Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Thursday, October 19, 2017

All About Vitamins: Vitamin B5 Deficiency and Risk of Auto immunity

Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid deficiency may have an implicated effect on promoted immune system in production of proinflammatroy status, a renowned institute study suggested.

In the study of vitamin D replacement slowly induced a secondary pantothenic acid deficiency with oral administration of vitamin D + B100 (100mg of all B vitamins except 100mcg of B12 and biotin and 400mcg of folate) to over 1000 neurology patients, researchers found that the vitamin D supplement reduced expression of pro inflammatry cytokins in improved sleep, reduced pain and unexpected resolution of bowel symptoms.

Vitamin D-supplement ameliorated vitamin B5 deficiency also created an intestinal environment that favors the return of the four specific species, Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria through regulating inflammation of intestinal system.

Dr. Gominak SC, also said, "... Improved sleep and more cellular repairs eventually depletes body stores of pantothenic acid, causing reduced cortisol production, increased arthritic pain and widespread "pro-inflammatory" effects on the immune system" and "Pantothenic acid deficiency also decreases available acetylcholine, the neurotransmitter used by the parasympathetic nervous system".

According to Dr. Tautt J. in the experiments carried out to test the length of time necessary to induced vitamin deficiency by removing vitamins from the diet or by giving the rabbits antibiotics of different activity spectrum when the animals kept on a diet without vitamins, said, "(observation by microbiological assay) the time after which changes in vitamin levels developed as well as the intensity of changes differ, depending on the experimental model used, but the sequence of vitamin disappearance from the organism is always the same. The first to disappear were vitamins B1, followed by vitamin B6 and pantothenic acid"

Taking altogether, vitamin B5 deficiency induced by diet deficiency or antibiotics stimulated Immune expression of pro inflammatory cytokins in various types of disease.



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Sources
(1) Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity by Gominak SC1.(PubMed)



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, October 18, 2017

All About Vitamins: Vitamin B5 Improved Intestinal Bacterial Expression

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.


Vitamin B5 deficiecy may have a negative effect in balancing the gut bacterial expression, a recent study suggested.

And, long term PA deficiency may induced weight loss or reduced growth, hair loss and exudation around the eyes, then diarrhea and hindleg paralysis and splenomegaly, and finally death.

According to Dr. Tautt J. in the experiments carried out to test the length of time necessary to induce vitamin deficiency by removing vitamins from the diet or by giving the rabbits antibiotics of different activity spectrum when the animals kept on a diet without vitamins, said, "(observation by microbiological assay) the time after which changes in vitamin levels developed as well as the intensity of changes differ, depending on the experimental model used, but the sequence of vitamin disappearance from the organism is always the same. The first to disappear were vitamins B1, followed by vitamin B6 and pantothenic acid".

Truly, in the evaluated intestinal pantothenic acid (PA) uptake in mice fed diets with high, normal and deficient PA levels researchers found that
1, Treatment of antibitics have a positive effect to reduced intestinal pantothenic acid (PA)
2. Dietary PA levels had no effect on intestinal PA uptake at 5 microM

There fore, the study postulated, " intestinal transporters may be regulated only for vitamins absorbed predominantly by carrier-mediated transport and subject to natural deficiency states."

Taking altogether, there is no doubt that vitamin B5 deficiency caused by environment ethanol and intake of antibiotics may have a significant effect in over exhibition of bacterial expression in  inducing intestinal disorder,


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Sources
(1) Changes in the levels of certain vitamins from B group under conditions of vitamin deficiency by Tautt J.(PubMed)
(2) Do dietary levels of pantothenic acid regulate its intestinal uptake in mice?by Stein ED1, Diamond JM.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, October 17, 2017

All About Vitamins: Vitamin B5 on implication of Brain Acetylcholine

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid may have a profound effect in improved brain activities through influencing function of acetylcholine, neurotransmitter.

Acetylcholine as a neurotransmitter, is a chemical released by nerve cells to send signals to other cells.

In a study to measure brain acetylcholine (ACh) synthesis from precursor [14C]-pyruvate, pantothenic acid (PA) concentration in the brain of rats treated with either ethanol (5-6 g kg-1 body wt daily) alone or ethanol with PA supplementation (100-200 mg kg-1 body wt daily), researchers found that chronic ethanol exposure in rats showed a significant decreased ACh synthesis caused by depleting PA, in negated function of neurotransmitters induced by acetylcholine (ACh).

Other, in the compared 3 studies of rats fed Lieber-DeCarli formula diet with either 5% ethanol or maltose-dextrin (controls) for 19-36 d, researchers filed the following reports
1. The heart pantothenate levels of ethanol-fed rats were 51-78% in compared to control
2. The heart total CoA levels, the precursor of vitamin B5 of ethanol-fed rats were 78-90% in compared to  controls.
3. Liver total CoA and pantothenate levels were lower in ethanol-fed rats than in controls in one and two studies,
4. Rats fed with 0.5-2.5 g ethanol/kg body weight, showed an acute effect of ethanol on pantothenate conversion to CoA in liver.

