Coffee, a popular drink may be an excellent beverage for induced weight loss and weight management, a reviewed study by respectable university revealed.
Coffee, emerging as a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
Weight loss is an intentional reduction of the total body mass, according to the definition stated by medicine, health, or physical fitness experts.
According to the University of Exeter, in the reviewed data from human clinical trials, differentiated 8 eligible trials, green coffee extract (GCE) have moderated or significant effect in reduced weight loss in compared to placebo.
In rat model, 48t rats fed with either a control diet with water (C) or a control diet with a coffee solution (CF). At the end of week 4, animals in each dietary group were subdivided into three exercise groups: before exercise (BE), during exercise (DE), and after exercise (AE), group fed with coffee solution showed a significant in reduced total weight compared diet with water group.
The efficacy of dietary coffee in decreased total weight loss may be attributed to the extract function in stimulated the production of antioxidant in suppressed free radical expression. as well as increasing total cholesterol.
Dr. Choi EY the lead author said,"freeze-dried instant coffee can promote activities of antioxidant enzymes and induce weight loss but also aggravate the plasma cholesterol profile in rats".
Additionally, in the compared the daily consumption of coffee and caffeinated beverages between 494 weight loss maintainers and 2129 individuals from the general population, consumed significantly more cups of coffee are found in the weight loss maintainers than the general population group.
Other researchers insisted that the efficacy of coffee in induced weight loss, probably due to activities of caffeine and other chemical constituents of coffee, such as chlorogenic acid and quinides.
Collective findings suggested that coffee may have a potentially therapeutic property in weight deduction. But some reviewed trials were associated with a high risk of bias. poor methodological quality, therefor, more studies are necessary to confirm the promising validity, some researchers suggested.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials by Onakpoya I1, Terry R, Ernst E.(PubMed)
(2) Caffeine intake is related to successful weight loss maintenance by Icken D1, Feller S2, Engeli S3, Mayr A4, Müller A1, Hilbert A5, de Zwaan M1.(PubMed)
(3) Freeze-dried instant coffee can promote the activities of antioxidant enzymes and induce weight loss but also aggravate the plasma cholesterol profile in rats byChoi EY1, Park SY, Cho YO.(PubMed)
(4) Coffee, diabetes, and weight control by Greenberg JA1, Boozer CN, Geliebter A.(PubMed)
------------------------------------------------------------------------------------------------------------
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Tuesday, June 4, 2019
Monday, June 3, 2019
Herbal Turmeric's Curcumin, Protects the Blood Vessels Against the Onset of Stroke, in Vivo
A stroke is a medical condition caused by poor blood flow to the brain, leading to the death of the neurons.
Besides cancer and heart diseases, stroke is the third leading cause of death in the US. According to the statistics, approximate 1/4 of all stroke victims die as a direct result of the stroke or its complications.
The causes of stroke are either associated with plaque build-up on the arteries, leading to reduce blood flow to the brain, depending on the location of an obstruction or the breaking of small blood vessels in the brain.
In other words, strokes can be classified into 2 types
* Ischemic stroke caused by a clot or other blockage within an artery which leads to the brain.
* Hemorrhagic stroke caused by the vessel in the brain rupturing that results in blood leaking into the brain.
Stroke is caused by a number of factors. Epidemiological studies suggested high blood pressure, medical conditions such as diabetes, heart disease, smoking, age, gender ethnicity and personal or family history of stroke are some of the prevalent risk factors.
Some researchers in the examination of the rise of stroke in North American suggested that stroke may be associated with the promotion of the Western diet over the past few decades.
The American Heart Association wrote, "Western" diets consisting of red and processed meats, refined grains, sweets, and desserts may be associated with a greater risk of stroke, according to a study published in this week's rapid access issue of Stroke: Journal of the American Heart Association".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of stroke prevention scientists evaluated the protective effects of curcumin, the best-known member and is mainly extracted from turmeric preventive effect on stroke.
The study included stroke-prone spontaneously hypertensive rats (SHRsp) randomly divided into either a control group (n = 10, saline or curcumin (100 mg/kg/day)) or curcumin group (n = 10) administrated daily.
