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Thursday, December 14, 2017

All About Vitamins: Antiepileptic Drugs in Vitamin B6 Metabolism

By Kyle J. Norton.

Antiepileptic drugs are class of anticonvulsants used in the treatment of epileptic seizures.

Epilepsy is a neuro disease characterized by abnormal electrical activity in the brain with condition of sudden recurrent episodes of sensory disturbance.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Although vitamin B6 and its derivative have shown a strong impact in treatment of all groups of epilepsy, intake of antiepileptic drugs do not influence to the expression of plasma levels of vitamin B6, according to the University Hospital Zurich, in the study of analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n=385), untreated (n=15) and healthy controls (n=233).

But further differentiation of the interaction of vitamin B6 in patient with epilepsy underdone treatment of antiepileptic drugs (AEDs) including phenytoin or carbamazepine) and non-inducing AED (levetiracetam, lamotrigine, or topiramate), researcher found that
1. Contrast to general belief that intake of antiepileptic drugs did not lower either levels of folate nor vitamin B12, observed by blood test.
2. Vitamin B6 deficiency was found in 16/33 patients (48%) in compared to 1/11 controls (9%; p=0.031)
3. Patients in antiepileptic drugs group showed a significant in vitamin B6 deficiency of only 7 patients (21%) .after switching to non inducers.

After taking into account of con founders, Dr. Mintzer S, the lead author said, "The incidence of deficiency was similar regardless of which inducing or non-inducing AED was being taken" and "treatment with inducing AEDs commonly causes pyridoxine deficiency, often severe".

Intrusively, the study also address that other health conditions in patients with epilepsy also must be taken into consideration before injection of older AED as the medicine may induced neuro damage and chronic heath difficulties.

More importantly, in the study to determine the means of determination of activity of EGOT in 30 and of serum pyridoxal phosphate in 27 epileptic children under antiepileptic treatment with various antiepileptic drugs and with hydantoin and succinimide alone, 25 healthy infants and children were controls, researchers indicated that
1. Application of antiepileptic drugs, especially with hydantoin and succinimide depressed the level of pyridoxal-phosphate in serum
2. Injection of various antiepileptic drugs may disturb the vitamin B6 metabolism through inhibition of activity of pyridoxalkinase.

Therefore, vitamin B6 testing in patients treated with hydantoin and succinimide may be necessary to prevent risk of reduced vitamin b6 metabolism cause of toxic effects in several neurological pathologies.

Taking altogether, injection of antiepileptic drugs  may have a complicative effect in reduced vitamin B6 metabolism in induction of neuro damage and chronic heath difficulties.



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Sources
(1) Antiepileptic drugs and vitamin B6 plasma levels in adult patients by Linnebank M1, Moskau S, Semmler A, Widman G, Weller M, Kallweit U, Elger CE.(PubMed)
(2) B-vitamin deficiency in patients treated with antiepileptic drugs by Mintzer S1, Skidmore CT, Sperling MR.(PubMed)
(3) The influence of antiepileptic drugs on vitamin B6 metabolism by Reinken L.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, December 11, 2017

All About Vitamins: Vitamin B6 and Treatment of Pyridoxine-Dependent Epilepsy

By Kyle J. Norton.

Epilepsy is a neuro disease characterized by abnormal electrical activity in the brain with condition of sudden recurrent episodes of sensory disturbance.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions in stimulation of carbohydrate metabolism, brain health, and liver detoxification, etc.

The effect of vitamin B6 in treatment of pyridoxine-dependent epilepsy was under microscopic investigations extensively through many aspects, particularly in vitamin B6 application.

In inborn errors of autosomal recessive inheritance that lead to vitamin B6-dependent seizures, after taking account of other con founders, researchers suggested that a vitamin B6 withdrawal for diagnose should also be considered as an therapy for resistant neonatal seizures as early consideration of a vitamin B6 trial over 3 consecutive days is crucial in order to prevent irreversible brain damage, instead of only for patients with a clear vitamin B6 response.

Neonatal seizures, a medical condition of occurrence of seizures due to neurologic dysfunction in the neonatal period.

Pyridoxine, an the active form of vitamin B6 would be effective commonly in treatment of vitamin B6-dependent seizures, but pyridoxine showed no signs of potency in patients with neonatal seizures due to PNPO deficiency.

Pyridoxal 5'-phosphate-dependent epilepsy(PNPO) is a condition with failure response to vitamin B6 treatment in seizures patients.

The use of PLP in patients with resistant neonatal seizures should be taken with care with resuscitation equipment at hand during a first pyridoxine/PLP administration, as severe apnea has been occurred in patients, researcher continued.

Unfortunately, due to PLP is unlicensed within Europe and North America, pyridoxine is widely used as the first line drug, therefore for patient do not response to the treatment of PLP, some researchers suggested that PLP injection may be necessary and should be followed by a trial, especially in neonates.

Furthermore, caregivers, including parents with children with epilepsy should be inform about the lifelong dependency and recurrence risks in forthcoming pregnancies.

Further analysis of  the resistant conventional antiepileptic medications of early-onset epilepsy in children with neonates caused by hypophosphatasia and congenital rickets and in compared to patients of hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency of epilepsy, also indicated that although many patients with epilepsy are response to treatment of vitamin B6 injection but PLP treatment was more effective than pyridoxine, through some unknown mechanisms.

Dr. Wang HS, the lead author said, "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Additionally, Pyridoxine-dependent epilepsy (PDE) may also be caused by genetic mutation of certain genes, such as c.1597_1597delG mutations in ALDH7A1 gene.

Observation of patients data in 3 groups with complete seizure control with pyridoxine and normal development (group 1), complete seizure control with pyridoxine and development delay (group 2), and patients with persistent seizures despite pyridoxine treatment and with development delay (group 3) researchers at the Çukurova University Faculty of Medicine found that early diagnosis and treatment of these patients is vital. Patients with persistent seizure despite pyridoxine treatment and with development delay should be diagnosed in condition of any neonate with signs of encephalopathy and refractory seizures.

