All About Vitamins: Vitamin B6 for Treatment of inborn errors Epilepsy

By Kyle J. Norton.

Vitamin B6  supplement may have a profound effect in reduced risk of childhood epilepsy, a renowned institute study suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In concern of inborn errors of metabolism in affecting vitamin B6 concentrations in the brain in induced early-onset epilepsy, without showing hyperprolinemia type 2, antiquitin deficiency, and pyridoxine phosphate oxidase deficiency researchers at the Chang Gung University found that pyridoxal phosphate (PLP), the active form of vitamin B6 displayed a significant effect in treating patients without the above four disorders.

The study also indicated that patients with pyridoxine phosphate oxidase deficiency also responded to pyridoxal phosphate (PLP) instead of pyridoxine.

DR. Wang HS, the led author said, "patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known" and "Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy".

Others, in the support of the about differentiation also postulated that PLP therapy also found to be effective in treatment of all four disorders, but pyridoxine oral intake failed to improved seizures in PNPO deficiency.

However, PLP treatment in epilepsy expressed some adverse effect in severe apnea, therefore  resuscitation equipment should be at hand during a first pyridoxine/PLP administration. 

Interestingly, in he study of four genetic epilepsies with vitamin B6 dependent seizures, particularly, to pyridoxine therapy resistant seizures in the neonatal period with PNPO patients researchers found these patients may need PLP substitution and therapy resistant seizures diagnosed early can prevent irreversible neurologic damage.

Taking altogether, there is no doubt that vitamin B6 in form of pyridoxine and PLP may have a therapeutic effect in treatment childhood epilepsy. But in case of therapy of resistant seizures, substitution of pyridoxine by PLP are always necessary.

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Sources
(1) Vitamin B6 related epilepsy during childhood by Wang HS1, Kuo MF.(PubMed)
(2) Pyridoxine and pyridoxalphosphate-dependent epilepsies by Plecko B1.(PubMed)
(3) Vitamin B6 dependent seizures by Plecko B1, Stöckler S.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.