Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrant the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicine such as fennel was showed to induce the function of overexpression of levels of free radical in initiating cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigated several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukaemia, J-45.01—human acute T cell leukaemia, EOL—human eosinophilic leukaemia, HL-60—human Caucasian promyelocytic leukaemia, 1301—human T cell leukaemia lymphoblast, C-8166—human T cell leukaemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. vulgare shows the highest mortality in Trypan blue test for J45 cell line with 4% of viable cells and a C8166 cell line with 100% of mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 with 60%, EOLwith 48%, and ML1 with 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, in the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel showed to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI-assay.
More importantly, application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promoted of MCF-7 cells death.experienment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
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Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Thursday, January 17, 2019
Wednesday, January 16, 2019
Green Tea Improves The Brain Functions in All Aspects, Studies Show
Green tea intake regularly may have a potential influence of many aspects of the brain functions some scientists suggested.
The brain and the spinal cord form a central nervous system that consists of the ability to control our thoughts, memory, and speech, muscles, and the function of many organs.
People with brain impairment caused by a disease or injury may experience the decline of some conscious mental activity, including speech, learning, and memory. In severe cases, patients may also have a reduced daily function and independence.
In neurodegenerative disease, the progressive death, and loss of neurons function that affects the different regions of the brain may facilitate memory loss, forgetfulness, apathy, anxiety, agitation. a loss of inhibition and mood changes. In severe cases, the disease can cause a substantial reduction of the quality of life.
As of today, the treatment of neurodegenerative disease in conventional medicine is limited only to the symptoms. None of the currently available therapies slow or stop the continued loss of neurons.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
With an aim to find a natural and potential source which processes the ability in enhancing brain function, researchers at the University of South Australia conducted a review of the association between two dietary components of tea, caffeine, and L-theanine, and the psychological outcomes of consumption.
After taking an assessment of the all the selected studies, researchers found that caffeinated tea, injecting at regular intervals, maintains alertness, focused attention, and accuracy and may modulate the more acute effects of higher doses of caffeine.
The interaction of L-theanine on the brain and caffeine exerted the neurochemical effects to enhance performance in terms of attention switching and the ability to ignore the distraction,
However, although, injection of tea stimulated a higher-level cognitive activity, caffeinated tea can cause the detrimental effects to the brain as a result of overstimulation
Additionally, the in-depth differentiation of L-theanine in the modulation of the aspects of brain function suggested* L-theanine found in tea has a direct effect on the brain.
* L-theanine significantly increases activity in the alpha frequency band which indicates the relaxation of the mind without inducing drowsiness.
These results were provided by the final report of EEG recording in the study of young participants with rest at the baseline and 45, 60, 75, 90 and 105 minutes after ingestion of 50mg L-theanine (n=16) or placebo (n=19). The similar results also observed even when the subjects engaged in a passive activity.
Benefits of the increase of Alpha Brain Waves are the deep relaxation of body and mind accompanied with no stresses and worries.
Intesterestly, in the study to examine whether L-theanine injection reduced stress by blocking the binding of L-glutamic acid to glutamate receptors in the brain, researchers launched an investigation including fourteen participants each underwent three separate trials, in which they orally took either L-theanine + placebo, caffeine + placebo, or placebo only.
All participants were assessed on mental task performance and physiological activities under conditions of physical or psychological stress in humans.
Application of L-theanine significantly inhibited the blood-pressure increase in a high-response group, which consisted of participants whose blood pressure increased more than average by a performance of a mental task after placebo intake.
Caffeine exerted a similar but smaller inhibition of the blood-pressure increase caused by the mental tasks.
Also, according to the Profile of Mood States after the mental tasks, L-theanine reduced the Tension-Anxiety scores as compared with placebo intake.
These results suggested that the application of green tea L-theanine not only reduces anxiety but also attenuates the increase in the levels of stress.
Taken altogether, there is no doubt that moderate consumption of green tea or tea with abundant of L-theanine processes a positive and profound effect in enhancing brain function in many aspects. However, excessive green tea and tea drinking may cause overstimulation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Psychological effects of dietary components of tea: caffeine and L-theanine by Bryan J1.(PubMed)
(2) L-theanine, a natural constituent in tea, and its effect on mental state by Nobre AC1, Rao A, Owen GN.(PubMed)
(3) Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses by Yoto A1, Motoki M, Murao S, Yokogoshi H.(PubMed)
The brain and the spinal cord form a central nervous system that consists of the ability to control our thoughts, memory, and speech, muscles, and the function of many organs.