Taken together, if patients with epilepsy do not response to treatment of application of vitamin B6, PLP injection may be considered but substantial care must be taken  to reduce risk of complications of severe apnea.
 

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Sources
(1) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(2) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(3) Pyridoxine-dependent epilepsy in two Turkish patients in Turkey and review of the literature by Gül-Mert G1, İncecik F, Hergüner MÖ, Ceylaner S, Altunbaşak Ş.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thursday, December 7, 2017

All About Vitamins: Vitamin B6 in Reduced Risk and Treatment of non-small cell lung cancer (NSCLC)

By Kyle J. Norton.

Vitamin B6 may have a profound effect in reduced non-small cell lung cancer (NSCLC), some scietists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Non-small cell lung cancer is the most common type of lung cancer with characteristic to grow and spread methodically and predictably.

In the study to examine the clinical outcomes of the sodium cantharidinate/vitamin B6/GP regimen in the treatment of middle-late stage Non-small-cell lung carcinoma (NSCLC) with
86 cases of NSCLC selected and randomized into two groups; 45 cases in the treatment group were given 30 ml cantharidinate/vitamin B6+ GP regimen, for four 21-day cycles and 41 cases in the control group were subject to regular GP regimen, for four 21-day cycles, at the end of experiment, researchers found
1. Treatment group showed a significant improvement with effectiveness rate of 57.8% in compared to 36.6% in the control group,
2. Patients in group demonstrated an improvement of quality of life
3. Treatment group also displayed a lower toxic/adverse effects in compared with that in the control group.

After taking into account of other risk factors, Dr. Wang B, the lead author said, "odium cantharidinate/vitamin B6/GP regimen had fair effectiveness and synergistically improved the clinical outcomes. It lowered the toxic/adverse effects and its application is worth further investigation and promotion".

Other, in the study to examine the effect vitamin B6 for treatment of non-small cell lung cancer, after observation of vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo, researchers at the INSERM showed that
1. Vitamin B6 sensitized lung cancer cells to apoptosis induction by distinct types of physical and chemical stress.
2. Pyridoxal kinase (PDXK), the enzyme played an important role in generated the bioactive form of vitamin B6 and deficiency of PDXK expression levels were associated with poor disease outcome in two independent cohorts of patients with NSCLC.

The result of the study demonstrated the important role of pyridoxal kinase (PDXK) in exhibited vitamin B6 in reduced risk and treatment of NSCLC.
In fact, most patients with NSCLC are found to correlation with low levels of pyridoxal kinase (PDXK).

Taking altogether, vitamin B6 may be considered as a secondary and therapeutic treatment of NSCLC.


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Sources
(1) Treatment of mid-late stage NSCLC using sodium cantharidinate/vitamin B6/GP regimen in clinic by Wang B, Cui J1.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, December 4, 2017

All About Vitamins: Vitamin B6 in Reduced Risk of Depression

By Kyle J. Norton.

Vitamin B6 may have a intrinsic effect in reduced symptoms of depression, some scientists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

In the study to investigate whether different intake levels of folate, vitamin B6 and B12 were associated with a 3-year depression incidence among generally healthy, community-dwelling older men and women conducted by the joint study lead by the St Francis Xavier University, researchers showed that
1. Vitamin B6 intake from foods were associated to 43% less likely to become depressed when adjusting for demographic and health factors in women.
2. Risk of depression also decreased in men who took dietary vitamin B6 during the study.


The results indicated that dietary vitamin B6 may be the choice for both men and women to reduced risk of depression.

Other in the study to investigate whether adolescent pregnant women were on greater risk of nutritional deficits in stress, and depression than their adult counterparts, and these risk factors associated to adverse pregnancy outcomes, researchers at the joint study lead by the Columbia University Medical Center, suggested that vitamin B6 was one of many micro nutrients found in deficient status in these group of women.

After taking into account of other risk factors, Dr. Singh A, the lead author postulated, "mood and dietary factors are associated and should be considered together for health interventions during adolescent pregnancy for the young woman and her future child".

Taking altogether, vitamin B6 may be considered as an adjunct supplement with standard therapy for reducing risk of depression in general population.
 
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Sources
(1) Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging by Gougeon L1,2, Payette H3,4, Morais JA5, Gaudreau P6,7, Shatenstein B8,9, Gray-Donald K2.(PubMed)
(2) Micronutrient Dietary Intake in Latina Pregnant Adolescents and Its Association with Level of Depression, Stress, and Social Support by Singh A1,2,3, Trumpff C4, Genkinger J5,6, Davis A7, Spann M8,9, Werner E10,11, Monk C12,13,14.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, December 1, 2017

All About Vitamins: Vitamin B6 in Reduced Psychological symptoms of Schizophrenia

By Kyle J. Norton.

Vitamin B6 may have a potential effect in reduced psychological symptoms in chronic schizophrenic and schizoaffective patients, some researchers suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Schizophrenia is a severe mental disorder characterized with inability to interpret reality normally and Schizoaffective disorder is also a chronic mental health condition characterized primarily by symptoms of schizophrenia.

In a study to examine the effects of vitamin B6 reduced psychotic symptoms of psychopharmacologic treatment of patients suffering from schizophrenia or organic mental disorder, of spanning 9 weeks with all patients with stable psychopathology for at least 1 month before entry and randomly received placebo or vitamin B6, starting at 100 mg/day in the first week and increasing to 400 mg/day in the fourth week by 100-mg increments each week, researchers found that there are no differences between vitamin B6- and placebo-treated patients in amelioration of mental state of attendees.

Dr. Lerner V, after taking into account of other confounders, said, "Further studies with larger populations and shorter duration of illness are needed to clarify the question of the possible efficacy of vitamin B6 in treatment of psychotic symptoms in schizophrenia".

