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Friday, August 31, 2018
The 12 Impressive Health Benefits of Coffee, You Might Not Know
Coffee, emerging as a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
Recent studies suggested that coffee may process various health benefits through its antioxidants and caffeine activities.
(For health benefits from 1-11, do to this link https://kylejnorton.blogspot.ca/2018/03/intake-of-roasted-bean-coffee-beverage.html)
12. Ulcerative Colitis
Epidemiological studies do not agreed that intake of coffee and coffee caffeine regularly may have a profound effect in attenuated risk of ulcerative colitis.
Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
Ulcerative colitis is an inflammatory bowel disease characterized by long-lasting inflammation and ulcers (sores) in the digestive tract.
In the reviewed study of a total of 442 patients 73% regularly consume coffee. 96% of patients attributing a positive and 91% of patients attributing no impact of coffee intake on IBD regularly drink coffee and surprisingly even 49% of those patients that assign a negative impact on disease symptoms, researchers at the University Hospital Zurich found that most patient with IBD showed a coffee drinking habit and addressed that coffee has helped modifying symptoms of the disease.
Other in the total of 81 UC patients recruited at all stages of the disease process, after completion of a 7 d diet diary, Caffeine and decaffeinated coffee showed a clinical significance in reduced risk of UC and may be considered a functional food included in potentially therapeutic diet.
Dr. Magee EA, the lead author said, " ......decaffeinated coffee was associated with a better clinical state than the caffeine containing version".
Contrastively, the investigation of a population-based, case-control study of the risk of ulcerative colitis associated with coffee and alcohol use among the 304,000 members of a prepaid health plan, coffee expressed no association with either amount of coffee consumed daily, or cumulative coffee consumption before disease onset and altered the risk of developing ulcerative colitis.
13. Melanoma, Particular in People with Altered GSTM1 and GSTT1 Gene
Intake of coffee regularly may have positive effect in reduced risk of Melanoma, particular in healthy people with alternated genes GSTM1 and GSTT1 expression, a renowned institute study suggested.
Melanoma is a type of malignant skin cancer caused by DNA damage, most often caused by ultraviolet radiation from sunshine or tanning beds inducing irregular growth of skin cells.
Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the Istituto Dermopatico dell'Immacolata, in compared to low coffee intake, high frequency of coffee drinking (>once daily) with ≤7 times weekly , showed a significant lower risk of melanoma.
Interestingly, in the group people with GSTM1 and GSTT1 null polymorphisms(altered gene expression) subjects, coffees showed an extreme high protective effect against forming of Melanoma.
Also in the searching of PubMed and EMBASE databases from the earliest available online indexing year to March 2017 for a dose-response meta-analysis on prospective cohort studies, researchers at the Jagiellonian University Medical College, insisted that linear dose dependent are associated to the development of melanoma risk and total coffee consumption.
Risk of melanoma is reduced by 3% for every cup of coffee intake per day.
Dr. Micek A, the lead author in the joint study said, "(According to) a total of seven studies eligible for meta-analysis were identified that comprised 1,418,779 participants and 9211 melanoma cases,......coffee intake may be inversely associated with incidence of melanoma".
Further in the demonstration of 2 case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases), in compared the lower and higher caffeine intake daily, caffeinated coffee showed a the pooled relative risk (RR) of 0.81.
Risk of additional cup of coffee caffeine consumption, relative odd ratio of risk of melanoma deceased by 0.955
Importantly, the study found no correlated and linear dose dependent of decaffeinate coffee and risk melanoma regardless to volume of daily intake in teasing subjects.
!4. Breast Cancer Selectively
Recent studies suggested that coffee and coffee caffeine may have a potentially effect in reduced risk and treatment of breast cancer, selectively.
Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
In the review of literature from database of PubMed with selection of 37 published articles, involving 59,018 breast cancer cases and 966,263 participants, suggested that
1. There are no significant association of coffee and coffee caffeine intake and breast cancer risk
2. Post menopause women drinking coffee daily and regularly have a reduced risk of breast cancer developing.
3. Women who are BRCA1 mutation carriers showed a positive risk of breast cancer from coffee intake
The study also indicated that for additional cup of coffee consumed risk of breast caner decrease by 2% and 1% for every 200mg/day increment in caffeine intake.
Contrastively, in a case-control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries.to determine coffee and coffee caffeine intake against the risk of breast cancer, returned self-administered questionnaire. showed a significant correlation of coffee intake in the elevated breast caner risk.
Women with breast cancer in BRCA carriers who habitually drank 0, 1-3, 4-5 and 6 or more cups of coffee showed a relative risk odd ratio of 1.00, 0.90, 0.75 and 0.31, respectively.
The finding evidences of relative odd ratio of suggested that risk of breast cancer was reduced in this group of women linearly to numbers of coffee and coffee caffeine consumed daily.
Dr, Jiang W, lead author said, " (According to the findings) women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of consumption may in fact be related to reduced breast cancer risk"
Interesting, in the investigated the common A to C polymorphism in the CYP1A2 gene associated with decreased enzyme inducibility and impaired caffeine metabolism of caffeine to examine the risk of breast caner in BRCA1 mutation carriers of 411 BRCA1 mutation carriers (170 cases and 241 controls) researchers at the University of Toronto found that risk of breast cancer decrease significantly by 64% in BRCA1 mutation carriers with at least one C polymorphism in the CYP1A2 gene but not in CYP1A2 AA group in compared to women who never consumed coffee.
15. Depression
Epidemiological studies do not agreed that coffee and coffee caffeine have a positive effect in reduced depression, a review literature study suggested.
Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
Depression is a normally neuro response as part of our daily lives such as the loss of s job, the death of a love one, and illness.
Over 30 million Americans suffer from depression and the amounts are increasing in an alarming rate.
According to the University of Naples Federico II, over 2 decades, many studies addressed the concerns of coffee intake may have a implication of incidence of depression, but several phytochemical studies indicated a different outcome as caffeine and certain major phyto constituents exhibited antidepressant effects through multiple molecular mechanisms.
Dr. Tenore GC, the lead researcher said, "coffee can be considered a drink which has different positive effects on human health such as cardioprotective, neuroprotective, hepatoprotective, nephroprotective, etc. However, heavy coffee consumption may be related to some unpleasant symptoms, mainly anxiety, headache, increased blood pressure, nausea, and restlessness".
Contrastively, caffeine in coffee showed a strongly inverse association in cases of postpartum depression and comorbid panic disorder.
Other researchers in the searching of the efficacy of coffee and risk of depression through data base from PubMed and PsychINFO insisted that although literature data are conflicting, caffeine found in coffee indicated a significant reduced effect on symptoms of clinical depression.
Additionally, in a cross-sectional study in 10,177 Korean individuals aged 20-97 years with prevalence of self-reported depression of 14.0% and that of self-reported clinical depression of 3.7%. participated in the fifth Korean National Health and Nutrition Examination Survey. to determine the effect of consumption of coffee and risk of depression, after adjusting to other factors, returned survey from patients, can be cataloged into the followings
For general depression
1. The relative odd ratio of patients drinking less than one cup/week was 0.84
2. The relative odd ratio of patients drinking one to six cups/week was 0.63
3. The relative odd ratio of patients drinking for one cup/day was 0.69
4. The relative odd ratio of patients drinking for two cups/day was 0.54
5. The relative odd ratio of patients drinking for three or more cups/day was .58
For clinical depression, similar observations also have been recorded
1. The relative odd ratio of patients drinking less than one cup/week was 1.00
2. The relative odd ratio of patients drinking one to six cups/week was 0.51
3. The relative odd ratio of patients drinking for one cup/day was 0.57
4. The relative odd ratio of patients drinking for two cups/day was 0.57
5. The relative odd ratio of patients drinking for three or more cups/day was 0.41
The findings although is not linearly, coffee and coffee caffeine intake expressed a protective effect in ameliorated risk of depression.
16. Obesity
Obesity is a medical condition of excess body fat accumulated overtime. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity.
Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.
According to the joint study lead by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factors expression
According to animal studies.
In human, it is the result from decreased body weight and visceral fat stored within the abdominal cavity.
Further more, the study also expressed the important of coffee intake in influence the gut microbiota in obese animals and humans.
Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. GCBE treated group showed a significantly decreased body weight gain, liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.
2. The efficacy of treatment group in reduced obesity risk may also benefit to the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.
3. In compared to other treated group, GCBE treated mice displayed a lower fat mass and relative body weight and decreased fat mass.
More importantly, in the review of papers from in vivo, ex vivo, in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study lead by the South University School of Pharmacy said, " there are mounting evidences of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".
17. Metabolic Syndrome
Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes, including high blood pressure, abnormal high blood cholesterol and triglyceride levels,.....
