How to Optimize Your Immune System Against Pathogens Quickly and Permanently, PubMed Studies Suggest

Including a portion of lentil in your diet will have a profound and substantial effect in modulated immune response in acute phase of infection, some scientist suggested

Lentil is a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber, belongings genus Lens the Fabaceae family, native to Middle East.

Immune response is a natural reaction of immune system to protect our body against invasion of foreign substances.

In acute phase of infection, immune system initiated production of of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in induced apoptosis and reduced proliferation of bacteria or virus by attaching to the surface of the injure cells to initiation of alternation. however, over production of pro inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages which are responsible for cell-mediated immunity and phagocyte-dependent protective activity.


In the concerns of lectins adverse effecs may pose a potential threat to consumers due to their capacity to induce histamine release from basophils, after investigating over 16 common dietary produceds containing lectins researchers found that most plant lectins induce human basophils to produce interleukin 4 (IL-4) a anti inflammatory cytokine, which plays an important role in stimulated secretion of T cells and IL-13 another cytokines works conjunction with IL-4 in promoted the expression of T helper 2 (Th2) responses and regulation of Immunoglobulin E (IgE) synthesis.


All these expressed a significant effect of dietary lectin in reduced over expression of pro inflammatory factors in immune system during acute phase of infection in induced further cell damage and death in the infectious site through secretion of anti inflammatory cytokines without decreasing the immune protective activities.


Truly, further examine also found that concanavalin A, lentil lectin, phytohemagglutinin, , triggered basophils to release IL-4 at concentrations of up to 1 ng/10(6) basophils which in turn orchestrated the release of IL-13 and histamine and levels of IL-4 and IL-13 release reached a maximum after 4-6 h and more than 18 h, after injection, , respectively.


These activities demonstrated a significant effect of lentil lectin in inducing early IL-4 required to switch the immuneresponse towards a Th2 response and type I allergy, involving immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils.

Indeed, the relative balance between Th1 and Th2 cytokines appears crucial, as Th1 cells activated immune response during the early state of body injure or damage through evoking cell-mediated immunity and phagocyte-dependent inflammation, in stimulated production of several pro inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-2 and tumor necrosis factor (TNF)-beta which may also cause damage to the cell of the infectious region, leading to permanently additional damage to the tissues and Th2, under response to over expression of pro inflammatory cytokines stimulated the production of IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 of anti inimflammatory mytokines in evoked strong antibody responses (including those of the IgE class) and eosinophil accumulation, and inhibited several functions of phagocytic cells as indicated above.


Taken together, Lentil lectin may have a anti inflammatory effect in reduced over expression of pro inflammatory factors in initiation of symptoms of fever, headache, swelling, redness, loss of appetite, muscle stiffness through activating production of anti inflammatory mytokines.

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Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Role of Th1 and Th2 Cytokines in Immune Response to Uncomplicated Plasmodium falciparum Malaria by Donato Torre,1,* Filippo Speranza,1 Massimo Giola,1 Alberto Matteelli,2 Roberto Tambini,1 andGilberto Biondi1(PMC)
(2) Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils by Haas H1, Falcone FH, Schramm G, Haisch K, Gibbs BF, Klaucke J, Pöppelmann M, Becker WM, Gabius HJ, Schlaak M.(PubMed)
(3) T-cell subsets (Th1 versus Th2) by Romagnani S1(PubMed)

How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed

Add a portion of fennel in your daily diet may have a potential and positive effect in reduced pain caused by sensory neurons stimulus in women with primary dysmenorrhea, some scientists suggested.


Antinociceptive activity is an action or process of blocking the painful or injurious stimulus by sensory neurons.


The results of the investigation were carried out by numbers of respectable institutes, including the Babol University of Medical Sciences and Health Services and details of the experiment were published on online medical library.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

In order to compare the effect of combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study lead by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.


All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).


Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eighth hours in the group was significant lower than the group that had used ibuprofen.



Also, combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.