People with brain impairment caused by a disease or injury may experience the decline of some conscious mental activity, including speech, learning, and memory. In severe cases, patients may also have a reduced daily function and independence.
In neurodegenerative disease, the progressive death, and loss of neurons function that affects the different regions of the brain may facilitate memory loss, forgetfulness, apathy, anxiety, agitation. a loss of inhibition and mood changes. In severe cases, the disease can cause a substantial reduction of the quality of life.
As of today, the treatment of neurodegenerative disease in conventional medicine is limited only to the symptoms. None of the currently available therapies slow or stop the continued loss of neurons.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
With an aim to find a natural and potential source which processes the ability in enhancing brain function, researchers at the University of South Australia conducted a review of the association between two dietary components of tea, caffeine, and L-theanine, and the psychological outcomes of consumption.
After taking an assessment of the all the selected studies, researchers found that caffeinated tea, injecting at regular intervals, maintains alertness, focused attention, and accuracy and may modulate the more acute effects of higher doses of caffeine.
The interaction of L-theanine on the brain and caffeine exerted the neurochemical effects to enhance performance in terms of attention switching and the ability to ignore the distraction,
However, although, injection of tea stimulated a higher-level cognitive activity, caffeinated tea can cause the detrimental effects to the brain as a result of overstimulation
Additionally, the in-depth differentiation of L-theanine in the modulation of the aspects of brain function suggested* L-theanine found in tea has a direct effect on the brain.
* L-theanine significantly increases activity in the alpha frequency band which indicates the relaxation of the mind without inducing drowsiness.
These results were provided by the final report of EEG recording in the study of young participants with rest at the baseline and 45, 60, 75, 90 and 105 minutes after ingestion of 50mg L-theanine (n=16) or placebo (n=19). The similar results also observed even when the subjects engaged in a passive activity.
Benefits of the increase of Alpha Brain Waves are the deep relaxation of body and mind accompanied with no stresses and worries.
Intesterestly, in the study to examine whether L-theanine injection reduced stress by blocking the binding of L-glutamic acid to glutamate receptors in the brain, researchers launched an investigation including fourteen participants each underwent three separate trials, in which they orally took either L-theanine + placebo, caffeine + placebo, or placebo only.
All participants were assessed on mental task performance and physiological activities under conditions of physical or psychological stress in humans.
Application of L-theanine significantly inhibited the blood-pressure increase in a high-response group, which consisted of participants whose blood pressure increased more than average by a performance of a mental task after placebo intake.
Caffeine exerted a similar but smaller inhibition of the blood-pressure increase caused by the mental tasks.
Also, according to the Profile of Mood States after the mental tasks, L-theanine reduced the Tension-Anxiety scores as compared with placebo intake.
These results suggested that the application of green tea L-theanine not only reduces anxiety but also attenuates the increase in the levels of stress.
Taken altogether, there is no doubt that moderate consumption of green tea or tea with abundant of L-theanine processes a positive and profound effect in enhancing brain function in many aspects. However, excessive green tea and tea drinking may cause overstimulation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Psychological effects of dietary components of tea: caffeine and L-theanine by Bryan J1.(PubMed)
(2) L-theanine, a natural constituent in tea, and its effect on mental state by Nobre AC1, Rao A, Owen GN.(PubMed)
(3) Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses by Yoto A1, Motoki M, Murao S, Yokogoshi H.(PubMed)
Tuesday, January 15, 2019
Cinnamon: The Wholefood Medicine May Process Anti Cervical Cancer Potency, Studies Found
Whole food(herbal medicine), linking health benefits in the prevention, management, and treatment of diseases has placed an important role in human history over many centuries.
The finding of whole food medication by renowned scientists all over the world for the replacement of the single ingredient of the Western medicine with little or no side effect has been difficult due to no commercial benefit and patent right to producers.
Cinnamon may be the best wholefood medicine for the prevention, management, and treatment of cervical cancer, some scientists suggested.
Cervical cancer is a chronic and medical condition characterized by irregular and disorder cells growth in the cervical tissue. In the beginning, cancer starts in the cell of the cervical lining. After completely colonizing the cervix, malignant cells may travel a distance away through lymph and blood to infect other healthy tissue and organs.
According to the statistic, every year approximately, over 13,000 women in the United States are diagnosed with invasive cervical cancer.
Although the incidence rates for the disease dropped by 50% between 1975 and 2014 due to an increase in screening, cervical cancer still causes over 4,170 deaths this year.
The 5 years survival rate for women diagnosed in the early stage of invasive cervical cancer is 92%. However, in the advanced stage, when cervical cancer has spread to a distant part of the body, the 5-year survival rate is 17%.