A joint study by respectable institutes suggested that intake of coffee and coffee caffeine daily and regularly may associate to attenuated risk of metabolic syndrome.
Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the searching of database from f PubMed and the China National Knowledge Infrastructure (CNKI) for relevant articles published between 1 January 1999 and 31 May 2015, including 11 published reports and 13 studies with a total of 159,805 participants were eligible for our meta-analysis, the relative odd risk ratio of metabolic syndrome between the highest vs lowest category of coffee consumption was 0.872
The review also observed a non linear relationship between coffee and coffee caffeine consumption in ameliorated risk of metabolic syndrome, by dose-response analysis.
Additionally, in a cross-sectional population-based survey of 8,821 adults (51.4% female) conducted in Krakow, Poland. to evaluate the coffee and tea consumption and risk of metabolic syndrome, using food frequency questionnaires, observation of the questionnaire returned from participants expressed an interesting association between high coffee consumption of 3 cups and the clusters of lower BMI, waist circumference, systolic and diastolic blood pressure, triglycerides, and higher HDL cholesterol than those drinking less than 1 cup/day.
The study apparently indicated that people drinking 3 cups of coffee daily and regularly have a favorably ameliorated risk of metabolic syndrome even after adjusting for potential confounding factors.
More importantly, the study also pointed out that high coffee consumption was negatively associated with waist circumference, hypertension, and triglycerides in women but not in men.
Furthermore, in animal evaluation of the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats including Diabetic Zucker rats with metabolic syndrome and control Zucker rats, researchers at the Fluminense Federal Institute postulated that after animals received daily doses of coffee drink by gavage for 30 days, coffee consumption expressed a decreased risk of metabolic syndrome in reduced serum glucose, total cholesterol and triglycerides in compared to non treatment group.
Dr. Abrahão SA, the lead researchers said, "The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2".
18. Gallstone and Gallstone Diseases
Epidemiological studies, linking coffee consumption in reduced risk of gallstone, but not gallstone disease have been contradictory.
Gallstone is a stone formed within the gallbladder out of bile components as a result of building up of undissolved cholesterol over a prolonged period of time.
Coffee, a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
In the review of 174 cases of gallstones determined by ultrasonography, 104 cases of postcholecystectomy, and 6889 controls of normal gallbladder in the total of 7637 men received a health examination at four hospitals of the Self-Defense Forces (SDF) with 174 cases of prevalent gallstones, 50 had been aware of having gallstones, researchers found that coffee and coffee caffeine drinkers express a high risk of gallstone incidence in compared to non drinkers.
In these group of middle-aged Japanese men, the relative odds ratios of gallstone disease 1.7 for coffee consumption of five cups or more per day vs. no consumption and 2.2 for caffeine intake of 300 mg/day or more vs. less than 100 mg/day.
Obviously, these findings contradicted to other studies in support of risk of gallstone reduced by coffee and caffeine intake, including the study conducted by Harvard School of Public Health.
Other, in the review literature of database from PubMed and EMBASE of all published studies before June 2015 researchers at The First Affiliated Hospital of Zhengzhou University files the following results
1. Coffee intake regularly and daily had a significantly reduced risk of gallstone disease, in related females, but not in males. based on prospective studies.2. For patients drinking one cup of coffee per day, the risk of of gallstone disease was 0.95
3. For patients drinking 2, 4 and 6 cups of coffee per day, the estimated RRs of gallstone disease reduced to 0.89 (95% CI, 0.79 to 0.99), 0.81 and .75 respectively.
4, Coffee intake showed a linear association to ameliorated risk of gallstone diseases.
Interestingly, in a cohort of 80,898 women age 34-59 years in 1980 who had no history of gallstone disease, during 20 years of follow-up, researchers filed the below results
1. Compared to non caffeine coffee drinkers women, the multivariate relative risks of gallstone disease with cholecystectomy in compared to consistent intake of caffeinated coffee (0, 1, 2-3, and > or =4 cups/day) were 1.0, 0.91, 0.78, and 0.72 respectively.
2. Coffee caffeine intake was inversely associated to risk of cholecystectomy.
3. Caffeine intake (< or =25, 26-100, 101-200, 201-400, 401-800, and >800 mg/day) is linearly associated to reduced risk of gallstone disease with multivariate relative ratio of 1.0, 1.03, 1.01, 0.94, 0.85, and 0.85 4. Decaffienated coffee was not associated with risk.
19. Menopause Symptoms
Menopause is a natural and biological progression of women at certain age. The reduced hormone levels of inaction of ovaries induced menstruation stop and a set of symptoms
Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
A study conducted by a renowned institute suggested that coffee nd coffee caffeine may have potential effect in reduced severity of some menopause symptoms and elevation of others.
In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005 and July 25, 2011, caffeine intake in participants showed a greater positive effect in expression of vasomotor symptom of menopause women in compared to non drinkers group.
Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to non drinkers.
And caffeine intake also is found as one of predictor in exhibited both hot flashes (HF) and night sweats (NS) in the same study group.
But in animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.
Administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.
There is no doubt that the study addresses a significantly inverse association in reduced risk of gallstone disease among coffee drinkers linearly.
20. Esophageal Cancer
Intake of coffee regularly may have a profound effect in reduced risk of cancers, a recent study proposed.
Cancer is a group of diseases characterized by irregular cell growth in any tissue and organ in the body.
Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the joint study lead by the Università degli Studi di Milano-Bicocca, consumption of healthy foods, particularly coffee with rich in polyphenols might have a substantial influence in reduced prevalence of cancer incidence.
Coffee extract with high chlorogenic acids (CGAs) exhibited the beneficial biological effects in ameliorated risk of cancer through anti-inflammatory activity and anti-carcinogenic activity.
In Ras-dependent breast cancer cell line MDA-MB-231, CGAs also displayed a molecular basis of the activity and chemoprotective in induction of cell apoptosis.
Furthermore, in the review of literature in expression of the association between total, caffeinated and decaffeinated coffee consumption and melanoma risk in a dose-response meta-analysis on prospective cohort studies through searching the data base of PubMed and Embase, researchers indicated, seven studies eligible for meta-analysis, comprised 1,418,779 participants and 9211 melanoma cases. caffeine attenuated melanoma risk with a linear dose-response association between total coffee consumption.
Prevalence risk of melanoma reduced by 3% for additional cup of coffee intake per day.Dr. Micek A, the lead author said, "coffee intake may be inversely associated with incidence of melanoma".
In further demonstrated coffee and coffee caffeine in ameliorated risk of cancer, the Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for coffee consumption associated with death from all cancers combined and from specific cancer types among 922,896 Cancer with 1982 as a base line, researchers at joint study lead by the American Cancer Society found that only smokers showed a a non-linear association between coffee consumption and all-cancer death but not in never smokers.
Among non-smokers,drinking 2 cup/day or more showed a significantly inverse associated with death from colorectal, head and neck and female breast cancers, but positively associated with esophageal cancer death.
21. Stroke, Particularly in Women
A stroke is medical condition characterized by interrupted blood supply, thus reducing oxygen and nutrients delivery to the brain, resulting in death of brain cells.
Intake of coffee and coffee caffeine may have a profound effect in reduced risk of stroke incidence, a renowned institute study suggested.
In a third National Health and Nutrition Examination Survey (1988-1994; NHANES III) data to examine coffee consumption and stroke with participants aged ≥17 years old, researchers found that
coffee intake of this population showed a significantly inverse association to stroke risk incidence, regardless to smoke status.
Interestingly, the study also discovered that frequent coffee drinkers displayed a less occurrence of heart failure, diabetes, and hypertension but risk of high cholesterol for those consuming ≥3 cups per day.
Dr. Liebeskind DS, the lead author said, "Heavier daily coffee consumption is associated with decreased stroke prevalence" and ". Multivariate analyses revealed an independent effect of heavier coffee consumption (≥3 cups/day) on reduced stroke".
Further more, in an analyzed data from a prospective cohort of 83,076 women in the Nurses' Health Study without history of stroke, coronary heart disease, diabetes, or cancer at baseline, with coffee consumption assessed first in 1980, then repeatedly every 2 to 4 years, and follow-up through 2004, researchers at the Harvard School of Public Health filed the following results
1. The relative risk ratio of stroke in participants coffee consumption (<1 cup per month, 1 per month to 4 per week, 5 to 7 per week, 2 to 3 per day, and >or=4 per day) were 1, 0.98, 0.88, 0.81, and 0.80 repetitively.
2. Intake of coffee and coffee caffeine daily and regularly showed a significantly positive effect in reduced stroke risk after taking in to count of other favors, including high blood pressure, hypercholesterolemia, and type 2 diabetes.
