Lycopene Improves the Lung Function Against Allergic Airways Disease (AAD)

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove the carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.


In 2017, 28,600 Canadians were diagnosed with lung cancer, represented 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, smoking are some of the most prevalent factors associated with the onset of the disease.

Most common lung diseases in North America including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Allergic airways disease (AAD) is an inflammatory disease associated with the immune response to allergies.

In other words, allergic airway inflammation is an abnormal reaction of the immune system towards unharmfully common and environmental factors, such as pollen grains or dust mites.

Inflammation is a natural reaction of the immune system which protects our body against the stimuli of invasive pathogens.

Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines during the acute phase of infection.

The most common diseases associated with allergic airway inflammation are asthma and allergic rhinitis.

* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.
*Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose associated with the overreaction of the immune system against allergens in the air.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of allergic asthma, researchers examined the effects of lycopene, on allergic inflammation in a mouse model of AAD.

The study included BALB/c mice who received lycopene supplement or control induced AAD. by ovalbumin (OVA).

Based on the tested differentiation, lycopene supplementation reduced eosinophilic infiltrates associated with an inflammatory response in the bronchoalveolar lavage fluid, lung tissue, and blood, and mucus-secreting cell numbers in the airways.

The T helper cells (Th2) associated with the immune response in the production of pro0inflamamtory cytokines such as cytokines IL-4 and IL-5 were also significantly reduced by the administration of lycopene.

In other words, lycopene protects the airway cell integrity against the onset of allergic airway inflammation, particularly in allergic airways disease (AAD).

Based on the findings, researchers said, " Supplementation with lycopene reduces allergic inflammation both in the lungs and systemically, by decreasing Th2 cytokine responses. T" and " lycopene supplementation may have a protective effect against asthma".

Taken altogether, lycopene found in tomato may be considered a remedy for the prevention of allergic airways disease (AAD), pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma by Hazlewood LC1, Wood LG, Hansbro PM, Foster PS. (PubMed)