Other researchers in the confirmation of vitamin B6 great progress in the treatment of positive symptoms in schizophrenic patients and movement disorders induced by neuroleptics,at the Ben Gurion University of the Negev, launched a a double-blind crossover controlled during 9 weeks with patient treated with up to 400 mg/day vitamin B6 versus placebo, after reviewing the result taken from Positive and Negative Symptoms Scale (PANSS), Extrapyramidal Symptoms Rating Scale (ESRS) and a blood sample of level pyridoxal showed that vitamin B6 treated group demostrated a significant improvement in tardive dyskinesia and parkinsonian symptoms. but failed to express therapeutic effect of psychotic symptoms from vitamin B6 added to antipsychotic agents.

The contradictory findings suggested that further studies with larger samples and higher doses of vitamin B6 are necessary before clarifying the possibility of a positive therapeutic effect of vitamin B6 as an augmentation agent for the treatment of psychotic symptoms.



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Sources
(1) Vitamin B6 as add-on treatment in chronic schizophrenic and schizoaffective patients: a double-blind, placebo-controlled study by Lerner V1, Miodownik C, Kaptsan A, Cohen H, Loewenthal U, Kotler M.(PubMed)
(2) [Vitamin B6 add-on therapy in treatment of schizophrenic patients with psychotic symptoms and movement disorders].[Article in Hebrew] by Miodownik C1, Cohen H, Kotler M, Lerner V.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 29, 2017

All About Vitamins: Vitamin B6 for Treatment of Anxiety

By Kyle J. Norton.

Vitamin B6 may have an positive effect in reduced levels of anxiety, some scientists suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Anxiety, a psychological symptom caused by a feeling of worry, nervousness, or unease, particularly about an imminent event or something with an uncertain outcome.

According a randomized, double-blind, placebo-controlled and crossover design study to investigate single and combined effects of daily dietary supplementation with 50 mg of vitamin B6 and 200 mg magnesium (as MgO) for one cycle for the relief of mild premenstrual symptoms, among 44 assigned to treatments daily for one menstrual cycle: (1) 200 mg Mg, (2) 50 mg vitamin B6, (3) 200 mg Mg + 50 mg vitamin B6 and (4) placebo, after taking into account of other risk factors, researchers showed that treatment with 200 mg/day Mg + 50 mg/day vitamin B6 expressed a significant reduction of anxiety-related premenstrual symptoms (nervous tension, mood swings, irritability, or anxiety) in compared to other treated groups, specially in mild premenstrual anxiety-related symptoms.

Other in the study to evaluate the effect of combination of Magne-B6 used, in the treatment of 25 patients with different forms of epilepsy with psychiatric status of patients featured by depression, anxiety and some psychotic sighs researchers indicated that according to the results of self-rating scales for Zung anxiety and depression scale, SCL-90 and Global clinical impression (CGI) scale, the combination display a strong effect in non-specific influence on patient's mental state at between the 14 - 28 days of treatment without inducing serious side effects.

Taking altogethers, Vitamin B6 may be used alone or conjunction with other minerals supplement for treatment of anxiety.
 

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Sources
(1) A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study by De Souza MC1, Walker AF, Robinson PA, Bolland K.(PubMed)
(2) [A use of Magne-B6 in the treatment of anxiety-depressive states in patients with epilepsy].[Article in Russian] by Kalinin VV, Zheleznova EV, Rogacheva TA, Sokolova LV, Polianskiĭ DA, Zemlianaia AA, Nazmetdinova DM.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, November 27, 2017

All Above Vitamins: The Effect of Vitamin B6 on Central Nervous System

By Kyle J. Norton.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Central nervous system is a part of nervous system, including the brain and spinal cord.

Vitamin B6 may have a profound and positive effect in reduced neuro toxicity used conjunction with other herbal medicine, some scientists suggested

In a study to investigate the neuroprotective role of grape seed extract and/or vitamin B6 against Triton WR-1339 -induced neurotoxicity, with 35 adult male albino rats of the Sprague-Dawley strain, weighing 140-145 g, divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + tritonresearchers at the Alexandria University found that application of grape seed extract and/or vitamin B6 demonstrated a significant effect in attentuated disturbances in the hematological parameters, the neurological functions, and the antioxidant profile, caused py injection of the above product.

Further analysis suggested that grape seed extract and/or vitamin B6 protect against neuro damage caused by Triton WR-1339 through over expression of antioxidative and antiapoptotic capacities.

In support to the above study, researchers at the Laboratori di Ricerca della FIDIA S.p.A, launched a study to examine the effect of a brain cortex phospholipids (BC-PL) and vit. B6 association on animal behaviour and enzymatic activities specific for CNS postulated that although vitamin B6 showed a strong positive influence to BC-PL and  activities, the results obtained are very different in compared to  methamphetamine used for treatment of CNS.

The result suggests a different mechanism of action at CNS level, according to the motility and avoidance tests and cerebral L-amino acid aromatic decarboxylase assays.

Taking together, there is no doubt that vitmain B6 has a intrigue effect in improved and protective central nervous system activities.


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Sources
(1) Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity by Abdou HM1, Wahby MM2.(PubMed)
(2) [Neurochemical and behavioural alterations in animals due to a neurohomologous phospholipids and vitamin B6 association at CNS level].[Article in Italian] by Aporti F1, Toffano G, Castellani A.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, November 24, 2017

All About Vitamins: Vitamin B6 Deficiency and Risk of Type 2 Diabetes

By Kyle J. Norton.


Vitamin B6 may have a positive and profound impact in reduced risk of type 2 diabetes in patients with depression and other conditions, some studies suggested

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

Diabetes is a medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

According to Dr. Oxenkrug G, the lead author in the investigate the effects of vitamin B6 deficiency in risk of type 2 diabetes, as a cofactor of the key enzymes in regulating trytrophan metabolism, suggested that vitamin B6 deficiency may alter the formation of co enzyme (NAD) towards production of xanthurenic (XA) and kynurenic (KYNA) acids, which have a strong impact in the production, release and biological activity of insulin.

Where Xanthurenic acid is excreted by pyridoxine (vitamin B6) deficient and Kynurenic acid is a product of the normal metabolism of amino acid L-tryptophan.