3. Risk of stroke also associated stronger correlation among never and past smokers (RR for >or=4 cups a day versus <1 cup a month, 0.57) than among current smokers (RR for >or=4 cups a day versus <1 cup a month, 0.97).
4. Decaffeinated coffee intake also was associated to a trend in lower risk of stroke after adjustment for caffeinated coffee consumption.
5. Caffeine consumption of other beverage do not associate to risk or reduced risk of stroke.
The findings suggested that long-term coffee consumption was not associated to risk of stroke but modestly reduce risk of stroke.
Promisingly, a Asian study of data obtained from the Health Examinees (HEXA) Study, involved 146,830 individuals aged 40-69 years demonstrated that high coffee consumption was associated with a 38% lower odds ratio for stroke in women in compared to (none drinkers vs. ≥ 3 cups/day drinkers in women but not in men.
The expression of coffee intake in reduced risk of stroke also found greater in women who are healthy, younger, non-obese, non-hypertensive, non-diabetic, non-smokers, and non-alcohol drinkers.
22. Primary sclerosing cholangitis
Recent study suggested that coffee and caffeine consumption may be associated to reduced risk of primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a medical condition of inflammation and obliterative fibrosis of the bile ducts.
Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
In the study of 606 patients with primary biliary cirrhosis (PBC), 480 with primary sclerosing cholangitis (PSC), and 564 healthy volunteers acted as controls, researchers filed the following results
1. 24% of patients with PSC had never drunk coffee in compared to 16% of controls.
2. Patients with PSC also consumed fewer lifetime cups per month and spent a smaller percentage of their lifetime drinking coffee in compared to healthy adults.
Base on these information, Dr.Lammert C, the lead author opinionated, coffee consumption is lower among patients with PSC, in compared with controls.
Additionally, In patients with PSC, recruited from Oslo University Hospital Rikshospitalet in Norway through 2011, randomly chosen from the Norwegian Bone Marrow Donor Registry (control subjects) of 240 patients with PSC and 245 control subjects also indicated a similar conclusion as follow
1. In compared to control, PSC patients showed a lower daily drinking coffee habit as the time of study and at the age of 18 years observed in men.
2. Ever daily coffee drinker at the age of 18 years were independently and negatively associated with PSC.
These result showed that coffee intake may have a profound effect in protection against development of PSC.
Taking altogether, coffee and coffee caffeine may be considered as a function beverage for improvement of numbers of health benefit far more than those mentioned through its antioxidant properties and caffeine contents. Finally, if you are coffee lovers, as always, we recommended that you do not add sugar and high-fat dairy creams in your drinks.
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Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Patients' perceptions on the impact of coffee consumption in inflammatory bowel disease: friend or foe?--a patient survey by Barthel C1,2, Wiegand S3,4, Scharl S5, Scharl M6,7, Frei P8, Vavricka SR9, Fried M10, Sulz MC11,12, Wiegand N13,14, Rogler G15,16, Biedermann L17.(PubMed)
(2) Associations between diet and disease activity in ulcerative colitis patients using a novel method of data analysis by Magee EA1, Edmond LM, Tasker SM, Kong SC, Curno R, Cummings JH.(PubMed)
(3) Coffee and alcohol use and the risk of ulcerative colitis by Boyko EJ1, Perera DR, Koepsell TD, Keane EM, Inui TS.(PubMed)(4) The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms by Fortes C1, Mastroeni S, Boffetta P, Antonelli G, Pilla MA, Bottà G, Anzidei P, Venanzetti F.(PubMed)
(5) Caffeinated and decaffeinated coffee consumption and melanoma risk: a dose-response meta-analysis of prospective cohort studies by Micek A1, Godos J2, Lafranconi A3, Marranzano M2, Pajak A1(PubMed).
(6) Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies by Jiang W1, Wu Y, Jiang X.(PubMed)
(7) Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers by Nkondjock A1, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, Eng C, Sun P, Narod SA.(PubMed)
(8) The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers by Kotsopoulos J1, Ghadirian P, El-Sohemy A, Lynch HT, Snyder C, Daly M, Domchek S, Randall S, Karlan B, Zhang P, Zhang S, Sun P, Narod SA.(PubMed)
(9) Coffee and Depression: A Short Review of Literature by Tenore GC1, Daglia M, Orlando V, D'Urso E, Saadat SH, Novellino E, Nabavi SF, Nabavi SM.(PubMed)
(10) [Coffee consumption in depressive disorders: it's not one size fits all].[Article in Italian] by Rusconi AC, Valeriani G, Carluccio GM, Majorana M, Carlone C, Raimondo P, Ripà S, Marino P, Coccanari de Fornari MA, Biondi M.(PubMed)
(11) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(12) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(13) Coffee consumption, obesity and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)(14) Coffee consumption and risk of the metabolic syndrome: A meta-analysis by Shang F1, Li X1, Jiang X2.(PubMed)
(15) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)
(16) Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men by Ishizuk H1, Eguchi H, Oda T, Ogawa S, Nakagawa K, Honjo S, Kono S.(PubMed)
(17) Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease by Zhang YP1, Li WQ1, Sun YL1, Zhu RT1, Wang WJ1.(PubMed)
(18) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men by Leitzmann MF1, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E.(PubMed)
(19) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT.(PubMed)
(20) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(21) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)
(22) Natural Compounds in Cancer Prevention: Effects of Coffee Extracts and Their Main Polyphenolic Component, 5-O-Caffeoylquinic Acid, on Oncogenic Ras Proteins by Palmioli A1, Ciaramelli C1, Tisi R1,2, Spinelli M1, De Sanctis G1, Sacco E1,3, Airoldi C1,2,3.(PubMed)
(23) Caffeinated and decaffeinated coffee consumption and melanoma risk: a dose-response meta-analysis of prospective cohort studies by Micek A1, Godos J2, Lafranconi A3, Marranzano M2, Pajak A1.(PubMed)
(24) Associations of Coffee Drinking and Cancer Mortality in the Cancer Prevention Study-II by Gapstur SM1, Anderson RL2, Campbell PT2, Jacobs EJ2, Hartman TJ3, Hildebrand JS4, Wang Y2, McCullough ML2.(PubMed)
(25) The coffee paradox in stroke: Increased consumption linked with fewer strokes by Liebeskind DS1, Sanossian N2, Fu KA2, Wang HJ3, Arab L4(PubMed)
(2) Coffee consumption and risk of stroke in women by Lopez-Garcia E1, Rodriguez-Artalejo F, Rexrode KM, Logroscino G, Hu FB, van Dam RM.(PubMed)
(26) Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis by Lammert C1, Juran BD1, Schlicht E1, Xie X2, Atkinson EJ2, de Andrade M2, Lazaridis KN3.(PubMed)
Thursday, August 30, 2018
How To Reduce Daily Stress Naturally
Fennel may have a potential and positive effect in reduced stress implication, some scientists suggested.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Long term society and environment impact to stress conditions may induce change of behavior that can lead increased expression of free radicals, a major cause of abnormal physiological functioning in initiated early onset hypertension, neurosis, immune suppression and other physical and mental disorders.
In the study to evaluate the anti-stress and memory-enhancing properties of F. vulgare extract in experimentally stress rats at doses of 50, 100 and 200 mg/kg body weight administered orally with an orogastric tube researchers found that rats treated with all doses exert significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.
Further analysis of rat group treated fennel with additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41 and 125.82 μg/kg also within the same period on doses of 50, 100 and 200 mg/kg body weight respectively in compared to untreated control group.
These result indicated that fennel has a stronger impact in reduced chronic stress connotation in compared to both ascorbic acid and control groups.
Moreover, group treatment group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in induction of ROS production and reduced natural antioxidant defense in compared to rat group treated with ascorbic acid.
Dr. S Koppula,, the lead authors, aftertaking into account of other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".
Additionally, in the review literature of number of such drugs mostly in the form of their extracts (holistic approach) or in some, as active principles isolated from them, have been evaluated for their antistress activity by a number of tests which include open field behaviour, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association to stress in induction of anxiety.
* Fennel inhibited the production of level stress hormone corticosterone produced in the cortex of the adrenal gland.
* Fennel increased production antioxidant and enhanced the antioxidant defense of host such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibited over expression of ROS in initiated chain reaction caused by chronic stress.
* Fennel inhibited levels of MAO in association to alternation of mood and mental conditions.
Finally, application of fennel also reduced tension of central nervous system in response to stress impact, thus reducing neurotransmitter levels in stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......
The above illustration were supported by the application of fennel oil in exerted significant anti psychiatric disorders caused by chronic stress such as depressive and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg) and fennel oil (0.5 ml/day) conducted by the Aga Khan University
According to the study, repeated administration of fennel oil for 3 weeks exerted significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in elevated plus maze (EPM) in comparable to fluoxetine treatment group.
