Scientists may have discovered a bioactive and plan base ingredient for the prevention and treatment of polycystic ovarian syndrome (PCOs) with no side effects, according to studies.
The polycystic ovarian syndrome is an endocrinologic disease caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries.
Women with PCOs are found to produce an excessive amount of androgen, leading to a male pattern hair development, acne, irregular period or absence of period, weight gain and infertility.
The condition affects over 5% of women population or 1 in 20 women. However, the actual numbers may be substantial-high because a large percentage of women in the early stage of PCOs are undiagnosed.
Some researchers suggested that women with PCOs are at a higher risk of the onset of diabetes and heart disease.
What causes PCOs? Why some women are more susceptible to the incidence and others do not even have the same health condition and family history? No researchers can answer this question.
However, they do know according to the epidemiological studies that people who carry mutated genes inherited from the parent, with chronic inflammatory disease and having insulin resistance are at the increased risk of PCOs.
Treatment of PCOs can vary and totally depend on the range of symptoms, or just one.
Some researchers suggested that lifestyle change may be the best for reducing the symptoms in women with PCOs. Weight loss of just 5% can lead to a significant improvement in PCOS symptoms.
Dr. Sedigheh Sedigh in the study to compare the lifestyle in women with polycystic ovary syndrome and healthy women said, "there was a significant relationship between PCOS and inappropriate diet (p=0.009), low physical activity (p=0.009), but no relationship was observed between PCOS and unhealthy behaviors".
These results clearly suggested that women who follow the Western diet with lack of exercise are associated with a substantial risk of PCOs. In other words, a change to a healthy lifestyle has a strong impact on reducing the incidence onset for women without PCOs and symptoms for women with PCOs.
Berberine is a phytochemical found in the group of protoberberine groups of isoquinoline alkaloids, in many herbal plants including Oregon grape, barberry, turmeric, goldenseal, etc.
With an aim to find a natural ingredient for the treatment of the reproductive and metabolic disorder associated with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS), researchers at the Harbin Medical University examine the potential therapeutic value of berberine (BBR)for PCOS.
The study included 49 wone with PCOS and IR randomized assigned into one of three treatment groups: BBR+compound cyproterone acetate (CPA; n=31), MET+CPA (n=30), and placebo+CPA (n=28) for 3 months.
After 3 months, BBR treatment group showed a decrease in waist circumference and waist-to-hip ratio (WHR; P<0.01), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C; P<0.05) as well as increase in high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin (SHBG) compared to MET group.
Compared to the placebo, the BBR group demonstrated a similar effect as in the comparison with the control group.
These results suggested that BBR Intake of BBR improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS.
Dr. Wei W, the lead author in the final report wrote, "Main effects (of BBR) could be related to the changes in body composition in obesity and dyslipidemia."
Furthermore, in order to reconfirm the effect of Berberine in PCOs subjects, researchers launched a review of the photochemical activity on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).
The search od the database of medical literature for the randomized controlled trials in human beings up to July 2018, found a total of 9 randomized controlled trials satisfied the guidelines and criteria.
Berberine not only showed an effect in lowering blood sugar levels in db/db mice and anti-dyslipidemia inhuman.
Berberine exerted similar effects similar to those of metformin (MET) in alleviating insulin resistance, improving glycolipid metabolism, or reproductive endocrine condition.
MET combined with BBR was not superior to MET alone, but cyproterone acetate (CPA) combined with BBR was superior to CPA alone in improving some of the reproductive endocrine indices.
The combination of BBR and Chinese herbs also showed a positive effect on all the parameters mentioned above.
Dr. Meng-Fei Li, the lead scientist, at the final report, said, "BBR showed a promising prospect in treating PCOS-IR"
Although the results indicated that Berberine has a potential effect on the treatment of metabolic and hormonal derangements in women with PCOs, due to the limitation of the studies, further data collection large example size and multi-centers studies performed with human consumption of the bioactive compounds during the course of the disease will be necessary to complete the picture of Berberine anti PCOs possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (PubMed)
(2) The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review (Research Gate)
(3) Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women by Sedigheh Sedighi,1 Sedigheh Amir Ali Akbari,2 Maryam Afrakhteh,3 Taraneh Esteki,4Hamid Alavi Majd,5 and Zohreh Mahmoodi. (PMC)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Monday, October 28, 2019
3,3'-Diindolylmethane, the Potential Anti Colon Cancer Bioactive Compound, According to Researchers
3,3'-Diindolylmethane or DIM may have a profound and positive effect in reducing risk and treatment of colon cancer, according to studies.
Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.
However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.
According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.
The data of the colon provided by the CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.
Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Although there are many risk factors involved in the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.
Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining to cancer and the percentage of colon cancer cases in people aged 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".
The results strongly suggested that if you are at the age of 50 and a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.
Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.
The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.
In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.
Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.
Futhermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.
Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.
The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.
Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with a poor clinical outcome.
The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.
Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and comn=bined with primary medicine for the treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers
Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.
However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.
According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.
The data of the colon provided by the CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.
Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Although there are many risk factors involved in the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.
Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining to cancer and the percentage of colon cancer cases in people aged 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".
The results strongly suggested that if you are at the age of 50 and a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.
Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.
The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.
In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.
Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.
Futhermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.
Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.
The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.
Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with a poor clinical outcome.
The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.
Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and comn=bined with primary medicine for the treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers
Bioactive Compound Allicin, the Best in Normalizing High Blood Pressure
Scientists may have found a natural bioactive ingredient for the prevention and treatment of hypertension with no side effects, according to the studies.
Hypertension is a medical condition characterized by abnormally high blood pressure.
Acute high blood pressure is a rise of high blood pressure caused by sudden stress or physical activity in a short-term that will eventually fall back to the normal levels.
Chronic hypertension is a persistence if elevated high blood pressure which cannot be decreased without medication.
Chronic hypertension is one of the members of the cluster of conditions associated with metabolic syndrome and a major cause of cardiovascular disease.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
Some researchers suggested that hypertension may be caused by certain medical conditions, such as kidney disease, however, the cause of the syndrome is more likely as a result of an unhealthy lifestyle.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.
Therefore, if you are currently taking medicine for the treatment of hypertension, please make sure you know all side effects for preventive measure.
Dr. Beilin LJ, at the University Department of Medicine, and West Australian Heart Research Institute in the examine the lifestyle risk of hypertension wrote, High salt intakes remain a major contributor to hypertension, especially when potassium intake is low. Smoking has a dominant effect in increasing cardiovascular risk in hypertensives ".
And, "Clustering of risk factors is often associated with clustering of unhealthy lifestyle characteristics and both are most prominent in lower socio-economic groups and in Developing Countries adopting a more sedentary lifestyle and Western diet patterns".
This statement clearly suggested that making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
On finding a natural compound for the prevention and treatment of high blood pressure, one of a major condition associated with the onset of cardiovascular disease, researchers examined the antihypertensive phytochemical allicin isolated from garlic.
The study included nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg).
Administrated garlic preparation including 1.3% allicin at a large dose (2400 mg) showed a sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose.
From 5-14 hours after the dose, the preparation significantly decreased the diastolic blood pressure with no side effects.
Dr. McMahon FG, the lead scientist said, "Our results indicate that this garlic preparation can reduce blood pressure", after taking into account other factors.
Furthermore, in a total of 84 men with mild or moderate arterial hypertension, researchers compared the antihypertensive effects of time-released garlic powder tablets (Allicor) with that of regular garlic pills (Kwai)in a double-blind, placebo-controlled trial with an active control arm.
After an 8-week placebo treatment run-in phase, patients were randomized either to 600 mg Allicor (n=30) or to placebo (n=20) daily for 8 weeks and In addition, in the open-label branch, patients received either 2400 mg Allicor daily (n=18) or 900 mg Kwai daily (n=16).
Allicor treatment at a dose of t600 mg daily showed a decrease of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively.
However, Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit.
Treatment with Kwai exerted a similar effect in decreasing systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as those of Allicor, but no decrease in diastolic blood pressure.
The results clearly indicated that Allicor may process the prolonged action that was found in the Kwai treatment group.
Dr. Sobenin IA, the lead scientists wrote in the final report, "time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements".
