Ulcerative colitis (UC) is a type of inflammatory bowel disease induced chronic inflammation and ulcers (sores) in the digestive tract.
The other type of IBD is Crohn's disease, caused by inflammation of the lining of the digestive tract, other than the colon and rectum.
IBS affects the colon and the rectum, leading to bloody diarrhea accompanied by symptoms of belly pain, not feeling hungry, fatigue, weight loss, dehydration.
Some patients may also experience symptoms of joint pain or soreness and sudden urges to empty the colon right away.
Inflammation is a process of the immune system that responds to harmful pathogens.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.
According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.
More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.
Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.
The exact causes of UC are not identified. Many prevalent factors are associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.
Dr. Patricia Sarlos, the lead scientist in the study of the genetic preposition in the risk of UC, wrote, " Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals".
And, "Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play a central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease.".
The results strongly link the risk of IBD in people who process the mutated gene inherited from the parent
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of colitis researchers examined the protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in an animal model.
The study included conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) that were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as the reference drug, following by 4% AA to induce rats UC.
Based on the tested analysis, the levels of stress marker such as malondialdehyde (MDA), pro-inflammatory cytokines such as interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased in the both targeted groups compared to the AA group.
Levels of nuclear factor-erythroid 2-related factor 2 (Nrf-2) associated with the increased antioxidant enzymes produced by the host was also increased compared to control.
Furthermore, Tumor necrosis factor, a cell-signaling protein (cytokine) involved in systemic inflammation was significantly decreased and catalase activity (CAT) associated with levels of antioxidants increased in the TLC group, compared to the AA group
The results strongly suggested conventional and colon-targeted lycopene showed a significant effect in the reduced risk of UC.
Based on the findings, researchers said, "sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC".
Taken altogether, lycopene found in tomato combined with conventional medicine may be considered a remedy for the prevention and treatment of UC, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats by Tekeli İO1, Ateşşahin A2, Sakin F3, Aslan A4, Çeribaşı S5, Yipel M. (PubMed)
(2) Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature by Patricia Sarlos, Erzsebet Kovesdi, Lili Magyari, Zsolt Banfai, Andras Szabo, Andras Javorhazy, and Bela Melegh. (PMC)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Monday, March 16, 2020
Beta-Sitosterol Inhibits the Melanoma Brain Metastasis
Cancer is a class of diseases associated with irregular cell growth on the tissue of the specific organ.
Most cases of invasive cancer can spread to other organs in the body via lymph or blood.
According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).
The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.
Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.
Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which is the cell produced dark pigment for your skin.
Approximately 120,000 new cases of melanoma in the US are diagnosed in a year. Melanoma tends to spread along the skin in most of the cases, but also can grow down to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.
Melanoma brain metastasis is secondary cancer in the brain that causes by the spreading of melanoma.
Approximately, 20% of patients are found to have brain metastasis at the time of diagnosis of metastatic melanoma, and more than 50% develop brain metastasis during the course of the disease.
Brain metastases are a frequent and often deadly problem in patients with advanced melanoma. According to the statistics, patients with melanoma brain metastasis have an average survival of only 4 months.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention of cancer spreading, researchers elucidated the effects of β-sitosterol, a well-tolerated and brain-penetrable phytosterol on BRAF-mutant melanoma brain metastases.
According to the results of the differentiation,
* β-sitosterol attenuates melanoma cell growth in vitro and also inhibits brain metastasis formation in vivo.
* The efficacy of β-sitosterol was linked to mitochondrial interference.
* β-sitosterol effectively reduced mitochondrial respiratory capacity, mediated by an inhibition of mitochondrial complex I associated with the levels of oxidative stress that induce apoptosis in tumor cells.
* More importantly, on the large-scale analyses of human melanoma brain metastases, Beta-Sitosterol played a significant role in mitochondrial complex I compared to brain metastases from other cancers.
* The combination of vemurafenib with either β-sitosterol or a functional knockdown of mitochondrial complex I completely abrogated BRAF inhibitor resistance.
Based on the findings, researchers said, "β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with or at risk for, melanoma brain metastases".
