Antioxidant Tocopherols May Inhibit the Initiation, Progression and Treatment of Lung Cancer, Scientists Suggest

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.

In the US, lung cancer is the leading cause of cancer deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

Researchers do not the exact causes of lung cancer.


Genetic mutation inherited from the parents is a result of an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase a person's chance of developing lung cancer.

However, not all people who carry mutated lung cancer genes will develop lung cancer.

On the cigarette smoking in risk of lung cancer, researchers believe cigarettes containing high amount of cancer-causing substances (carcinogens), when inhaled, the cigarette smoke carried the chemical toxins to the lung cell directly, and prolonged periods exposed to such chemicals can alternate lung cell DNA, leading to the early onset of lung cancer.

Some researchers suggested genetic mutation and long-term cigarette smoking are 2 major risk factors associated with the alternative of lung cell DNA.

Truly, according to the statistic, approximately 8% of lung cancers are inherited or occur as a result of a genetic predisposition.

On finding a potential phytochemical for the treatment of lung diseases, researchers examined the growth inhibitory effect of a gamma-tocopherol-enriched tocopherol mixture (gammaTmT) against CL13 murine lung cancer cells grown in culture and as subcutaneous tumors in A/J mice.

According to the analysis,
* GammaTmT had no effect after 2 days and weakly inhibited the growth of CL13 in culture after 5 days (28% growth inhibition at 80 microM).

* Furthermore, dietary treatment at doses of 0.1 and 0.3% gammaTmT for 50 days inhibited the growth of CL13 tumors in A/J mice by 53.9 and 80.5%, respectively.

* According to the histopathological analysis, gammaTmT revealed an increase in tumor necrosis compared to control tumors.

* Moreover, dietary treatment with gammaTmT dose-dependently increased gamma- (10.0-37.6-fold) and delta-tocopherol (8.9-26.7-fold) in the tumors of treated mice compared to controls.


* Additionally, dietary treatment with gammaTmT also increased plasma gamma- (5.4-6.7-fold) and delta-tocopherol (5.5-7-fold). Whereas others have demonstrated the cancer-preventive activity of gammaTmT against mammary and colon cancer, this is the first report of growth inhibitory activity against lung cancer.


Taken altogether, tocopherols may be considered a supplement for reducing the risk of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols and tocotrienols as anticancer treatment for lung cancer: future nutrition by Zarogoulidis P1, Cheva A, Zarampouka K, Huang H, Li C, Huang Y, Katsikogiannis N, Zarogoulidis K. (PubMed)
(2) Inhibition of lung cancer growth in mice by dietary mixed tocopherols by Lambert JD1, Lu G, Lee MJ, Hu J, Ju J, Yang CS. (PubMed)

Antioxidant Lycopene Inhibits the Onset of Obesity

Obesity is a progressive chronic disease, associated with abnormal or excessive fat accumulation in the body.

People who have a BMI of over 30 are considered to be obese.

According to the statistics provided by Obesity Cabada, the rate of obesity has increased at an alarming rate in Canada over the past few decades.

Approximately over 30% of Canadian adults are considered obese that may require medical support to manage their disease.

Epidemiologically, type 2 diabetes, high blood pressure, heart disease, stroke, arthritis, cancer, and other major health problems have been found in most obese patients, causing concern to the scientific community in the health care system.

Furthermore, obesity is associated with increased mortality and a number of complications including diabetes, heart disease, dementia, and cancer.

Believe it or not, obesity has been found to contribute to one in 10 premature deaths among Canadian adults aged 20 to 64. As of today, the health care system in Canada has spent between $5 billion and $7 billion for the treatment of obese-related complications.

Conventionally, treatment of obesity is depending on the medical condition, however, the commitment of reduced weight through a healthy diet accompanied by moderate exercise has been proposed to target the complications.

Dr. Angela Makris, the lead scientist in examining dietary approaches to the treatment of obesity
wrote, "Popular dietary approaches for weight loss have generated widespread interest and considerable debate. While energy balance remains the cornerstone of weight control (i.e., calories still count), new diets and books promising weight loss by limiting certain foods or macronutrients rather than energy are constantly emerging and hitting the bestseller list".

And, "More effective weight loss options are needed to support healthy and sustainable eating behaviors".


Lycopene is a phytochemical found in tomatoes in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the prevention of obesity, researchers examined and compared the effect of lycopene and tomato powder on obesity-associated disorders.

Male C57BL/J6 mice selected to the study were assigned into four groups to receive: control diet (CD), high-fat diet (HFD), a high-fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.

In male C57BL/J6 mice fed by the HFD, increased adiposity index, organ, and relative organ weights were significantly reduced by lycopene and TP supplementation.