Taken altogether, allicin, a bioactive compound processed antihypertensive property may be used for the prevention and treatment of high blood pressure, pending to the validation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. (PubMed)
(3) Lifestyle and hypertension--an overview by Beilin LJ. (PubMed)
Hypertension is a medical condition characterized by abnormally high blood pressure.
Acute high blood pressure is a rise of high blood pressure caused by sudden stress or physical activity in a short-term that will eventually fall back to the normal levels.
Chronic hypertension is a persistence if elevated high blood pressure which cannot be decreased without medication.
Chronic hypertension is one of the members of the cluster of conditions associated with metabolic syndrome and a major cause of cardiovascular disease.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
Some researchers suggested that hypertension may be caused by certain medical conditions, such as kidney disease, however, the cause of the syndrome is more likely as a result of an unhealthy lifestyle.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.
Therefore, if you are currently taking medicine for the treatment of hypertension, please make sure you know all side effects for preventive measure.
Dr. Beilin LJ, at the University Department of Medicine, and West Australian Heart Research Institute in the examine the lifestyle risk of hypertension wrote, High salt intakes remain a major contributor to hypertension, especially when potassium intake is low. Smoking has a dominant effect in increasing cardiovascular risk in hypertensives ".
And, "Clustering of risk factors is often associated with clustering of unhealthy lifestyle characteristics and both are most prominent in lower socio-economic groups and in Developing Countries adopting a more sedentary lifestyle and Western diet patterns".
This statement clearly suggested that making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
On finding a natural compound for the prevention and treatment of high blood pressure, one of a major condition associated with the onset of cardiovascular disease, researchers examined the antihypertensive phytochemical allicin isolated from garlic.
The study included nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg).
Administrated garlic preparation including 1.3% allicin at a large dose (2400 mg) showed a sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose.
From 5-14 hours after the dose, the preparation significantly decreased the diastolic blood pressure with no side effects.
Dr. McMahon FG, the lead scientist said, "Our results indicate that this garlic preparation can reduce blood pressure", after taking into account other factors.
Furthermore, in a total of 84 men with mild or moderate arterial hypertension, researchers compared the antihypertensive effects of time-released garlic powder tablets (Allicor) with that of regular garlic pills (Kwai)in a double-blind, placebo-controlled trial with an active control arm.
After an 8-week placebo treatment run-in phase, patients were randomized either to 600 mg Allicor (n=30) or to placebo (n=20) daily for 8 weeks and In addition, in the open-label branch, patients received either 2400 mg Allicor daily (n=18) or 900 mg Kwai daily (n=16).
Allicor treatment at a dose of t600 mg daily showed a decrease of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively.
However, Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit.
Treatment with Kwai exerted a similar effect in decreasing systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as those of Allicor, but no decrease in diastolic blood pressure.
The results clearly indicated that Allicor may process the prolonged action that was found in the Kwai treatment group.
Dr. Sobenin IA, the lead scientists wrote in the final report, "time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements".
Taken altogether, allicin, a bioactive compound processed antihypertensive property may be used for the prevention and treatment of high blood pressure, pending to the validation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. (PubMed)
(3) Lifestyle and hypertension--an overview by Beilin LJ. (PubMed)
Sunday, October 27, 2019
Bromelain Modulated the Immune System Against the Development of Diseases
The immune system is a network of cells, tissues, and organs that provide the body's defense against infectious organisms and pathogens.
The immune system can be classified into innate immunity and adaptive immunity
* Innate immunity comprised the cells and mechanisms is the process of the immune response against infection in a non-specific manner.
* Adaptive immunity or acquired immunity is the process to destroy pathogens or prevent their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.
Diseases associated with the immune system can also be classified into underactive immunity and overactive immunity
* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly and children with immature immunity.
People with a weakened immune system are prone to infectious diseases.
* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.
In an inflammatory perspective, the chronic inflammatory diseases are also caused by the immune system failure in destroying all foreign invaders in the acute infection in a set period of time, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.
Diseases associated with chronic inflammation include type II diabetes, cardiovascular disease.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.
Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10.
In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocyte.
In order to obtain more information of bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely encephalomyelitis disseminate (ED) as well as from healthy controls.