Interestingly, rats treated group also exhibited a high levels of antioxidant in inhibited ROS in facilitated production of free radicals through lipid peroxidation.
Taken together, fennel with abundant phytochemicals may be considered as a functional food in reduced stress implication in initiation of related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) (2) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Wednesday, August 29, 2018
10 Health Benefits of Peppers' Bioactive Phytochemical Piperine
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper,....
1. Antimicrobial activity
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
In the study of piperine combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus, the combination showed more effective against the tested subject when compared with the commercially available formulation of 2 % mupirocin alone(1). Other in the study of the same subject showed the enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine(2).
2. Breast Cancer
Breast cancer (malignant breast neoplasm) is an abnormal cells growth disoerderly and uncontrolably in the breast tissue, either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
Piperine, a chemical component of black pepper, showed a strongly inhibited proliferation and induced apoptosis of breast caner cells and HER2 (Human epidermal growth factor receptor 2, HER2-positive breast cancer tends to be more aggressive) gene expression. Pretreatment of piperine also enhanced sensitization to paclitaxel killing in HER2-overexpressing breast cancer cells of that reduces the risk of cancer from occurring(3).
Other study of piperine against breast cancer also showed that Piperine (35-280 μmol/L) inhibited the growth of 4T1 cells in time- and dose-dependent manners (the IC(50). Treatment of 4T1 cells with piperine(70-280 μmol/L) induced apoptosis of 4T1 cells, accompanying activation of caspase 3. As the results, the phytochemical piperine may be a potential agent for treating breast cancer(4).
3. Angiogenesis
Angiogenesis is the action in stimulated production of new blood vessels to support the growth and cells.
Piperine, a major alkaloid constituent of black pepper, exerted it anti angiogenic effect to cause apoptosis in some cancer cell lines such as in inhibited the proliferation and G(1)/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death, as well as collagen-induced angiogenic activity by rat aorta explants and breast cancer cell-induced angiogenesis in chick embryos(5). Piperine in the co administration with curcumin, enhancing the functions of curcumin in suppression of many diseases including angiogenesis(6).
4. Cognitive Impairment
Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem solving, and decision making.
In chronic unpredictable stress (CUS)-induced cognitive impairment and oxidative stress in mice,
Piperine showed to potentiate the protective effects of curcumin in significantly improved behavioral and biochemical alterations, restored mitochondrial enzyme complex activities and attenuated increased acetylcholinesterase and serum corticosterone levels(7).
In olfactory bulbectomy induced depression in rats, co-administration of piperine with curcumin significantly potentiated the effects in behavioral, biochemical, mitochondrial, molecular and histopathological alterations(8).
These potentiation of co administration also showed to prevented all the behavioral, cellular, and neurochemical changes associated with the chronic administration of haloperidol, as compared to their effects alone(9).
5. Obesity's Inflammatory Metabolic Dysfunctions
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
Study of combination of bioactive food ingredients, including piperine in Forty-one patients and 45 patients in control group, showed a significantly greater decrease in insulin resistance, with leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group compared to the placebo(10).
In mice fed with high fat diet-induced hepatic steatosis, administration of piperine (50 mg/kg body weight) significant increased in plasma adiponectin levels, induced elevated plasma concentrations of insulin and glucose. Piperine also reversed HFD-induced down-regulation of adiponecitn-AMP-activated protein kinase (AMPK)( a metabolic enzyme in controls a number of metabolic pathways) signalling molecules linking to lipogenesis, fatty acid oxidation and insulin signalling in the livers of mice(11).
Also in Male Wistar rats fed with high fat diet study, piperine supplementation also improved the plasma levels of apo A-I, T3, T4, testosterone, and I and significantly reduced apo B, TSH, and insulin to near normal levels(12).
6. Diabetes
Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Administration of piperine isolated from the fruits of Piper nigrum crude extract diabestes induced in albino mice using alloxan, showed the crude extract exhibit its anti-diabetic effect inducing a significant blood glucose lowering at dose of 20 mg/kg on day 14(13).
In other alloxan-induced diabetic models study, piperine (10 mg/kg) significantly increased the dose-dependent anti-hyperglycemic activity of nateglinide(a drug for the treatment of type 2 diabetes), leading to synergistic anti-hyperglycemic activity of the diabetic medicine(14).
In diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats, piperinetreatment (10 mg/kg/day, intraperitoneally for 14 days) reversed the diabetic effects on oxidized glutathione concentration in brain, on renal glutathione peroxidase and superoxide dismutase activities, and on cardiac glutathione reductase activity and lipid peroxidation(15).
7. Allergic Effect
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
In picryl chloride (PC)-induced ear swelling in PC sensitized mice, PN-ext exhibited its histamine release inhibitory activity, in vitro on compound 48/80-induced histamine release from rat peritoneal mast cells(16).
Piperine(4.5 and 2.25 mg/kg) orally administered 5 times a week for 8 weeks in a murine model of asthma, showed an effectiveness in suppressed eosinophil infiltration, allergic airway inflammation and airway hyperresponsiveness by sinduced the production of interleukin-4, interleukin-5(white blood cells expression), immunoglobulin E and histamine(17).
8. Immunity
Ethanolic extract of fruits of Piper longum L.(PLE) and piperine was found to inhibit the lethal action of venom both in the in vitro lethality neutralization assay and in vivo lethality neutralization assay against Russell's viper venom in mice by enhancing production of antigen and antibodies response(18).
In the study of the same subject, administration of PLE and piperinesignificantly (p<0.01) inhibited venom induced lethality, haemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose dependent manner, reduced venom induced mast cell degranulation in rats(19).
9. Asthma
Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
Study of bacterial infections causes of frequent respiratory infections, including bacterial infections provoke asthma attack, showed a positive effect of Piper Longum L. Extract (20% Piperine) in exhibition of a moderate activity antibacterial activity against selected strains, such as Haemophilus influenzae , Streptococcus pneumoniae , Streptococcus pyrogene and Staphylococcus aureus(20).
In the study of antioxidant defenses of asthma patient, Piper longum extract (20% Piperine) showed a potent antioxidant activiy by scavenging Nitric oxide to prevent the bronchial inflammation in asthmatic patients(21).
The information finding, suggested that peppers including white and black pepper and thier major bioactive compound may be considered as function food for prevention and treatment of ailments indicated above. However, intake of pepper supplement should be taken with care in prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper,....
1. Antimicrobial activity
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
In the study of piperine combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus, the combination showed more effective against the tested subject when compared with the commercially available formulation of 2 % mupirocin alone(1). Other in the study of the same subject showed the enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine(2).
2. Breast Cancer
Breast cancer (malignant breast neoplasm) is an abnormal cells growth disoerderly and uncontrolably in the breast tissue, either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
Piperine, a chemical component of black pepper, showed a strongly inhibited proliferation and induced apoptosis of breast caner cells and HER2 (Human epidermal growth factor receptor 2, HER2-positive breast cancer tends to be more aggressive) gene expression. Pretreatment of piperine also enhanced sensitization to paclitaxel killing in HER2-overexpressing breast cancer cells of that reduces the risk of cancer from occurring(3).
Other study of piperine against breast cancer also showed that Piperine (35-280 μmol/L) inhibited the growth of 4T1 cells in time- and dose-dependent manners (the IC(50). Treatment of 4T1 cells with piperine(70-280 μmol/L) induced apoptosis of 4T1 cells, accompanying activation of caspase 3. As the results, the phytochemical piperine may be a potential agent for treating breast cancer(4).
3. Angiogenesis
Angiogenesis is the action in stimulated production of new blood vessels to support the growth and cells.
Piperine, a major alkaloid constituent of black pepper, exerted it anti angiogenic effect to cause apoptosis in some cancer cell lines such as in inhibited the proliferation and G(1)/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death, as well as collagen-induced angiogenic activity by rat aorta explants and breast cancer cell-induced angiogenesis in chick embryos(5). Piperine in the co administration with curcumin, enhancing the functions of curcumin in suppression of many diseases including angiogenesis(6).
4. Cognitive Impairment
Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem solving, and decision making.
In chronic unpredictable stress (CUS)-induced cognitive impairment and oxidative stress in mice,
Piperine showed to potentiate the protective effects of curcumin in significantly improved behavioral and biochemical alterations, restored mitochondrial enzyme complex activities and attenuated increased acetylcholinesterase and serum corticosterone levels(7).
In olfactory bulbectomy induced depression in rats, co-administration of piperine with curcumin significantly potentiated the effects in behavioral, biochemical, mitochondrial, molecular and histopathological alterations(8).
