Skin is the largest organ in the body with the function to protect the internal organs and tissue against foreign organisms infection, leading organs and tissue injury and damage.
It also is the third organ behind the liver and kidney to eliminate body toxins if the first 2 fail to cleanse them all.
Skin diseases are conditions of skin damage and are classified according to each pathogenic cause.
Most cases of skin disease are involved in allergens, irritants. However certain medical conditions such as irritable bowel disease, autoimmune diseases, and genetic preposition can also cause r skin diseases.
Recent studies suggested that a poor diet is also associated with the onset of skin diseases such as dermatological disease which may be linked to systemic disease, and dietary changes which may affect health outcomes, as in psoriasis.
Photodamage is a type of skin damage caused by long-term exposure to the sunlight or tanning bed.
Photodamage skin is one most common forms of skin damage in the US, due to misunderstanding the benefits and adverse effects of light exposure.
Believe it or not, a quarter of lifetime sun exposure occurs before the end of the teenage years. Most cases of photo skin damage can also stimulate some unwanted skin conditions, including advanced aging or wrinkling, uneven skin, hyperpigmentation, telangiectasias, actinic keratoses liver, and age spots.
In severe cases, long-term photodamaged skin can also lead to skin cancer. More people in the US are diagnosed with skin cancer each year than all other cancers combined.
According to the statistic, 1 in 5 Americans will develop skin cancer by the age of 70.
Conventionally, most cases of early-stage and mild damage of skin are treated by topical Levulan that removes scaly patches of actinic keratoses from your skin.
UVB-induced skin damage is a condition of skin damage caused by overexposure to UVB.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of skin diseases, researchers examined the protective capacity of alpha-tocopherol and beta-carotene during UVA and UVB irradiation of human melanocytes in vitro.
According to the primary cultures of normal human melanocytes irradiated by different wavelengths within the UV spectrum (UVA 6 J cm(-2), UVB 60 mJ cm(-2)),* UVA and UVB irradiation decreased the intracellular concentration of reduced glutathione associated with an antioxidant enzyme produced by the host and activated the transcription factor nuclear factor (NF)-kappaB, involved in the production of pro-inflammatory cytokines.
Furthermore, UVA and UVB irradiation increased the level of the p65 subunit in the activation of the potential of NF-kappa Band translocation to the nucleus.
Moreover, UVA and UVB caused apoptotic cell death as detected by nuclear fragmentation and caspase activation 24 h postirradiation.
Pretreatment with alpha-tocopherol prevented UVA- and UVB-induced glutathione loss, NF-kappaB translocation, and diminished apoptosis. However, beta-carotene did not show a similar protective capacity. Further, exposure to alpha-tocopherol by itself reduced cell proliferation rate.
Based on the results, researchers said, "UVA and UVB irradiation affected the intracellular redox state and increased the frequency of apoptosis in human melanocytes in vitro. alpha-Tocopherol might be a useful substance in protecting melanocytes from UV-induced damage".
Taken altogether, tocopherols may be considered a supplement for the treatment of UVB-induced skin damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ultraviolet (UV)A- and UVB-induced redox alterations and activation of nuclear factor-kappaB in human melanocytes-protective effects of alpha-tocopherol by Larsson P1, Ollinger K, Rosdahl I. (PubMed)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Friday, March 25, 2022
Saturday, March 19, 2022
Tocopherols Destroy Oral Cancer Cells in Vitro
Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissues of the mouth caused by genetic alteration of the cell DNA.
Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that lines the lips and the inside of the mouth.
According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die because of these cancers in the United States.
The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection, and genetic mutation is the most common prevalent risk factors found in people with mouth cancer.
The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
Stages
1. Stage O
Benign tumor
2. Stage I
The cancer is < 2 cm in size (about 1 inch), with no lymph nodes spreading found in the area.
3. Stage II
The cancer is ≥ 2 cm in size, but < 4 cm (less than 2 inches), with no lymph nodes spreading found in the area.4. Stage III
The cancer is ≥ cm in size or any size with only one lymph node on the same side of the neck as of cancer. The cancerous node is ≤ 3 cm (about one inch).
5. Stage IV
Cancer has spread to tissues around the lip and oral cavity with lymph nodes in the area may or may be infected. The cancer of any size has spread to more than one lymph node on the same side of the neck or lymph nodes on one or both sides of the neck, or to any lymph node that measures ≥ 6 cm (over 2 inches) in size or to distant parts of the body.
Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of chronic diseases associated with inflammation, researchers examined the effects of α-tocopherol on the oral squamous carcinoma cells ORL-48.
According to the experimental results,
* In vitro study, α-tocopherol exhibited effective antitumor activity on ORL-48 at 2.5 ± 0.42 µg/mL.
* Although Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL, compared to α-tocopherol which exhibited cytotoxicity on normal human epidermal keratinocytes at very low concentration (<0.1 µg/mL).
* Despite the lower potency of α-tocopherol, signs of apoptosis such as the shrinkage of cells and appearance of apoptotic bodies were observed much earlier than cisplatin in time-lapse microscopy.
* Both applications increased the number of cell accumulation in the G0/G1 phase with ultrastructural changes of the cellular structures verified the apoptotic mode of cell death by both agents.
Based on the findings, researchers said, " Both cisplatin and α-tocopherol displayed cell cycle arrest at the Sub G0 phase. α-tocopherol thus showed potential as an antitumor agent for the treatment of oral cancer and merits further research".
Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48 by Zulkapli R1,2, Abdul Razak F1, Zain RB. (PubMed)
Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that lines the lips and the inside of the mouth.
According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die because of these cancers in the United States.
The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection, and genetic mutation is the most common prevalent risk factors found in people with mouth cancer.
The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
Stages
1. Stage O
Benign tumor
2. Stage I
The cancer is < 2 cm in size (about 1 inch), with no lymph nodes spreading found in the area.
3. Stage II
The cancer is ≥ 2 cm in size, but < 4 cm (less than 2 inches), with no lymph nodes spreading found in the area.4. Stage III
The cancer is ≥ cm in size or any size with only one lymph node on the same side of the neck as of cancer. The cancerous node is ≤ 3 cm (about one inch).
5. Stage IV
Cancer has spread to tissues around the lip and oral cavity with lymph nodes in the area may or may be infected. The cancer of any size has spread to more than one lymph node on the same side of the neck or lymph nodes on one or both sides of the neck, or to any lymph node that measures ≥ 6 cm (over 2 inches) in size or to distant parts of the body.
Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of chronic diseases associated with inflammation, researchers examined the effects of α-tocopherol on the oral squamous carcinoma cells ORL-48.
According to the experimental results,
* In vitro study, α-tocopherol exhibited effective antitumor activity on ORL-48 at 2.5 ± 0.42 µg/mL.
* Although Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL, compared to α-tocopherol which exhibited cytotoxicity on normal human epidermal keratinocytes at very low concentration (<0.1 µg/mL).
* Despite the lower potency of α-tocopherol, signs of apoptosis such as the shrinkage of cells and appearance of apoptotic bodies were observed much earlier than cisplatin in time-lapse microscopy.
* Both applications increased the number of cell accumulation in the G0/G1 phase with ultrastructural changes of the cellular structures verified the apoptotic mode of cell death by both agents.
Based on the findings, researchers said, " Both cisplatin and α-tocopherol displayed cell cycle arrest at the Sub G0 phase. α-tocopherol thus showed potential as an antitumor agent for the treatment of oral cancer and merits further research".
Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48 by Zulkapli R1,2, Abdul Razak F1, Zain RB. (PubMed)
Saturday, March 12, 2022
Antioxidant Lycopene Protects the Kidney Cell Integrity Against Damage
The kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.
Besides being accompanied by the liver and skin to form a detox system in the body, the kidneys also process significant effects that maintain the body fluid balance, regulate the production of red blood cell and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
CKD can cause dangerous levels of fluid, electrolytes, and wastes to build up in the body.
According to statistics, approximately 14 percent of the US general population suffers from CKD. More than 661,000 Americans are living with kidney failure, including 468,000 individuals on dialysis.
People with reduced kidney function do not experience any symptoms until the advanced stage. In other words, kidney disease in the advanced stage can lead to dangerous levels of fluid, electrolytes, and building toxins in the body.
Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent factors found in most patients.
In this advanced stage, patients also experience symptoms of gastrointestinal discomforts, weakness,
sleep problems, changes of urination, decreased mental sharpness, muscle twitches and cramps, and swelling of feet and ankles, particularly the persistent itching.
Some researchers suggested high blood pressure is one of the major causes of CKD.
The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"
And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".