The experiment carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain and with trypsin (final concentrations 10-1000 microg/ml).
Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.
Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cells associated with the adaptive immunity process independently from the underlying disease.
Taken altogether, bromelain may be considered a remedy for the modulation of immune function, pending to the confirmation of large sample size and multicenter study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)
The immune system can be classified into innate immunity and adaptive immunity
* Innate immunity comprised the cells and mechanisms is the process of the immune response against infection in a non-specific manner.
* Adaptive immunity or acquired immunity is the process to destroy pathogens or prevent their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.
Diseases associated with the immune system can also be classified into underactive immunity and overactive immunity
* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly and children with immature immunity.
People with a weakened immune system are prone to infectious diseases.
* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.
In an inflammatory perspective, the chronic inflammatory diseases are also caused by the immune system failure in destroying all foreign invaders in the acute infection in a set period of time, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.
Diseases associated with chronic inflammation include type II diabetes, cardiovascular disease.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.
Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10.
In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocyte.
In order to obtain more information of bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely encephalomyelitis disseminate (ED) as well as from healthy controls.
The experiment carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain and with trypsin (final concentrations 10-1000 microg/ml).
Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.
Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cells associated with the adaptive immunity process independently from the underlying disease.
Taken altogether, bromelain may be considered a remedy for the modulation of immune function, pending to the confirmation of large sample size and multicenter study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)
Turmeric Protects the Brain Cells Against Memory Deficit
Memory impairment is a condition associated with a slow decline in memory, thinking and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory change can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neurons capacity cannot be revered such as dementia.
According to statistics, in the US, approximately 5.7 million people are living with dementia. Most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.
Most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.
Out of many risk factors, aging may be one of the major culprits that cause memory deficit in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.
Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, healthy diet and lifestyle choice.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD-related to memory retrieval deficit.
Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar day 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.
According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.
In other words, curcumin at the tested concentration effective protect the Akt and GSK pathways which play are a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.
After taking others into account, Dr. Lv KJ, wrote in the final report, "pre-test scopolamine administration disrupts memory retrieval along with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)
Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory change can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neurons capacity cannot be revered such as dementia.
According to statistics, in the US, approximately 5.7 million people are living with dementia. Most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.
Most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.
Out of many risk factors, aging may be one of the major culprits that cause memory deficit in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.
Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, healthy diet and lifestyle choice.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD-related to memory retrieval deficit.
Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar day 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.
According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.
In other words, curcumin at the tested concentration effective protect the Akt and GSK pathways which play are a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.
After taking others into account, Dr. Lv KJ, wrote in the final report, "pre-test scopolamine administration disrupts memory retrieval along with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)
Phytochemical Allyl isothiocyanate, the Anti Prostate Cancer Bioactive Ingredient
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.
Bioactive compound Allyl isothiocyanate have a profound and potential effect in reducing the risk and treatment of prostate cancer, some scientists suggested.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Prostate cancer is a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth in the prostate tissue.
Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissue. At this stage, patients do not experience any symptoms.
However, as the tumor continued to grow, in the short distance in the future, it will suppress the nearby healthy tissue and nerve cells, leading to localized symptoms and severe pain.
At the advanced stage, most primary prostate cancer cells can travel a distance away to infect other healthy tissue and organ, leading to secondary cancer metastasis.
According to the statistic, In the US, approximately 164,690 new cases of prostate cancer were diagnosed and 29,430 will die from prostate cancer in 2018.
In fact, more than 2.9 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.
Early diagnosis is the key to survival in prostate cancer. The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years.
Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
The causes of prostate cancer are unknown. However, certain risk factors, epidemiologically are associated with an increased risk of the disease, including the increase in age, ethnicity, family history, genetic preposition, and poor diet.
Dr. Amir Bagheri, the lead author in the study "Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men" firmly suggested that a healthy dietary pattern was associated with a decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81;trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037).
Therefore, by a chance of the diet pattern which contains high in fruits and vegetables and whole-grain and few in saturated and trans fat, red meat and processed foods, a healthy man can substantially decrease the risk of prostate cancer
On finding a natural ingredient or whole food for the prevention and treatment of prostate cancer, researchers evaluated the effects of allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, against the growth of human prostate cancer xenografts in vivo.