Beta-Sitosterol may be considered a remedy in a BRAF inhibitor therapy in patients with, or at risk for, melanoma brain metastases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis by Sundstrøm T1,2,3, Prestegarden L1,2,4, Azuaje F5,6, Aasen SN1,7, Røsland GV8, Varughese JK1, Bahador M1, Bernatz S9, Braun Y9, Harter PN9, Skaftnesmo KO10, Ingham ES11, Mahakian LM11, Tam S11, Tepper CG12, Petersen K13, Ferrara KW11, Tronstad KJ8, Lund-Johansen M2,3, Beschorner R14, Bjerkvig R1,5, Thorsen F. (PubMed)
Most cases of invasive cancer can spread to other organs in the body via lymph or blood.
According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).
The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.
Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.
Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which is the cell produced dark pigment for your skin.
Approximately 120,000 new cases of melanoma in the US are diagnosed in a year. Melanoma tends to spread along the skin in most of the cases, but also can grow down to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.
Melanoma brain metastasis is secondary cancer in the brain that causes by the spreading of melanoma.
Approximately, 20% of patients are found to have brain metastasis at the time of diagnosis of metastatic melanoma, and more than 50% develop brain metastasis during the course of the disease.
Brain metastases are a frequent and often deadly problem in patients with advanced melanoma. According to the statistics, patients with melanoma brain metastasis have an average survival of only 4 months.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention of cancer spreading, researchers elucidated the effects of β-sitosterol, a well-tolerated and brain-penetrable phytosterol on BRAF-mutant melanoma brain metastases.
According to the results of the differentiation,
* β-sitosterol attenuates melanoma cell growth in vitro and also inhibits brain metastasis formation in vivo.
* The efficacy of β-sitosterol was linked to mitochondrial interference.
* β-sitosterol effectively reduced mitochondrial respiratory capacity, mediated by an inhibition of mitochondrial complex I associated with the levels of oxidative stress that induce apoptosis in tumor cells.
* More importantly, on the large-scale analyses of human melanoma brain metastases, Beta-Sitosterol played a significant role in mitochondrial complex I compared to brain metastases from other cancers.
* The combination of vemurafenib with either β-sitosterol or a functional knockdown of mitochondrial complex I completely abrogated BRAF inhibitor resistance.
Based on the findings, researchers said, "β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with or at risk for, melanoma brain metastases".
Beta-Sitosterol may be considered a remedy in a BRAF inhibitor therapy in patients with, or at risk for, melanoma brain metastases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis by Sundstrøm T1,2,3, Prestegarden L1,2,4, Azuaje F5,6, Aasen SN1,7, Røsland GV8, Varughese JK1, Bahador M1, Bernatz S9, Braun Y9, Harter PN9, Skaftnesmo KO10, Ingham ES11, Mahakian LM11, Tam S11, Tepper CG12, Petersen K13, Ferrara KW11, Tronstad KJ8, Lund-Johansen M2,3, Beschorner R14, Bjerkvig R1,5, Thorsen F. (PubMed)
Sunday, March 15, 2020
Omega 3 Protects Against the Heart Abnormal Rate or Rhythm of the Heartbeat
Cardiovascular disease is a medical condition affecting the cardiovascular system, including heart, blood vessels(arteries and veins).
Heart diseases are a class of diseases characterized by a wide range of conditions, such as coronary artery disease, heart rhythm problems (arrhythmias), and heart defects......
The term of heart disease is used interchangeably with cardiovascular diseases in expressed conditions that can lead to a heart attack, chest pain (angina) or stroke, involving narrowed or blocked blood vessels,
According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year, representing 1 in every 4 deaths. And coronary heart disease(CHD) is the most common type of heart disease, which kills over 300,000 people in 2015.
Coronary heart disease (CHD) kills over 370,000 people annually.
An arrhythmia is a condition associated with an abnormal rate or rhythm of the heartbeat.
The condition is caused by the electrical impulses that coordinate the heartbeats don't work properly, causing your heart to beat too fast, too slow or irregularly
The most common symptoms of arrhythmia are, a fluttering in the chest, a racing heartbeat, a slow heartbeat, chest pain and shortness of breath.
Conventionally, treatments of arrhythmias include medications that stop or prevent arrhythmia or control the rate of arrhythmia and cardioversion, which uses electricity to shock the heart back into a normal rhythm.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of heart diseases, researchers examined the Omega 3 fatty acid effects of marine omega-3 polyunsaturated fatty acids (PUFAs) in relation to ventricular arrhythmia.