These result suggested that fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by over expression prostaglandins hormone in induction of abdominal muscle constriction in compared to conventional medicine ibuprofen.


Dr. Nasehi M, the lead author, after taking into account of other co and con founders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".




In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and menorrheal duration, 80 female students satisfied the criteria and guideline were randomly divided in to two groups of intervention (n = 40) and control (n = 40).



The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day and continued for 3 months. The control group received no medication.


According to the result of the experiments, fennel treated group exerted significant decrease of the mean of nausea intensity and weakness from 1.93, and 2.88 after 3 months, in compared to control group from 2.37, 6.65 in control group.


Also in compared to control group, fennel group reduced the duration of menstrual period after two and three months of use.


Moreover, Fennel treated group demonstrated a strong improvement of quality and feelings of well-being after 1 and 3 months.

Taken together, fennel may be considered as functional food for treatment of Primary Dysmenorrhea without inducing adverse effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2.(PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)

How to Improve Your Heart Functioning Naturally and Permanently, Medline Studies Show

Kyle J. Norton

Fennel may have a potential and positive effect in improvement of cardiovascular activity, some scientists suggested.

The results of vascular and cardiovascular protective effect were reported by numbers of universities including the Birzeit University and published on online medical literature.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc


In the study to investigate the vascular effects of aqueous extracts of Foeniculum vulgare leaves in pentobarbital-anaesthetised rats, researchers found that intravenous administration of the lyophilized boiled water extract exerted a significant dose-related reduction in arterial blood pressure, without affecting the heart rate or respiratory rate in compared to histamine antagonists.




However, application of non-boiled aqueous extract showed very little hypotensive activity.



Contrast to the conventional medicine histamine antagonists, the hypotensive effect of the boiling water extract appeared not to be mediated by adrenergic, muscarinic, ganglionic or serotonergic receptors.


Furthermore, in the examine the cardiovascular effect of main component of the oil, anethole isolated from on tested guinea pig fennel oil in inhibited arachidonic acid, collagen-, ADP- and U46619-induced aggregation, researchers found that application of anethole displayed comparable NO-independent vasorelaxant activity at anti platelet concentrations.



Anethole also prevented thrombin-induced clot retraction at concentrations similar to fennel oil in comparison of U46619-induced aggregation (IC(50) from 4 to 147 microg ml(-1)). These results were confirmed in tested mice with application F. vulgare essential oil and anethole in a subacute treatment of 30 mg kg(-1)day(-1) for 5 days.




F. vulgare essential oil and anethole also showed significant antithrombotic activity in prevented paralysis induced by collagen-epinephrine intravenous injection with 70% and 83% protection, respectively.

In rat model, both F. vulgare essential oil and anethole (100 mg kg(-1) oral administration) provided significant protection toward ethanol induced gastric lesions.

After taking into account of other co and confounders, togther with the collected information Dr. Tognolini M, the lead author said, " F. vulgare essential oil, and its main component anethole, a safe antithrombotic activity that seems due to their broad spectrum antiplatelet activity, clot destabilizing effect and vasorelaxant action".


Further to re assess other cardiovascular activity of Foeniculum vulgare L, researchers at the UFR Physiologie-Pharmacologie, launched an investigation to compared the effects of Marrubium vulgare L. and Foeniculum vulgare L. in spontaneously hypertensive rats (SHR).



Interestingly, oral application of Foeniculum extract exerted lowered the systolic blood pressure of SHR without induced change of normotensive Wistar-Kyoto rats (WKY).



These results was probably associated to function of Foeniculum in increased water, sodium and potassium excretion.



More importantly, Foeniculum extract hypertensive efficacy was decreased substantially in rat and mice presented with N-nitro-L-arginine.




The results indicated that fennel demonstrated the vascular protective activity as a diuretic and a natriuretic.



Taken together, Fennel and its essential oil and bioactive compound anethole may be considered as a function substance in promote cardiovascular and vascular activity, particularly in animal models with high risk of cardiovascular disease.