These potentiation of co administration also showed to prevented all the behavioral, cellular, and neurochemical changes associated with the chronic administration of haloperidol, as compared to their effects alone(9).
5. Obesity's Inflammatory Metabolic Dysfunctions
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
Study of combination of bioactive food ingredients, including piperine in Forty-one patients and 45 patients in control group, showed a significantly greater decrease in insulin resistance, with leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group compared to the placebo(10).
In mice fed with high fat diet-induced hepatic steatosis, administration of piperine (50 mg/kg body weight) significant increased in plasma adiponectin levels, induced elevated plasma concentrations of insulin and glucose. Piperine also reversed HFD-induced down-regulation of adiponecitn-AMP-activated protein kinase (AMPK)( a metabolic enzyme in controls a number of metabolic pathways) signalling molecules linking to lipogenesis, fatty acid oxidation and insulin signalling in the livers of mice(11).
Also in Male Wistar rats fed with high fat diet study, piperine supplementation also improved the plasma levels of apo A-I, T3, T4, testosterone, and I and significantly reduced apo B, TSH, and insulin to near normal levels(12).
6. Diabetes
Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Administration of piperine isolated from the fruits of Piper nigrum crude extract diabestes induced in albino mice using alloxan, showed the crude extract exhibit its anti-diabetic effect inducing a significant blood glucose lowering at dose of 20 mg/kg on day 14(13).
In other alloxan-induced diabetic models study, piperine (10 mg/kg) significantly increased the dose-dependent anti-hyperglycemic activity of nateglinide(a drug for the treatment of type 2 diabetes), leading to synergistic anti-hyperglycemic activity of the diabetic medicine(14).
In diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats, piperinetreatment (10 mg/kg/day, intraperitoneally for 14 days) reversed the diabetic effects on oxidized glutathione concentration in brain, on renal glutathione peroxidase and superoxide dismutase activities, and on cardiac glutathione reductase activity and lipid peroxidation(15).
7. Allergic Effect
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
In picryl chloride (PC)-induced ear swelling in PC sensitized mice, PN-ext exhibited its histamine release inhibitory activity, in vitro on compound 48/80-induced histamine release from rat peritoneal mast cells(16).
Piperine(4.5 and 2.25 mg/kg) orally administered 5 times a week for 8 weeks in a murine model of asthma, showed an effectiveness in suppressed eosinophil infiltration, allergic airway inflammation and airway hyperresponsiveness by sinduced the production of interleukin-4, interleukin-5(white blood cells expression), immunoglobulin E and histamine(17).
8. Immunity
Ethanolic extract of fruits of Piper longum L.(PLE) and piperine was found to inhibit the lethal action of venom both in the in vitro lethality neutralization assay and in vivo lethality neutralization assay against Russell's viper venom in mice by enhancing production of antigen and antibodies response(18).
In the study of the same subject, administration of PLE and piperinesignificantly (p<0.01) inhibited venom induced lethality, haemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose dependent manner, reduced venom induced mast cell degranulation in rats(19).
9. Asthma
Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
Study of bacterial infections causes of frequent respiratory infections, including bacterial infections provoke asthma attack, showed a positive effect of Piper Longum L. Extract (20% Piperine) in exhibition of a moderate activity antibacterial activity against selected strains, such as Haemophilus influenzae , Streptococcus pneumoniae , Streptococcus pyrogene and Staphylococcus aureus(20).
In the study of antioxidant defenses of asthma patient, Piper longum extract (20% Piperine) showed a potent antioxidant activiy by scavenging Nitric oxide to prevent the bronchial inflammation in asthmatic patients(21).
The information finding, suggested that peppers including white and black pepper and thier major bioactive compound may be considered as function food for prevention and treatment of ailments indicated above. However, intake of pepper supplement should be taken with care in prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus by Mirza ZM, Kumar A, Kalia NP, Zargar A, Khan IA.(PubMed)
(2) Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus by Khan IA, Mirza ZM, Kumar A, Verma V, Qazi GN.(PubMed)(3) Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells by Do MT, Kim HG, Choi JH, Khanal T, Park BH, Tran TP, Jeong TC, Jeong HG.(PubMed)
(4) Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model by Lai LH, Fu QH, Liu Y, Jiang K, Guo QM, Chen QY, Yan B, Wang QQ, Shen JG.(PubMed)
(5) Piperine, a dietary phytochemical, inhibits angiogenesis by Doucette CD, Hilchie AL, Liwski R, Hoskin DW.(PubMed)
(6) Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature by Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB.(PubMed)(7) iperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice by Rinwa P, Kumar A.(PubMed)
(8) Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression by Rinwa P, Kumar A, Garg S.(PubMed)
(9) Protective effect of curcumin and its combination with piperine(bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence by Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK.(PubMed)
(10) Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects by Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Cava E, Paolini M, Scavone L, Ceccarelli P, Castellaneta E, Savina C, Donini LM.(PubMed)
(11) Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice by Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.(PubMed)
(12) Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats by Vijayakumar RS, Nalini N.(PubMed)(13) Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice by Atal S, Agrawal RP, Vyas S, Phadnis P, Rai N.(PubMed)
(14) Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide by Sama V, Nadipelli M, Yenumula P, Bommineni MR, Mullangi R.(PubMed)
(15) Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats by Rauscher FM, Sanders RA, Watkins JB 3rd.(PubMed)
(16) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(17) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC.(18) Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(19) Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(20) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(21) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus by Mirza ZM, Kumar A, Kalia NP, Zargar A, Khan IA.(PubMed)
(2) Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus by Khan IA, Mirza ZM, Kumar A, Verma V, Qazi GN.(PubMed)(3) Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells by Do MT, Kim HG, Choi JH, Khanal T, Park BH, Tran TP, Jeong TC, Jeong HG.(PubMed)
(4) Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model by Lai LH, Fu QH, Liu Y, Jiang K, Guo QM, Chen QY, Yan B, Wang QQ, Shen JG.(PubMed)
(5) Piperine, a dietary phytochemical, inhibits angiogenesis by Doucette CD, Hilchie AL, Liwski R, Hoskin DW.(PubMed)
(6) Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature by Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB.(PubMed)(7) iperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice by Rinwa P, Kumar A.(PubMed)
(8) Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression by Rinwa P, Kumar A, Garg S.(PubMed)
(9) Protective effect of curcumin and its combination with piperine(bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence by Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK.(PubMed)
(10) Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects by Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Cava E, Paolini M, Scavone L, Ceccarelli P, Castellaneta E, Savina C, Donini LM.(PubMed)
(11) Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice by Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.(PubMed)
(12) Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats by Vijayakumar RS, Nalini N.(PubMed)(13) Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice by Atal S, Agrawal RP, Vyas S, Phadnis P, Rai N.(PubMed)
(14) Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide by Sama V, Nadipelli M, Yenumula P, Bommineni MR, Mullangi R.(PubMed)
(15) Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats by Rauscher FM, Sanders RA, Watkins JB 3rd.(PubMed)
(16) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(17) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC.(18) Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(19) Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(20) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(21) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
Tuesday, August 28, 2018
15 Health Benefits Green Tea's Major Bioactive Polyphenols Catechin That You May Not Realize, According to Medical Publication Online
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
Catechin is phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in white tea, green tea, black tea, grapes, wine, apple juice, cocoa, lentils,......
1. Body-weight regulation
Green tea has been proposed as a tool for obesity management as strategies for weight loss and weight maintenance.
In the investigated green tea dody-weight regulation effect, researchers found that a green tea-caffeine mixture improves weight maintenance, through thermogenesis, fat oxidation, and sparing fat free mass.
Furthermore, the study also suggested, the sympathetic nervous system is involved in the regulation of lipolysis in breakingdown of lipids and involves hydrolysis of triglycerides into glycerol and free fatty acid.
Moreover, green tea modulated effect of the sympathetic innervation of white adipose tissue may play an important role in the regulation of total body fat in general.(1)
2. Cholesterol
In a systematic review and meta-analysis of randomized controlled trials thst evaluates the relationship between GTCs and serum lipid levels, including total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol, and triglycerides, scientists found that the consumption of GTCs is associated with a statistically significant reduction in total and LDL cholesterol levels; however,
However, after taking into account of co and con founders, there was no significant effect on HDL cholesterol or triglyceride levels.(2)
3. Anti liver cancers
In the examination ofthe effect of catechins on the antitumor efficacy of doxorubicin (DOX) in a murine model, researchers found that tea catechins at non-toxic doses can augment DOX-induced cell killing and sensitize chemoresistant HCC cells to DOX.
3. Anti liver cancers
In the examination ofthe effect of catechins on the antitumor efficacy of doxorubicin (DOX) in a murine model, researchers found that tea catechins at non-toxic doses can augment DOX-induced cell killing and sensitize chemoresistant HCC cells to DOX.