According to the tested assays, administration of curcumin significantly delayed the onset of stroke and increased the survival of SHRsp by decreasing the expression of ROS and improving endothelial-dependent relaxation of carotid arteries.
However, according to the RT-PCR and immunoblotting, curcumin showed no statistical significance in the presence of UCP2 inhibitor genipin by blocking the decrease of ROS and increase of NO production.
Where genipin is a chemical compound found in gardenia fruit extract.
In other words, in order for curcumin to exert its stroke preventive activity, curcumin cannot be consumed together with gardenia fruit.
Additionally, in the study to examine the curcumin effect during the stroke, researchers found that curcumin encapsulated in exosomes, nano-vesicles (<200 nm), shows therapeutic effects in brain diseases, such as stroke.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of stroke, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function by Lan C1,2, Chen X1,2,3, Zhang Y1,2, Wang W1,2, Wang WE1,2, Liu Y1,2, Cai Y1,2,4, Ren H1,2, Zheng S1,2, Zhou L5,6, Zeng C. (PubMed)
(2) Epigenetic impact of curcumin on stroke prevention by Kalani A1, Kamat PK, Kalani K, Tyagi N. (PubMed)
(3) Western' Diets May Be Linked To Greater Stroke Ris by the American Heart Association. (Science Daily)
Besides cancer and heart diseases, stroke is the third leading cause of death in the US. According to the statistics, approximate 1/4 of all stroke victims die as a direct result of the stroke or its complications.
The causes of stroke are either associated with plaque build-up on the arteries, leading to reduce blood flow to the brain, depending on the location of an obstruction or the breaking of small blood vessels in the brain.
In other words, strokes can be classified into 2 types
* Ischemic stroke caused by a clot or other blockage within an artery which leads to the brain.
* Hemorrhagic stroke caused by the vessel in the brain rupturing that results in blood leaking into the brain.
Stroke is caused by a number of factors. Epidemiological studies suggested high blood pressure, medical conditions such as diabetes, heart disease, smoking, age, gender ethnicity and personal or family history of stroke are some of the prevalent risk factors.
Some researchers in the examination of the rise of stroke in North American suggested that stroke may be associated with the promotion of the Western diet over the past few decades.
The American Heart Association wrote, "Western" diets consisting of red and processed meats, refined grains, sweets, and desserts may be associated with a greater risk of stroke, according to a study published in this week's rapid access issue of Stroke: Journal of the American Heart Association".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of stroke prevention scientists evaluated the protective effects of curcumin, the best-known member and is mainly extracted from turmeric preventive effect on stroke.
The study included stroke-prone spontaneously hypertensive rats (SHRsp) randomly divided into either a control group (n = 10, saline or curcumin (100 mg/kg/day)) or curcumin group (n = 10) administrated daily.
According to the tested assays, administration of curcumin significantly delayed the onset of stroke and increased the survival of SHRsp by decreasing the expression of ROS and improving endothelial-dependent relaxation of carotid arteries.
However, according to the RT-PCR and immunoblotting, curcumin showed no statistical significance in the presence of UCP2 inhibitor genipin by blocking the decrease of ROS and increase of NO production.
Where genipin is a chemical compound found in gardenia fruit extract.
In other words, in order for curcumin to exert its stroke preventive activity, curcumin cannot be consumed together with gardenia fruit.
Additionally, in the study to examine the curcumin effect during the stroke, researchers found that curcumin encapsulated in exosomes, nano-vesicles (<200 nm), shows therapeutic effects in brain diseases, such as stroke.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of stroke, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function by Lan C1,2, Chen X1,2,3, Zhang Y1,2, Wang W1,2, Wang WE1,2, Liu Y1,2, Cai Y1,2,4, Ren H1,2, Zheng S1,2, Zhou L5,6, Zeng C. (PubMed)
(2) Epigenetic impact of curcumin on stroke prevention by Kalani A1, Kamat PK, Kalani K, Tyagi N. (PubMed)
(3) Western' Diets May Be Linked To Greater Stroke Ris by the American Heart Association. (Science Daily)
Coffee, The Anti Edema Therapeutic Beverage
Edema is a condition characterized by excess fluid retained in body's tissues, inducing swelling.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the joint study lead by the Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.