The study also indicated that increased intake of vitamin B6 supplement and monitored formation of diabetogenic KYN derivatives might help to identify subjects-at-risk for the development of diabetes.

Further analysis, the authors also said, "Pharmacological down-regulation of the TRP - KYN - NAD pathway and maintenance of adequate vitamin B6 status might help to prevent the development of diabetes in depression and other conditions associated with inflammation/stress- induced excessive production of KYN and vitamin B6 deficiency, e.g., o".


In support to the above differentiation, the Tufts University School of Medicine conducted a study to review literature published data for evidences that dysregulation of tryptophan (TRP)-kynurenine (KYN) and KYN-nicotinamide adenine dinucleotide (NAD) metabolic pathways is one of the mechanisms of IR suggested that vitamin B6 deficiency may impair the function of key enzymes of tryptophan (TRP)-kynurenine (KYN) and KYN-nicotinamide adenine dinucleotide (NAD) in production, release, and biological activity of insulin, thus increasing risk of type 2 development.

Taking together, thee is no doubt that vitamin B6 deficiency may have a significant effect in the onset of type 2 diabetes by alternating the production, release, and biological activity of insulin, through trytophan metabolic pathway.


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Sources
(1) Kynurenines and vitamin B6: link between diabetes and depression by Oxenkrug G, Ratner R, Summergrad P.(PubMed)
(2) Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways by Oxenkrug G1.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 22, 2017

All About Vitamins: Vitamin B6 deficiency in Risk of Hyperhomocysteinaemia

By Kyle J. Norton.

Vitamin B6 deficiency may have a strong implication on  hyperhomocysteinaemia in increased risk of cardiovascular disease, some studies suggested

Homocysteinaemia, a maker for heart disease development, is a medical condition characterized by an abnormally level of homocysteine in the blood stream.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

According to the study conducted by the The Aga Khan University, to evaluate the homocysteine levels of 290 apparently healthy hospital personnel from institutions in two cities of Pakistan, deficiency of vitamin B6 and other vitamins may be associated to higher risk of  homocysteine in compared to control.

Indeed, Dr. Iqbal MP, the lead author indicated that serum/plasma levels of micro nutrients have a significant negatively correlated with plasma homocysteine.

In other word, Deficiency of certain micro nutrients, including vitamin B6 may increase substantial risk to hyperhomocysteinaemia.

The result strongly support that mass micro nutrient supplementation are necessary in this group of people to prevent the high incidence of cardiovascular disease.

Other study in the instigation of the same group of Pakistani people, involving 224 AMI patients (age 30-70 years; 55 females and 169 males) and 126 normal healthy subjects (age 31-70 years; 35 females and 91 males) for risk of hyperhomocysteinaemia in micro nutrients deficiency aspects, researchers showed that a lower levels of vitamin B6 and other micro nutrients, including folate and vitamin B6 demonstrated a significant effect in the onset of hyperhomocysteinaemia in both control and study group.

Dr. Iqbal MP, the lead author said, "Substantial nutritional deficiencies of these three vitamins along with mild hyperhomocysteinemia, perhaps through an interplay with the classical cardiovascular risk factors". 

Taking altogether, vitamin B6 may have a profound effect in combined with deficiencies of other nutrients in induced risk of hyperhomocysteinaemia development, a marker of CVD.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Folic acid and vitamin B6 deficiencies related hyperhomocysteinemia in apparently healthy Pakistani adults; is mass micronutrient supplementation indicated in this population? by Iqbal MP1, Lindblad BS, Mehboobali N, Yusuf FA, Khan AH, Iqbal SP.(PubMed)
(2) Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction by Iqbal MP1, Ishaq M, Kazmi KA, Yousuf FA, Mehboobali N, Ali SA, Khan AH, Waqar MA.(PubMed)

Monday, November 20, 2017

All About Vitamins: Vitamin B6 In reduced Risk of hypertriglyceridemia

By Kyle J. Norton.

Vitamin B6 may have a positive and profound effect in reduced risk of hypertriglyceridemia some studies suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In the study to investigate the effect of lysine, vitamin B(6), and carnitine supplementation on both glycemia and the lipid profiles, specifically triglyceride (TG) levels of a total of 85 hypertriglyceridemic (TG> 150 mg/dL) male patients randomizedly assigned to 1 of 5 groups given supplements of lysine (1 g/d), vitamin B(6) (50 mg/d), lysine (1 g/d) + vitamin B(6) (50 mg/d), carnitine (1 g/d), or placebo for 12 weeks, after taking into account of other con founders, researchers filed the following report
1. VitaminB(6) supplementation given in an equated amount was associated with a significant reduction in total cholesterol and HDL-C of 10%.
2. Plasma total cholesterol TG was reduced by 36.6 mg/dL at 6 weeks
3. Administration of lysine and carnitine groups showed no change in lipid file

Interestingly, although chemical compound lysine and carnitine play an important role in alternating fat metabolism to induce hypertriglyceridemia, they have no impact in expression of total cholesterol and HDL-C concentrations

Further analysis, Dr. Hlais S the dead author said, "Vitamin B(6) supplementation in these male patients with hypertriglyceridemia reduced plasma total cholesterol and HDL-C concentrations". 

Other in the study to investigate the effect of elevated plasma concentrations of homocysteine, a sulfur-containing amino acid, are a risk factor for coronary, cerebral and peripheral artery disease caused by vitamin B6 and other micro nutrients deficiency suggested that the use of addition of folic acid, vitamin B12 and B6 to fibrates reduced intake of two important classes of drugs, lipid-lowering drugs and anti-hypertensive drugs, on homocysteine metabolism for prevention of CVD.

Dr. said, "(drugs) used for treatment of hypertriglyceridemia and low HDL-cholesterol, are associated with an increase of homocysteine by 20%-50%".

