LDH secretion in turning sugar into energy for the cells, compared to that of the UV-B-RF ".

The study also suggested that riboflavin under UV-B irradiation is seen as a modulator of neuroprotective signaling pathway compared RF treated group.

Tuesday, August 1, 2017

All About Vitamins: Thiamine Antimicrobial Activity

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recent study suggested that thiamine process an anti microbial effect through increased antioxidant and immunomodutaroy actions.

Vitamin B1 is one of the members of the vitamin B complex, known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS,  discovered in 1910 by Umetaro Suzuki in Japan. The vitamin is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

 Antimicrobial Activity is the expression of immune system in inhibited the microbial organisms in induced infection and inflammation due to injure or tissues damage.

According to the joint study lead by the United States Department of Agriculture - Agricultural Research Service Wyndmoor, thiamine Dilauryl Sulfate(TD) showed a significant effects against pathogenic Salmonella spp. and Listeria spp and Candida bombicola.

In Gram-positive Listeriaspp, TDS with an initial concentration of 7.2 log CFU/mL reduced the population of Gram-negative Salmonella spp. Listeria, shinficantly.

Dr. Zhang X the lead author said," TDS was more effective than the SLs against Salmonella and Listeria spp. Scanning electron microscopy and transmission electron microscopy images showed that....TDS damaged Listeria cell membranes and resulted in cell lysis".

In support of the above differentiation, Thiamine dilaurylsulphate (TLS), in the study of effect on apple juice and sterilised milk, had strong growth-inhibitory effects on Gram-positive bacteria, yeasts, and moulds, but had weak inhibitory effects on Gram-negative bacteria such as Escherichia coli.

Also, the formulation containing TLS showed no significant difference in apple juice (pH 3.98) in compared to milk in anti bacterial activities.

Taking together, thiamine may be added to formula as a preservative, to ensure food safety.


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Sources
(1) Inactivation of Salmonella spp. and Listeria spp. by Palmitic, Stearic, and Oleic Acid Sophorolipids and Thiamine Dilauryl Sulfate by Zhang X1, Ashby R2, Solaiman DK2, Uknalis J2, Fan X2.(PubMed)
(2) A novel formulation of thiamine dilaurylsulphate and its preservative effect on apple juice and sterilised milk by Wei L1, Cheng J1, Meng Y2, Ren Y1, Deng H1, Guo Y1.(PubMed)

Monday, July 31, 2017

All About Vitamins: The Effects of Vitamin B2 In Reduced Risk of Congenital Heart Defects in Offspring

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Levels of Riboflavin may be associated to risk in developed  congenital heart defects in offspring, a recent study suggested.

In a total of 276 mothers of a child with a CHD in case-control family study, comprising of 190 outflow tract defects (OTD) and 86 non-outflow tract defects (non-OTD) and 324 control mothers of a non-malformed child, in mothers filled out general and food frequency questionnaires at 16 months after the index-pregnancy, maternal diet high in saturated fats and low in riboflavin and nicotinamide seems to contribute to CHD risk, in particular OTDs.

The study also found that mother who had a low dietary intakes of both riboflavin (<1.20 mg/d) and nicotinamide (<13.5 mg/d) expressed the increased more than two-fold the risk of a child with an OTD,

Dr. Smedts HP, the lead author said," mothers of a child with OTD, had higher dietary intakes of saturated fat, 30.9 vs. 29.8 g/d; P < 0.05. Dietary intakes of riboflavin and nicotinamide were lower in mothers of a child with an OTD than in controls (1.32 vs. 1.41 mg/d; P < 0.05 and 14.6 vs. 15.1 mg/d; P < 0.05, respectively)".

Although vitamin B2 plays an important role in reduced risk in developed congenital heart defects, other research suggested that diet low in vitamin B12 and imbalance in the maternal intake of proteins and low folate intake may also associate with an increased risk of a child with a CHD, according to the study of 192 mothers of a child with a CHD and 216 mothers of a healthy child. filling out food frequency questionnaires covering the current dietary intake.

Other study suggested that maternal diet high in saturated fats and low in riboflavin and nicotinamide seems to contribute to CHD risk, in particular OTDs.

Therefore, vitamin B2, may be associated to reduce risk of congenital heart defects, other nutrients factors should also be taken into account as well.