The exact causes of cervical cancer are unknown, However, infected by human papillomavirus (HPV) infection due to having sex with men who carry the virus is a major cause of the disease.
Furthermore, women who have many sexual partners, are smoking, use birth control pills (oral contraceptives) for the long-term and engaging in early sexual contact are associated with the increased risk of cervical cancer.
Women, on the early stage of cervical cancer, may not experience any symptoms. If you are having persistent symptoms of abnormal vaginal bleeding, increased vaginal discharge, bleeding after menopause and severe pain during sex and pelvic pain, please check with your doctor to rule out the possibility of cervical cancer.
Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the family Lauraceae.
The spicy herb has been used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
According to the Manipal University, Eugenol, a potential chemopreventive agent, one of the components of cinnamon possesses antiseptic, analgesic, antibacterial, and anticancer properties in the expression of apoptosis and inflammation against cervical cancer cell lines.
In SiHa cancer cell line, established from cancerous tissues of the cervix uteri, methanol extracts of Gymnema sylvestre (GS) leave and Cinnamomum zeylanicum (CZ) bark exhibited dose-dependent cytotoxicity in inducing apoptosis.
Other researchers suggested that the effects of cinnamon against tumor activity, particularly in cervical cancer cell line SiHa may be the result in the reduced number of colonies, the risk of migration potential through down-regulated normal physiological processes.
Dr. Kwon HK, the lead researcher at the Gwangju Institute of Science and Technology, insisted, Cinnamomum cassia bark,.. containing several active components such as essential oils, expressed anti-tumor effect via enhanced pro-apoptotic and inhibited pro-inflammatory activities, in vitro, and in vivo mouse melanoma model.
In fact, the potential anti-tumor effects of cinnamon may be due to the activities that suppress the cancer progression by increasing the levels of cytolytic molecules and functioning.
Although the whole herb medicine may be a potential agent for reduced risk and treatment of cervical cancer, oral use of cinnamon should be taken with care and only prescribed by a herbalist.
Additional data collection on large example size and multi-centers studies performed with human consumption of the whole food cinnamon during the course of the disease will be necessary to complete the picture of the spicy herb anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells by Hussain A1, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C.(PubMed)
(2) Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa) by Sujima Anbu A1, Velmurugan P2, Lee JH3, Oh BT4, Venkatachalam P5. (PubMed)
(3) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential by Koppikar SJ1, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R.(PubMed)
(4) Cinnamon extract induces tumor cell death through inhibition of NF-kappaB and AP1 by Kwon HK1, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. (PubMed)
(5) Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells by Kwon HK1, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.(PubMed)
The finding of whole food medication by renowned scientists all over the world for the replacement of the single ingredient of the Western medicine with little or no side effect has been difficult due to no commercial benefit and patent right to producers.
Cinnamon may be the best wholefood medicine for the prevention, management, and treatment of cervical cancer, some scientists suggested.
Cervical cancer is a chronic and medical condition characterized by irregular and disorder cells growth in the cervical tissue. In the beginning, cancer starts in the cell of the cervical lining. After completely colonizing the cervix, malignant cells may travel a distance away through lymph and blood to infect other healthy tissue and organs.
According to the statistic, every year approximately, over 13,000 women in the United States are diagnosed with invasive cervical cancer.
Although the incidence rates for the disease dropped by 50% between 1975 and 2014 due to an increase in screening, cervical cancer still causes over 4,170 deaths this year.
The 5 years survival rate for women diagnosed in the early stage of invasive cervical cancer is 92%. However, in the advanced stage, when cervical cancer has spread to a distant part of the body, the 5-year survival rate is 17%.
The exact causes of cervical cancer are unknown, However, infected by human papillomavirus (HPV) infection due to having sex with men who carry the virus is a major cause of the disease.
Furthermore, women who have many sexual partners, are smoking, use birth control pills (oral contraceptives) for the long-term and engaging in early sexual contact are associated with the increased risk of cervical cancer.
Women, on the early stage of cervical cancer, may not experience any symptoms. If you are having persistent symptoms of abnormal vaginal bleeding, increased vaginal discharge, bleeding after menopause and severe pain during sex and pelvic pain, please check with your doctor to rule out the possibility of cervical cancer.
Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the family Lauraceae.
The spicy herb has been used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
According to the Manipal University, Eugenol, a potential chemopreventive agent, one of the components of cinnamon possesses antiseptic, analgesic, antibacterial, and anticancer properties in the expression of apoptosis and inflammation against cervical cancer cell lines.