The result implicated an important result of environment ethanol in reduced levels of brain acetylcholine (ACh) and Total coenzyme A (CoA), thus attenuating brain function in regulating in arousal, attention, memory and motivation.
Taking altogether, there is no doubt that exposure to environment ethanol may have a negative effect the function of motor neurons release  in order to activate muscles in nervous system

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Sources
(1) Effects of acute and chronic ethanol ingestion on pantothenate and CoA status of rats by Israel BC, Smith CM.(PubMed)
(2) Effects of ethanol and pantothenic acid on brain acetylcholine synthesis by Rivera-Calimlim L1, Hartley D, Osterhout D.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, October 16, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) in Reduced Risk Of Non Alcoholic Liver Disease?

By Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5

Vitamin B5 deficiency may have a significant effect in Risk Of Non Alcoholic Liver Disease, a respectable institute study suggested.

In the evaluated methionine-choline deficient (MCD) and Western diet mouse models of NASH, with MCD diet-fed mice treated with pantothenate and N-acetylcysteine or placebo, researcher at the joint study lead by the Duke University Medical Center, suggested that treatment with pantothenate and N-acetylcysteine did not inhibit caspase-2 activation, improve NASH, normalize PANK expression, or restore free CoA levels in MCD diet-fed mice evn though antothenic acid (PaA) is a vitamin fromed an integral part of coenzyme A (CoA).

The result indicated that Pantothenic acid have a insignificant effect in reduced risk and treatment of Nonalcoholic fatty liver disease (NAFLD).

Contrast to the above differentiation, the university of Shiga Prefecture study of PaA deficiency in increased risk of accumulation of tissue fats, with Weaning rats fed the PaA-free diet for 30 d. Rats, then divided into two groups. One group was continuously fed the PaA-free diet, and the other was fed the PaA-containing diet for an additional 13 d, reported the following results
1. Fat accumulated by consuming the PaA-free diet for 30 d was decreased by consuming the PaA-containing diet for an additional 13 d.
2. PaA-free diet feeding elicited much greater accumulation of liver, perinephric, and plasma fats.
3.. Administration of PaA expressed a strong effect in decreased accumulated fat.

Dr. Shibata K, the lead author said, "PaA deficiency causes fat accumulation, and re administration of PaA decreases the tissue fat in rats fed the pantothenic acid-free diet".

Furthermore, in the evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine the role of ketogenesis in preventing diet-induced steatohepatitis, researchers showd that intake of supplementation of the CoASH precursors pantothenic acid and cysteine normalized TCA intermediates and gluconeogenesis in the liver, resulting in ameliorately hepatocyte injury and inflammation, decreased glycemia,.......

In regard to the information collected, further cohost and large sample size studies are necessary to confirm either ways.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model by Machado MV1,2, Kruger L1, Jewell ML1, Michelotti GA1, Pereira Tde A1, Xie G1, Moylan CA1, Diehl AM3.(PubMed)
(2) Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption by Shibata K1, Fukuwatari T, Higashiyama S, Sugita C, Azumano I, Onda M.(PubMed)
(3) Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia by Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA.(PubMed)

Friday, October 13, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) Deficiency in Risk Of Osteoarthritis

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid deficiency may be associated to risk of osteoarthritis, a study by renowned institute suggested.

In the study of 77 osteoarthritis patients assessed biweekly for 12 weeks as part of a multidisciplinary approach to the management of osteoarthritis, nutrient information and food frequency questionnaire returned by patients, showed a significantly correlated between obesity pain from osteoarthritis and vitamins deficiency, particularly vitamin B5.

According to the study, obese osteoarthritis patients may benefit from weight loss if meal were chosen with care to include nutrients in which they are deficient.

Dr. White-O'Connor B, the lead author said, " In addition to providing nutritional recommendations to avoid dietary deficiencies, a registered dietitian can assist in the multidisciplinary treatment of osteoarthritis by providing weight-control counseling and follow-up".

In deed, further differentiation showed that  dietary intake of these group of patients were below 80% of pantothenic acid, the recommended dietary allowance daily. 

Other, in the study of vitamin therapy in the absence of obvious deficiency opinionated that deficiency of vitamin may lead to a specific deficiency syndrome, which may be primary (due to inadequate diet) or secondary (due to malabsorption or to increased metabolic need), and it is rational to use high-dose vitamin supplementation in situations where these clinical conditions exist and vitamin B5 deficiency is associated to increased risk and progression of osteoarthritis.

Dr. Ovesen L. said, "Most of the vitamins have been reported to cause adverse effects when ingested in excessive doses" and "therefore worthwhile to consider the risk-benefit ratio before embarking upon the use of high-dose vitamin supplementation for disorders were proof of efficacy is lacking".

Taking altogether, vitamin B5 deficiency may be one of major factor in increased incidence and progression of osteoarthritis, therefore intake of supplement may be necessary but please consult with your doctor before applying in large doses.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Nutrient intake and obesity in a multidisciplinary assessment of osteoarthritis by White-O'Connor B, Sobal J.(PubMed)

Thursday, October 12, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) Deficiency in Risk Of Hypertension

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Vitamin B5 deficiency may have a profound and positive effect in promoted hypertension, an Asian study postulated.

In the study of endemic pantothenic acid deficiency of some Japanese populations and risk of increased occurrence of hypertension suggested that pantothenic acid deficiency is a factor in the experimental origin of hypertension due to adrenal regeneration, but in most cases, blood samples observations of vitamin B5 expression have largely been ignored.

