Herbal Coltsfoot May Process Antitussive Activity Against Coughing

Coughing is a natural reflex that clears the throat of mucus or foreign pathogens. Frequent coughing may be a condition of infection caused by inflammation of the airway.

An acute cough is a condition that lasts for less than three weeks. Chronic coughing that lasts more than 3 weeks may be a condition of respiratory diseases, including asthma, allergies, gastroesophageal reflux disease (GERD), or bronchitis.


Phlegm produced in the lungs and lower respiratory tract is a type of mucus found mostly in acutely sick or longstanding health conditions patients.

Chronic mucus collected in the lungs has been associated with patients with tuberculosis (TB), pneumonia, a fungal infection, whooping cough early in life, and measles.

Seriously, chronic mucus collected in the lungs increases a significant risk of further infections and more damage.

Antitussive is a type of substance used to prevent or relieve a cough.

The most common type of antitussive drugs used for the treatment of cough is dextromethorphan

Another expectorant available in OTC products is guaifenesin.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of chronic cough, researchers examined the anti-antitussive effect of Tussilagone (TSL) chemical constituents, chlorogenic acid (1), 3,5-dicaffeoylquinic acid (2), 3,4-dicaffeoylquinic acid (3), and 4,5-dicaffeoylquinic acid (4).isolated from the flower of buds of Tussilago farfara (Compositae).

The study included selected mice orally treated with these compounds and their mixture (in a ratio of 5:28:41:26 as in EtE) at doses of 10 and 20 mg/kg once daily for 3 days.

According to the tested analysis, chemical compounds 4,5-dicaffeoylquinic acid (4) exerted a significant anti-inflammatory activity by 49.7%.observed by the leukocyte count in the bronchoalveolar lavage fluid associated with acute airway inflammation compared to the other compounds.


Moreover, 4,5-dicaffeoylquinic acid (4) also inhibited 58.0% in cough frequency.

Based on the findings, researchers said, "The caffeoylquinic acids and their mixture, exhibiting significant antitussive,...and anti-inflammatory effects, could be considered as the main effective ingredients of FTF, and they may act in a collective and synergistic way.".

Taken altogether, coltsfoot may be considered an antitussive remedy, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara by Wu QZ1, Zhao DX1, Xiang J1, Zhang M1, Zhang CF1, Xu XH. (PubMed)