According to the tested analysis, marine omega-3 PUFAs not only showed a strong activity on atrial fibrillation but also in ventricular arrhythmias.
Moreover, according to the results of studies chosen to the investigation
* Rats fed diets enriched in fish oil, sunflower oil, or beef tallow for 6 weeks, with the hearts either subjected to ischemic preconditioning or not showed ischemic preconditioning reduced ventricular arrhythmias in all dietary groups.
* According to the results of heart rate and heart rate variability recorded at rest, during submaximal exercise, and during a 2-min coronary artery occlusion at rest in dogs with a healed myocardial infarction before and after 3 months supplementation with a fish oil or corn oil, fish oil, but not corn oil reduced heart rate and heart variability at rest, but not during exercise or during coronary occlusion
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of diseases abnormal heart rhythm, pending to the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 fatty acids and cardiac arrhythmias by Rix TA1, Christensen JH, Schmidt EB. (PubMed)
(2) Omega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both? by C. von Schacky. (PMC)
Heart diseases are a class of diseases characterized by a wide range of conditions, such as coronary artery disease, heart rhythm problems (arrhythmias), and heart defects......
The term of heart disease is used interchangeably with cardiovascular diseases in expressed conditions that can lead to a heart attack, chest pain (angina) or stroke, involving narrowed or blocked blood vessels,
According to the statistics, heart disease is the leading cause of death in the US, approximately 610,000 people die of heart disease every year, representing 1 in every 4 deaths. And coronary heart disease(CHD) is the most common type of heart disease, which kills over 300,000 people in 2015.
Coronary heart disease (CHD) kills over 370,000 people annually.
An arrhythmia is a condition associated with an abnormal rate or rhythm of the heartbeat.
The condition is caused by the electrical impulses that coordinate the heartbeats don't work properly, causing your heart to beat too fast, too slow or irregularly
The most common symptoms of arrhythmia are, a fluttering in the chest, a racing heartbeat, a slow heartbeat, chest pain and shortness of breath.
Conventionally, treatments of arrhythmias include medications that stop or prevent arrhythmia or control the rate of arrhythmia and cardioversion, which uses electricity to shock the heart back into a normal rhythm.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of heart diseases, researchers examined the Omega 3 fatty acid effects of marine omega-3 polyunsaturated fatty acids (PUFAs) in relation to ventricular arrhythmia.
According to the tested analysis, marine omega-3 PUFAs not only showed a strong activity on atrial fibrillation but also in ventricular arrhythmias.
Moreover, according to the results of studies chosen to the investigation
* Rats fed diets enriched in fish oil, sunflower oil, or beef tallow for 6 weeks, with the hearts either subjected to ischemic preconditioning or not showed ischemic preconditioning reduced ventricular arrhythmias in all dietary groups.
* According to the results of heart rate and heart rate variability recorded at rest, during submaximal exercise, and during a 2-min coronary artery occlusion at rest in dogs with a healed myocardial infarction before and after 3 months supplementation with a fish oil or corn oil, fish oil, but not corn oil reduced heart rate and heart variability at rest, but not during exercise or during coronary occlusion
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of diseases abnormal heart rhythm, pending to the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 fatty acids and cardiac arrhythmias by Rix TA1, Christensen JH, Schmidt EB. (PubMed)
(2) Omega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both? by C. von Schacky. (PMC)
Moronic acid, A Potential Anti- Epstein-Barr Virus Infectious Remedy
Infection is an inflammatory condition caused by a microbial invasion on body tissues.
Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.
Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.
More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.
A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.
In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,
The viral infection o\has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.
Epstein-Barr virus (EBV) a member of the herpes virus family is one of the most common human viruses that infects at least 95% of the population. Most persons are infected during infancy and early childhood.
Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.
On finding a potential phytochemical for the treatment of infectious diseases, researchers examined the moronic acid, found in galls of Rhus Chinensis and Brazilian propolis, at 10microM in the inhibition of Epstein-Barr virus (EBV).
According to the results of the experiment,* Moronic acids inhibit the capacity of Rta to activate a promoter that contains a Rta-response element associated with the immediate-early stage of the lytic cycle on the transcription of viral lytic genes without influencing the transactivation function of Zta, a promotor of Epstein-Barr virus denes.