Furthermore, elevated serum triglycerides, free fatty acids, and 8-iso-prostaglandin GF2α associated with lipid peroxidation and glucose homeostasis involved in the secretion of insulin from pancreatic beta cells were significantly improved by the administration of lycopene and TP supplementation.


Liver tissue's oxidative stress markers induced overexpression of free radicals was reduced by lycopene and TP supplementation through a decrease of inflammatory proteins in adipose tissue.


Based on the findings, researchers said, "These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies.".


Taken altogether, lycopene found in tomatoes may be considered a functional remedy, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)
(2) Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats by Luvizotto Rde A1, Nascimento AF, Imaizumi E, Pierine DT, Conde SJ, Correa CR, Yeum KJ, Ferreira AL. (PubMed)
(3) Dietary Approaches to the Treatment of Obesity by Angela Makris, Ph.D., R.D. and Gary D. Foster, Ph.D. (PMC)

Antioxidant Omega -3 Fatty Acids Inhibits the Prevalent Factors Involved in the Onset of colorectal cancer

Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA, including

*Rectal cancer is the slowest growing cancer. Therefore, most cases of rectal cancer are diagnosed at the advanced stage in the older population.
* Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

The common type of colorectal cancer are adenocarcinomas, which originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells,

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of clonic diseases, researchers examined omega-3 PUFAs influences on DNA methylation level in colorectal cancer (CRC) rat model.

According to the tested analysis of N-methyl phosphite nitrourea and omega-3, PUFAs fed to the rats during tumor induction, tumor incidence in omega-3 treated rats was much lower than in CRC model rats.
In other words, omega-3 PUFAs process anti colorectal cancer properties.

More precisely, 6 PUFA members categorized to omega-3 and omega-6 families showed similar activity in lowering the ratio of omega-6/omega-3 PUFAs in the omega-3 PUFAs treatment group than in the CRC model group.

Interestingly, the normal cytosine nucleotide DNA (5 mC) content, in omega-3 PUFAs treated rats was higher than in CRC model rats. These results suggested that omega-3 PUFAs promoted 5 mC synthesis.

Where 5mC oxidation reaction is mutated in human tumors.

Based on the findings, researchers said, "omega-3 PUFAs probably inhibited tumor growth via regulating DNA methylation process, which provided a novel anticancer mechanism of omega-3 PUFAs from epigenetic view".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Polyunsaturated Fatty Acids Inhibited Tumor Growth via Preventing the Decrease of Genomic DNA Methylation in Colorectal Cancer Rats by Huang Q1, Wen J1, Chen G1, Ge M1, Gao Y1, Ye X1, Liu C1, Cai C. (PubMed)
(2) Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: a study protocol for a double blind randomized controlled trial by Haidari F1, Abiri B2, Iravani M3, Razavi SM4, Sarbakhsh P5, Ahmadi-Angali K6, Vafa M. (PubMed)

Phytochemical Omega 3 Fatty Acid Inhibits the Onset of Acute Dyslipidemia

Fat including cholesterol and triglycerides consists of hydrocarbon molecules.


Dyslipidemia is a condition of abnormal levels of lipids in their blood.

Hyperlipidemia is a medical condition characterized by abnormally high levels of cholesterol in the bloodstream.

Overexpression of cholesterol levels in the bloodstream has been linked to plaques accumulation on the arterial walls, a major cause of some forms of heart disease and stroke.


Cholesterol is the type of fat produced by the liver or from fat intake playing a critical role in the building of strong cell walls, production of vitamin D and steroid hormones, and bile acid to aid digestion in the small intestine.

Cholesterol produced by the liver in a healthy individual is returned to the liver by high-density lipoprotein (HDL).

The healthy ratio of HDL/LDL cholesterol is any numbers that are less than 1/4.

On the other hand, triglyceride is fat in the blood that comes from the outside source used by the body to convert to energy.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

Triglyceride is stored in the fat cells used to produce energy between meals and in the case when food is scarce.

Compared to cholesterol, triglycerides in high levels are also associated with the risk of heart disease, particularly in people with high levels of LDL and low levels of HDL.

On finding a potential phytochemical for the treatment of diseases associated with high blood cholesterol, researchers examined the Omega 3 fatty acid activity in the management of hypertriglyceridemia.


According to the results of the study,
* Omega 3 fatty acids lowered LDL cholesterol and reduced CV risk.

* Omega 3 fatty acid also lowered triglyceride (TG) levels and elevated the high-density lipoprotein (HDL) cholesterol levels.

* Omega3 fatty acid inhibited the elevated TG levels that increased the risk of CV events and very high TG levels are associated with acute pancreatitis.

Collectively, researchers said, " This review focuses on the clinical practice guidelines for the management of hypertriglyceridemia and the role of prescription omega-3 fatty acids in preventing pancreatitis and CV disease in individuals with high and very high TG levels".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of dyslipidemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(2) A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids by Karalis DG. (PubMed)