The chemosensitizing effect of catechins may occur directly or indirectly by reversal of multidrug resistance, involving the suppression of multi-drug resistance dene (MDR1) expression, or by enhancement of intracellular DOX accumulation, involving inhibition of P-gp function(3).
4. Antioxidant activity
The review on polyphenolic compounds (included catechins) in the berries of edible honeysuckle and their biological effects on medical literature found that berries seem to be prospective sources of health-supporting phytochemicals that exhibit beneficial anti-adherence and chemo-protective activities, thus they may provide protection against a number of chronic conditions, e.g., cancer, diabetes mellitus, tumour growth or cardiovascular and neurodegenerative diseases(4)
The review on polyphenolic compounds (included catechins) in the berries of edible honeysuckle and their biological effects on medical literature found that berries seem to be prospective sources of health-supporting phytochemicals that exhibit beneficial anti-adherence and chemo-protective activities, thus they may provide protection against a number of chronic conditions, e.g., cancer, diabetes mellitus, tumour growth or cardiovascular and neurodegenerative diseases(4)
5. Severe dyslipidemia
In the observation of three-month old ATX mice treated, or not, for 3 months with the polyphenol (+)-catechin (CAT, 30 mg/kg/day) and compared to wild-type (WT) controls, scientists found that mice treated with catechin expresses an active remodeling of the cerebrovascular wall.
These results suggested that catechin at dose of 30 mg/kg/day significant reduced plague accumulated through normalizing the levels of pro-metalloproteinase-9 activity(5).
High levels of pro-metalloproteinase-9 are correlated to high levels of blood cholesterol
Green tea catechin processed a strong effect in preservation of the endothelial function. Long term use of the phytochemical exerted a preventive activity that only deletes the severe dyslipidemia on cerebral artery wall structure and bio mechanical properties but also contributes to preserving resting cerebral blood flow(5).
6. Anti-inflammatory effect
In the preparation of the gel of Chinese medicine catechu, and to observe the release mechanism in vitro and anti-inflammatory activity in rats, researchers found that the optimum condition of extraction in exerting anti inflammatory effect are totally depended to doses at the concentration of ethanol, ratio of raw material to solvent, ultrasonic time, and extraction temperature were 50% , 1: 12, 35 min and 60 degrees C, respectively.
6. Anti-inflammatory effect
In the preparation of the gel of Chinese medicine catechu, and to observe the release mechanism in vitro and anti-inflammatory activity in rats, researchers found that the optimum condition of extraction in exerting anti inflammatory effect are totally depended to doses at the concentration of ethanol, ratio of raw material to solvent, ultrasonic time, and extraction temperature were 50% , 1: 12, 35 min and 60 degrees C, respectively.
The formulation of catechu gel of carbomer-9 400.5 g, glycerol 5.0 g, the extracts of catechu 50.0 mL, and triethanomine 0.5 mL not only was found to be semitransparent and stable, but also can released quickly.
The catechu gel reduced the paw edema considerably in dose-dependent manner in compared to non treated carrageenan-induced rat(6).
7. Neuropathic pain
In the investigation of Epigallocatechin-3-gallate (EGCG), the major catechin in green tea and its effect on intrathecal EGCG in neuropathic pain induced by spinal nerve ligation, scientists found that
Additionalli, intrathecal EGCG also blocked the increase in nNOS expression in the spinal cord of spinal nerve-ligated rats, but iNOS expression was not significantly suppressed.
These findings suggest that intrathecal EGCG could produce an antiallodynic effect against spinal nerve ligation-induced neuropathic pain, mediated by blockade of nNOS protein expression and inhibition of the pronociceptive effects of NO.(7).
8. Cholesterol and glucose levels
The examination of the effect of the main green tea catechin, epigallocatechin gallate (EGCG), taken in a green tea extract, Polyphenon E (PPE) and their effect on circulating hormone levels, an established breast cancer risk factor, found that glucose and insulin levels decreased non significantly in the PPE groups but increased in the placebo group.
8. Cholesterol and glucose levels
The examination of the effect of the main green tea catechin, epigallocatechin gallate (EGCG), taken in a green tea extract, Polyphenon E (PPE) and their effect on circulating hormone levels, an established breast cancer risk factor, found that glucose and insulin levels decreased non significantly in the PPE groups but increased in the placebo group.
Furthermore, Polyphenon E (PPE) caused statistically significant differences in changes in glucose and insulin.
In compared to doses of green tea intake of (400 and 800 mg EGCG as PPE; ~5-10 cups) that equivalences to supplmentation , researchers suggested supplementation for 2 months had suggestively beneficial effects on LDL cholesterol concentrations and glucose-related markers(8)
9. Neuroprotective effects
The evaluation the neuroprotective effects of theanine and catechins contained in green tea, found that the mechanism of the neuroprotective effect of theanine is related not only to the glutamate receptor but also to other mechanisms such as the glutamate transporter.
One of the onset mechanisms for arteriosclerosis, a major factor in ischemic cerebrovascular disease, is probably the oxidative alteration of low-density lipoprotein (LDL) by active oxygen species.
The oxidative alterations of LDL was shown to be prevented by tea catechins.
Scavenging of *O(2)(-) was also exhibited by tea catechins.(9).
10. Anti-obesity effects
In the elucidation of the anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, female ICR mice, researchers found that the body weight increase and weight of IPAT were significantly reduced by the diets containing green tea, caffeine, theanine, caffeine + catechins, caffeine + theanine and caffeine + catechins + theanine.
Noticeably, the IPAT weight decreased by 76.8% in the caffeine + catechins compared to the control group.
Serum concentrations of triglycerides (TG) and non-esterified fatty acids (NEFA) were decreased by green tea, catechins and theanine. Moreover, caffeine + catechins, caffeine + theanine and caffeine + catechins + theanine also decreased NEFA in the serum.
The TG level in the liver was significantly reduced by catechins and catechins + theanine in comparison with the control(10).
11. Nonalcoholic fatty liver disease
The investigation of green tea's effect on nonalcoholic fatty liver disease (NAFLD), a constellation of progressive liver disorders, suggested, green tea is rich in polyphenolic catechins that have hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities that may mitigate the occurrence and progression of NAFLD.
11. Nonalcoholic fatty liver disease
The investigation of green tea's effect on nonalcoholic fatty liver disease (NAFLD), a constellation of progressive liver disorders, suggested, green tea is rich in polyphenolic catechins that have hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities that may mitigate the occurrence and progression of NAFLD.
Application of green tea that demonstrates the hepatoprotective properties may be considered as functional food and targeted dietary agents to protect the liver against onset of NAFLD(11).
12. Age-related Neurodegeneration
The identification of green tea (GT) and the effect of large amounts of brain-accessible polyphenols, found, the beneficial action of catechinsin learning and memory with a particular focus on the hippocampal formation.
GT polyphenols which exert significant neuro protective effect may have a promising role in the reversal of age-related loss of neuronal plasticity and recovery after neuronal lesions associated with aging12)
13. Anti-influenza virus activity
In the study of Polyphenolic compounds present in green tea, particularly catechins, and its effect on strong anti-influenza activity, researchers showed that therapeutic administration of green tea by-products via feed or water supplement resulted in a dose-dependent expressed a significant antiviral effect in chickens, with a dose of 10 g/kg of feed being the most effective(13).
14. Prostate Cancer
Epidemiological studies suggest that tea consumption has protective effects against a variety of human cancers, including that of the prostate.
13. Anti-influenza virus activity
In the study of Polyphenolic compounds present in green tea, particularly catechins, and its effect on strong anti-influenza activity, researchers showed that therapeutic administration of green tea by-products via feed or water supplement resulted in a dose-dependent expressed a significant antiviral effect in chickens, with a dose of 10 g/kg of feed being the most effective(13).
14. Prostate Cancer
Epidemiological studies suggest that tea consumption has protective effects against a variety of human cancers, including that of the prostate.
Laboratory and clinical studies have demonstrated that green tea components, specifically the green tea catechin (GTC) epigallocatechin gallate, can induce apoptosis, suppress progression, and inhibit invasion and metastasis of prostate cancer..(14)
15. Breast cancer
In the developing a chronically induced breast cell carcinogenesis model to the exposure of non-cancerous, human breast epithelial MCF10A cells to bioachievable picomolar concentrations of environmental carcinogens, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P), to progressively induce cellular acquisition of cancer-associated properties, as measurable end points, found that green tea catechins (GTCs) , at non-cytotoxic levels, were able to suppress chronically induced cellular carcinogenesis by blocking carcinogen-induced ROS elevation, ERK activation, cell proliferation and DNA damage in each exposure cycle.
