All About Vitamins: Vitamin B6 deficiency in Risk of Hyperhomocysteinaemia

By Kyle J. Norton.

Vitamin B6 deficiency may have a strong implication on  hyperhomocysteinaemia in increased risk of cardiovascular disease, some studies suggested

Homocysteinaemia, a maker for heart disease development, is a medical condition characterized by an abnormally level of homocysteine in the blood stream.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

According to the study conducted by the The Aga Khan University, to evaluate the homocysteine levels of 290 apparently healthy hospital personnel from institutions in two cities of Pakistan, deficiency of vitamin B6 and other vitamins may be associated to higher risk of  homocysteine in compared to control.

Indeed, Dr. Iqbal MP, the lead author indicated that serum/plasma levels of micro nutrients have a significant negatively correlated with plasma homocysteine.

In other word, Deficiency of certain micro nutrients, including vitamin B6 may increase substantial risk to hyperhomocysteinaemia.

The result strongly support that mass micro nutrient supplementation are necessary in this group of people to prevent the high incidence of cardiovascular disease.

Other study in the instigation of the same group of Pakistani people, involving 224 AMI patients (age 30-70 years; 55 females and 169 males) and 126 normal healthy subjects (age 31-70 years; 35 females and 91 males) for risk of hyperhomocysteinaemia in micro nutrients deficiency aspects, researchers showed that a lower levels of vitamin B6 and other micro nutrients, including folate and vitamin B6 demonstrated a significant effect in the onset of hyperhomocysteinaemia in both control and study group.

Dr. Iqbal MP, the lead author said, "Substantial nutritional deficiencies of these three vitamins along with mild hyperhomocysteinemia, perhaps through an interplay with the classical cardiovascular risk factors". 

Taking altogether, vitamin B6 may have a profound effect in combined with deficiencies of other nutrients in induced risk of hyperhomocysteinaemia development, a marker of CVD.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Folic acid and vitamin B6 deficiencies related hyperhomocysteinemia in apparently healthy Pakistani adults; is mass micronutrient supplementation indicated in this population? by Iqbal MP1, Lindblad BS, Mehboobali N, Yusuf FA, Khan AH, Iqbal SP.(PubMed)
(2) Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction by Iqbal MP1, Ishaq M, Kazmi KA, Yousuf FA, Mehboobali N, Ali SA, Khan AH, Waqar MA.(PubMed)