Taking altogether, vitamin B6 have a significant effect in reduced risk of CVD through lowering the levels of bad cholesterol and total cholesterol and reduced production of  homocysteine drugs used for treatment hypertriglyceridemia.

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial by Hlais S1, Reslan DR, Sarieddine HK, Nasreddine L, Taan G, Azar S, Obeid OA.(PubMed)
(2) Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels by Dierkes J1, Luley C, Westphal S.(PubMed)

Monday, November 13, 2017

All About Vitamins: Vitamin B6 In decreased Symptoms Severity In Premenstrual Syndrome

By Kyle J. Norton.

Vitamin B6 may have a strong impact in reduced symptoms in women with premenstrual syndrome, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts, effecting over 70% to 90% of women in the US.

In the study of 84 female students lived at the university dorm, randomly selected and allocated into two groups of 42 with the first group received auriculotherapy (10 sessions) for two menstrual cycles and the second group consumed 40 mg of vitamin B6 daily from a week before their menstruation for two menstrual cycles, after examining the returned questionnaire, researchers filed the following results
1. Both groups showed a significant difference compared to before the intervention
2. Vitamin B6 treated group displayed a mean score of 22.60 (10.87) and 24.17 (14.15), in the first and second cycles in compared to the auriculotherapy group of 26.70 (19.49) and 24.76 (17.07)
3. After considering other risk factors, in comparing the total score of symptoms in the first and second cycles after the intervention, both groups showed no significant difference.

In other word, both vitamin B6 and  auriculotherapic treatment expressed an decreased symptoms of  premenstrual syndrome.

Additionally, in a two-stage double-blind clinical trial conducted on 126 women and randomly allocated into 3 groups to receive magnesium, vitamin B6, or placebo performed in 10 selected health centers in Isfahan and lasted for 4 months, researchers reported that all groups showed a significantly decreased the mean scores of premenstrual syndrome after the intervention.

However, in compared to magnesium treatment group, vitamin B6 and placebo had the most and least efficiency in improving the mean premenstrual syndrome score.

Interestingly, in a double blind randomized controlled carried out on 76 students of Hamadan University of Medical Sciences and randomly allocated to two groups, 38 people in each group either received calcium tablet (500mg) and vitamin B6 (40 mg) or only vitamin B6 twice a day for two consecutive months, researchers indicated that although vitamin B6 alone treatment group expressed some improvement of symptoms pf PMS, but combination of calcium and vitamin B6 are far more better in controlling of the premenstrual syndrome symptoms.

Taking altogether, There is no doubt that vitamin B6 may be recommended as a potential and therapeutic supplement in reduced the severity of symptoms of PMS.




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Sources
(1) Comparing the Effect of Auriculotherapy and Vitamin B6 on the Symptoms of Premenstrual Syndrome among the Students who Lived in the Dorm of Isfahan University of Medical Sciences by Koleini S1, Valiani M2.(PubMed)
(2) Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms by Ebrahimi E1, Khayati Motlagh S1, Nemati S1, Tavakoli Z1(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 8, 2017

All About Vitamins: Vitamin B6 in Improved Infant childhood Neuromotor Activities

By Kyle J. Norton.

Vitamin B6 deficiency may have a strong impact in behavioral effects in child neuro development, a renowned study suggested.
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In animal study to investigate behavioral effects of preweaning pyridoxine deficiency, researchers filed the following results
1. Rat with vitamin B6 deficiency expressed less the body weight in compared to control
2. The vitamin B6 deficiency rat also displayed a delay of supported standing and eye opening
3. Reduced open-field activity reflected by the exploratory score was also observed in vitamin-deficient rats

Dr. Krishna AP, after taking account of other co founders said, "considerable effects of prenatal pyridoxine deficiency were observed in the neonatal pups as stunting of growth and in the delayed onset of neuromotor coordination as well as a low level of open-field activity".

These results reflected the important role of of maternal pyridoxine supplementation during pregnancy in reduced risk of child neuro development abnormality, particularly in neuromotor coordinations.

Other, in the support of the above analysis, researchers at the A.B. Shetty Memorial Institute of Dental Sciences, conducted a review of the effect of preweaning pyridoxine deficiency in induced lower the body weight and brain weight in compared to control found that
1. Vitamin B6 deficiency rat showed a delay of stabilisation of reflex reactions
2. Reaction of these group of rat expressed in maturation of neuromotor coordination also significantly slow

Dr. Krishna AP, the led author said, "This suggests that the importance of maternal pyridoxine supplementation cannot be overlooked in pregnant women especially after prolonged use of anovulatory steroids".

Taking altogether, Oral administrated of vitamin B6 may have a profound effect in reduced risk of 
childhood neuromotor abnormality if taken with recommended dose during pregnancy, particularly in women with prolonged use of anovulatory steroids'.


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Sources
(1) Effect of pyridoxine deficiency on the exploratory behavior of rats by Krishna AP, Ramakrishna T.(PubMed)
(2) Effect of pyridoxine deficiency on maturation of neuromotor coordinations by Krishna AP1, Ramakrishna T.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Monday, November 6, 2017

All About Vitamins" Vitamin B6 in Improved Cognitive Function?

By Kyle J. Norton.

Vitamin B6 may have a therapeutic effect in improved cognitive development of offsring, a Johns Hopkins University School of Hygiene and Public Health study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In the study the effect of vitamin B6 in pregnant and lactating women,  researchers found that recommended dietary allowance of vitamin B6 may have a strong effect in improved cognitive and brain development as the nutrient is an essential cofactor in the developing central nervous system of fetus.

Dr. Guilarte TR, at the study said, " Recent work in animal models suggests that vitamin B6 deficiency during gestation and lactation alters the function of N-methyl-D-aspartate receptors, a subtype of receptors of the glutamatergic neurotransmitter system thought to play an important role in learning and memory".

Other, in the study of nutrient effect on cognitive impairment, patients with AD expressed a 50% deficits of various nutrients, including folic acid, vitamin B12, B6, C, E, A, D, K, beta carotene and omega 3 fatty acids.