Dr. Schwabedal PE, ignorance of vitamin B5 deficiency may put many patient of these group at risk of cardiovascular disease due to undiscovered of high blood pressure, one of risk factors of CVD incidence.

Other, in the examined 171 patients with hypertension and coronary heart disease, researchers found that there are association between vitamin decreased as the disease progressed and heart failure supervened.

More interestingly, in the study of Vitamin D and B100 oral administration to 1000 neurology patients with sleep characteristics, pain levels, neurologic symptoms, and bowel complaints were recorded by the author at routine appointments, researchers indicated that oral administrated group showed to improve sleep and more cellular repairs eventually depletes body stores of pantothenic acid, causing reduced cortisol production, and increased sympathetic tone in produced hypertension  and a "hyper-adrenergic" state known to predispose to heart disease and stroke.

Taking together, vitamin B5 deficiency may have a profound effect in increased risk of hypertension, a major risk factor of CVD development.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pantothenic acid deficiency as a factor contributing to the development of hypertension by Schwabedal PE, Pietrzik K, Wittkowski W.(PubMed)
(2) [Pantothenic acid metabolic disorder and its relation to the change in energy processes in patients with ischemic heart disease and hypertension].[Article in Russian] by Borets VM, Ovchinnikov VA, Mironchik VV, Moĭseenok AG, Lis MA.(PubMed)

Wednesday, October 11, 2017

All About Vitamins: Vitamin B5(pantothenic acid) and Oral Contraceptive

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Women, using oral contraceptives agents may have a profound effect in reduced pantothenic acid levels during menstrual cycle, a study by renowned institute suggested.

In a total of 13 young women, ages 19-25, at the beginning and end of a 12-day confined study. 9 women using (+OCA) oral contraceptives and the other 4 were not (-OCA), entered the metabolic unit during the 1st week of their menstrual cycle and fed a constant formula diet containing 2.0 mg thiamin, 3.0 mg riboflavin, and 10 mg pantothenic acid then from 3-day dietary records, subjects were fed with 1/2 of the thiamin, riboflavin, and pantothenic acid levels, researchers found that in compared to the blood urine collected at the beginning, groups treated with +OCA group showed a significantly lower than the -OCA group.

Dr. Lewis CM, the lead author said, "At the beginning of the study, blood and urine pantothenic acid levels were significantly lower in the +OCA group than the -OCA group. These differences were no longer evident by the end of the study".

The expression showed some effects of oral contraceptive in influence to levels of pantothenic acid, but this effect can be controllable through intake of vitamin B5 rich diet during menstrual cycle.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of oral contraceptives agents on thiamin, riboflavin, and pantothenic acid status in young women by Lewis CM, King JC.(PubMed)

Tuesday, October 10, 2017

All About Vitamins: Vitamin B5 (Pantothenic acid) Promoted Integrity of Skin Tissue with Less Scar Formation

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

 Pantothenic acid  may have a profound effect in promotion of skin tissues including collagen in fibroblasts, a recent study by respectable institute suggested.

According to study by the Tohoku University, pantothenic acid topical administration showed a significant benefit in moisturization of the skin tissues. Deficiency of the vitamin may affect skin function in maintaining the structural integrity of the connective tissue.

In fact, the study also found that pantothenic acid depletion decreased the synthesis of keratinocyte growth factor in speedup wound healing and reduced skin tissue integration.

Noscarna, a reduced scar appearance commercial product, included vitamin B5 derivative, applied to hypertrophic scars in the rabbit ear model. showed a enormous improvements of scar healing and skin pigment in compared to non treatment group.

Truly, according to the study, the efficacy of the production in reduced scar forming is attributed to many mechanisms, including a significant reduction in scar elevation index, anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts.

Dr. Lee DW , the lead author said, "(The promotion of reduced scar forming of ) Noscarn showed more favorable effects on hypertrophic scars than a commercial product, Contractubex".

More interesting, in the support of the above analysis, Dr.Ebner F postulated , " The topical use of dexpanthenol, the stable alcoholic analog of pantothenic acid, is based on good skinpenetration and high local concentrations of dexpanthenol when administered in an adequate vehicle, such as water-in-oil emulsions. Topical dexpanthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with dexpanthenol".

According to the study, topical use of dexpanthenol in skin disorders, after 3 - 4 weeks, expressed considerably improvement of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures.

Taking altogether, there is no doubt that vitamin B5 may be considered as an topical ingredient used in cosmetic care for treatment of speedup skin healing with less scar formation.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts by Kobayashi D1, Kusama M, Onda M, Nakahata N.(PubMed)
(2) Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects by Lee DW1, Ku SK, Cho HJ, Kim JH, Hiep TT, Han SD, Kim BG, Kang MK, Do ES, Jun JH, Jang SW, Son MW, Sohn YT, Choi HG, Yong CS, Kim JO.(PubMed)
(3) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)

Monday, October 9, 2017

All About Vitamins: Pantothenic acid in Neuro Degenerative Risk

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Deprivation of pantothenic acid (PA; vitamin B5) may associate to the early onset of neurodegenerative disease, a study bu renowned university suggested.