Chlorogenic acid (CGA) found abundantly in roasted coffee through expression of ester of caffeic acidand (−)-quinic acid, is an powerful antioxidant with profound effect in induced weight loss and edema.
Middle cerebral artery is a carotid artery supplied blood to the brain region involved the primary motor and sensory areas of the face, throat, hand and arm, and in the dominant hemisphere, the areas for speech.
The protective effect in reduced on ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA), formed in metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.
Dihydrocaffeic acid (DHCA) is a metabolite of caffeic acid with potent antioxidant properties.
Matrix metalloproteinase-2 and 9, (MMP-2 - 9) are enzymes with function in activated extracellular matrix (ECM), a collection of extracellular molecules secreted by cells to support the structure of cell. Over expression of MMP-2 and MMP-9 are found to associate to increased risk of disease progression, including arthritis and cancers.
In a rat model of transient middle cerebral artery occlusion, CGA directly showed a significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.
The study also addressed that the attenuation of brain edema may also be resulted by the chemical compound's anti lipid peroxidation (LPO) activity through increased antioxidant expression.
Lipid peroxidation (LPO) is a free radical-related process occurred under enzymatic control, through the activity of oxidative degradation of lipids.
Other study in the investigation of anti-inflammatory activity against carrageenan, PGE(2) and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), also exerted a significant anti-inflammatory and antinociceptive activity against serotonin-induced hind paw edema and TPA-induced mouse ear edema, researchers at the Gazi University postulated.
Carrageenan is a mixture of polysaccharides extracted from red and purple seaweeds.
Prostaglandin E2 (PGE2) is a conventional medicine used for treatment of pain and inflammation in numbers of disease, including rheumatoid arthritis and osteoarthritis.
12-O-Tetradecanoylphorbol-13-acetate is one of chemical compound used in experiment to induce endogenous superoxide production. In other word, it is a chemical used routinely in enhanced free radical expression for researcher in animal models.
Finally, researchers in the concerns of the caffeine in reduced risk of edema strongly insisted that injection of caffeine induced diminution in the amount of edema in the body cavities was a result of an inhibition of the production of edema and not to an increased absorption of fluid from the serous body cavities.
The findings suggested that coffee may be used as a functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)
(4) STUDIES IN EDEMA : VIII. THE INFLUENCE OF CAFFEINE ON ABSORPTION FROM THE PERITONEAL CAVITY AND THE INFLUENCE OF DIURESIS ON EDEMA by Fleisher MS1, Loeb L.(PubMed)
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the joint study lead by the Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.
Chlorogenic acid (CGA) found abundantly in roasted coffee through expression of ester of caffeic acidand (−)-quinic acid, is an powerful antioxidant with profound effect in induced weight loss and edema.
Middle cerebral artery is a carotid artery supplied blood to the brain region involved the primary motor and sensory areas of the face, throat, hand and arm, and in the dominant hemisphere, the areas for speech.
The protective effect in reduced on ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA), formed in metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.
Dihydrocaffeic acid (DHCA) is a metabolite of caffeic acid with potent antioxidant properties.
Matrix metalloproteinase-2 and 9, (MMP-2 - 9) are enzymes with function in activated extracellular matrix (ECM), a collection of extracellular molecules secreted by cells to support the structure of cell. Over expression of MMP-2 and MMP-9 are found to associate to increased risk of disease progression, including arthritis and cancers.
In a rat model of transient middle cerebral artery occlusion, CGA directly showed a significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.
The study also addressed that the attenuation of brain edema may also be resulted by the chemical compound's anti lipid peroxidation (LPO) activity through increased antioxidant expression.
Lipid peroxidation (LPO) is a free radical-related process occurred under enzymatic control, through the activity of oxidative degradation of lipids.
Other study in the investigation of anti-inflammatory activity against carrageenan, PGE(2) and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), also exerted a significant anti-inflammatory and antinociceptive activity against serotonin-induced hind paw edema and TPA-induced mouse ear edema, researchers at the Gazi University postulated.
Carrageenan is a mixture of polysaccharides extracted from red and purple seaweeds.