In SiHa cancer cell line, established from cancerous tissues of the cervix uteri, methanol extracts of Gymnema sylvestre (GS) leave and Cinnamomum zeylanicum (CZ) bark exhibited dose-dependent cytotoxicity in inducing apoptosis.
Other researchers suggested that the effects of cinnamon against tumor activity, particularly in cervical cancer cell line SiHa may be the result in the reduced number of colonies, the risk of migration potential through down-regulated normal physiological processes.
Dr. Kwon HK, the lead researcher at the Gwangju Institute of Science and Technology, insisted, Cinnamomum cassia bark,.. containing several active components such as essential oils, expressed anti-tumor effect via enhanced pro-apoptotic and inhibited pro-inflammatory activities, in vitro, and in vivo mouse melanoma model.
In fact, the potential anti-tumor effects of cinnamon may be due to the activities that suppress the cancer progression by increasing the levels of cytolytic molecules and functioning.
Although the whole herb medicine may be a potential agent for reduced risk and treatment of cervical cancer, oral use of cinnamon should be taken with care and only prescribed by a herbalist.
Additional data collection on large example size and multi-centers studies performed with human consumption of the whole food cinnamon during the course of the disease will be necessary to complete the picture of the spicy herb anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells by Hussain A1, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C.(PubMed)
(2) Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa) by Sujima Anbu A1, Velmurugan P2, Lee JH3, Oh BT4, Venkatachalam P5. (PubMed)
(3) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential by Koppikar SJ1, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R.(PubMed)
(4) Cinnamon extract induces tumor cell death through inhibition of NF-kappaB and AP1 by Kwon HK1, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. (PubMed)
(5) Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells by Kwon HK1, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.(PubMed)
Monday, January 14, 2019
Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrant the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicine such as fennel was showed to induce the function of overexpression of levels of free radical in initiating cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigated several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukaemia, J-45.01—human acute T cell leukaemia, EOL—human eosinophilic leukaemia, HL-60—human Caucasian promyelocytic leukaemia, 1301—human T cell leukaemia lymphoblast, C-8166—human T cell leukaemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. vulgare shows the highest mortality in Trypan blue test for J45 cell line with 4% of viable cells and a C8166 cell line with 100% of mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 with 60%, EOLwith 48%, and ML1 with 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, in the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel showed to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI-assay.
More importantly, application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promoted of MCF-7 cells death.experienment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
Cell death is a natural process to warrant the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicine such as fennel was showed to induce the function of overexpression of levels of free radical in initiating cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigated several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukaemia, J-45.01—human acute T cell leukaemia, EOL—human eosinophilic leukaemia, HL-60—human Caucasian promyelocytic leukaemia, 1301—human T cell leukaemia lymphoblast, C-8166—human T cell leukaemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. vulgare shows the highest mortality in Trypan blue test for J45 cell line with 4% of viable cells and a C8166 cell line with 100% of mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 with 60%, EOLwith 48%, and ML1 with 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, in the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel showed to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI-assay.
More importantly, application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3 and DNA fragmentation in the promoted of MCF-7 cells death.experienment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
Sunday, January 13, 2019
The Best Whole Food Medicine That Process Anti Acute and Chronic Inflammatory Potency, Scientists Say
Intake of cruciferous vegetable may be inversely correlated with circulating of proinflammatory levels of in women, some scientists suggested.
Inflammation is a natural immune response involving the stimulated production of pro-inflammatory activity with a target to protect our body against foreign invasions such as virus and bacteria after injury and damage.
In other words, pro-inflammatory cytokines are activated through systematic immune response to the damage cells which release chemicals including histamine, bradykinin, and prostaglandins to protect the injure area or location against infection, leading to blood vessels to leak fluid into the tissues, causing swelling and other symptoms such as pain, swelling, and redness.
However, in most cases, over-response of the immune system can lead to over expressions of certain pro-inflammatory cytokines, depending to the injured location such as Interleukin (IL)-1 and tumor necrosis factor (TNF) which can lead shock and death of healthy cells in the infectious location.
In most cases, long-term overexpression of pro-inflammatory cytokines can lead to chronic inflammatory disease as the immune system no longer can kill the invasive agents and heal the damage caused by acute infection.
Dr. Dinarello CA, the lead author in the study of pro and anti-inflammatory cytokines said, " Some cytokines act to make disease worse (proinflammatory), whereas others serve to reduce inflammation and promote healing (anti-inflammatory). Attention also has focused on blocking cytokines, which are harmful to the host, particularly during overwhelming infection".