Interestingly, In the investigation of whether baseline folate, vitamin B-6, and/or vitamin B-12 intake, alone or in combination, are associated with incident MCI/probable dementia among older women containing 7030 Postmenopausal women free of MCI/probable dementia at baseline in the Women's Health Initiative Memory Study, after carefully examine the returned questionnaire, researchers indicated that vitamin B6 showed no effect in improved symptoms of dementia in this group of women.

Taking together, vitamin B6 may have a profound effect in reduced risk of brain and cognitive abnormality in infant if taken according to recommended doses during pregnant. However, the vitamin does not reduce symptoms in patient with dementia.

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Sources
(1) Vitamin B6 and cognitive development: recent research findings from human and animal studies by Guilarte TR1(PubMed)
(2) Nutrition and cognitive impairment by [Article in Spanish; Abstract available in Spanish from the publisher] by Hernando-Requejo V1.(PubMed)
(3) Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study by Agnew-Blais JC, Wassertheil-Smoller S, Kang JH, Hogan PE, Coker LH, Snetselaar LG, Smoller JW.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thursday, November 2, 2017

All About Vitamins: Vitamin B6 for Treatment of Symptoms of Carpal Tunnel Syndrome?

By Kyle J. Norton.

Vitamin B6  may have a profound effect in reduced symptoms of  Carpal Tunnel Syndrome, an Iran study suggested

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Carpal Tunnel Syndrome is a condition, characterized by numbness, tingling, weakness, or muscle damage in the hand and fingers, as a result of the pressure on the median nerve.

In the study of Forty patients (67 hands) with mild-moderate CTS initially selected and randomly assigned into two groups as follows: 1) Case group with 20 subjects (32 affected hands) receiving vitamin B6 (120 mg/day for 3 months) and splinting. 2) Control group with 19 subjects (35 affected hands) only received splinting, researchers filed the following reports
1. Vitamin B6 treatment group expressed a strong improvement of nocturnal awakening frequency due to pain, daily pain, daily pain frequency, daily pain persistence, hand numbness, hand weakness, hand tingling, severity of nocturnal numbness and tingling, nocturnal awakening frequency owing to hand numbness and tingling, and clumsiness in handling objects. in compared to other groups
2. However, oral administrated vitamin B6 group displayed insignificant result in opening a jam bottle and handling phone in compared to control
3. Vitamin B6 groups also demonstrated an improvement of median nerve sensory latency mean decreased and the median nerve sensory amplitude mean and sensory conduction velocity mean increased.

Dr. Talebi M, the led author said, "vitamin B6 treatment improves clinical symptoms and sensory electrodiagnostic results in CTS patients" and "(it) is recommended for CTS treatment".

Other, in the study of a 42-year-old woman with carpal tunnel syndrome started taking vitamin B6 supplement to relieve her symptoms, researchers indicated that vitamin B6 is often used as a conservative and adjunct therapy for patients with carpal tunnel syndrome, but patients attempted to treat their symptoms with vitamin B6 on their own should be aware that Vitamin B6 at more than 200 mg daily may induce some unpredictable adverse effects.

Dr. Ryan-Harshman M, the led authorsaid, " Vitamin B6 at less than 200 mg daily is not likely to cause any adverse effects, but patients should be monitored for changes in symptoms, particularly when high doses are taken over long periods".

Contrastively, in the Electroencephalogram (EEG) studies to evaluate the role of vitamin B6 as a therapeutic agent in the treatment of carpal tunnel syndrome by monitoring both the standard clinical and electrophysiological parameters for entrapment neuropathy at the wrist, researchers disagreed that vitamin B6 may be sued for treatment of carpal tunnel syndrome, as patients in the tested showed no changes occurred during the treatment period. Motor latency, while the most common screening test for carpal tunnel syndrome, was not significantly changed during the course of treatment.

Taking altogether, Vitamin B6  may have a profound effect in reduced symptoms of  Carpal Tunnel Syndrome, but large sample size and cohost studies are necessary to prove this validity.


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Sources
(1) Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome by Talebi M1, Andalib S, Bakhti S, Ayromlou H, Aghili A, Talebi A.(PubMed)
(2) Carpal tunnel syndrome and vitamin B6 by Ryan-Harshman M1, Aldoori W.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Wednesday, November 1, 2017

All About Vitamins: Vitamin B6 for Treatment of inborn errors Epilepsy

By Kyle J. Norton.

Vitamin B6  supplement may have a profound effect in reduced risk of childhood epilepsy, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In concern of inborn errors of metabolism in affecting vitamin B6 concentrations in the brain in induced early-onset epilepsy, without showing hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency researchers at the Chang Gung University found that pyridoxal phosphate (PLP), the active form of vitamin B6 displayed a significant effect in treating patients without the above four disorders.

The study also indicated that patients with pyridoxine phosphate oxidase deficiency also responded to pyridoxal phosphate (PLP) instead of pyridoxine.

DR. Wang HS, the led author said, "patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known" and "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Others, in the support of the about differentiation also postulated that PLP therapy also found to be effective in treatment of all four disorders, but pyridoxine oral intake failed to improved seizures in PNPO deficiency.

However, PLP treatment in epilepsy expressed some adverse effect in severe apnea, therefore  resuscitation equipment should be at hand during a first pyridoxine/PLP administration. 

Interestingly, in he study of four genetic epilepsies with vitamin B6 dependent seizures, particularly, to pyridoxine therapy resistant seizures in the neonatal period with PNPO patients researchers found these patients may need PLP substitution and therapy resistant seizures diagnosed early can prevent irreversible neurologic damage.

Taking altogether, there is no doubt that vitamin B6 in form of pyridoxine and PLP may have a therapeutic effect in treatment childhood epilepsy. But in case of therapy of resistant seizures, substitution of pyridoxine by PLP are always necessary.


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Sources
(1) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(2) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(3) Vitamin B6 dependent seizures by Plecko B1, Stöckler S.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Tuesday, October 31, 2017

All About Vitamins: Vitamin B6(pyridoxine), the Best in Prevented Hair Loss

By Kyle J. Norton.