Lycopene is a phytochemical found in tomatoes in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potent ingredient for the protection of kidney damage, researchers examined the effect of lycopene on the nephrotoxicity of deltamethrin.
The study included male albino rats that were divided into four groups with10 animals each: group I served as control, which received standard diet; group II received oral administration of deltamethrin (1.28 mg/kg per day) for 30 days; group III received both deltamethrin and lycopene (1 mg/kg per day); group IV received lycopene (1 mg/kg per day).
According to the results of the end of the experiment, the deltamethrin-treated group not only showed significantly increased expression of the pro-inflammatory cytokine, TNF-α but also caused mild necrotic changes of the kidney associated with localized cell death due to interruption of the blood supply.
Renal proximal tubules in the deltamethrin treated group also showed an increased number and irregular shape of mitochondria causing the reduced function of the cell in the kidney to take nutrients from the cell breaks it down and turn it into energy.
Vacuolar degeneration in the epithelial cells, increased number of lysosomes, and loss of apical microvilli associated with the reduced function of kidney cells in the absorptive and secretory function, may lead to the decrease of the detoxed function of the kidney.
Moreover, focal segmental thickening and the duplication of the glomerular basement membrane and podocyte changes are involved in kidney damage. were also found in the deltamethrin treated group.
Pretreatment of lycopene demonstrated a strong effect either restored the kidney tissue damage or inhibited the parameters that cause the kidney disease.
Based on the findings, researchers said, "Histopathological and ultrastructural study showed some protective effect of lycopene on kidney tissues".
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats by El-Gerbed MS. (PubMed)
(3) High Blood Pressure & Kidney Disease. What is high blood pressure? the Natural Kidney Foundation. (NIH)
Besides being accompanied by the liver and skin to form a detox system in the body, the kidneys also process significant effects that maintain the body fluid balance, regulate the production of red blood cell and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
CKD can cause dangerous levels of fluid, electrolytes, and wastes to build up in the body.
According to statistics, approximately 14 percent of the US general population suffers from CKD. More than 661,000 Americans are living with kidney failure, including 468,000 individuals on dialysis.
People with reduced kidney function do not experience any symptoms until the advanced stage. In other words, kidney disease in the advanced stage can lead to dangerous levels of fluid, electrolytes, and building toxins in the body.
Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent factors found in most patients.
In this advanced stage, patients also experience symptoms of gastrointestinal discomforts, weakness,
sleep problems, changes of urination, decreased mental sharpness, muscle twitches and cramps, and swelling of feet and ankles, particularly the persistent itching.
Some researchers suggested high blood pressure is one of the major causes of CKD.
The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"
And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".
Lycopene is a phytochemical found in tomatoes in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potent ingredient for the protection of kidney damage, researchers examined the effect of lycopene on the nephrotoxicity of deltamethrin.
The study included male albino rats that were divided into four groups with10 animals each: group I served as control, which received standard diet; group II received oral administration of deltamethrin (1.28 mg/kg per day) for 30 days; group III received both deltamethrin and lycopene (1 mg/kg per day); group IV received lycopene (1 mg/kg per day).
According to the results of the end of the experiment, the deltamethrin-treated group not only showed significantly increased expression of the pro-inflammatory cytokine, TNF-α but also caused mild necrotic changes of the kidney associated with localized cell death due to interruption of the blood supply.
Renal proximal tubules in the deltamethrin treated group also showed an increased number and irregular shape of mitochondria causing the reduced function of the cell in the kidney to take nutrients from the cell breaks it down and turn it into energy.
Vacuolar degeneration in the epithelial cells, increased number of lysosomes, and loss of apical microvilli associated with the reduced function of kidney cells in the absorptive and secretory function, may lead to the decrease of the detoxed function of the kidney.
Moreover, focal segmental thickening and the duplication of the glomerular basement membrane and podocyte changes are involved in kidney damage. were also found in the deltamethrin treated group.
Pretreatment of lycopene demonstrated a strong effect either restored the kidney tissue damage or inhibited the parameters that cause the kidney disease.
Based on the findings, researchers said, "Histopathological and ultrastructural study showed some protective effect of lycopene on kidney tissues".
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats by El-Gerbed MS. (PubMed)
(3) High Blood Pressure & Kidney Disease. What is high blood pressure? the Natural Kidney Foundation. (NIH)
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