Injection of 10 micromol AITC, three times per week (Monday, Wednesday and Friday) beginning the day of tumor cell implantation significantly inhibited the growth of PC-3 xenograft.
On the 26 days after tumor cell implantation, the average tumor volume in control mice (1025 +/- 205 mm3) was approximately 1.7-fold higher compared with AITC-treated mice.
According to the histological analysis of tumors excised at the termination of the experiment, revealed a statistically significant increase in a number of apoptotic bodies with a concomitant decrease in cells undergoing mitosis in the tumors of AITC-treated mice compared with that of control mice.
The Western blot analysis indicated the injection of AITC inhibited the 70% of the levels of anti-apoptotic protein in the tumor lysate of AITC-treated mice compared with that of control mice.
The injection of AITC also exerted a statistically significant reduction in the expression of several proteins associated with the regulation of G2/M progression.
The finding suggested that AITC administration inhibits the growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity.
Futhermore, in order to understand the effect of dietary isothiocyanates (ITCs) in the protection against chemically induced cancers in laboratory animals, researchers examined the allyl isothiocyanate (AITC) anti-cancer activity in the cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cell.
Application of AITC inhibited all the tested cancer cell lines in a dose-dependent manner with an IC(50) of approximately 15-17 micro M.without affecting the normal prostate cancer cells.
The inhibition of the proliferation of PC-3 as well as LNCaP cells in the presence of AITC is correlated with the accumulation of cells in the G(2)/M phase and induction of apoptosis.
At 24 h treatment of PC-3 and LNCaP cells with 20 micro M, AITC scored a similar effect as that of the previous study by causing a significant decrease in the levels of proteins that regulate G(2)/M progression, and the levels of anti-apoptotic protein.
Taken altogether, Allyl isothiocyanate may be considered a dietary source for the prevention and treatment of prostate cancer with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits the growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV. (PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis by Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV. (PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)
Bioactive compound Allyl isothiocyanate have a profound and potential effect in reducing the risk and treatment of prostate cancer, some scientists suggested.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Prostate cancer is a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth in the prostate tissue.
Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissue. At this stage, patients do not experience any symptoms.
However, as the tumor continued to grow, in the short distance in the future, it will suppress the nearby healthy tissue and nerve cells, leading to localized symptoms and severe pain.
At the advanced stage, most primary prostate cancer cells can travel a distance away to infect other healthy tissue and organ, leading to secondary cancer metastasis.
According to the statistic, In the US, approximately 164,690 new cases of prostate cancer were diagnosed and 29,430 will die from prostate cancer in 2018.
In fact, more than 2.9 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.
Early diagnosis is the key to survival in prostate cancer. The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years.
Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
The causes of prostate cancer are unknown. However, certain risk factors, epidemiologically are associated with an increased risk of the disease, including the increase in age, ethnicity, family history, genetic preposition, and poor diet.
Dr. Amir Bagheri, the lead author in the study "Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men" firmly suggested that a healthy dietary pattern was associated with a decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81;trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037).
Therefore, by a chance of the diet pattern which contains high in fruits and vegetables and whole-grain and few in saturated and trans fat, red meat and processed foods, a healthy man can substantially decrease the risk of prostate cancer
On finding a natural ingredient or whole food for the prevention and treatment of prostate cancer, researchers evaluated the effects of allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, against the growth of human prostate cancer xenografts in vivo.
Injection of 10 micromol AITC, three times per week (Monday, Wednesday and Friday) beginning the day of tumor cell implantation significantly inhibited the growth of PC-3 xenograft.
On the 26 days after tumor cell implantation, the average tumor volume in control mice (1025 +/- 205 mm3) was approximately 1.7-fold higher compared with AITC-treated mice.
According to the histological analysis of tumors excised at the termination of the experiment, revealed a statistically significant increase in a number of apoptotic bodies with a concomitant decrease in cells undergoing mitosis in the tumors of AITC-treated mice compared with that of control mice.
The Western blot analysis indicated the injection of AITC inhibited the 70% of the levels of anti-apoptotic protein in the tumor lysate of AITC-treated mice compared with that of control mice.