This explanation showed that under normal conditions, some anti-inflammatory cytokines may have a strong effect in reducing inflammation in the body daily to speed up the healing, caused by various events.
Cruciferous vegetables are the group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
In the study to investigate whether higher intakes of cruciferous vegetables or their constituents can decrease the levels of inflammation in humans, researchers conducted an experiment to evaluate associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women.
After observation of the returned a food frequency questionnaire, researchers found that
* Multivariable-adjusted circulating concentrations of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 were lower among women with higher intakes of cruciferous vegetables.
* The differences in concentrations of inflammatory biomarkers between extreme quintiles of cruciferous vegetable intake were 12.66% for TNF-α (Ptrend=0.01), 18.18% for IL-1β (Ptrend=0.02), and 24.68% for IL-6 (Ptrend=0.02).
* Inverse association was found for intakes of all vegetables combined but not for noncruciferous vegetables
* Levels of the urinary oxidative stress markers F2-isoprostanes and their major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-IsoP, were not associated with intakes of cruciferous vegetables or all vegetables combined.
These results suggested that daily intake of cruciferous vegetables may have a profound effect in reducing the risk of overexpression of inflammation in inducing chronic inflammatory diseases.
Dr. Jiang Y, the lead author, after taking into account co and con-founders said, " he previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables".
Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells, both in vivo and in vitro models exerted a significant effect in killing cancer cells through a change of tumor cells membrane blebbing, DNA condensation, and also by nuclear DNA fragmentation.
Additional differentiation suggested that apoptosis of cancer cells induced by Sulforaphane (SFN) and Diallyl disulfide(DAFDs) was attributed to the involvement of proinflammatory cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-12p40, and granulocyte-macrophage-colony-stimulating factor (GM-CSF).
Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through an induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.
Other phytochemical found the vegetables, such as 3,3'-diindolylmethane (DIM), a derivative of indole-3-carbinol, also expressed anti proinflammatory effect through interleukin (IL)-1beta, IL-6 and tumor necrosis factor.
In fact, chemical compounds found in the vegetable inhibited the pro-inflammatory cytokines in the expression of chronic diseases and cancers, involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.
However, due to the limitation of above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH. (PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)
Inflammation is a natural immune response involving the stimulated production of pro-inflammatory activity with a target to protect our body against foreign invasions such as virus and bacteria after injury and damage.
In other words, pro-inflammatory cytokines are activated through systematic immune response to the damage cells which release chemicals including histamine, bradykinin, and prostaglandins to protect the injure area or location against infection, leading to blood vessels to leak fluid into the tissues, causing swelling and other symptoms such as pain, swelling, and redness.
However, in most cases, over-response of the immune system can lead to over expressions of certain pro-inflammatory cytokines, depending to the injured location such as Interleukin (IL)-1 and tumor necrosis factor (TNF) which can lead shock and death of healthy cells in the infectious location.
In most cases, long-term overexpression of pro-inflammatory cytokines can lead to chronic inflammatory disease as the immune system no longer can kill the invasive agents and heal the damage caused by acute infection.
Dr. Dinarello CA, the lead author in the study of pro and anti-inflammatory cytokines said, " Some cytokines act to make disease worse (proinflammatory), whereas others serve to reduce inflammation and promote healing (anti-inflammatory). Attention also has focused on blocking cytokines, which are harmful to the host, particularly during overwhelming infection".
This explanation showed that under normal conditions, some anti-inflammatory cytokines may have a strong effect in reducing inflammation in the body daily to speed up the healing, caused by various events.
Cruciferous vegetables are the group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
In the study to investigate whether higher intakes of cruciferous vegetables or their constituents can decrease the levels of inflammation in humans, researchers conducted an experiment to evaluate associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women.
After observation of the returned a food frequency questionnaire, researchers found that
* Multivariable-adjusted circulating concentrations of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 were lower among women with higher intakes of cruciferous vegetables.
* The differences in concentrations of inflammatory biomarkers between extreme quintiles of cruciferous vegetable intake were 12.66% for TNF-α (Ptrend=0.01), 18.18% for IL-1β (Ptrend=0.02), and 24.68% for IL-6 (Ptrend=0.02).
* Inverse association was found for intakes of all vegetables combined but not for noncruciferous vegetables
* Levels of the urinary oxidative stress markers F2-isoprostanes and their major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-IsoP, were not associated with intakes of cruciferous vegetables or all vegetables combined.
These results suggested that daily intake of cruciferous vegetables may have a profound effect in reducing the risk of overexpression of inflammation in inducing chronic inflammatory diseases.