15. Breast cancer
In the developing a chronically induced breast cell carcinogenesis model to the exposure of non-cancerous, human breast epithelial MCF10A cells to bioachievable picomolar concentrations of environmental carcinogens, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P), to progressively induce cellular acquisition of cancer-associated properties, as measurable end points, found that green tea catechins (GTCs) , at non-cytotoxic levels, were able to suppress chronically induced cellular carcinogenesis by blocking carcinogen-induced ROS elevation, ERK activation, cell proliferation and DNA damage in each exposure cycle.
The findings may help accelerate the identification of preventive agents to intervene in carcinogenesis induced by long-term exposure to environmental carcinogens, thereby safely and effectively reducing the health risk of sporadic breast cancer(15).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20156466
(2) http://www.ncbi.nlm.nih.gov/pubmed/22027055
(3) http://www.ncbi.nlm.nih.gov/pubmed/20514403
(4) http://www.ncbi.nlm.nih.gov/pubmed/22269864
(5) http://www.ncbi.nlm.nih.gov/pubmed/22268108
(6) http://www.ncbi.nlm.nih.gov/pubmed/22256752
(7) http://www.ncbi.nlm.nih.gov/pubmed/22249118
(8) http://www.ncbi.nlm.nih.gov/pubmed/22246619
(9) http://www.ncbi.nlm.nih.gov/pubmed/12499631
(10) http://www.ncbi.nlm.nih.gov/pubmed/15011752
(11) http://www.ncbi.nlm.nih.gov/pubmed/22221215
(12) http://www.ncbi.nlm.nih.gov/pubmed/22211685
(13) http://www.ncbi.nlm.nih.gov/pubmed/22184430
(14) http://www.ncbi.nlm.nih.gov/pubmed/22098273
(15) http://www.ncbi.nlm.nih.gov/pubmed/2204502
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20156466
(2) http://www.ncbi.nlm.nih.gov/pubmed/22027055
(3) http://www.ncbi.nlm.nih.gov/pubmed/20514403
(4) http://www.ncbi.nlm.nih.gov/pubmed/22269864
(5) http://www.ncbi.nlm.nih.gov/pubmed/22268108
(6) http://www.ncbi.nlm.nih.gov/pubmed/22256752
(7) http://www.ncbi.nlm.nih.gov/pubmed/22249118
(8) http://www.ncbi.nlm.nih.gov/pubmed/22246619
(9) http://www.ncbi.nlm.nih.gov/pubmed/12499631
(10) http://www.ncbi.nlm.nih.gov/pubmed/15011752
(11) http://www.ncbi.nlm.nih.gov/pubmed/22221215
(12) http://www.ncbi.nlm.nih.gov/pubmed/22211685
(13) http://www.ncbi.nlm.nih.gov/pubmed/22184430
(14) http://www.ncbi.nlm.nih.gov/pubmed/22098273
(15) http://www.ncbi.nlm.nih.gov/pubmed/2204502
Monday, August 27, 2018
Herbal Chaste Tree Berry, The Potential Queen Herb That Protects Against Ageing, Menstrual Disorders,.Menopause Symptoms and More.......
Chaste tree berry processes both estrogenic and anti extrogenic properties may be considered as functional food for women in delayed aging progression, restored hormone balance in ameliorated menstrual disorders, and alleviated menopausal symptoms and more........
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
Estrogenic Property
Chaste-tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.
According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.
Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that beside linoleic acid, flavones derivative vitexin and penduletin. isolated from vitex agnus-castus (VAC) also expressed estrogenic effect as most active ERss-selective phytoestrogens.
Anti estrogen Property
Chaste tree berry(Vitex agnus-castus), also processes anti estrogenic property in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.
Anti estrogenic effects is an action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulation in the body.
According to the University of Alabama in Huntsville, in the study of potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.
Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed anti estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti estrogenic effect.
In a hyperprolactinemia (MIHP) induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, application of casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.
More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti estrogenic activity in decrease excessive levels of 17β-Estradiol (E2) significantly
Summary
Chaste tree berry(Vitex agnus-castus) exerts estrogenic components of plant extracts may constitute a potential use for some dietary supplements in human for treatment of various estrogen related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration and anti estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.
In other words, chaste tree berry stimulated estrogen receptors in release estrogen into the blood in case of deficiency or inhibited extra levels of estrogen in case of excess in maintenance hormone balancing with other sexual hormones.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(5) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(6) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
Posted by kyle J. Norton at 05
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
Estrogenic Property
Chaste-tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.
According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.
Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that beside linoleic acid, flavones derivative vitexin and penduletin. isolated from vitex agnus-castus (VAC) also expressed estrogenic effect as most active ERss-selective phytoestrogens.
Anti estrogen Property
Chaste tree berry(Vitex agnus-castus), also processes anti estrogenic property in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.
Anti estrogenic effects is an action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulation in the body.
According to the University of Alabama in Huntsville, in the study of potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.
Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed anti estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti estrogenic effect.
In a hyperprolactinemia (MIHP) induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, application of casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.
More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti estrogenic activity in decrease excessive levels of 17β-Estradiol (E2) significantly
Summary
Chaste tree berry(Vitex agnus-castus) exerts estrogenic components of plant extracts may constitute a potential use for some dietary supplements in human for treatment of various estrogen related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration and anti estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.
In other words, chaste tree berry stimulated estrogen receptors in release estrogen into the blood in case of deficiency or inhibited extra levels of estrogen in case of excess in maintenance hormone balancing with other sexual hormones.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(5) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(6) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
Posted by kyle J. Norton at 05
Sunday, August 26, 2018
Intake of Herbal Turmeric(1) To Discover 15 Incredible Medical Benefits and Optimal Health, According to Phytochemical Properties
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. Curcumin, isolated from the turmeric extract and natural phenols in the plant. have been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations,……
1. Cancers
According to the study of `Induction of apoptosis by curcumin and its implications for cancer therapy.` by Karunagaran D, Rashmi R, Kumar TR. (Cancer Biology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695 014, India.dkarunagaran@hotmail.com), posted in US National Library of Medicine National Institutes of Health, reseachers found that this review describes the mechanisms of curcumin-induced apoptosis currently known, and suggests several potential strategies that include down-regulation of antiapoptotic proteins by antisense oligonucleotides, use of proapoptotic peptides and combination therapy, and other novel approaches against chemoresistant tumors. Several factors including pharmacological safety, scope for improvement of structure and function of curcumin and its ability to attack multiple targets are in favor of curcumin being developed as a drug for prevention and therapy of various cancers.
In an article of `Don’t Go Easy on Turmeric: It Prevents and Cures Cancer` by By VIJI SUNDARAM, India-West Staff Reporter(WEST PUBLICATIONS(Copyright India-West, July 15, 2005, www.indiawest.com), receptor wrote that Dr. Bharat Aggarwal, who headed the 12-member team of researchers at UT’s M.D. Anderson Cancer Center, told India-West in a telephone interview earlier this week that his clinical research has made available not only “the master switch to turn off cancer, but also a cure for it. It was already known that curcumin can prevent cancer,” Aggarwal said. “Now it can also be used to cure cancer.” And, he added: “We are providing evidence that curcumin can work on at least one dozen cancers.” Because of turmeric’s extensive use in foods in India and Pakistan, the incidence of cancer, especially breast, colon, prostate and lung, is a lot less in those countries, Aggarwal said. And because south Indians use turmeric more widely than north Indians, “the prevalence of cancer is less among them than among north Indians,” he said.
2. Alzheimer’s disease
According to Aggarwal, the team determined that curcumin is more effective in inhibiting formation of the protein fragments than many other drugs being tested to treat Alzheimer’s. The prevalence of the disease among older adults in India is 4.4 times less than in the U.S., suggesting that many Indians might be benefiting from having turmeric as a dietary staple.
In other study of `NSAID and antioxidant prevention of Alzheimer’s disease: lessons from in vitro and animal models.`by Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. (Source from Greater Los Angeles Healthcare System, Veterans Administration Medical Center, North Hills, CA 91343, USA. gmcole@ucla.edu) posted in US National Library of Medicine National Institutes of Health, reseachers found that the unconventional NSAID/antioxidant curcumin was effective, lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid deposition. Curcumin proved to be immunomodulatory, simultaneously inhibiting cytokine and microglial activation indices related to neurotoxicity, but increasing an index of phagocytosis. Curcumin directly targeted Abeta and was also effective in other models, warranting further preclinical and clinical exploration.
3. Anti-inflammatory agent
According to the study of evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. by Satoskar RR, Shah SJ, Shenoy SG., poated in US National Library of Medicine National Institutes of Health, researchers wrote that In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo.