Intake of fennel extract should be taken with extreme care as overdoses may induce liver toxicity.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis by Tognolini M1, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E.(PubMed)
(2) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
(3) The vascular action of aqueous extracts of Foeniculum vulgare leaves by Abdul-Ghani AS1, Amin R.(PubMed)

How to Normalize Your High Blood Pressure, Cholesterol and Sugar Quickly and Permanently, According to PubMed

Add a portion of dried peas in your daily diet will normalize the levels of High Blood Pressure, Cholesterol and Glucose, according to PubMed.

Hypertension, hyperglycemia and hyperlipidemia are most prevalent modifiable risk factors for development of diabetes, cardiovascular diseases and stroke.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

The Nutrients and Chemical constituents
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A ( Beta carotene, lutein and zeaxanthin)
6. B vitamins
7. Vitamin C
8. Calcium
9. Iron
10. Magnesium
11. Phosphorus
12. Potassium
13. Zinc
14. Chemical constituents include saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside,....




1. The Effects of Dried Peas on High Blood Pressure
Hypertension is a chronic condition characterized by abnormal high blood pressure.

According to the Veterans' Affairs Medical Center, daily intake of fiber has emerged not only to prevent and treat various types of chronic diseases.but also reduced risk of hypertension.

Dr. Anderson JW, the led author said, "Dried beans, oat products, and certain fruits and vegetables are good sources of soluble fiber" and "Current guidelines advise a doubling of dietary fiber intake for Americans. Inclusion of ample servings of fruits and vegetables, whole grains, and dried beans and peas will help individuals meet these guidelines".

Additionally, in the examined iineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation researcher found that high fiber diet not only modified the gut microbiota populations and also increased the abundance of acetate-producing bacteria independently of mineralocorticoid excess and reduced systolic and diastolic blood pressures.

Dr. Marques FZ, the led researcher said, "The favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the gut microbiota, the short-chain fatty acid acetate. Acetate effected several molecular changes associated with improved cardiovascular health and function".

These result demonstrated a significant effect of fibers intake in promoted health gut microbiota in regulating molecular changes associated with improved risk factor related to cardiovascular health and function, including blood pressure.

Other, in the examined cross-sectional studies of dietary intake as one of the major determinants in hypertension development and Dietary Approach to Stop Hypertension and the risk of incident hypertension in a large cohort study including incidence of hypertension among 80 426 French adults, researchers at the joint study led by the Paris-Descartes University found that
1. During a mean follow-up of 3.4±2.1 years, 2413 cases of incident hypertension were documented
2. Fiber intake displayed a strong effect in reduced risk of hypertension with relative odd risk of 0.81 in compared to the baseline.
3. Adopting a global healthy diet associated to several nutritional factors intake may be one of the best solution in reduced hypertensive incidence.


2. The Effects of Dried Peas on High Blood Cholesterol
Hyperlipidemia is a condition characterized by high levels of cholesterol in the blood stream.

In a study of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomizedly assigned to a high-fibre bean-rich diet that achieved mean (SD) fibre intakes of 35.5 (18.6) g day for women and 42.5 (30.3) g day for men, or a low-carbohydrate diet, researchers found that
1. High bean fiber intake showed a better weight loss and weight control in compared to low carbohydrate diet group.
2. Intake of bean fiber group expressed a significant decreased of Low-density lipoprotein (LDL)-cholesterol and total cholesterol levels in compared to other group.

Dr. Tonstad S, the led author said, "A high-fibre bean-rich diet was as effective as a low-carbohydrate diet for weight loss, although only the bean-rich diet lowered atherogenic lipids".

Additionally, in dyslipidemia rats study to evaluate the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding by randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group, researchers after adjusting to other risk factors filed the following results
1. Rats in hyperlipidemic model group showed a increased total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) in compared to groups
2. In compared to hyperlipidemic model group, grain-bean package group, grain-bean package DF group, expressed significantly decreased total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose and significantly increased HDL-C levels.