In a study of Wild-type and Pank2 mutant mice fed pantothenic acid-deficient diets monitored for general health, fertility and movement and compared with animals on control diets over time, showed a significant effect in manifested azoospermia (a phenotype also seen in Pank2 mice) and exhibited movement disorder with a low-lying pelvis and slow steps.

Mice fed with vitamin B5 deficit diet also effect the physical movement of the limbs caused by muscular spasm and abnormal posture in both mice groups.

According to the University of California, the result of the testing indicated that vitamin B5 deficiency may express the similar expression in neuro degernerative effect as seen in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz syndrome)

Further more, in the study of a mouse knock-out of the orthologous murine gene (Pank2) to enhance the understanding of the mechanisms of disease and serve as a testing ground for therapies, researchers found that overtime, murine mice manifest retinal degeneration,   progressive photoreceptor decline, decreased cell number and disruption of the outer segment and reduced pupillary constriction response.

More interestingly, in compared to wild type, experiment mice showed a significantly ameliorated fertility in displayed a condition of no sperm semen.

The reduced fertility and physical move and retinal degeneration caused by vitamin B5 deficiency 
demonstrated a similarity to in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz syndrome) cause ofvitamin B5 deficit, therefore, vitamin B5 may be considered as a therapeutic supplemnt in reduced risk neuro degenerative disease caused by acute vitamin B5 deficiency individuals.

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Sources
(1) Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration by Kuo YM1, Hayflick SJ, Gitschier J.(PubMed)
(2) Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia by Kuo YM1, Duncan JL, Westaway SK, Yang H, Nune G, Xu EY, Hayflick SJ, Gitschier J.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, October 6, 2017

All About Vitamins: Pantothenic Acid in Hair Thickening

By Kyle J. Norton.
Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Vitamin B5 used combination with other ingredients may have a potential effect in protected against hair loss and treatment of hair thinning, a renowned institute study suggested.

In the study to examine the growth and quality of hair after treatment with Pantogar, another prescription (Verum-2) and placebo for four months in 60 patients with diffuse effluvium capillorum and agnogenic structural alternations of hair, group treated with Pantogar, a formula including vitamin B5 as a main ingredients, demonstrated not only improvement of quality of hair and but also reduced the retarded hair loss in compared to other groups.

More importantly, application of Pantogar were well tolerance and adverse effects could not be substantiate.

Other in the study of the ability of a novel leave-on technology combination of caffeine, niacinamide, panthenol, dimethicone and an acrylate polymer (CNPDA), showed a significant effect in thicken the hair growth in the applied area as well as increased suppleness/pliability (decreased shear modulus) and better ability to withstand force without breaking (increased break stress).

Dr, Davis MG, the lead author said, "significantly increased the diameter of individual, existing terminal scalp hair fibres by 2-5 μm, which yields an increase in the cross-sectional area of approximately 10%. Beyond the diameter increase"

The astonished result from the cosmetic treatments, may have a therapeutic effect in hair thinning individuals, but can not reverse the condition of hair loss.

Taking altogether, vitamin B5 may be considered as hair thicken ingredient used combination with with other agent for reduced risk of hair loss caused by hair thinning individuals. It is recommended that you consult your doctor before applying.


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Sources
(1) A novel cosmetic approach to treat thinning hair by Davis MG1, Thomas JH, van de Velde S, Boissy Y, Dawson TL Jr, Iveson R, Sutton K.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thursday, October 5, 2017

All About Vitamins: Vitamin B5 (Pantothenic acid) in Reduced Risk and Treatment of Acne

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid may have a profound effect in reduced risk and treatment in acne, according to the renowned institute study.

In a randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris randomized to application of pantothenic acid-based dietary supplement, or a placebo for 12 weeks (endpoint), group treated pantothenic acid-based dietary supplement with showed a significant mean reduction in total lesion count in compared to placebo at week 12.

According to the Global Assessment and Dermatology Life Quality Index (DLQI) scores, pantothenic acid-based dietary supplement group scored a higher expression in a reduced effect in facial skin inflammation as well.

In fact and more precisely, the application showed a significantly reduced area-specific with acne and inflammatory blemishes.

Dr. Yang M, the lead researchers said, "Administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration".

Other researchers also expressed  a concern of acne besides caused by hormone factors, it may also be induced in person with vitamin B5 deficiency.

Dr. Leung LH, said, "a radically different theory for its pathogenesis and relate its basic pathology to a deficiency in pantothenic acid, a vitamin hitherto not known to cause any deficiency syndrome in humans. Hence, the effect of hormonal factors in this disease entity becomes secondary to that of the availability of pantothenic acid".

Taking altogether, there is no doubt that vitamin B5 have a therapeutic effect in reduced risk and treatment of acne vulgaris, particular in patients with pantothenic acid deficiency.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne by Yang M1, Moclair B, Hatcher V, Kaminetsky J, Mekas M, Chapas A, Capodice J.(PubMed)
(2) Pantothenic acid deficiency as the pathogenesis of acne vulgaris by Leung LH1.(PubMed)

Wednesday, October 4, 2017

All About Vitamins: Vitamin B5 and Weight loss

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

The prevalence of extreme overweight and obesity has caused concerns of scientific community. According to the statistic, approximately, over 68% of US population are either overweight or obese. Intake of vitamin B5 supplement may have a potential effect in induced weight loss, according to the study by the Hong Kong Central Hospital.