Dr. Jiang Y, the lead author, after taking into account co and con-founders said, " he previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables".
Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells, both in vivo and in vitro models exerted a significant effect in killing cancer cells through a change of tumor cells membrane blebbing, DNA condensation, and also by nuclear DNA fragmentation.
Additional differentiation suggested that apoptosis of cancer cells induced by Sulforaphane (SFN) and Diallyl disulfide(DAFDs) was attributed to the involvement of proinflammatory cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-12p40, and granulocyte-macrophage-colony-stimulating factor (GM-CSF).
Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through an induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.
Other phytochemical found the vegetables, such as 3,3'-diindolylmethane (DIM), a derivative of indole-3-carbinol, also expressed anti proinflammatory effect through interleukin (IL)-1beta, IL-6 and tumor necrosis factor.
In fact, chemical compounds found in the vegetable inhibited the pro-inflammatory cytokines in the expression of chronic diseases and cancers, involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.
However, due to the limitation of above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH. (PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)
Saturday, January 12, 2019
Carrot, the Potent Veggie Which Detoxes Your Liver Against Toxicity, Scientists Say
Including a portion of carrot in your daily diet may have a protective effect against the liver diseases, some scientists suggested.
Hepatoprotection is the ability of certain agents which process the properties to reduce the injurious effects or to preserve the normal hepatic physiological mechanisms. In most cases, liver injury is the result of overexpression of toxin accumulation in the liver.
The exact causes of liver diseases are unknown. However, researchers believed that liver disease can be caused by genetic mutation gene inherited from the parents or by viruses and excessive alcohol drinking.
Some researchers also suggested that liver damage also associated with patients who are obese.
Long-term use of certain medications, such as antibiotics, anticonvulsants, and antidepressants are also found to damage the liver.
Untreated liver damage can lead to liver scars, which in long run can increase the risk of liver failure, a life-threatening complication.
Besides symptoms of digestive discomforts, depending on the stage of the live damage, patients may also experience symptoms of jaundice on skin and eyes, abdominal pain and swelling, particularly, swelling in the legs and ankles and darkening urine color.
If you have experienced some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigation of the liver protective activity of methanolic extract of Daucus carota (D. carota) seeds in experimental rats model, researchers at the Rawatpura Sarkar Institute of Pharmacy assigned randomly into 4 groups of rats (two tests, standard and toxic control).
Two test groups received D. carota seeds extract (DCSE) at doses of 200 mg/kg and 400 mg/kg.
The standard group received silymarin (25 mg/kg) and toxic control received only thioacetamide. Control group received the only vehicle.
All animal were given thioacetamide 100 mg/kg s.c to induce oxidative stress through overproduction of ROS and reduced levels of antioxidant in the hosts.
At the 8th day, in observation of animal liver before treatment researchers found that levels of the antioxidant enzymes produced by the host, such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GRD), glutathione peroxidase (GPX), glutathione-S-transferase (GST) were decreased and levels of lipid peroxidation (LPO) were significantly higher compared to control.
However, rat group treated with methanolic extract of Daucus carota (D. carota) seeds showed a significant decrease of serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) which are associated to several expressions of liver diseases and increased levels of natural antioxidants produced by the body.
These results suggested that methanolic extract of Daucus carota (D. carota) seeds processes properties on inhibition of oxidative stress facilitated liver damage and stimulation of the host in the production of antioxidant from the hosts.
In other words, methanolic extract of Daucus carota (D. carota) seeds exerted liver protective effect by restoring the ratio of levels of reactive oxygen species and antioxidants in the tested animals.
Further analysis of the efficacy of carrot, mango, and wheat extracts against carbon tetrachloride (CCl4)-induced oxidative stress and hepatotoxicity, researchers at the Ain Shams University conducted an animal study including 4 albino rats.
Rats used in the experiment were divided randomly into 5 groups. Group 1 was fed a basal diet and group 2 was fed a basal diet and CCl4. Groups 3, 4, and 5 were treated with carrot, mango, and wheat extracts, respectively, in addition to a basal diet and CCl4.
Observation of the tested rats liver fed with the extract displayed anti hepatocellular toxicity caused by injection CCL4 decreased significantly compared to before treatment.
According to assays, lipid profile and liver enzymes markers were decreased remarkably and total protein and high-density lipoprotein (HDL) increased dramatically.
Makers of oxidative stress expressed through levels of Malondialdehyde (MDA) were also decreased noticeably
These results indicated a strong effect of the extracts in reduced lipid peroxidation by increased levels of antioxidant in inhibition of the reactive oxygen species in the induction of oxidative stress.