Prostaglandin E2 (PGE2) is a conventional medicine used for treatment of pain and inflammation in numbers of disease, including rheumatoid arthritis and osteoarthritis.
12-O-Tetradecanoylphorbol-13-acetate is one of chemical compound used in experiment to induce endogenous superoxide production. In other word, it is a chemical used routinely in enhanced free radical expression for researcher in animal models.
Finally, researchers in the concerns of the caffeine in reduced risk of edema strongly insisted that injection of caffeine induced diminution in the amount of edema in the body cavities was a result of an inhibition of the production of edema and not to an increased absorption of fluid from the serous body cavities.
The findings suggested that coffee may be used as a functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)
(4) STUDIES IN EDEMA : VIII. THE INFLUENCE OF CAFFEINE ON ABSORPTION FROM THE PERITONEAL CAVITY AND THE INFLUENCE OF DIURESIS ON EDEMA by Fleisher MS1, Loeb L.(PubMed)
Sunday, June 2, 2019
Herbal Turmeric Inhibits the Onset and Progression of Chronic Prostatitis
Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.
According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.
Believe it or not, in 2000, prostatitis has cost over $84 million, including the charge of diagnosis and treatment.
Most common symptoms of prostatitis are painful, difficult and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.
In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction and blood in the urine.
The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.
Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha blockers to relax the bladder neck and the muscle fibers and anti-inflammatory medicine to ease pain and discomforts.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.
The phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.
At the end of the experiment, the treatment group showed a significant improvement of National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p < 0.01), particularly other symptomatic parameters compared to placebo.
Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.
The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and of inflammatory cells.
Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".
Taken altogether, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.
Believe it or not, in 2000, prostatitis has cost over $84 million, including the charge of diagnosis and treatment.
Most common symptoms of prostatitis are painful, difficult and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.
In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction and blood in the urine.
The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.
Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha blockers to relax the bladder neck and the muscle fibers and anti-inflammatory medicine to ease pain and discomforts.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.
The phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.
At the end of the experiment, the treatment group showed a significant improvement of National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p < 0.01), particularly other symptomatic parameters compared to placebo.
Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.
The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and of inflammatory cells.
Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".
Taken altogether, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Bromelain Suppresses Rheumatoid Arthritis in Vivo
Rheumatoid Arthritis (RA) a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1).
According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2).
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
Most common symptoms of RA are
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates with valgus deformities of the feet and gait due to body function in an effort to support the collapsing longitudinal arch of the foot.
* The gait
Rheumatoid arthritis (RA) causes a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range.
* The hands
The effects of deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease(12).
* The Muscle strength
The effects of muscle strength in a patient with RA may contribute to the prevalence of functional limitations physically of that can affect daily living and quality of life.
* Rheumatoid Nodules
Rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.
* Conjunctival nodule
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the
the severity of the underlying disease.
* Morning stiffness
Morning stiffness, as a marker of inflammatory activity that reflects the functional disability and pain is a very common symptom of patients in early rheumatoid arthritis.
Conventionally, there is no cure for RA. Medication is to relieve symptoms such as pain, slow the progression and improve quality of life, including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural agent for the treatment of adjuvant rheumatic diseases, researchers examined the anti-inflammatory property of both enzyme therapy and combined therapy with cyclosporin in an animal model.
The study included rats with adjuvant-induced arthritis administered either cyclosporin A (2.5 or 5.0 mg/kg/day per os), a mixture of enzymes (Phlogenzym (PHL); 45 mg/kg twice daily intrarectally), or a combination of 2.5 mg cyclosporin A and 90 mg PHL for a period of 40 days.
According to the tested assays, the combination therapy with cyclosporin A plus PHLshowed a significantly inhibited both the inflammation and destructive arthritis-associated changes, such as serum albumin, changes in hind paw swelling and bone erosions.
Compared to the higher dose, 2.5 mg of cyclosporin A and PHL alone inhibited the disease markers to a lesser extent and a later stage of arthritis development.
In other words, the combination inhibited all parameters associated with the onset of adjuvant rheumatic diseases in a dose-dependent manner.
Based on the findings, researchers wrote, "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].
[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(3) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton
The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1).
According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2).