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Sources
(1) Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects by Smedts HP1, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, Steegers-Theunissen RP.(PubMed)
(2) Dietary intake of B-vitamins in mothers born a child with a congenital heart defect by Verkleij-Hagoort AC1, de Vries JH, Ursem NT, de Jonge R, Hop WC, Steegers-Theunissen RP.(PubMed)
(3) Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects by Smedts HP1, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, Steegers-Theunissen RP.(PubMed)

Friday, July 28, 2017

All About Vitamins: Thiamine in Reduced Risk of Vascular Disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

The association of thiamine deficiency among diabetes mellitus without treatment may increased risk of vascular disease involving blood vessels – the arteries and veins of the circulatory system.

According to the Queen Alexandra Hospital, thiamine deficiency may lead to hyperglycaemic-induced damage, affecting vascular disease in promoting cardiovascular risk.

In a study of diabetic patients (26 type 1 and 48 type 2) with and without microalbuminuria and 20 normal healthy control volunteers, researchers found that decrease plasma volumes are associated to patients with diabetes as shown in the scale. Patient with diabetes showed a plasma thiamine concentration decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients in compared to normal volunteers.
Diabetic patients also showed an increased urinary excretion of thiamine, which may be a leading cause of thiamine deficiency.

Dr. Thornalley PJ, the lead author said, "low plasma thiamine concentration is prevalent in patients with type 1 and type 2 diabetes, associated with increased thiamine clearance".

Taking altogether, low plasma thiamine concentration in diabetic patients showed to increased risk of vascular disease. Intake of high dose thiamine may be beneficiary to dysfunction of intracellular transport or enzymatic abnormalities in ameliorate the development of vascular dysfunction in inducing stroke.


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Sources
(1) Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease by Page GL1, Laight D, Cummings MH.(PubMed)
(2) High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease by Thornalley PJ1, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW.(PubMed)
(3) High-dose thiamine improves fatigue after stroke: a report of three cases by Costantini A1, Pala MI, Catalano ML, Notarangelo C, Careddu P.(PubMed)

Thursday, July 27, 2017

All About Vitamins: Thiamine and Parkinson Disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Thiamine deficiency and dysfunction of thiamine-dependent is found to associate of the development and progression of Parkinson Disease.

According to the Villa Immacolata Clini, administration of high-dose thiamine was effective in reversing motor and nonmotor symptoms, in the patients with PD.

In the recruited 50 patients with PD (33 men and 17 women; mean age, 70.4 ± 12.9 years; mean disease duration, 7.3 ± 6.7 years) with 100 mg of thiamine administered intramuscularly twice a week, without any change to personal therapy, thiamine group showed a significant improvement of symptoms of PD, reduced selective neural damage in the centers and provoking neurodegeneration.
And the re-evaluated after 1 month and then every 3 months during treatment showed a clinical stable improvement over time in all the patients.

Other study suggested that high dose of thiamine as initial treatment may attenuated motor and non-motor deficits of patients with PD.

A recruited three patients with newly diagnosed PD who are not involved in anti-Parkinson's therapy. with Plasmatic thiamine within healthy reference range study, therapy with high doses of thiamine showed a considerable improvement in the motor part of the Unified Parkinson's Disease Rating Scale(UPDRS) ranging from 31.3% to 77.3% which is considered as impotant levels in reduced risk of selective neuronal damage caused by thiamine deficiency due to a dysfunction of thiamine metabolism.

In support to the above analysis, researchers at the Vietnamese American Medical Research Foundation insisted that thiamine supplement can act through a number of non-genomic mechanisms that include protein expression, oxidative stress, inflammation which may link to development of PD.
Taking together, elevated thiamine levels might provide protection against PD, but using high doses can only be prescribed by profession medical doctors.

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Sources
(1) Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study by Costantini A1, Pala MI1, Grossi E2, Mondonico S3, Cardelli LE4, Jenner C1, Proietti S1, Colangeli M5, Fancellu R6.(PubMed)
(2) High-dose thiamine as initial treatment for Parkinson's disease by Costantini A1, Pala MI, Compagnoni L, Colangeli M.(PubMed)
(3) Thiamine and Parkinson's disease by Lu'o'ng Kv1, Nguyên LT.(PubMed)

Wednesday, July 26, 2017

All About Vitamins: Thiamine in Reduced Risk of Complications and Treatment of Type II diabetes

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Diabetes is a condition caused by insufficient insulin entering the bloodstream in regulating the glucose. The disease is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Thiamine therapy induced a significant change of protein functions in reduced symptoms and complications in patients with Type II diabetes, a study by renowned Institute suggested.