Intake of vitamin b5 may relieve weigh watchers against sensation of hunger and temptation of fasting through providing sufficient amount of energy released from storage fat.

Dr Leung LH, the author of the study suggested, "Supplementation of this vitamin would facilitate complete catabolism of fatty acids and thus the formation of ketone bodies could be circumvented" and "using this method for weight reduction together with a careful observation of calorie intake, I have great success in treating overweight-to-obese patients to lose weight".

Other study in support above differentiation in different way, in a study of libitum or pair-feeding of 3- or 6-wk-old rats in compared to rats fed purified diets supplemented with 0 to 1600 mg pantothenate per kilogram of diet with blood sampling from 3 to 24 h after feeding, vitamin B5 deficiency mice displayed a insignificant of weight loss but elevated serum triglyceride and free fatty acid levels in compared to non deficiency groups.

But Wittwer CT, the lead author said, "Mild pantothenate deficiency appears to have observable in vivo effects on triglyceride metabolism before severe deficiency causes significant weight loss".

Taking together, there is no doubt that vitamin B5 deficiency is associated to weight loss involuntary. People who would like to use vitamin B5 supplement as a weight loss supplement should consult with their doctor before applying.


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Sources
(1) Pantothenic acid as a weight-reducing agent: fasting without hunger, weakness and ketosis by Leung LH1.(PubMed)
(2) Mild pantothenate deficiency in rats elevates serum triglyceride and free fatty acid levels by Wittwer CT1, Beck S, Peterson M, Davidson R, Wilson DE, Hansen RG.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, October 3, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) in Wound Healing Processes

By Kyle J. Norton.


Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Would healing is the natural process of the body in protection against infection, inflammation and further injure to the damage of the original site.

Intake of itamin B5(Pantothenic acid) may have a potential effect in speedup would healing after injure, a hospital study suggested.

According to the INSERM Unité 61-Service de Chirurgie B, Hôpital Civil, application of combined pantothenic acid (PA) and ascorbic acid (AA) exhibited speed of wound healing processes through stimulated the growth of fibroblasts, in human fetal skin or foreskin.

Dr. Lacroix B, the lead author said, "When cultures were incubated with PA and AA, the release of intracellular protein into the culture medium increased."

The expression of combination showed a significant would healing through increased production of protein in regulation intracellular differentiation.

Additionally, in the study of PA (40 micrograms/ml) added to the basal culture medium, vitamin B5 displayed a significant increase of cell proliferation by thymidine Incorporation Assay and involved in stimulated secretion of intracellular protein synthesis in production of fibroblast in cell cultures.
 without inducing a release of other proteins which is important as would healing have caused Therefore, in treating wounded patients in prevent substantial loss of protein during the process,  protein diet is most recommended.

Taking together, there is not doubt that vitamin B5 have a therapeutic effect in wound healing process in exhibited production of  fibroblast through stimulated secretion of intracellular protein. 

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Role of pantothenic and ascorbic acid in wound healing processes: in vitro study on fibroblasts by Lacroix B1, Didier E, Grenier JF.(PubMed)
(2) Effects of pantothenic acid on fibroblastic cell cultures by Lacroix B1, Didier E, Grenier JF.(PubMed)

Monday, October 2, 2017

All About Vitamins: Niacin in Inhibited Inflammatory Expression

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Inflammation is a natural response of immune system in protection of our body against foreign invasion and prevent further damage to injured or damage body's tissues and organs. Over expression of immunity in this case may cause complications if not under controlled.

Niacin is found to inhibit inflammatory expression through its anti-nociceptive activity, a renowned institutes joint study suggested.

According to the Universidade de São Paulo, nicotinic acid (Hnic) and its isomer isonicotinic acid (ina) activated ligands (L) from niacin displayed anti inflammatory effect in inhibition of mechanical hyperalgesia induced by prostaglandin E2, carrageenan, a common food additive and antigen-induced arthritis.

Furthermore, in animal study, mice induced inflammation by formalin.fed with nicotinic acid (250, 500 or 1000 mg/kg, -1 h) showed a significant effect in demonstrated anti the first and the second phases of the nociceptive response against pain expression.
At dose (250 or 500 mg/kg, -1 and 3 h) nicotinic acid also displayed a decreased mechanical allodynia in triggering pain response from stimuli which provoke pain induced by carrageenan, in rat model.

Additionally, besides reduced inflammatory activity against pain, nicotinic acid (250 or 500 mg/kg, p.o., -1 and 3 h) also expressed an ameliorated paw edema caused by carrageenan.

Dr. Godin AM, the lead author said, " our results represent the first demonstration of the activity of nicotinic acid in experimental models of nociceptive and inflammatory pain and also provide further support to its anti-inflammatory activity. It is unlikely that conversion to nicotinamide represents an important mechanism to explain the antinociceptive and anti-inflammatory activities of nicotinic acid".

