Compared to acute brain infarction that is a medical condition characterized by the obstruction of the blood supply to the brain, causing local death of the brain tissue. The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
Myocardial ischemia injury is a medical condition caused by severe impairment of coronary blood supply induced damage or dysfunction of the cardiac tissue.
Myocardial reperfusion is the process to restore the coronary blood flow after a period of coronary blockage that leads to severely reduced or no oxygen .blood flow to the heart.
The condition severity is totally dependent on the intensity and duration of the coronary occlusion.
According to the statistics from the WHO, in 2008, 12% of all death or approximately 7,254,000 deaths worldwide have directly or indirectly caused by myocardial ischemia injury.
Atherosclerosis, one of the major causes of cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing the arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.
Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.
A plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact on inducing plaque accumulation.
Coronary heart disease causes 1/4 total death in the worldwide population and 50% of the death associated with other forms of heart disease.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of post-stroke, researchers examined the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury.
The study included 60 Sprague-Dawley rats that were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model.
* The sham group received continuous perfusion of 150 min.
* The remaining three I/R-treated groups sequentially received 30-min perfusion, a 30-min cardioplegia, and 90-min reperfusion.
* The I/R-ischemic preconditioning (IP) group additionally received three cycles of 20-s reperfusion and 20-s coronary re-occlusion preceded the 90 min of reperfusion.
* The I/R-ω group was perfused with ω-3 PUFAs for 15 min before the 90 min of reperfusion.
According to the results of the study,
* Compared with the I/R group, the I/R-ω group had significantly reduced myocardial infarct size, reduced levels of lactate dehydrogenase and malondialdehyde associated with cardio-stress markers.
* Furthermore, Omega 3 fatty acids elevated superoxide dismutase level involved in antioxidant production and elevated rising (+dp/dtmax) and descending (-dp/dtmax) rate of left ventricular pressure against myocardial ischemia-injury.
* Moreover, The I/R-ω group had a significantly lower rate of mitochondrial damage in myocardial tissue compared with the I/R and I/R-IP groups.
In other words, Omega-3 fatty acids protect the heart tissues and muscles against damage after stroke.
Moreover, researchers said, " ω-3 PUFA postconditioning possesses good cardioprotective effects and may be developed into a therapeutic strategy for myocardial I/R injury".
Taken altogether, Omega-3 fatty acids may be considered a remedy for the treatment of myocardial ischemia injury, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury by Zhang FW1, Tong J1, Yan YS1, Chen QQ1, Zhao XP. (PubMed)
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