4. Antioxidants
In a study of `Protective Role of Curcumin Against Oxidative Stress,Immunosuppressive and Cytotoxic Effects of Lead Exposure` by Mahmoud El-sherbiny, Azza Araffa, Mona Mantawy and Hany M. Hassan (Therapeutic Chemistry Department, National Research Centre – Dokki, Giza, Egypt. Immunology Department, Animal Reproduction Research Institute (ARRI), Giza, Egypt), posted in World Applied Sciences Journal 12 (10): 1832-1838, 2011, researchers found that
ground, curcumin’s benefits on tumorigenesis are thought to be mediated by its antiinflammatory activity; however, these effects have not been well characterized in a mouse model of colon cancer. Briefly, curcumin is efficacious for chronic nonbacterial prostatitis in rats and the action mechanism may be associated with its decreasing effect on the proinflammatory cytokines IL-8 and TNF-alpha in the blood and tissues. Curcumin has protective effect on DNA of pulmonary cells. There was direct evidence for an involvement of curcumin in reducing arsenic and lead induced oxidative stress in Swiss albino mice by virtue of its antioxidant potential and trapping of free radicals. The current investigation concluded that curcumin has protective role against cytotoxic, immunosuppressive , oxidative and immunosuppressive profile that perform due to lead acetate exposure.
5. Amyloidosis
In a study of `Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.`by Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. (Source from Department of Medicine, UCLA, Los Angeles, CA 90095, USA.) posted in US National Library of Medicine National Institutes of Health, researchers found that curcumin labeled plaques and reduced amyloid levels and plaque burden. Hence, curcumin directly binds small beta-amyloid species to block aggregation and fibril formation in vitro and in vivo. These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD.
6. Chronic anterior uveitis
In a study of `Efficacy of curcumin in the management of chronic anterior uveitis.`by Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, Srimal RC. (Source from Department of Ophthalmology, K.G. Medical College, Lucknow, India.) posted in US National Library of Medicine National Institutes of Health, researchers found that the efficacy of curcumin and recurrences following treatment are comparable to corticosteroid therapy which is presently the only available standard treatment for this disease. The lack of side effects with curcumin is its greatest advantage compared with corticosteroids. A double blind multi-centric clinical trial with this drug in CAU is highly desirable to further validate the results of the present study.
7. Improve Learning and Memory Ability
According to the researcher of `Curcumin improves learning and memory ability and its neuroprotective mechanism in mice.`by Pan R, Qiu S, Lu DX, Dong J. (Source from Department of Orthopedics, the First Affiliated Hospital, Medical College of Jinan University, Guangzhou, Guangdong, China.) posted in US National Library of Medicine National Institutes of Health, the result of the study indicated that curcumin significantly improved the memory ability of AD mice in the step-through test, as indicated by the reduced number of step-through errors (P < 0.05) and prolonged step-through latency (P < 0.05). Curcumin also attenuated the neuropathological changes in the hippocampus and inhibited apoptosis accompanied by an increase in Bcl-2 level (P < 0.05), but the activity of Bax did not change (P > 0.05). AlCl(3) significantly reduced the viability of PC12 cells (P < 0.01). Curcumin increased cell viability in the presence of AlCl(3) (P < 0.01). The rate of apoptosis decreased significantly in the curcumin group (P < 0.05) when measured by flow cytometric analysis. Curcumin protected cells by increasing Bcl-2 level (P < 0.05), but the level of Bax did not change (P > 0.05)., researchers conclude that this study demonstrates that curcumin improves the memory ability of AD mice and inhibits apoptosis in cultured PC12 cells induced by AlCl(3). Its mechanism may involve enhancing the level of Bcl-2.
8. Gall-bladder function
In a study of `The effect of curcumin and placebo on human gall-bladder function: an ultrasound study.`by Rasyid A, Lelo A. ( from Source Department of Radiology, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia.) posted in posted in US National Library of Medicine National Institutes of Health, researchers found that The fasting gall-bladder volumes of 15.74 +/- 4.29 mL on curcumin and 15.98 +/- 4.08 mL on placebo were similar (P > 0.20). The gall-bladder volume was reduced within the period after curcumin administration. The percentage of gall-bladder volume reduction at 0.5, 1.0, 1.5 and 2.0 h after 20 mg curcumin administration were 11.8 +/- 6.9, 16.8 +/- 7.4, 22.0 +/- 8.5 and 29. 3 +/- 8.3%, respectively, which was statistically significant compared to placebo.
9. Eicosanoidand Blood Platelets
In a study of `Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets.`by Srivastava KC, Bordia A, Verma SK. (Source from Department of Environmental Medicine, Odense University Denmark.) posted in US National Library of Medicine National Institutes of Health, researchers found that this compound inhibited thromboxane B2 (TXB2) production from exogenous [14C] arachidonate in washed platelets with a concomitant increase in the formation of 12-lipoxygenase products. Moreover, curcumin inhibited the incorporation of [14C]AA into platelet phospholipids and inhibited the deacylation of AA-labelled phospholipids (liberation of free AA) on stimulation with calcium ionophore A23187. Curcumin’s anti-inflammatory property may, in part, be explained by its effects on eicosanoid biosynthesis.
10. Cellular Processing
According to the research of `Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.`by Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS. (Source from Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA. Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.) posted in US National Library of Medicine National Institutes of Health, researchers found that assay of serum curcumin by ethyl acetate extraction followed by liquid chromatography/mass spectrometry indicated a maximum serum concentration of 60 nm, well below that of 5-15 microm, where cellular effects by sarcoplasmic/endoplasmic reticulum calcium pump inhibition are proposed to occur. Our results do not support further evaluation of curcumin for cystic fibrosis therapy.
11. Chemopreventative blocking agents
In a study of Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene.
Singletary K, MacDonald C, Iovinelli M, Fisher C, Wallig M. by (Source from Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana 61801, USA.)
posted in US National Library of Medicine National Institutes of Health, reseachers found that Female rats provided diets supplemented with dibenzoylmethane at 0.1, 0.5 and 1.0% for 14 days prior to dosing with DMBA exhibited a significant decrease in mammary tumor development, compared with controls. However, tumor development for animals fed diets containing 1.0% curcumin was not different from that of controls. Therefore, dibenzoylmethane, and possibly other structurally-related beta-diketones, warrant examination as breast cancer chemopreventative blocking agents.
12. Lymphomas/Leukemias
In a study of `Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice.`by Huang MT, Lou YR, Xie JG, Ma W, Lu YP, Yen P, Zhu BT, Newmark H, Ho CT. (Source from Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854-8020, USA.) US National Library of Medicine National Institutes of Health, researchers found that the incidence of lymphomas/leukemias was completely inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or no effect on the incidence of mammary tumors, and the incidence of lymphomas/leukemias was reduced by 53%.
13. Angiogenesis Inhibitor
According to the study of `Curcumin as an inhibitor of angiogenesis.`by Bhandarkar SS, Arbiser JL.(Source from Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA. ssbhand@emory.edu) posted in PubMed, researchers indicated that Curcumin shows a dose-dependent inhibition on tumor necrosis factor, a versatile cytokine, which has its effect on angiogenesis through the signal transduction pathways, expression of proangiogenic factors, and cell adhesion molecules. Curcumin’s effect on the overall process of angiogenesis compounds its enormous potential as an antiangiogenic drug.
14. Perisinusoidal Cells (Hepatic Stellate Cell (HSC))
In a study of `De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation.`by Zheng S, Yumei F, Chen A. (Source from Department of Pharmacology, Nanjing Medical University, China.) posted in PubMed, researchers found that
De novo synthesis of GSH is a prerequisite for curcumin to inhibit HSC activation. These results provide novel insights into the mechanisms of curcumin as an antifibrogenic candidate in the prevention and treatment of hepatic fibrosis.
15. Liver Disease
According to the study of `Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes.`by Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ. (Source from Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283, USA. amin.nanji@uphs.upenn.edu) posed in PubMed, researchers found that treatment with curcumin prevented both the pathological and biochemical changes induced by alcohol. Because endotoxin and the Kupffer cell are implicated in the pathogenesis of ALD, we investigated whether curcumin suppressed the stimulatory effects of endotoxin in isolated Kupffer cells. Curcumin blocked endotoxin-mediated activation of NF-kappaB and suppressed the expression of cytokines, chemokines, COX-2, and iNOS in Kupffer cells. Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes.
Side effects
1. Overdose may cause gastrointestinal discomfort such as nausea and diarrhea and liver damage.
2. Topical use may be allergic to skin such irritation to certain peoples
3. Do not use the herb in new born, children or if you are pregnant and breast feeding without approval from the related field specialist.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
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