Taking together, nicotinic acid, a drug that has already been approved for clinical use with a positive safety record to treat high cholesterol and heart disease , may be used as anti inflammatory agent in reduced complications caused over reaction of immunity.



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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands by Freitas CS1, Roveda AC Jr2, Truzzi DR2, Garcia AC2, Cunha TM1, Cunha FQ1, Franco DW2.(PubMed)
(2) Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models by Godin AM1, Ferreira WC, Rocha LT, Ferreira RG, Paiva AL, Merlo LA, Nascimento EB Jr, Bastos LF, Coelho MM.(PubMed)

Friday, September 29, 2017

All About Vitamins: Niacin in Reduced Complications and Treatment of Gestational Diabetes

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin and its derivative may have a profound effect in reduced risk of complications caused by gestational diabetes mellitus, a university study suggested.

Gestational diabetes mellitus, is a type of  glucose intolerance occurred only in the first recognition of pregnancy. The condition will resolve itself after giving birth.

Unfortunately, women with gestational diabetes is susceptible to increased risk of  early onset of diabetes.

According to the study conducted by the Universiti Teknologi MARA (UiTM), oral administration of nicotinamide supplementation exhibited anti gestational diabetes mellitus, effect in lower elevated glucose and reduced insulin through all aspects of diabetic parameters.

In animal study, nicotinamide in doses of 50, 100 and 200 mg/kg applied to gestational diabetic fed to rats from days 6 through 20 of gestation showed a significant in reduced diabetes symptoms through increased production of antioxidants, reduced inflammatory cytokins and genes in controlling expression of free radicals.

The doses of 100 and 200 mg/kg t showed an extensive effect against the oxidative burst activity of neutrophils in response to cell differentiation of phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) in elevated risk of diabestes complications as well as activating T helper (CD4+CD25+) cells and inducing proliferation of splenocytes, a type of white blood cell involved autoimmune diabetes mellitus expression.

The findings propsoed that nicotinamide as supplement may be used as therapeutic agent in support  existing treatment for gestational diabetes and pregnant individuals with weakened immune systems.


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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) Cells by Guoqiang Jiang‡, Qing Dallas-Yang, Franklin Liu, David E. Moller and Bei B. Zhang by (Journal Biological Chemistry)
(2) Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses by John CM1, Ramasamy R, Al Naqeeb G, Al-Nuaimi AH, Adam A.(PubMed)

Thursday, September 28, 2017

All About Vitamins: Niacin Overdoses and The Risk of Toxicity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may induce liver toxicity if over dose, a joint study lead by the Mayo Clinic insisted.

In a analysis of a A 17-year-old male was transferred to the pediatric intensive care unit for evaluation of acute liver failure, researchers found that elevated liver transaminases induced acute liver toxicity caused by over dose of niacin intake to alter the outcome of an upcoming drug test.

Due to the severity of the case, Dr. Ellsworth MA, the lead author said, "Pediatric providers should be aware of the risks associated with niacin toxicity and other experimental medical therapies that may be described on the Internet or other nonreputable ".

Other in the differentiation of a 23-year-old healthy man presented to an Emergency Department with altered mental status, fever, acute renal failure, microangiopathic hemolytic anemia, thrombocytopenia, and coagulopathy,doctors at the Carolinas Medical Center, found that respiratory failure and hemodialysis for acute renal failure were caused by intake of 22.5 g of sustained-release niacin over the preceding 48 h with an attempt to pass a pre-employment urine drug screen.

Dr, Daul AM, the lead researcher warmed, " Although this patient was fortunate to make a full recovery, the case highlights the potential for multi-system toxicity with niacin overdose, and the potential for harm posed by medical misinformation on the Internet".

Taking altogether, overdoses of niacin may cause significant damage to your health in exhibited long term liver and kidney damage if not treated immediately.


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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Acute liver failure secondary to niacin toxicity by Ellsworth MA1, Anderson KR2, Hall DJ2, Freese DK3, Lloyd RM4.(PubMed)
(2) Niacin toxicity resulting from urine drug test evasion by Daul AM1, Beuhler MC.(PubMed)

Wednesday, September 27, 2017

All About Vitamins: Niacin as Antioxidant

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Antioxidant is a chemical compound with function in inhibited oxidation caused by imbalance of oxygen molecules.

Niacin may have a profound effect in reduced risk of free radical expression by exhibiting antioxidant activity, a renowned study suggested.

In the study of animals, randomly assigned to one of 4 groups (n = 6): Group I, control, received distilled water by gavage; Group II, received MeHg (100 µg/kg/d) by gavage; Group III, received NA (50 mg/kg/d) in drinking water; Group IV, received MeHg (100 µg/kg/d) by gavage + NA (50 mg/kg/d) in drinking water, niacin fed mice exerted a significant effect in reduced adverse effects of toxicity produced by MeHg, through its the intrinsic antioxidant property.

The interaction of niacin also ameliorated oxidative stress through improved the presence of antioxidants of glutathione peroxidase (GPx) and catalase (CAT) and reduced levels of free radicals of glutathione (GSH), malondialdehyde (MDA), and nitric oxide.