Administrated vitamin B6 may have a strong impact in prevented hair loss, a respectable institute study suggested

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Androgenic alopecia hair loss are caused by shrieked the follicles in inducing hair thins and hair receding at the forehead, crown and temple for men and thins over the entire scalp for women.

According to the joint study led by the University of Genova, injection of vitamin B6 (pyridoxine) of 160 or 80 mg/kg body weight/day) used conjunction with chemopreventive treatment against adverse effect caused by doxorubicin in treatment of various types of cancer expressed a significant reduced hair loss in C57BL/6 mice.

In the study of C57BL/6 mice exposed whole-body to environmental cigarette smoke in a smoking machine, assigned to groups received in the diet, at three dose levels, a mixture of L-cystine with vitamin B6 after 6 months of experiment, researchers found that L-Cystine/vitamin B6 treated group displayed a strong effect in inhibited alopecia in a dose-dependent manner.

However, the study also indicated that micronucleated erythrocytes as an Index of Cytogenetic Damage if frequently increased due to continuous exposure ECS may negate treatment with L-cystine/vitamin B6. ECS-induced alopecia and promoted apoptosis of hair bulb cells.

Additionally, in a clinical and trichological examination (trichogram and hair loss evaluation) conducted comparatively before and after the treatment in 46 women between pubescence and 30 years of age with symptoms of diffuse alopecia, given the following adminitration
1. Calcium pantothenate twice a day orally in doses 100 mg for 4-5 months.
2. Vitamin B6 was injected every day (i ampoule intramusculary) for the period of 20 to 30 days and repeated again after 6 month.
researchers at the Katedry i Kliniki Dermatologii Slaskiej Akademii Medycznej w Katowicach reported the results as follows
1. Vitamin B6 administered parenterally expressed a significant improvement in the hair condition in a number of women for a period of several weeks.
2. Vitamin B6 group also reduced the hair loss especially in alopecia of telogenic patomechanism in compared to calcium group

Taking together, there is no doubt that vitamin B6 is effective in reduced hair loss used in conjunction of chemo medicine and alone. high dose of intake should only prescribed by professional doctors.


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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of L-cystine and vitamin B6  by D'Agostini F1, Fiallo P2, Ghio M3, De Flora S4.(PubMed)
(2) Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6 by D'Agostini F1, Fiallo P, Pennisi TM, De Flora S.(PubMed)
(3) [Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women].[Article in Polish]by Brzezińska-Wcisło L1.(PubMed)

Monday, October 30, 2017

All About Vitamins: Vitamin B6 in Reduced Risk and Treatment of Gestational Diabetes?

By Kyle J. Norton.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Vitamin B6 may have a potential effect in controlling blood glucose and plasma insulin in pregnancy with gestational diabetes mellitus, a renowned institute study suggested.

In the study of 13 woman with gestational diabetes mellitus treated with 100 mg. of vitamin B6 per day for 2 weeks than tested with an intravenous glucose tolerance for both blood glucose and plasma insulin levels, researchers filed the following results
1. Vitamin B6 treatment induced a statistically significant improvement in the glucose tolerance in all aspects
2. Vitamin B6 group also enhanced glucose effect with unchanged or lowered plasma insulin level.

After taking into account of other factors, researchers insisted that women with a relative deficiency in vitamin B6 associated with some cases of gestational diabetes mellitus are most beneficial with replacement of this vitamin in improved the metabolic state.

Dr. Spellacy WN, the led author said, "The low vitamin B6levels appear to alter metabolic pathways which result in a lowering of the biologic activity of endogenous insulin".

More interestingly, in a study of 14 pregnant women with gestational diabetes caused by increased xanthurenic-acid synthesis during pregnancy treated with vitamin B6 (pyridoxine) 100 mg/day for 14 days by mouth resaerchers found that
1. Treatment of vitamin B6 not only reduced the deficiency but also improved glucose tolerance considerably.
2. Treatment with vitamin B6 normalized the production of xanthurenic-acid by restoring tryptophan metabolism.

Contrastively, in the investigate the potential simplicity and far-reaching benefits of the amelioration or prevention of gestational diabetes mellitus by pyridoxine, researcher showed that vitamin B6 showed no beneficial effects on abnormal glucose tolerance in pregnancy in 4 cases studied and These studies failed to confirm their results statistically significant in compared to previous studies.

Dr, Perkins RP said, the reason behind these failure may be a result of "the dietary alterations made during pyridoxine therapy in the previous report had a greater effect on outcome than the authors had suspected".

Taking altogether, vitamin B6 administration may have positive effect in reduced symptoms and treatment of gestational diabetes only to vitamin B6 deficient pregnant women. For other use of vitamin B6, particularly in gestational diabetes women without expressing vitamin B6 deficiency,  may require further confirmation of large sample sizes and cohost studies.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Vitamin B6 treatment of gestational diabetes mellitus: studies of blood glucose and plasma insulin by Spellacy WN, Buhi WC, Birk SA(PubMed)
(2) Failure of pyridoxine to improve glucose tolerance in gestational diabetes mellitus by Perkins RP.(PubMed)
(3) Improvement of oral glucose tolerance in gestational diabetes by pyridoxine by Bennink HJ, Schreurs WH.(PubMed)

Friday, October 27, 2017

All About Vitamins: Vitamin B6 for Treatment of Nausea and Vomiting in Early Stage of Pregnancy

By Kyle J. Norton.