Dr. Ebeid HM, the lead author after taking into account of other co and confounders said, "Microscopic examination of the treated rats exhibited a normal histopathological structure" and "carrot, mango, and wheat extracts could be used as nutraceuticals for the prophylaxis and treatment against hepatotoxicity and oxidative stress".
Taken together, carrot and its bioactive extracts used alone or combined with mango, and wheat extracts may be considered a functional food for reduced risk of liver diseases caused by overexpression of free radicals.
Intake of supplementation should be taken with exceptional care in the prevention of acute liver toxicity.
However, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrots liver protective possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals by Singh K1, Singh N, Chandy A, Manigauha A.(PubMed)
(2) Hepatoprotective and antioxidant effects of wheat, carrot, and mango as nutraceutical agents against CCl4-induced hepatocellular toxicity by Ebeid HM1, Gibriel AA, Al-Sayed HM, Elbehairy SA, Motawe EH.(PubMed)
Hepatoprotection is the ability of certain agents which process the properties to reduce the injurious effects or to preserve the normal hepatic physiological mechanisms. In most cases, liver injury is the result of overexpression of toxin accumulation in the liver.
The exact causes of liver diseases are unknown. However, researchers believed that liver disease can be caused by genetic mutation gene inherited from the parents or by viruses and excessive alcohol drinking.
Some researchers also suggested that liver damage also associated with patients who are obese.
Long-term use of certain medications, such as antibiotics, anticonvulsants, and antidepressants are also found to damage the liver.
Untreated liver damage can lead to liver scars, which in long run can increase the risk of liver failure, a life-threatening complication.
Besides symptoms of digestive discomforts, depending on the stage of the live damage, patients may also experience symptoms of jaundice on skin and eyes, abdominal pain and swelling, particularly, swelling in the legs and ankles and darkening urine color.
If you have experienced some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigation of the liver protective activity of methanolic extract of Daucus carota (D. carota) seeds in experimental rats model, researchers at the Rawatpura Sarkar Institute of Pharmacy assigned randomly into 4 groups of rats (two tests, standard and toxic control).
Two test groups received D. carota seeds extract (DCSE) at doses of 200 mg/kg and 400 mg/kg.
The standard group received silymarin (25 mg/kg) and toxic control received only thioacetamide. Control group received the only vehicle.
All animal were given thioacetamide 100 mg/kg s.c to induce oxidative stress through overproduction of ROS and reduced levels of antioxidant in the hosts.
At the 8th day, in observation of animal liver before treatment researchers found that levels of the antioxidant enzymes produced by the host, such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GRD), glutathione peroxidase (GPX), glutathione-S-transferase (GST) were decreased and levels of lipid peroxidation (LPO) were significantly higher compared to control.
However, rat group treated with methanolic extract of Daucus carota (D. carota) seeds showed a significant decrease of serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) which are associated to several expressions of liver diseases and increased levels of natural antioxidants produced by the body.
These results suggested that methanolic extract of Daucus carota (D. carota) seeds processes properties on inhibition of oxidative stress facilitated liver damage and stimulation of the host in the production of antioxidant from the hosts.
In other words, methanolic extract of Daucus carota (D. carota) seeds exerted liver protective effect by restoring the ratio of levels of reactive oxygen species and antioxidants in the tested animals.
Further analysis of the efficacy of carrot, mango, and wheat extracts against carbon tetrachloride (CCl4)-induced oxidative stress and hepatotoxicity, researchers at the Ain Shams University conducted an animal study including 4 albino rats.
Rats used in the experiment were divided randomly into 5 groups. Group 1 was fed a basal diet and group 2 was fed a basal diet and CCl4. Groups 3, 4, and 5 were treated with carrot, mango, and wheat extracts, respectively, in addition to a basal diet and CCl4.
Observation of the tested rats liver fed with the extract displayed anti hepatocellular toxicity caused by injection CCL4 decreased significantly compared to before treatment.
According to assays, lipid profile and liver enzymes markers were decreased remarkably and total protein and high-density lipoprotein (HDL) increased dramatically.
Makers of oxidative stress expressed through levels of Malondialdehyde (MDA) were also decreased noticeably
These results indicated a strong effect of the extracts in reduced lipid peroxidation by increased levels of antioxidant in inhibition of the reactive oxygen species in the induction of oxidative stress.
Dr. Ebeid HM, the lead author after taking into account of other co and confounders said, "Microscopic examination of the treated rats exhibited a normal histopathological structure" and "carrot, mango, and wheat extracts could be used as nutraceuticals for the prophylaxis and treatment against hepatotoxicity and oxidative stress".