Promisingly, in the study of 21 patients older than 18 years, with HDL-C ≤40 mg dl-1 (men) or ≤50 mg dl-1 (women), randomly assigned to receive daily ERN (n = 10) or placebo (n = 11) for two sequential 12-week periods, with 4 weeks of wash-out before cross-over, niacin treatment showed positive outcomes in activated paraoxonase-1 (PON1) function in anti-atherosclerotic component of high-density lipoprotein (HDL). and promoted the anti-oxidant and anti-inflammatory functions of HDL.

Although, niacin expressed the impressive effect in improved antioxidant status in treated patients, the amounts do not match up to rise in HDL-C achieved in induced aApoA-I antibodies activity, Dr. Batuca JR, the lead author said, " (due to these result) niacin and other lipid lowering agents fail to reduce cardiovascular risk".

Taking together, there is not doubt that niacin or its derivative Extended-release niacin (ERN) may have a potential effect in reduced risk of lipid peroxidation through increasing high-density lipoprotein-cholesterol (HDL-C) and be considered as therapeutic treatment of abnormal cholesterol expression.



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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Protective effects of niacin against methylmercury-induced genotoxicity and alterations in antioxidant status in rats by Silva de Paula E1, Carneiro MF1, Grotto D2, Hernandes LC3, Antunes LM3, Barbosa F Jr1.(PubMed)
(2) Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidanteffect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial by Batuca JR1, Amaral MC1,2, Favas C2, Paula FS1,2, Ames PRJ1, Papoila AL3, Delgado Alves J1,2.(PubMed)

Tuesday, September 26, 2017

All About Vitamins: Niacin, A Potent Anti Acne Vitamin

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin and its derivatives may have a potential effect used over counter medicine for treatment of acne, a joint study led by the University of Miami Miller School of Medicine. suggested.

In the review of database from PubMed for clinical studies, using nicotinamide for treatment of acne vulgaris, including 10 studies met search criteria, in compared to baseline or other standard-of-care acne treatment, 6 out of 8 studies expressed the positive effect of topical nicotinamide in reduction in acne.

Oral supplement containing nicotinamide from other studies showed a significantly improved  reduction in acne in compared with baseline.

Either topical and oral administration showed no major adverse side effects, the study also found.

Other in a randomized, double-blind clinical trial, patients with moderate inflammatory facial acne vulgaris randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily, group treated with topical 4% nicotinamide showed an  acne grade decreased from an average of 5.93 at baseline to 4.03 at week 4 and 2.08 at week 8 in compared to
5.70 at baseline to 3.85 at week 4 and 2.03 at week 8 in the clindamycin group.

Further consultation insisted that skin types of patients may play an important role in choosing products as nicotinamide and clindamycin gels were significantly more efficacious in oily and non-oily skin types, respectively.

Both products showed insignificantly adverse side effects during the course of study.

Due to the limited nature of the available literature, some researchers suggested that additional studies are needed in comparing nicotinamide to other first-line acne treatments over an extended period of time may be necessary.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The role of nicotinamide in acne treatment by Walocko FM1, Eber AE2, Keri JE2,3, Al-Harbi MA4, Nouri K2.(PubMed)
(2) Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris by Khodaeiani E1, Fouladi RF, Amirnia M, Saeidi M, Karimi ER.(PubMed)

Monday, September 25, 2017

All About Vitamins: Niacin Overload in increased Risk of Obesity

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Chronic niacin excessive intake may be associated to risk of obesity a study by the Medical College, Dalian University suggested.

Obesity is a medical condition of excess body fat has accumulated overtime with a BMI of over 30.
 According to the statistic, 68% of American population are either overweight or obese.

According to the examine between the niacin consumption and the obesity prevalence among US children using the data from the Economic Research Service of the US Department of Agriculture and from US Centers for Disease Control and Prevention, respectively, increased consumption of grain niacin-fortification and fortified ready-to-eat cereal consumption, with a 10-year lag increased per capita niacin consumption among Us children may be one of the risk factor in elevated obese risk.

Dr. Li D, the lead author said, " The regression analyses showed that the obesity prevalence in the US children of all age groups was determined by niacin consumption (R(2) = 0.814, 0.961 and 0.94 for 2-5 years, 6-11 years and 12-19 years age groups, respectively)".

In deed, the appetite-stimulating effect of nicotinamide involved oxidative stress may be directly induced excess niacin consumption and considered as a major factor in the increased obesity prevalence in US children.

Additionally, in the study to determine whether and how long-term treatment with nicotinamide) NAM at lower dose would affect insulin sensitivity in mice fed chow diet with NAM (100 mg/kg/day) and normal chow for 8 weeks, researchers found that NAM (100 mg/kg/day) injection group induced obesity and expressed a significant in increased glucose intolerance and skeletal muscle lipid accumulation through impaired mitochondrial respiration capacity and energy production in skeletal muscle.

The excessive niacin overload also showed a persistent rate of oxidative stress in compared to high-fat diet (HFD) and resveratrol (RSV; 100 mg/kg/day) group.

Taking together, there is no doubt that niacin overload may have a direct influence to increased risk of obesity through expression of oxidative stress induced increased glucose intolerance and skeletal muscle lipid accumulation


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Sources
(1) Chronic niacin overload may be involved in the increased prevalence of obesity in US children by Li D1, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M.(PubMed)
(2) Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity by Qi Z1, Xia J2, Xue X2, He Q2, Ji L2, Ding S3.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, September 22, 2017

All About Vitamins: Niacin Lowers Hypercholesterol and risk of CVD in Diabetic patients

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may have a potential in reduced risk of hypercholesterol and cardiovascular disease in patients with diabetes, a Medical institute suggested.