In other words, moronic acid treatment is attributable to the inhibition of the expression of Zta, EA-D and many EBV lytic genes that are depending on Rta
* Furthermore, the treatment of P3HR1 cells with moronic acid substantially reduces the numbers of EBV particles produced by the cells after lytic induction.
Based on the findings, researchers said, "This study suggests that moronic acid is a new structural lead for anti-EBV drug development".
Taken altogether, moronic acid, may be a promising phytochemicals for the treatment of Epstein-Barr virus infection, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of the Epstein-Barr virus lytic cycle by moronic acid by Chang FR1, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK. (PubMed)
Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.
Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.
More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.
A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.
In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,
The viral infection o\has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.
Epstein-Barr virus (EBV) a member of the herpes virus family is one of the most common human viruses that infects at least 95% of the population. Most persons are infected during infancy and early childhood.
Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.
On finding a potential phytochemical for the treatment of infectious diseases, researchers examined the moronic acid, found in galls of Rhus Chinensis and Brazilian propolis, at 10microM in the inhibition of Epstein-Barr virus (EBV).
According to the results of the experiment,* Moronic acids inhibit the capacity of Rta to activate a promoter that contains a Rta-response element associated with the immediate-early stage of the lytic cycle on the transcription of viral lytic genes without influencing the transactivation function of Zta, a promotor of Epstein-Barr virus denes.
In other words, moronic acid treatment is attributable to the inhibition of the expression of Zta, EA-D and many EBV lytic genes that are depending on Rta
* Furthermore, the treatment of P3HR1 cells with moronic acid substantially reduces the numbers of EBV particles produced by the cells after lytic induction.
Based on the findings, researchers said, "This study suggests that moronic acid is a new structural lead for anti-EBV drug development".
Taken altogether, moronic acid, may be a promising phytochemicals for the treatment of Epstein-Barr virus infection, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of the Epstein-Barr virus lytic cycle by moronic acid by Chang FR1, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK. (PubMed)
Saturday, March 14, 2020
Gamma-linolenic Acid Ameliorates the Symptoms of Diabetic Neuropathy
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.
* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Diabetic neuropathy is a complication of patients with diabetes associated with nerve damages, ranging from pain and numbness in your legs and feet to problems with your digestive system.
Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.
Diabetic neuropathy can be classified into 4 main types, including.
* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.
* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.
* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.
* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.
The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage of nerves and blood vessels in the affected area has been found to induce by overtime, uncontrolled high blood sugar.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant that processes anti-diabetic activity, researchers examined the effect of gamma-linolenic acid on diabetic complications of neuropathy.
A multicenter, parallel-group, double-blind, double-dummy, randomized, noninferiority joint study include the evaluation of the efficacy and safety of γ-linolenic acid (GLA) relative to α-lipoic acid (ALA) over a 12-week treatment period in type 2 diabetes mellitus (T2DM) patients with painful diabetic peripheral neuropathy (DPN) was conducted.
According to the results of the analysis of 100 T2DM patients between 20 and 75 years of age who had painful DPN and received either GLA (320 mg/day) and placebo or ALA (600 mg/day) and placebo for 12 weeks,* There was a significant decrease in the mean visual analog scale (VAS) and the total symptom scores (TSS). scores compared to baseline in both groups, but there were no significant differences between the groups.
* The treatment difference for the VAS (95% confidence interval [CI]) between the two groups was -0.65 (-1.526 to 0.213) and the upper bound of the 95% CI did not exceed the predefined noninferiority margin (δ₁=0.51).
* For the TSS, the treatment difference was -0.05 (-1.211 to 1.101) but the upper bound of the 95% CI crossed the noninferiority margin (δ₂=0.054).
* There were no serious adverse events associated with the treatments.
Collectively, researchers said, "GLA treatment in patients with painful DPN was noninferior to ALA in terms of reducing pain intensity measured by the VAS over 12 weeks".
Taken altogether, gamma-linolenic acid may be considered a functional food for reducing the painful diabetic neuropathy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial by Won JC1, Kwon HS2, Moon SS3, Chun SW4, Kim CH5, Park IB6, Kim IJ7, Lee J8, Cha BY9, Park TS. (PubMed)
In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.
* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Diabetic neuropathy is a complication of patients with diabetes associated with nerve damages, ranging from pain and numbness in your legs and feet to problems with your digestive system.
Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.
Diabetic neuropathy can be classified into 4 main types, including.
* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.
* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.
* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.
* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.
The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage of nerves and blood vessels in the affected area has been found to induce by overtime, uncontrolled high blood sugar.
Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.
On finding a potential plant that processes anti-diabetic activity, researchers examined the effect of gamma-linolenic acid on diabetic complications of neuropathy.
A multicenter, parallel-group, double-blind, double-dummy, randomized, noninferiority joint study include the evaluation of the efficacy and safety of γ-linolenic acid (GLA) relative to α-lipoic acid (ALA) over a 12-week treatment period in type 2 diabetes mellitus (T2DM) patients with painful diabetic peripheral neuropathy (DPN) was conducted.
According to the results of the analysis of 100 T2DM patients between 20 and 75 years of age who had painful DPN and received either GLA (320 mg/day) and placebo or ALA (600 mg/day) and placebo for 12 weeks,* There was a significant decrease in the mean visual analog scale (VAS) and the total symptom scores (TSS). scores compared to baseline in both groups, but there were no significant differences between the groups.
* The treatment difference for the VAS (95% confidence interval [CI]) between the two groups was -0.65 (-1.526 to 0.213) and the upper bound of the 95% CI did not exceed the predefined noninferiority margin (δ₁=0.51).
* For the TSS, the treatment difference was -0.05 (-1.211 to 1.101) but the upper bound of the 95% CI crossed the noninferiority margin (δ₂=0.054).
* There were no serious adverse events associated with the treatments.
Collectively, researchers said, "GLA treatment in patients with painful DPN was noninferior to ALA in terms of reducing pain intensity measured by the VAS over 12 weeks".
Taken altogether, gamma-linolenic acid may be considered a functional food for reducing the painful diabetic neuropathy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial by Won JC1, Kwon HS2, Moon SS3, Chun SW4, Kim CH5, Park IB6, Kim IJ7, Lee J8, Cha BY9, Park TS. (PubMed)
The Secondary Metabolites Berberine Reverses Polycystic Ovarian Syndrome (PCOs), Human Studies Show
Scientists may have discovered a bioactive and plan base ingredient for the prevention and treatment of polycystic ovarian syndrome (PCOs) with no side effects, according to studies.
Polycystic ovarian syndrome is an endocrinologic disease caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries.
Women with PCOs are found to produce an excessive amount of androgen, leading to a male pattern hair development, acne, irregular period or absence of period, weight gain and infertility.
The condition affects over 5% of women population or 1 in 20 women. However, the actual numbers may be substantially high because a large percentage of women in the early stage of PCOs are undiagnosed.
Some researchers suggested that women with PCOs are at a higher risk of the onset of diabetes and heart disease.
What causes PCOs? Why some women are more susceptible to the incidence and others do not even have the same health condition and family history? No researchers can answer this question.
However, they do know according to the epidemiological studies that people who carry mutated genes inherited from the parent, with chronic inflammatory disease and having insulin resistance are at the increased risk of PCOs.
Treatment of PCOs can vary and totally depend on the range of symptoms, or just one.
Some researchers suggested that lifestyle change may be the best for reducing the symptoms in women with PCOs. Weight loss of just 5% can lead to a significant improvement in PCOS symptoms.
Dr. Sedigheh Sedigh in the study to compare the lifestyle in women With polycystic ovary syndrome and healthy women said, "there was a significant relationship between PCOS and inappropriate diet (p=0.009), low physical activity (p=0.009), but no relationship was observed between PCOS and unhealthy behaviors".
These results clearly suggested that women who follow the Western diet with a lack of exercise are associated with a substantial risk of PCOs. In other words, a change to a healthy lifestyle has a strong impact on reducing the incidence onset for women without PCOs and symptoms for women with PCOs.
Berberine is a phytochemical found in the group of protoberberine groups of isoquinoline alkaloids, in many herbal plants including Oregon grape, barberry, turmeric, goldenseal, etc.
With an aim to find a natural ingredient for the treatment of the reproductive and metabolic disorder associated with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS), researchers at the Harbin Medical University examine the potential therapeutic value of berberine (BBR)for PCOS.