Taken together, carrot and its bioactive extracts used alone or combined with mango, and wheat extracts may be considered a functional food for reduced risk of liver diseases caused by overexpression of free radicals.
Intake of supplementation should be taken with exceptional care in the prevention of acute liver toxicity.
However, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrots liver protective possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals by Singh K1, Singh N, Chandy A, Manigauha A.(PubMed)
(2) Hepatoprotective and antioxidant effects of wheat, carrot, and mango as nutraceutical agents against CCl4-induced hepatocellular toxicity by Ebeid HM1, Gibriel AA, Al-Sayed HM, Elbehairy SA, Motawe EH.(PubMed)
Friday, January 11, 2019
The Potent Anti Liver Cancer Legume
People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient.
Compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending on the stage of the treatment which directly addresses the cause of disease.
Intake of black bean regularly may have a profound effect in reducing risk and treatment of liver cancer, a renowned institute study proposed.
Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue.
According to statistics approximated 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.
The exact causes of liver cancer. However, researchers believed that age, gender, excessive use of alcohol, obesity, are ethnicity are associated with the increased risk of liver cancer.
Furthermore, gene mutation such as inherited metabolic diseases is also considered as the major prevalent risk factor of liver cancer onset.
More importantly, certain chronic diseases, such as diabetes, infection by hepatitis virus, liver diseases, including cirrhosis, and non-alcoholic fatty liver disease chemical toxins and long-term use of certain medication such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, also have the potential to increased risk of liver cancer.
Besides sharing the general symptoms of cancers, patients with liver cancer also experience symptoms of upper abdominal pain and swelling, yellow discoloration of the skin, jaundice,.... and chalky stool.
If you have some of the above symptoms, please check with your doctor to rule out the possibility.
Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.
The legume can be bought in most grocery stores all around the year in dried and canned forms.
It is believed that black bean was first domesticated growth in South America.
According to the Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.
The efficacy of black bean on the ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.
Additionally, consumption of bean not only played a prominent role of gene expression involved the regulation of gene Hspa8 on reduced risk of liver disease but also addressed the important issue of attenuating hepatic stress or toxicity in the rat model.
In fact, increased beans consumption in rats exhibits changes of the hepatic damage caused by liver toxicity. Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.
More interestingly, dietary bean concentrations.is found to associate to the cholesterol 7α hydroxylase and UDP-glucuronosyltransferase genes increased with a connection to the development of liver cancer, in a dose-dependent manner.
These findings suggested that dietary black(dried) bean may have a potential effect in reducing risk and treatment of liver cancer through antioxidant activity and regulated genes involved early onset of the disease.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ. (PubMed)
Compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending on the stage of the treatment which directly addresses the cause of disease.
Intake of black bean regularly may have a profound effect in reducing risk and treatment of liver cancer, a renowned institute study proposed.
Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue.
According to statistics approximated 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.
The exact causes of liver cancer. However, researchers believed that age, gender, excessive use of alcohol, obesity, are ethnicity are associated with the increased risk of liver cancer.
Furthermore, gene mutation such as inherited metabolic diseases is also considered as the major prevalent risk factor of liver cancer onset.
More importantly, certain chronic diseases, such as diabetes, infection by hepatitis virus, liver diseases, including cirrhosis, and non-alcoholic fatty liver disease chemical toxins and long-term use of certain medication such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, also have the potential to increased risk of liver cancer.
Besides sharing the general symptoms of cancers, patients with liver cancer also experience symptoms of upper abdominal pain and swelling, yellow discoloration of the skin, jaundice,.... and chalky stool.
If you have some of the above symptoms, please check with your doctor to rule out the possibility.
Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.
The legume can be bought in most grocery stores all around the year in dried and canned forms.
It is believed that black bean was first domesticated growth in South America.
According to the Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.
The efficacy of black bean on the ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.
Additionally, consumption of bean not only played a prominent role of gene expression involved the regulation of gene Hspa8 on reduced risk of liver disease but also addressed the important issue of attenuating hepatic stress or toxicity in the rat model.
In fact, increased beans consumption in rats exhibits changes of the hepatic damage caused by liver toxicity. Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.
More interestingly, dietary bean concentrations.is found to associate to the cholesterol 7α hydroxylase and UDP-glucuronosyltransferase genes increased with a connection to the development of liver cancer, in a dose-dependent manner.
These findings suggested that dietary black(dried) bean may have a potential effect in reducing risk and treatment of liver cancer through antioxidant activity and regulated genes involved early onset of the disease.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ. (PubMed)
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