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
Most common symptoms of RA are
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates with valgus deformities of the feet and gait due to body function in an effort to support the collapsing longitudinal arch of the foot.
* The gait
Rheumatoid arthritis (RA) causes a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range.
* The hands
The effects of deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease(12).
* The Muscle strength
The effects of muscle strength in a patient with RA may contribute to the prevalence of functional limitations physically of that can affect daily living and quality of life.
* Rheumatoid Nodules
Rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.
* Conjunctival nodule
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the
the severity of the underlying disease.
* Morning stiffness
Morning stiffness, as a marker of inflammatory activity that reflects the functional disability and pain is a very common symptom of patients in early rheumatoid arthritis.
Conventionally, there is no cure for RA. Medication is to relieve symptoms such as pain, slow the progression and improve quality of life, including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural agent for the treatment of adjuvant rheumatic diseases, researchers examined the anti-inflammatory property of both enzyme therapy and combined therapy with cyclosporin in an animal model.
The study included rats with adjuvant-induced arthritis administered either cyclosporin A (2.5 or 5.0 mg/kg/day per os), a mixture of enzymes (Phlogenzym (PHL); 45 mg/kg twice daily intrarectally), or a combination of 2.5 mg cyclosporin A and 90 mg PHL for a period of 40 days.
According to the tested assays, the combination therapy with cyclosporin A plus PHLshowed a significantly inhibited both the inflammation and destructive arthritis-associated changes, such as serum albumin, changes in hind paw swelling and bone erosions.
Compared to the higher dose, 2.5 mg of cyclosporin A and PHL alone inhibited the disease markers to a lesser extent and a later stage of arthritis development.
In other words, the combination inhibited all parameters associated with the onset of adjuvant rheumatic diseases in a dose-dependent manner.
Based on the findings, researchers wrote, "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].
[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(3) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton
Saturday, June 1, 2019
Whole Food Tomato Normalizes Hepatic Markers Against Liver Damage and Injury
Hepatic marker is a blood test that measures the function of the liver. In other words, according to the blood test results, your doctor may know the severity of the liver damage.
The liver is the largest internal organ in the body which plays a critical role to filter out blood from the digestive system before passing them to other parts of the body.
Furthermore, the liver also produces bile which has a strong impact on the building of cell membranes, production of steroid hormones and vitamin D and aiding the digestive system in the absorption of nutrients.
Liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are some of the liver markers used by researchers to measure liver injury in a patient with some degree of intact liver function.
Aspartate transaminase (AST) is an enzyme found primarily in the liver and kidney. High levels of ALT is associated with liver damage. ALT screening is used often in patients with
liver disease.
Alanine aminotransferase (ALT) is a liver enzyme. increased levels of ALT has been found in patients with liver damage.
Other liver enzymes such as Alkaline phosphatase (ALP) and Gamma-glutamyl transpeptidase (GGT) also have a similar effect as seen in ALT and AST.
More precisely, elevated liver enzymes is an indication of liver inflammation or cell damage.
Dr. Edoardo G. Giannin, the lead scientist in the explanation of liver enzymes alternation, wrote, "Abnormal liver enzyme levels may signal liver damage or alteration in bile flow. Liver enzyme alteration may be either the accompanying biochemical picture in a patient with symptoms or signs suggestive of liver disease or an isolated, unexpected finding in a patient who has undergone a wide range of laboratory tests for a nonhepatic disease or for minor, vague complaints".
And, "The pattern of enzyme abnormality, interpreted in the context of the patient's characteristics, can aid in directing the subsequent diagnostic work-up. Awareness of the prevalence of the determined liver disease in specific populations and of possible hepatic involvement during systemic illnesses or drug therapies may help the clinician identify the cause of alterations efficiently".
The results strongly suggested that testing hepatic markers of patients with liver disease may be helpful to identify the causes.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods which process liver protective effects, researchers examined the effect of dry tomato peel (DTP) on hepatic markers on a high-saturated-fat (HSF) diet animal model for 12 weeks.
The study included 40 8 weeks old, weighing 22.2±1.0 g) BALB/c male mice (n=40) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.