The study included 49 wone with PCOS and IR randomized assigned into one of three treatment groups: BBR+compound cyproterone acetate (CPA; n=31), MET+CPA (n=30), and placebo+CPA (n=28) for 3 months.
After 3 months, BBR treatment group showed a decrease in waist circumference and waist-to-hip ratio (WHR; P<0.01), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C; P<0.05) as well as an increase in high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin (SHBG) compared to MET group.
Compared to the placebo, the BBR group demonstrated a similar effect as in the comparison with the control group.
These results suggested that BBR Intake of BBR improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS.
Dr. Wei W, the lead author in the final report wrote, "Main effects (of BBR) could be related to the changes in body composition in obesity and dyslipidemia."
Furthermore, in order to reconfirm the effect of Berberine in PCOs subjects, researchers launched a review of the photochemical activity on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).
The search od the database of medical literature for the randomized controlled trials in human beings up to July 2018, found a total of 9 randomized controlled trials satisfied the guidelines and criteria.
Berberine not only showed an effect in lowering blood sugar levels in db/db mice and anti-dyslipidemia inhuman.
Berberine exerted similar effects similar to those of metformin (MET) in alleviating insulin resistance, improving glycolipid metabolism, or reproductive endocrine condition.
MET combined with BBR was not superior to MET alone, but cyproterone acetate (CPA) combined with BBR was superior to CPA alone in improving some of the reproductive endocrine indices.
The combination of BBR and Chinese herbs also showed a positive effect on all the parameters mentioned above.
Dr. Meng-Fei Li, the lead scientist, at the final report, said, "BBR showed a promising prospect in treating PCOS-IR"
Although the results indicated that Berberine has a potential effect on the treatment of metabolic and hormonal derangements in women with PCOs, due to the limitation of the studies, further data collection large example size and multi-centers studies performed with human consumption of the bioactive compounds during the course of the disease will be necessary to complete the picture of Berberine anti PCOs possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (PubMed)
(2) The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review (Research Gate)
(3) Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women by Sedigheh Sedighi,1 Sedigheh Amir Ali Akbari,2 Maryam Afrakhteh,3 Taraneh Esteki,4Hamid Alavi Majd,5 and Zohreh Mahmoodi. (PMC)
Polycystic ovarian syndrome is an endocrinologic disease caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries.
Women with PCOs are found to produce an excessive amount of androgen, leading to a male pattern hair development, acne, irregular period or absence of period, weight gain and infertility.
The condition affects over 5% of women population or 1 in 20 women. However, the actual numbers may be substantially high because a large percentage of women in the early stage of PCOs are undiagnosed.
Some researchers suggested that women with PCOs are at a higher risk of the onset of diabetes and heart disease.
What causes PCOs? Why some women are more susceptible to the incidence and others do not even have the same health condition and family history? No researchers can answer this question.
However, they do know according to the epidemiological studies that people who carry mutated genes inherited from the parent, with chronic inflammatory disease and having insulin resistance are at the increased risk of PCOs.
Treatment of PCOs can vary and totally depend on the range of symptoms, or just one.
Some researchers suggested that lifestyle change may be the best for reducing the symptoms in women with PCOs. Weight loss of just 5% can lead to a significant improvement in PCOS symptoms.
Dr. Sedigheh Sedigh in the study to compare the lifestyle in women With polycystic ovary syndrome and healthy women said, "there was a significant relationship between PCOS and inappropriate diet (p=0.009), low physical activity (p=0.009), but no relationship was observed between PCOS and unhealthy behaviors".
These results clearly suggested that women who follow the Western diet with a lack of exercise are associated with a substantial risk of PCOs. In other words, a change to a healthy lifestyle has a strong impact on reducing the incidence onset for women without PCOs and symptoms for women with PCOs.
Berberine is a phytochemical found in the group of protoberberine groups of isoquinoline alkaloids, in many herbal plants including Oregon grape, barberry, turmeric, goldenseal, etc.
With an aim to find a natural ingredient for the treatment of the reproductive and metabolic disorder associated with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS), researchers at the Harbin Medical University examine the potential therapeutic value of berberine (BBR)for PCOS.
The study included 49 wone with PCOS and IR randomized assigned into one of three treatment groups: BBR+compound cyproterone acetate (CPA; n=31), MET+CPA (n=30), and placebo+CPA (n=28) for 3 months.
