Vitamin B6 may have a positive and profound impact in reduced risk of type 2 diabetes in patients with depression and other conditions, some studies suggested
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.
Diabetes is a medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.
According to Dr. Oxenkrug G, the lead author in the investigate the effects of vitamin B6 deficiency in risk of type 2 diabetes, as a cofactor of the key enzymes in regulating trytrophan metabolism, suggested that vitamin B6 deficiency may alter the formation of co enzyme (NAD) towards production of xanthurenic (XA) and kynurenic (KYNA) acids, which have a strong impact in the production, release and biological activity of insulin.
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.
According to Dr. Oxenkrug G, the lead author in the investigate the effects of vitamin B6 deficiency in risk of type 2 diabetes, as a cofactor of the key enzymes in regulating trytrophan metabolism, suggested that vitamin B6 deficiency may alter the formation of co enzyme (NAD) towards production of xanthurenic (XA) and kynurenic (KYNA) acids, which have a strong impact in the production, release and biological activity of insulin.
Where Xanthurenic acid is excreted by pyridoxine (vitamin B6) deficient and Kynurenic acid is a product of the normal metabolism of amino acid L-tryptophan.
The study also indicated that increased intake of vitamin B6 supplement and monitored formation of diabetogenic KYN derivatives might help to identify subjects-at-risk for the development of diabetes.
Further analysis, the authors also said, "Pharmacological down-regulation of the TRP - KYN - NAD pathway and maintenance of adequate vitamin B6 status might help to prevent the development of diabetes in depression and other conditions associated with inflammation/stress- induced excessive production of KYN and vitamin B6 deficiency, e.g., o".
In support to the above differentiation, the Tufts University School of Medicine conducted a study to review literature published data for evidences that dysregulation of tryptophan (TRP)-kynurenine (KYN) and KYN-nicotinamide adenine dinucleotide (NAD) metabolic pathways is one of the mechanisms of IR suggested that vitamin B6 deficiency may impair the function of key enzymes of tryptophan (TRP)-kynurenine (KYN) and KYN-nicotinamide adenine dinucleotide (NAD) in production, release, and biological activity of insulin, thus increasing risk of type 2 development.
Taking together, thee is no doubt that vitamin B6 deficiency may have a significant effect in the onset of type 2 diabetes by alternating the production, release, and biological activity of insulin, through trytophan metabolic pathway.
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Sources
(1) Kynurenines and vitamin B6: link between diabetes and depression by Oxenkrug G, Ratner R, Summergrad P.(PubMed)
(2) Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways by Oxenkrug G1.(PubMed)
Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
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