According to the tested assays, without supplement with DTP, HSF/HC diet treated mice showed significantly increased body weight gain, adipose tissue weight, insulin resistance and lipid peroxidation in the liver as well as the onset of liver steatosis and inflammation.
Upon the injection of DTP, HSF/HC diet mice demonstrated a significant increase in plasma lycopene concentration and reduced markers associated with metabolic syndrome developing.
In other words, DTP inhibited the liver damage and injury marker through its anti-inflammatory and antioxidant activity and lipid metabolism
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for liver protection, pending to large sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats by Liu AG1, Volker SE, Jeffery EH, Erdman JW Jr. (PubMed)
(3) Liver enzyme alteration: a guide for clinicians by Edoardo G. Giannini, Roberto Testa, and Vincenzo Savarino. (PMC)
The liver is the largest internal organ in the body which plays a critical role to filter out blood from the digestive system before passing them to other parts of the body.
Furthermore, the liver also produces bile which has a strong impact on the building of cell membranes, production of steroid hormones and vitamin D and aiding the digestive system in the absorption of nutrients.
Liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are some of the liver markers used by researchers to measure liver injury in a patient with some degree of intact liver function.
Aspartate transaminase (AST) is an enzyme found primarily in the liver and kidney. High levels of ALT is associated with liver damage. ALT screening is used often in patients with
liver disease.
Alanine aminotransferase (ALT) is a liver enzyme. increased levels of ALT has been found in patients with liver damage.
Other liver enzymes such as Alkaline phosphatase (ALP) and Gamma-glutamyl transpeptidase (GGT) also have a similar effect as seen in ALT and AST.
More precisely, elevated liver enzymes is an indication of liver inflammation or cell damage.
Dr. Edoardo G. Giannin, the lead scientist in the explanation of liver enzymes alternation, wrote, "Abnormal liver enzyme levels may signal liver damage or alteration in bile flow. Liver enzyme alteration may be either the accompanying biochemical picture in a patient with symptoms or signs suggestive of liver disease or an isolated, unexpected finding in a patient who has undergone a wide range of laboratory tests for a nonhepatic disease or for minor, vague complaints".
And, "The pattern of enzyme abnormality, interpreted in the context of the patient's characteristics, can aid in directing the subsequent diagnostic work-up. Awareness of the prevalence of the determined liver disease in specific populations and of possible hepatic involvement during systemic illnesses or drug therapies may help the clinician identify the cause of alterations efficiently".
The results strongly suggested that testing hepatic markers of patients with liver disease may be helpful to identify the causes.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods which process liver protective effects, researchers examined the effect of dry tomato peel (DTP) on hepatic markers on a high-saturated-fat (HSF) diet animal model for 12 weeks.
The study included 40 8 weeks old, weighing 22.2±1.0 g) BALB/c male mice (n=40) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.
According to the tested assays, without supplement with DTP, HSF/HC diet treated mice showed significantly increased body weight gain, adipose tissue weight, insulin resistance and lipid peroxidation in the liver as well as the onset of liver steatosis and inflammation.
Upon the injection of DTP, HSF/HC diet mice demonstrated a significant increase in plasma lycopene concentration and reduced markers associated with metabolic syndrome developing.
In other words, DTP inhibited the liver damage and injury marker through its anti-inflammatory and antioxidant activity and lipid metabolism
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for liver protection, pending to large sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats by Liu AG1, Volker SE, Jeffery EH, Erdman JW Jr. (PubMed)
(3) Liver enzyme alteration: a guide for clinicians by Edoardo G. Giannini, Roberto Testa, and Vincenzo Savarino. (PMC)
Phytochemical Lycopene Inhibits Cancer Metastasis in Vitro and Vivo
Cancer is a class of disease associated with irregular cell growth on the tissue of the specific organ.
Most cases of invasive cancer can spread to other organs in the body via lymph or blood.
According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).
The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.
Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.
Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors. Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.
In cancer cells, due to the alternation of DNA, can grow indefinitely.
Cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.
Dr. RUI-AN WANG, the lead scientist in the explanation of the reasons for cancer metastasis, wrote, "Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process".
And, "Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis".