In a double-blind, randomised trial, where 12 hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes mellitus) received both placebo and thiamine capsules (3 × 100 mg/day) for six weeks in a cross-over manner, high dosed vitamin group showed a significant effects on the blood pressure of individuals with hyperglycemia at early stages, and prevention of vascular complications.

Furthermore,  high-dose thiamine supplementation also displayed an impact on glucose tolerance in patients with impaired glucose metabolism.

Dr. Alaei Shahmiri F, the lead researcher on the study said, " supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with impaired glucose regulation"

Further study also suggested that increase supplement intake may reduce risk thiamine deficiency in the diabetic population and ameliorate the early sign of diabetic kidney disease and improve lipid profile.

Taking altogether, intake of thiamine should have a potential effect in reduced risk of complications and treatment of Type II diabetic patients, pending to further studies.

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Sources
(1) Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 by Riaz S1.(PubMed)
(2) The impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trial by Alaei-Shahmiri F1, Soares MJ2, Zhao Y2, Sherriff J2.(PubMed)

Tuesday, July 25, 2017

All About Vitamins: Thiamine Reduced Risk of Oxidative Stress

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Oxidative stress is essentially an imbalance between the production of free radicals and levels of antioxidant, which plays an important role in neutralized the domino's process causes of varies diseases.

Thiamine deficiency induced production of oxidative stress has found to associate to the development of structural lesions, including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, the renowned institute study suggested.

According to the joint study lead by the University of Liege, thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). 

In C57BL6/J mice with predator stress for 5 consecutive nights, new born babies showed a significant abnormality of brain lesion of immature neurons but the recovery of this process is promptly reduced when the mice were treated (200mg/kg/day in drinking water for 20days) with thiamine or benfotiamine.

The study also suggested that reverse of brain immature neuron is the result of function of thiamine and thiamine derivative in protected the brain tissues against paraquat-induced oxidative stress.

Furthermore, thiamine compounds function in boosting anti-oxidant cellular defenses of the test subjects may also express through the prevention of stress-induced inhibition of hippocampal neurogenesis and accompanying physiological changes.

Taking together, thiamine and benfotiamine, a derivative of thiamine have played an important role in the development of brain neurons of the new born and prevention of oxidative stress in induction of brain tissues damage.


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Sources
(1) The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue by Hazell AS1, Faim S, Wertheimer G, Silva VR, Marques CS.(PubMed)
(2) Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels by Vignisse J1, Sambon M1, Gorlova A2, Pavlov D2, Caron N1, Malgrange B1, Shevtsova E3, Svistunov A2, Anthony DC4, Markova N5, Bazhenova N6, Coumans B1, Lakaye B1, Wins P1, Strekalova T7, Bettendorff L8.(PubMed)

Monday, July 24, 2017

All About Vitamins: High Dose of Thiamine(Vitamin B1) in Reduced Risk of Neurodegeneration

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1, also known as thiamin or thiamine, one of the members of the vitamin B complex is a colorless chemical compound with the formula C12H17N4OS., discovered in 1910 by Umetaro Suzuki in Japan. Vitamin B1 is a water soluble vitamin.

Vitamin B1 is found to associate to prevent neurodegeneraive diseases, a recently study conducted by a renown institute suggested.

According to the joint study lead by the Aichi Human Service Center, mice fed with thiamine-restricted diet (thiamine: 0.60 mg/100 g food) died within 30 and 12 days period respectively, induced the dramatically decreased thiamine concentration in the blood and brain, causing acute neurodegeneration.

The development of thiamine metabolism dysfunction syndrome 2(THMD2) exerted anti neurodegeneration probably is the result of thiamine-restricted diet in ameliorate the levels of thiamine (vitamin B1) derivative, namely the thiamine pyrophosphate.

Dr. Suzuki K, the lead author said, "acute neurodegeneration caused by thiamine deficiency is preventable in most parts, and prompt high-dose thiamine administration is critical for the treatment of THMD2".

In fact, reduced thiamine levels can also promote AD-like abnormalities, including memory deficits, neuritic plaques, and hyperphosphorylation of tau. In the study of classical thiamine deficiency and dementia, thiamine deficiency is associate to cognitive deficits and reductions in brain glucose metabolism, affecting function of the thiamine-dependent enzymes.