The results of these findings demonstrated that dietary fiber can improve blood lipids levels indyslipidemic subject, decrease FAS activity and regulating SREBP-1c mRNA in glucose metabolic expression.


3. The Effects of Dried Peas on High Blood Glucose
Hyperglycemia is a medical condition characterized by abnormal high levels of glucose circulated in the blood stream.

Dried peas, a good sources of protein and fiber, is one of many rich-protein recommended for vegetarian.


Together with a low glycemic index, the peas may be considered as a high-fiber foods for daily carbohydrate intake in prediabetes.


Evidences of studies showed that a low-glycemic load meal containing psyllium soluble fiber is significantly improves the breakfast postprandial glycemic, insulinemic in adults with Type 2 DM.


In the study to compare the glycemic and insulinemic responses to 3 different meals based on dried peas, potatoes, or both in patients with type 2 diabetes, intake of the pea meal expressed a significant in tine delay of the increased postprandial plasma glucose and insulin concentrations, in compared to other meal.


Since carbohydrates counting in dried peas have been disregarded, the nutrient dried peas should be included in the consumption of low-glycemic, high-fiber foods at the expense of high-glycemic, low-fiber foods for prediabetes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Health benefits and practical aspects of high-fiber diets by Anderson JW1, Smith BM, Gustafson NJ.(PubMed)
(2) High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques FZ1, Nelson E2, Chu PY2, Horlock D2, Fiedler A2, Ziemann M2, Tan JK2, Kuruppu S2, Rajapakse NW2, El-Osta A2, Mackay CR2, Kaye DM1(PubMed)
(3) Individual and Combined Effects of Dietary Factors on Risk of Incident Hypertension: Prospective Analysis From the NutriNet-Santé Cohort by Lelong H1, Blacher J2, Baudry J1, Adriouch S1, Galan P1, Fezeu L1, Hercberg S1, Kesse-Guyot E1.(PubMed)(4) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(5) [Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].[Article in Chinese] by Liu Y, Zhai C, Sun G, Zhang H, Jiang M, Zhang H, Guo J, Lan X.(PubMed)
(6) Evaluation of a high-fiber diet in hyperlipidemia: a review by Ullrich IH.(PubMed)(7) Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus by Clark CA, Gardiner J, McBurney MI, Anderson S, Weatherspoon LJ, Henry DN, Hord NG.(PubMed)
(8) Comparison of the effects of dried peas with those of potatoes in mixed meals on postprandial glucose and insulin concentrations in patients with type 2 diabetes by Schäfer G, Schenk U, Ritzel U, Ramadori G, Leonhardt U.(PubMed)

How to Replace Salt to Get Rewards of Lower Blood Pressure and 14 Health Benefits, According to PubMed

Too much salt intake has been proven to be a major cause of hypertension, leading to increase risk factor of heart disease and stroke.

Some researchers also found that too much salt intake are associated to higher probability of developing kidney diseases and stomach cancer as well as increasing risk of immune dysfunction.

According to statistic, from 2011 to 2012, the average daily sodium intake among U.S. adults was 3,592 mg far more than the max of 2300 mg recommended by FDA.


According to the joint study lead by Chonbuk National University, Korean low salt fermented soy sauce with yeasts in production of high ethanol and 3-methyl-1-butanol for bacterial nilation is a balance of more complex and richer flavors with an identical flavor profile pattern to that obtained from high salt soy sauce(1).

Dr. Song YR, the lead scientist said, "using functional yeast cultures offers a technological option to manufacture salt-reduced soy sauce while preserving its typical sensory characteristics without affecting safety"(1)

Contrary to general belief, soy sauce was found to lower risk of hypertension through inhibiting activity of an angiotensin I-converting enzyme (ACE)(2) which is needed to constrict our blood vessels[1].
The information findings suggested that Korean low salt fermented soy sauce may be a good replacement of salt daily without affecting the taste of high salt intake individual as well as reducing risk of hypertension.