In other words, for the tumor to survive that must metastasize.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
In the urgency to find a natural ingredient for the inhibition of cancer cell metastasis, researchers examined the apo-10'-lycopenoic acid (ALA), a derivative of lycopene through cleavage by carotene-9',10'-oxygenase, on tumor progression and metastasis in both liver and lung cancer animal models.
According to the tested assays, ALA showed significant activity in a dose-dependent manner in inhibiting migration and invasion of liver and lung cancer cells (HuH7 and A549).
In other words, ALA constrained lung cancer cell from the induction of mechanisms associated with cancer cell spreading.
Furthermore, in HuH7 and immortalized lung BEAS-2B cells, ALA suppressing the function of remodeling actin in stimulating cancer cell mobility and membrane formation.
More importantly, ALA also inhibited both HuH7 and A549 cells. proliferation and migration by suppressing the genes associated with angiogenesis.
Moreover, according to the tested assays, ALA also decreased the expression of enzyme which plays a pivotal role in cell migration during physiological and pathological processes.
In human THE-2 liver cells, ALA in a dose-dependently increased the mRNA expression and protein levels of peroxisome proliferator‑activated receptor‑γ (PPARγ) involved in controlling angiogenesis, tumor progression and metastasis.
Based on the findings, Dr. Cheng J., the lead scientist wrote, "ALA inhibits cancer cell motility and angiogenesis and induces PPARγ expression, which could be one of the potential mechanisms for ALA protecting against tumor progression".
Taken altogether, phytochemical lycopene may be considered supplements for the prevention of cancer cell metastasis, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN by Li Y1, Zhang DW1, Lin DQ1, Cao LQ1. (PubMed)
(1) Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ by Cheng J1, Miao B1, Hu KQ1, Fu X1, Wang XD. (PubMed)
(3) Reasons for cancer metastasis: A holistic perspective by RUI-AN WANG,1,2,3 YOU-YONG LU,4 and DAI-MING FAN (PubMed)
Most cases of invasive cancer can spread to other organs in the body via lymph or blood.
According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).
The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.
Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.
Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors. Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.
In cancer cells, due to the alternation of DNA, can grow indefinitely.
Cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.
Dr. RUI-AN WANG, the lead scientist in the explanation of the reasons for cancer metastasis, wrote, "Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process".
And, "Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis".
In other words, for the tumor to survive that must metastasize.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
In the urgency to find a natural ingredient for the inhibition of cancer cell metastasis, researchers examined the apo-10'-lycopenoic acid (ALA), a derivative of lycopene through cleavage by carotene-9',10'-oxygenase, on tumor progression and metastasis in both liver and lung cancer animal models.
According to the tested assays, ALA showed significant activity in a dose-dependent manner in inhibiting migration and invasion of liver and lung cancer cells (HuH7 and A549).
In other words, ALA constrained lung cancer cell from the induction of mechanisms associated with cancer cell spreading.
Furthermore, in HuH7 and immortalized lung BEAS-2B cells, ALA suppressing the function of remodeling actin in stimulating cancer cell mobility and membrane formation.
More importantly, ALA also inhibited both HuH7 and A549 cells. proliferation and migration by suppressing the genes associated with angiogenesis.
Moreover, according to the tested assays, ALA also decreased the expression of enzyme which plays a pivotal role in cell migration during physiological and pathological processes.
In human THE-2 liver cells, ALA in a dose-dependently increased the mRNA expression and protein levels of peroxisome proliferator‑activated receptor‑γ (PPARγ) involved in controlling angiogenesis, tumor progression and metastasis.
Based on the findings, Dr. Cheng J., the lead scientist wrote, "ALA inhibits cancer cell motility and angiogenesis and induces PPARγ expression, which could be one of the potential mechanisms for ALA protecting against tumor progression".
Taken altogether, phytochemical lycopene may be considered supplements for the prevention of cancer cell metastasis, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN by Li Y1, Zhang DW1, Lin DQ1, Cao LQ1. (PubMed)
(1) Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ by Cheng J1, Miao B1, Hu KQ1, Fu X1, Wang XD. (PubMed)
(3) Reasons for cancer metastasis: A holistic perspective by RUI-AN WANG,1,2,3 YOU-YONG LU,4 and DAI-MING FAN (PubMed)
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