Intake of vitamin B6 in the early stage of pregnancy may have a profound effect in reduced symptoms of nausea and vomiting, a renowned study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In a comparison of the effects of quince fruit and vitamin B6 intake on symptoms of mild-to-moderate nausea and vomiting (NVP) of 76 pregnant women with a gestational age of 6-14 weeks presented (40 in the quince and 36 in the B6 group), researchers found that
1. The score of the PUQE was decreased from 8.4 at baseline to 7.3 and 7.7 on the 14th day (p < .001) in the vitamin B6 group, respectively
2. Symptoms of mild-to-moderate nausea and vomiting (NVP) also decreased in both groups, according to assay

Although vitamin B6 intake group showed a significantly reduced symptoms of mild-to-moderate nausea and vomiting in lesser effective in compared to quince (Cydonia oblonga) fruit group.
Dr. Jafari-Dehkordi E, the led researchers, due to the nature of stage of pregnancy said," Pregnancy-induced nausea and vomiting (NVP) is one of the most common problems during gestation. Treatment is mainly symptomatic, ranging from dietary changes and oral pharmacological treatment to hospitalization in severe forms. In early pregnancy, the use of chemical drugs is avoided, so there is an increasing tendency to use alternative therapies".

Additionally, in a triple blind clinical trial on pregnant women suffering mild to moderate NVP between 6 and 16 weeks of pregnancy randomized assign to ginger, 500 mg twice daily, vitamin B6 40 mg twice daily and placebo twice daily for 4 days, according to the returned questionnaire, researchers filed the following results
1. All 3 groups pisplayed a significant improvement of nausea
2. All 3 group expressed a similar reduction of vomiting but lesser effective in placebo
3. Both Ginger and vitamin B6 groups reduced the severity of all items of Rhodes questionnaire significantly but less effective in frequency of nausea, intensity of vomiting and frequency of retching in compared to placebo.
4. Ginger and vitamin B6 groups did not show significant difference in total score in Rhodes

Dr. Sharifzadeh F, after taking into account of other factors, such as age, gestational age, parity, and severity of each symptom, said, "Ginger is more effective than placebo for the treatment of mild to moderate NVP and comparable to vitamin B6".

In support of the above differentiation, the study a 126 pregnant women, with a gestational age of < or = 16 weeks who had nausea and vomiting, required anti-emetics, had no medical complication, and not hospitalized, randomly allocated to receive either 650 mg of ginger or 25 mg of vitamin B6 conducted by the Bangkok Metropolitan Administration Medical College and Vajira Hospital, researchers illustrated that
1. Ginger and vitamin B6 significantly reduced scores
2. Vitamin B6 even thought improved symptoms of nausea and vomiting,but lesser effective in compared to ginger group.
3. Side effect of both group are well tolerated.

Taking altogether, there is no doubt that vitamin B6 may be used as therateutic treatment in reduced symptoms of nausea and vomiting in early stage of pregnancy


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A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Comparison of quince with vitamin B6 for treatment of nausea and vomiting in pregnancy: a randomised clinical trial by Jafari-Dehkordi E1, Hashem-Dabaghian F1, Aliasl F2, Aliasl J1, Taghavi-Shirazi M1, Sadeghpour O1, Sohrabvand F3, Minaei B4, Ghods R1.(PubMed)
(2) A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP) by Sharifzadeh F1, Kashanian M1, Koohpayehzadeh J2, Rezaian F1, Sheikhansari N3, Eshraghi N1.(PubMed)
(3) Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial by Chittumma P1, Kaewkiattikun K, Wiriyasiriwach B.(PubMed)

Thursday, October 26, 2017

All About Vitamins: Vitamin B6 in Reduced Symptoms of PMS

By Kyle J. Norton.


Vitamin B6 may have a profound effect in reduced symptoms and risk PMS, a joint study led by the Isfahan University of Medical Sciences suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, effected over 70% to 90% of women in the US and lesser for women in Southeast Asia because of difference in living style and social structure. The syndrome also interferes women's physical and emotional states, and daily activities as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts.

In the study of 84 students lived at the university dorm randomly selected and allocated into two groups of 42 with the first group received auriculotherapy (10 sessions) for two menstrual cycles and the second group consumed 40 mg of vitamin B6 daily from a week before their menstruation for two menstrual cycles, researchers found that group treated vitamin B6 showed a significant improvement of 22.60 and 24.17 of he mean score of symptoms in the first and second cycles in compared to auriculotherapy group of 26.70 and 24.76, respectively.

However, after taking into account of other risk factors, researchers indicated that both group expressed a ameliorated severity of symptoms of premenstrual syndrome with no difference in the pain scores.

Dr. Koleini S, the led author said, "Auriculotherapy, similar to vitamin B6, decreases the severity of PMS symptoms".
Additionally, in support of the above analysis, a study of two-stage double-blind clinical trial conducted on 126 women, selected from 10 health centers in Isfahan and lasted for 4 months,  randomly allocated into 3 groups in received magnesium, vitamin B6, or placebo  researchers showed that vitamin B6 group demonstrated a strong improvement in the mean scores of premenstrual syndrome by significantly decreased symptoms of severity.

But after taking into account of other factors, vitamin B6 showed a lesser effective in compared to magnesium intake group.

More interestingly, in a double blind randomized controlled carried out on 76 students of Hamadan University of Medical Sciences, randomly allocated to two groups. (38 people in each group) with intervention groups received calcium tablet (500mg) and vitamin B6 (40 mg) and student in intervention groups received only vitamin B6 twice a day for two consecutive months, after adjusting to other factors, researchers suggested that both groups expressed an enormous improvement in symptoms of severity but this improvement was more significant in the combined calcium and vitamin B6 group.

The information collected indicated that vitamin B6 used alone or combined with calcium or magnesium may have a positive effect in reduced symptoms of PMS.


 
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A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half




Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Comparing the Effect of Auriculotherapy and Vitamin B6 on the Symptoms of Premenstrual Syndrome among the Students who Lived in the Dorm of Isfahan University of Medical Sciences by Koleini S1, Valiani M2.(PubMed)
(2) Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms by Ebrahimi E1, Khayati Motlagh S1, Nemati S1, Tavakoli Z1.(PubMed)
(3) Comparing the Effect of Auriculotherapy and Vitamin B6 on the Symptoms of Premenstrual Syndrome among the Students who Lived in the Dorm of Isfahan University of Medical Sciences by Koleini S1, Valiani M2.(PubMed)