Here are health benefits of Korean low salt fermented soy sauce

A. Health benefits according to studies
[2]. Cardiovascular health
In the investigation of dietary proteins and their effect in heart diseases found that a direct cholesterol lowering effect of proteins has not been shown. Despite earlier research indicating that soy protein has cardioprotective effects as compared to other proteins, these observations have not been confirmed by randomized placebo-controlled trials. However, most experts recommend the consumption of foods rich in plant proteins as alternatives to meat and dairy products rich in saturated fat and containing cholesterol, according to "Dietary proteins and atherosclerosis" by Darioli R.(a)

[3]. Perennial allergic rhinitis (PAR)
In the study of isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi and the its effect on serum total immunoglobulin E, found that The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject and concluded that Th221 can be expected to safely improve the symptoms of PAR, according to "Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy saucemoromi for perennial allergic rhinitis" by Nishimura I, Igarashi T, Enomoto T, Dake Y, Okuno Y, Obata A.(b)

[4]. Anti-allergic activities
In the assessment of oral supplementation of Shoyu polysaccharides (SPS) and its effective intervention for patients with perennial allergic rhinitis found that evaluation of the medication's effectiveness after 4 weeks treatment showed significant differences between the SPS- and placebo-treated groups (p<0.05). In conclusion, SPS of soy sauceimproved the quality of life for patients with perennial allergic rhinitis, and soy sauce would be useful in an anti-allergic therapy utilizing everyday foods, according to "Quality of life improvement with soy sauceingredients, Shoyu polysaccharides, in perennial allergic rhinitis: a double-blind placebo-controlled clinical study" by Kobayashi M, Matsushita H, Shioya I, Nagai M, Tsukiyama R, Saito M, Sugita T, Sugimura T, Yamamoto K.(c)

[5]. Breast cancer
In the analyzing of Shoyu and on the gastric mucosa of the rat found that the animals given shoyu were smaller than the controls; 15 intact rats receiving the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50 operated rats lived 33 months. Breast tumors developed in 10 control rats but in none given shoyu. The distribution of other tumors was the same,... and concluded that Shoyu did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity. Long-term use was associated with gastric mucus loss and nuclear changes in a few rats, occasionally with a mild gastritis. according to "Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat" by MacDonald WC, Dueck JW.(4)

[6]. Hypolipidemic effect
In the observation of Soy sauce (Shoyu), a traditional Japanese fermented seasoning and its effect on cholesterol level found that in a 4-week randomized, double-blind, placebo-controlled parallel group study, hyperlipidemic men (TG >150 mg/dl) were treated with 600 mg of SPS (n=15) or placebo (n=15) daily. After 4 weeks, serum TG levels in the SPS-treated group were significantly (P<0.05) lower than the baseline (0 week). In conclusion, SPS of soy sauce reduce lipid absorption, and soy sauce is a potentially promising seasoning for the treatment of hyperlipidemia through food, according to "Hypolipidemic effect of Shoyu polysaccharides from soy sauce in animals and humans" by Kobayashi M, Magishi N, Matsushita H, Hashimoto T, Fujimoto M, Suzuki M, Tsuji K, Saito M, Inoue E, Yoshikawa Y, Matsuura T.(e)


B. Health benefits according to concentration
[7]. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)

[8]. Manganese
Manganese beside plays an vital role for the proper and normal growth of human bone structure (accodring to the study of "Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants" by Pabbruwe MB, Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of "The effects of 3, 4 or 5 amino salicylic acids on manganese-induced neuronaldeath: ER stress and mitochondrial complexes" by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogues and the antioxidants did not mediate ER stress in this model. The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.