After 3 months, BBR treatment group showed a decrease in waist circumference and waist-to-hip ratio (WHR; P<0.01), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C; P<0.05) as well as an increase in high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin (SHBG) compared to MET group.
Compared to the placebo, the BBR group demonstrated a similar effect as in the comparison with the control group.
These results suggested that BBR Intake of BBR improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS.
Dr. Wei W, the lead author in the final report wrote, "Main effects (of BBR) could be related to the changes in body composition in obesity and dyslipidemia."
Furthermore, in order to reconfirm the effect of Berberine in PCOs subjects, researchers launched a review of the photochemical activity on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).
The search od the database of medical literature for the randomized controlled trials in human beings up to July 2018, found a total of 9 randomized controlled trials satisfied the guidelines and criteria.
Berberine not only showed an effect in lowering blood sugar levels in db/db mice and anti-dyslipidemia inhuman.
Berberine exerted similar effects similar to those of metformin (MET) in alleviating insulin resistance, improving glycolipid metabolism, or reproductive endocrine condition.
MET combined with BBR was not superior to MET alone, but cyproterone acetate (CPA) combined with BBR was superior to CPA alone in improving some of the reproductive endocrine indices.
The combination of BBR and Chinese herbs also showed a positive effect on all the parameters mentioned above.
Dr. Meng-Fei Li, the lead scientist, at the final report, said, "BBR showed a promising prospect in treating PCOS-IR"
Although the results indicated that Berberine has a potential effect on the treatment of metabolic and hormonal derangements in women with PCOs, due to the limitation of the studies, further data collection large example size and multi-centers studies performed with human consumption of the bioactive compounds during the course of the disease will be necessary to complete the picture of Berberine anti PCOs possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (PubMed)
(2) The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review (Research Gate)
(3) Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women by Sedigheh Sedighi,1 Sedigheh Amir Ali Akbari,2 Maryam Afrakhteh,3 Taraneh Esteki,4Hamid Alavi Majd,5 and Zohreh Mahmoodi. (PMC)
Friday, March 13, 2020
Cleaver(Galium aparine) Kills Resistant Laryngeal Cancer Cells in Vitro
The larynx is also known as the voice box, located between the pharynx and the trachea. Its function is to ensure the airways to open when we breathe and talk and closed when we swallow to ensure no food gets into the trachea.
Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.
The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, some are susceptible to the onset of the disease while others do not.
However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.
Genetic mutation inherited from the parents, such as TP53, GSTM3 and NAT2 and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factors for the disease development.
The most common symptoms of larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.
* A cough that doesn't go away or stridor
Due to blocking of the airway.
* Breathing difficulties
The tumor has grown large enough to block off the airway.
* Ear pain
The tumor has pressed onto the nerve.
*A lump or mass in the neck or throat
Cancer gas invaded the nearby lymph nodes in the neck and throat.
* Coughing up of blood
Breaking off of some malignant cells.
Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.
According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.
Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.
Interestingly, Galium decoction demonstrated an anti HLaC79 and Hep2, Hep2-Tax and HLaC79-Taxactivity with no influencing unique pathway activation.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken altogether, herbal cleaver may be considered as an anti resistant laryngeal cancer remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Galium verum aqueous extract on growth, motility and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)
Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.
The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, some are susceptible to the onset of the disease while others do not.
However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.
Genetic mutation inherited from the parents, such as TP53, GSTM3 and NAT2 and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factors for the disease development.
The most common symptoms of larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.
* A cough that doesn't go away or stridor
Due to blocking of the airway.
* Breathing difficulties
The tumor has grown large enough to block off the airway.
* Ear pain
The tumor has pressed onto the nerve.
*A lump or mass in the neck or throat
Cancer gas invaded the nearby lymph nodes in the neck and throat.
* Coughing up of blood
Breaking off of some malignant cells.
Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.
According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.
Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.
Interestingly, Galium decoction demonstrated an anti HLaC79 and Hep2, Hep2-Tax and HLaC79-Taxactivity with no influencing unique pathway activation.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken altogether, herbal cleaver may be considered as an anti resistant laryngeal cancer remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Galium verum aqueous extract on growth, motility and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)
Subscribe to:
Posts (Atom)