According to the School of Medicine and Pharmacology, niacin exhibited HDL metabolism in reduced all forms of bad cholesterol and increased good cholesterol level in patients with type 2 diabetes.

In a total of 12 men with type 2 diabetes mellitus recruited for a randomized, crossover design trial, patients randomized to rosuvastatin or rosuvastatin plus ER niacin for 12 weeks and then crossed over to the alternate therapy after a 3-week washout period, metabolic assay showed that extended-release (ER) niacin treatment significantly decreased plasma triglyceride, plasma cholesterol, non-HDL cholesterol, low-density lipoprotein cholesterol, articular in HDL cholesterol in compared to other groups.

Dr. the lead researcher said, " ER niacin increases HDL apoA-I concentration in statin-treated subjects with type 2 diabetes mellitus by lowering apoA-I(in measurement of cardiovascular risk) fractional catabolic rate".

In the same same group of patients with type 2 diabestes, in compared the effective of rosuvastatin or rosuvastatin plus ER niacin, extended-release (ER) niacin on apolipoprotein B-48 (apoB-48) kinetics in statin-treated treatment also showed a reduction of level of apoB-48 concentration, but significant lower than group treated with conventional treatment.

The study also emphasized that the ER niacin exhibition of reduced cardiovascular risk showed independent to the levels of triglyceride, according to testing assay.

In fact, the efficacy of ER in reduced risk of CVD may be resulted of reduction of apoB-48 concentration through lowering fasting and postprandial apoB-48 secretion rate.

Taking together, niacin injection may have a profound effect in treating diabetic patients in ameliorated risk of CVD through expression of lower level of total blood cholesterol.




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FOOD HACK for Weight Loss
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Impact In Rice, Pasta, And Potatoes In Half

Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of niacin on high-density lipoprotein apolipoprotein A-I kinetics in statin-treated patients with type 2 diabetes mellitus by Pang J1, Chan DC, Hamilton SJ, Tenneti VS, Watts GF, Barrett PH.(PubMed)
(2) Effect of niacin on triglyceride-rich lipoprotein apolipoprotein B-48 kinetics in statin-treated patients with type 2 diabetes by Pang J1, Chan DC1, Hamilton SJ1,2, Tenneti VS1, Watts GF1, Barrett PH1,3.(PubMed)

Thursday, September 21, 2017

All About Vitamins: Niacin in reduced Risk of High Levels of Phosphorus in Kidney Diseases

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Niacin may be considered a dietary supplement in reduced risk and progression of kidney diseases, a renowned institute study suggested.

Kidney diseases are medical condition characterized by impairment of kidney function in filter metabolic wastes from the blood.

According to the University of Karachi, niancin treatment over 4 months, showed a significant effect in reduced risk dyslipidemia and phosphorus level, in compared to control group treated with statin.
in a study of chronic kidney disease patients fulfilling the pre-defined criteria and randomly categorized into two groups of equal size (n=60) and prescribed either atorvastatin 20 mg/day or NER 500 mg/day with the same dose of statin.

In compared to conventional medicine atorvastatin, niacin extended release (NER) scored a significant result in decreased levels of phosphorus than atorvastatin, used as lone treatment.

Dr. Yasmeen G, the lead researcher said," its lowest prescribed dose once a day was well tolerated by most of the patients and demonstrated significant goal achievement of phosphorus reduction.".

Instantly, in the post hoc data analysis of serum phosphorus concentrations among 1547 patients with dyslipidemia and randomly assigned in a 3:2:1 ratio to treatment with extended release niacin (ERN; 1 g/d for 4 weeks and dose advanced to 2 g/d for 20 weeks) combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (L; n = 761), ERN alone (n = 518), or placebo (n = 268). only one of daily treatment of ERN-L  expressed a sustained 0.13-mmol/L (0.4-mg/dl) reduction in serum phosphorus concentrations, approximately 10% from baseline in compared to other groups.

Further more, the testing of extended release niacin (ERN) alone and ERN combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (ERN-L), treatment of extended release niacin (ERN) also showed a same effect in reduced serum FGF23 concentration in compared to 2 other groups, with equivalent declines in serum phosphorus in (ERN-L) group but not in placebo group.

Taking altogether, there is no doubt that niacin under the form extended release niacin (ERN) may have a potential used conjunction of with conventional medicine in reduced complications of kidney diseases caused high levels of phosphorus.


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A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half


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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Hypophosphatemic effect of niacin extended release in ischemic kidney disease by Yasmeen G1, Dawani ML2, Mahboob T3.(PubMed)
(2) Hypophosphatemic effect of niacin in patients without renal failure: a randomized trial by Maccubbin D1, Tipping D, Kuznetsova O, Hanlon WA, Bostom AG.(PubMed)
(3) Effect of niacin on FGF23 concentration in chronic kidney disease by Rao M1, Steffes M, Bostom A, Ix JH.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.