[9]. Protein
Protein beside is important building block of bones, muscles, cartilage, skin, and blood, it also enhances the nervous system in information transmitting between cells and cells of the other parts of the body, thus reducing the risk of nervous tension, (according to the study of "The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function" by Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SH, Abrous DN, Montcouquiol M, Sans N, posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20660256)


[10]. Niacin or vitamin B3
Niacin or vitamin B3 beside is important in production of energy in metabolism of carbohydrate, it also essential for DNA repairing, according to the study of `Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow`by Kostecki LM, Thomas M, Linford G, Lizotte M, Toxopeus L, Bartleman AP, Kirkland JB., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17618655), production of steroid hormones in the adrenal gland, improving blood circulation and lowering the bad cholesterol (LDL) levels., according to the study of `Lowering LDLcholesterol with margarine containing plant stanol/sterol esters: is it still relevant in 2011?`by Doggrell SA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21296266)


C. Other health benefits
[11]. Cholesterol
Certain studies found that certain types of soy sauce (popular in Chinese cookery) have been shown to reduce the levels of bad cholesterol (LDL) because of the existence of large amounts of the isoflavones, so choose your soy sauce wisely, according to the study of `Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials`by Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17413118)

[12]. Isoflavones
Isoflavones is one of the weak estrogen that can compete with estrogen for the same receptor sites, as it decreasing the health risks of excess estrogen, promoting healthy menstrual cycle and reducing the risk of cancers caused by high levels of strong estrogen., according to the study of `Red clover and soy isoflavones-an in vitro safety assessment`by Reiter E, Gerster P, Jungbauer A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21801124), researchers wrote that
Isoflavones and plant extracts significantly reduced the proliferation activity of the treated cancer cell lines.

[13]. Riboflavin
Riboflavin or vitamin B2 besides is important for the production of energy in the metabolism of fats, carbohydrates, and proteins due to its coenzymes, flavin adenine dinucleotide and Flavin mononucleotide properties, it also is the best of natural element for treating migraines and muscle pain reliever used together with magnesium, according to the study of `Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial`by Schoenen J, Jacquy J, Lenaerts M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/9484373)

[14]. Magnesium
Magnesium beside helps to maintain the right ratio with calcium, thus aiding the digestive system in absorption of calcium, according to the study of `Associations of calcium and magnesium in serum and hair with bone mineral density in premenopausal women`by Song CH, Barrett-Connor E, Chung JH, Kim SH, Kim KS., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17848724) it also reduces the risk of irregular heart beat and impairs glucose tolerance, according to the study of `Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women`by Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/17536123)

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Effects of indigenous yeasts on physicochemical and microbial properties of Korean soy sauce prepared by low-salt fermentation by Song YR1, Jeong DY2, Baik SH3.(PubMed)
(2) Purification and identification of an angiotensin I-converting enzyme inhibitor from soy sauce.
Kinoshita E1, Yamakoshi J, Kikuchi M(PubMed)



(a) http://www.ncbi.nlm.nih.gov/pubmed/22139566
(b) http://www.ncbi.nlm.nih.gov/pubmed/19240374
(c) http://www.ncbi.nlm.nih.gov/pubmed/15492861
(d) http://www.ncbi.nlm.nih.gov/pubmed?term=Shoyu%20and%20breast%20cancer
(e) http://www.ncbi.nlm.nih.gov/pubmed/18813866
(1) http://www.ncbi.nlm.nih.gov/pubmed/19539268

How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed

Add a portion of fennel in your daily diet may have a potential and positive effect in reduced pain caused by sensory neurons stimulus in women with primary dysmenorrhea, some scientists suggested.


Antinociceptive activity is an action or process of blocking the painful or injurious stimulus by sensory neurons.


The results of the investigation were carried out by numbers of respectable institutes, including the Babol University of Medical Sciences and Health Services and details of the experiment were published on online medical library.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

In order to compare the effect of combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study lead by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.


All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).


Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eighth hours in the group was significant lower than the group that had used ibuprofen.



Also, combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.



These result suggested that fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by over expression prostaglandins hormone in induction of abdominal muscle constriction in compared to conventional medicine ibuprofen.


Dr. Nasehi M, the lead author, after taking into account of other co and con founders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".




In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and menorrheal duration, 80 female students satisfied the criteria and guideline were randomly divided in to two groups of intervention (n = 40) and control (n = 40).



The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day and continued for 3 months. The control group received no medication.


