All About Vitamins: Vitamin B6 in Reduced Psychological symptoms of Schizophrenia

By Kyle J. Norton.

Vitamin B6 may have a potential effect in reduced psychological symptoms in chronic schizophrenic and schizoaffective patients, some researchers suggested.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

Schizophrenia is a severe mental disorder characterized with inability to interpret reality normally and Schizoaffective disorder is also a chronic mental health condition characterized primarily by symptoms of schizophrenia.

In a study to examine the effects of vitamin B6 reduced psychotic symptoms of psychopharmacologic treatment of patients suffering from schizophrenia or organic mental disorder, of spanning 9 weeks with all patients with stable psychopathology for at least 1 month before entry and randomly received placebo or vitamin B6, starting at 100 mg/day in the first week and increasing to 400 mg/day in the fourth week by 100-mg increments each week, researchers found that there are no differences between vitamin B6- and placebo-treated patients in amelioration of mental state of attendees.

Dr. Lerner V, after taking into account of other confounders, said, "Further studies with larger populations and shorter duration of illness are needed to clarify the question of the possible efficacy of vitamin B6 in treatment of psychotic symptoms in schizophrenia".

Other researchers in the confirmation of vitamin B6 great progress in the treatment of positive symptoms in schizophrenic patients and movement disorders induced by neuroleptics,at the Ben Gurion University of the Negev, launched a a double-blind crossover controlled during 9 weeks with patient treated with up to 400 mg/day vitamin B6 versus placebo, after reviewing the result taken from Positive and Negative Symptoms Scale (PANSS), Extrapyramidal Symptoms Rating Scale (ESRS) and a blood sample of level pyridoxal showed that vitamin B6 treated group demostrated a significant improvement in tardive dyskinesia and parkinsonian symptoms. but failed to express therapeutic effect of psychotic symptoms from vitamin B6 added to antipsychotic agents.

The contradictory findings suggested that further studies with larger samples and higher doses of vitamin B6 are necessary before clarifying the possibility of a positive therapeutic effect of vitamin B6 as an augmentation agent for the treatment of psychotic symptoms.

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Sources
(1) Vitamin B6 as add-on treatment in chronic schizophrenic and schizoaffective patients: a double-blind, placebo-controlled study by Lerner V1, Miodownik C, Kaptsan A, Cohen H, Loewenthal U, Kotler M.(PubMed)
(2) [Vitamin B6 add-on therapy in treatment of schizophrenic patients with psychotic symptoms and movement disorders].[Article in Hebrew] by Miodownik C1, Cohen H, Kotler M, Lerner V.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.