Researchers at the study also found that drugs or other manipulations interfered with thiamine absorption can cause thiamine deficiency and excess thiamine intake may diminishes AD-like diseases.

In animal models, thiamine deficiency elevates plaque formation, promotes phosphorylation of tau and impairs memory. In contrast, treatment with the thiamine derivative benfotiamine diminishes plaques, decreases phosphorylation of tau and reverses memory deficits..
Therefore, there is no doubt that thiamine deficiency diet may induce the development and progression of neuro degenerative diseases, but doses intake should only be prescribed by medical doctors.


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Sources
(1) High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice by Suzuki K1, Yamada K1, Fukuhara Y1, Tsuji A2, Shibata K2, Wakamatsu N1.(PubMed)
(2) Vitamin B1 (thiamine) and dementia by Gibson GE1, Hirsch JA2, Fonzetti P2, Jordan BD2, Cirio RT2, Elder J1.(PubMed)
(3) Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes by Gibson GE1, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J.(PubMed)

Friday, July 21, 2017

All About #CurableVitamins: Vitamin B1 Deficiency Associated to the Risk of Alzheimer's disease(AD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Alzheimer's disease (AD) patients is associated to impaired thiamine metabolites in energy metabolism and activities of thiamine-dependent enzymes (thiamine diphosphate (TDP)) in production of thiamine derivative.

In the recruited 45 AD patients clinically diagnosed and 38 age- and gender-matched control subjects without dementia study, the joint study lead by the Fudan University found that blood TDP contents of AD patients were significantly lower than those in control subjects (79.03 ± 23.24 vs. 127.60 ± 22.65 nmol/L, P<0.0001.

Dr. Pan X, the lead author in the joint study suggested, the imbalance activities of thiamine induced by addition and removal in monophosphatase (TMPase) and thiamine diphosphatase (TDPase) may be directly involved in thiamine and glucose metabolism.

In fact, vitamin deficiencies are causative for AD development, many researchers recommended that they should be tested for early detectable in patient with AD.

Thiamine deficiency (TD) result from inadequate intake, increased requirement, excessive deletion, and chronic alcohol consumption, according to the Shandong University School of Medicine, may play an critical role in central and peripheral nervous systems induced neuro-degenerative diseases, such as Alzheimer's disease(AD), Parkinson's disease (PD), and Huntington's disease (HD), through induced  oxidative stress and impaired natural, regulated, destructive mechanism of the cell in the brain.

There is no doubt that thiamine deficiency is associated to patients with Alzheimer's disease(AD). treatment of high quantity amount of thiamine should only be prescribed by related field specialist.


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Sources
(1) Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease by Pan X1,2, Sang S1,2, Fei G1, Jin L1, Liu H2, Wang Z3, Wang H3, Zhong C1,2.(PubMed)
92) Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy by Liu D1,2, Ke Z3, Luo J4,5.(PubMed)


Thursday, July 20, 2017

All About #CurableVitamins: Vitamin B1 deficiency to Obese and Obesity Complications

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.

Thiamine therapy may be beneficiary for obese patients, a renowned institute study suggested.

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

According to the University of the Punjab, obesity frequently have clinical thiamine deficiency with 18% prevalence of clinical thiamine deficiency after gastric bypass surgery and obesity associated diabetes mellitus is a mechanism for development of clinical thiamine deficiency.

Dr. Nath A, the lead author said, " Higher body mass index is a significant risk for clinical thiamine deficiency (P=.007). Clinical thiamine deficiency is common in these individuals and a higher body mass index is an identified risk factor".

In fact, in obese patients undergoing bariatric surgery, blood test before operation showed a significant thiamine deficiency.

In the total of 437 consecutive patients who underwent laparoscopic RYGB or laparoscopic adjustable gastric banding, 303 were included in the study, thiamine deficiency is found to associated with 15.5% of the participants with. male patients presented with greater mean preoperative thiamine levels (3.2 microg /dL) than female patients (2.4 microg/dL).

Taking altogether, intake of vitamin B1 in prescribed doses may reduce risk of thiamine deficiency complications in obese patients.


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A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Sources
(1) Prevalence of clinical thiamine deficiency in individuals with medically complicated obesity by Nath A1, Tran T2, Shope TR2, Koch TR3(PubMed)
(2) Preoperative thiamine deficiency in obese population undergoing laparoscopic bariatric surgery by Carrodeguas L1, Kaidar-Person O, Szomstein S, Antozzi P, Rosenthal R.(PubMed)