According to the result of the experiments, fennel treated group exerted significant decrease of the mean of nausea intensity and weakness from 1.93, and 2.88 after 3 months, in compared to control group from 2.37, 6.65 in control group.


Also in compared to control group, fennel group reduced the duration of menstrual period after two and three months of use.


Moreover, Fennel treated group demonstrated a strong improvement of quality and feelings of well-being after 1 and 3 months.

Taken together, fennel may be considered as functional food for treatment of Primary Dysmenorrhea without inducing adverse effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2.(PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)

All About Minerals: Chromium(chromium 3+): Chromium and Cholesterol

By Kyle J. Norton.

Chromium(chromium 3+) is a essential mineral for the body in fat and carbohydrate metabolism, found abundantly in Beef, Eggs, Chicken, Oysters, Wheat germ, Green peppers, Banana, Apple, Etc.


Chromium(chromium 3+): Chromium and Cholesterol


Chromium (Cr(3+)) supplementation facilitates normal protein, fat, and carbohydrate metabolism, and is widely used by the public in many countries.According to the study by the Louisiana State University Health Sciences Center, Chromium niacinate lowers blood levels of proinflammatory cytokines (TNF-alpha, IL-6, CRP), oxidative stress, and lipids levels in diabetic rats, and appears to be a more effective form of Cr(3+) supplementation. This study suggests that Cr(3+) supplementation can lower the risk of vascular inflammation in diabetes(10). Other study suggested a mechanism of Cr3+ action that fits with long-standing claims of its role in cholesterol homeostasis(10a).



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Sources
(10) http://www.ncbi.nlm.nih.gov/pubmed/17854708
(10a) http://www.ncbi.nlm.nih.gov/pubmed/21311039


Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Minerals: Chromium(chromium 3+): Is chromium an essential trace element?

By Kyle J. Norton.

Chromium(chromium 3+) is a essential mineral for the body in fat and carbohydrate metabolism, found abundantly in Beef, Eggs, Chicken, Oysters, Wheat germ, Green peppers, Banana, Apple, Etc.


Chromium(chromium 3+): Is chromium an essential trace element? 


It has been recognized that chromium is an essential trace element associated with carbohydrate metabolism, and chromium deficiency causes an impaired glucose tolerance. According to the study by Kansai University, the amount of chromium absorbed in humans estimated from chromium intake (20 to 80 μg/day), chromium absorption rate (1%), and urinary chromium excretion (<1 μg/day) is less than 1 μg/day, which is much lower than those of other essential trace elements. In addition, because there is an inconsistency between the chromium concentration in food and chromium intake, chromium intake seems to be dependent on chromium contamination during food processing and cooking. It is concluded that there is a high possibility that chromium is not an essential trace element(8).



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(8) http://www.ncbi.nlm.nih.gov/pubmed/23095360



Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Minerals: Chromium(chromium 3+): Cr supplementation as a growth enhancer

By Kyle J. Norton.

Chromium(chromium 3+) is a essential mineral for the body in fat and carbohydrate metabolism, found abundantly in Beef, Eggs, Chicken, Oysters, Wheat germ, Green peppers, Banana, Apple, Etc.


Chromium(chromium 3+):  Cr supplementation as a growth enhancer


In a growth trial conducted on juvenile mirror carp (Cyprinus carpio L.) for 8 weeks and to compare the efficacy of three chromium (Cr) compounds (Cr chloride, Cr picolinate, and Cr yeast) at a level 0.5 mg/kg as a potential growth enhancer, showed that there is a significantly (P < 0.05) increased DNA damage in fish fed on high level of Cr chloride (2.0 mg/kg) but the other treatments were not significantly different (P > 0.05) from the control groups. The concentration of Cr in the liver, gut, and whole fish tissues increased with increasing dietary Cr supplementation. Overall, Cr supplementation at a level 0.5 mg/kg from different sources may affect growth performance in carp by activation of some key liver enzymes (HK and G6PD)(9).



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(9) http://www.ncbi.nlm.nih.gov/pubmed/22351105



Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.