The injection of AITC also exerted a statistically significant reduction in the expression of several proteins associated with the regulation of G2/M progression.
The finding suggested that AITC administration inhibits the growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity.
Futhermore, in order to understand the effect of dietary isothiocyanates (ITCs) in the protection against chemically induced cancers in laboratory animals, researchers examined the allyl isothiocyanate (AITC) anti-cancer activity in the cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cell.
Application of AITC inhibited all the tested cancer cell lines in a dose-dependent manner with an IC(50) of approximately 15-17 micro M.without affecting the normal prostate cancer cells.
The inhibition of the proliferation of PC-3 as well as LNCaP cells in the presence of AITC is correlated with the accumulation of cells in the G(2)/M phase and induction of apoptosis.
At 24 h treatment of PC-3 and LNCaP cells with 20 micro M, AITC scored a similar effect as that of the previous study by causing a significant decrease in the levels of proteins that regulate G(2)/M progression, and the levels of anti-apoptotic protein.
Taken altogether, Allyl isothiocyanate may be considered a dietary source for the prevention and treatment of prostate cancer with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits the growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV. (PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis by Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV. (PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)
Phytochemical Anacardic Acid, the Natural Antibiotic Alternative with No Side Effects
Scientists may have found a bioactive compound for the replacement of antibiotics with no side effects, some studies suggested.
Infection is a human disease characterized by the invasion of an organism that multiplied in the specific tissue or organ.
In the bodily injury due to physical impact, the white blood cells of the immune first line of defense stimulates the production of proteins associated with the coagulation to cover the wound against the entrance of the microorganisms and inflammatory cytokines to kill off the infectious pathogens before they can enter the body and cause damage.
Most microorganisms were killed in the acute phase of the infection.
The infection is progressing through 5 stages, including
1. The incubation stage is a stage that the microorganisms have successfully entered the host and started a period of multiplication. At this period patients do not experience any symptoms.
2. The prodromal stage, followed after the incubation period, after gaining the strength in numbers and continued multiplication, the presence of the invasive pathogens is noticed by the immune system, leading to immune system response. At this period, patients may experience symptoms fever, pain, and swelling.
3. The stage of illness is a stage that disease is formed with signs and symptoms of the disease are most obvious and severe.
4. The stage of decline, the stage that saw the immune system has won the battle. In this stage, the number of pathogens and the signs and symptoms of illness begin to decline.
5. The stage of convalescence is a stage of recovery.
Some scientists in the study of the immune evolution suggested that the immune system is designed to kill off invasive pathogen in 3-8 weeks, otherwise, it will adapt to the change, leading to diseases associated with chronic infection.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.
With an aim to find a natural antibiotic for the replacement of conventional medicine for the prevention and treatment of microbial infection, researchers examined the anacardic acid mixture antibacterial quorum sensing (QS), which is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity.
An anacardic acid mixture (AAM) use in the experiment was produced by the A. adstringens hexane extract (HE) in bacterial strain Chromobacterium violaceum.
By comparing the 2 extracts, researchers found that
* HE induced a 91.6% of inhibition of the violecin production at 55 μg/mL concentration, whereas AAM showed 94% of inhibition at 166 μg/mL.
* Interestingly, both extracts were found to inhibit violacein production with affecting the viability of the bacterium.* Furthermore, AAM inhibited the substance which stimulates redox cycling in bacteria (pyocyanin 86% at 200 μg/mL) and glycolipid biosurfactants of bacterial structure (rhamnolipid, 91% at 500 μg/mL) production in a dose/response form and decrease the elastase (75% at 500 μg/mL) activity in P. aeruginosa without affecting its development.
Where violecin is a naturally-occurring bis-indole pigment with antibiotic properties produced by the bacteria.
These results indicated that Anacardic acid disrupts the quorum sensing (QS) of bacteria through inhibiting the substances which play a critical role in microbial survival in cell-cell communication.
Dr.Castillo-Juárez I, the lead scientist said, " anacardic acids mixture isolated from A. adstringens demonstrated anti-QS, it could be further exploited for novel molecules to treat the emerging infections of antibiotic-resistant bacterial pathogens".
Additionally, in the evaluated new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method, researchers showed that compounds 1-4 exhibited antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL.
Where compounds 1-4 are 6-[16'Z-nonadecenyl]-salicylic acid (1), 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0), (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4).
Taken altogether, anacardic acid and its bioactive derivatives may be considered antibiotics alternative for the prevention and treatment of bacterial infection with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)
Infection is a human disease characterized by the invasion of an organism that multiplied in the specific tissue or organ.
In the bodily injury due to physical impact, the white blood cells of the immune first line of defense stimulates the production of proteins associated with the coagulation to cover the wound against the entrance of the microorganisms and inflammatory cytokines to kill off the infectious pathogens before they can enter the body and cause damage.
Most microorganisms were killed in the acute phase of the infection.
The infection is progressing through 5 stages, including
1. The incubation stage is a stage that the microorganisms have successfully entered the host and started a period of multiplication. At this period patients do not experience any symptoms.
2. The prodromal stage, followed after the incubation period, after gaining the strength in numbers and continued multiplication, the presence of the invasive pathogens is noticed by the immune system, leading to immune system response. At this period, patients may experience symptoms fever, pain, and swelling.
3. The stage of illness is a stage that disease is formed with signs and symptoms of the disease are most obvious and severe.
4. The stage of decline, the stage that saw the immune system has won the battle. In this stage, the number of pathogens and the signs and symptoms of illness begin to decline.
5. The stage of convalescence is a stage of recovery.
Some scientists in the study of the immune evolution suggested that the immune system is designed to kill off invasive pathogen in 3-8 weeks, otherwise, it will adapt to the change, leading to diseases associated with chronic infection.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.
With an aim to find a natural antibiotic for the replacement of conventional medicine for the prevention and treatment of microbial infection, researchers examined the anacardic acid mixture antibacterial quorum sensing (QS), which is a process of bacterial cell-cell communication that controls a large number of systems affecting pathogenicity.
An anacardic acid mixture (AAM) use in the experiment was produced by the A. adstringens hexane extract (HE) in bacterial strain Chromobacterium violaceum.
By comparing the 2 extracts, researchers found that
* HE induced a 91.6% of inhibition of the violecin production at 55 μg/mL concentration, whereas AAM showed 94% of inhibition at 166 μg/mL.
* Interestingly, both extracts were found to inhibit violacein production with affecting the viability of the bacterium.* Furthermore, AAM inhibited the substance which stimulates redox cycling in bacteria (pyocyanin 86% at 200 μg/mL) and glycolipid biosurfactants of bacterial structure (rhamnolipid, 91% at 500 μg/mL) production in a dose/response form and decrease the elastase (75% at 500 μg/mL) activity in P. aeruginosa without affecting its development.
Where violecin is a naturally-occurring bis-indole pigment with antibiotic properties produced by the bacteria.
These results indicated that Anacardic acid disrupts the quorum sensing (QS) of bacteria through inhibiting the substances which play a critical role in microbial survival in cell-cell communication.
Dr.Castillo-Juárez I, the lead scientist said, " anacardic acids mixture isolated from A. adstringens demonstrated anti-QS, it could be further exploited for novel molecules to treat the emerging infections of antibiotic-resistant bacterial pathogens".
Additionally, in the evaluated new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds isolated from the bark of Amphipterygium adstringens using a bioassay-guided fractionation method, researchers showed that compounds 1-4 exhibited antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis with minimum inhibitory concentrations ranging from 7 to 104 µg mL and from 12 to 126 µg mL.
Where compounds 1-4 are 6-[16'Z-nonadecenyl]-salicylic acid (1), 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0), (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4).
Taken altogether, anacardic acid and its bioactive derivatives may be considered antibiotics alternative for the prevention and treatment of bacterial infection with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa by Castillo-Juárez I, García-Contreras R, Velázquez-Guadarrama N, Soto-Hernández M, Martínez-Vázquez M. (PubMed)
(2) Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis by Rivero-Cruz BE, Esturau N, Sánchez-Nieto S, Romero I, Castillo-Juárez I, Rivero-Cruz JF.(PubMed)
Subscribe to:
Posts (Atom)