Tocopherols Induce Cytotoxicity in Cancer Cells

Cytotoxicity is the process of the induction of cell death through toxins.
In other words, cell cytotoxicity is the process in which certain chemicals or mediator cells are used to destroy living cells.

In cancers, cytotoxicity can be benefits humans by destroying the cancer cells and preventing them from proliferation.


Most cases of cytotoxicity used by a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.


But, before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and Vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.

In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.


Some of the cancer drugs with cytotoxic activity have been found to induce cancer cell death accompanied by serious health problems, including weakened immune functioning such as low blood counts causing an increased possibility of developing infection or anemia, tiredness, mouth soreness, nausea, vomiting, loss of appetites, constipation or diarrhea, skin changes or reactions. particularly hair loss.


However, the combination used of chemo drug and herbal medicine and plant-based antioxidants that can also stimulate the ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.


Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer, researchers examined the cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells.

According to the tested analysis,
* Among tocopherols, only delta-T exhibited cytotoxicity.

* Among para quinones, alpha-TQ showed no cytotoxicity, while gamma-TQ and delta-TQ were highly cytotoxic in both CEM and CEM/VLB100 cell lines (LD50 < 10 muM).

* Delta-TQ and gamma-TQ were more cytotoxic than the widely studied chemotherapeutic agent doxorubicin, which also showed selective cytotoxicity to CEM cells.


* Compared to doxorubicin, the orthoquinone Tocored was less cytotoxic than doxorubicin in drug-sensitive cells but more cytotoxic than doxorubicin in multidrug-resistant cells.


* Cytotoxicity was not a function of the phytyl side-chain since both TMCQ and PR were cytotoxic in leukemia cells.


* Cytotoxicity was enhanced when the glutathione pool was depleted by preincubation with buthionine-[S,R]-sulfoximine, but cytotoxicity was diminished by the addition of N-acetylcysteine to cultures. alpha-T also diminished the cytotoxicity of para- and orthoquinones.


Collectively, researchers said, "tocopheryl quinones represent a new class of alkylating electrophilic quinones that function as highly cytotoxic agents and escape multidrug resistance in acute lymphoblastic leukemia cell lines".


Taken altogether, tocopherols may process cytotoxic activity against cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells by Cornwell DG1, Jones KH, Jiang Z, Lantry LE, Southwell-Keely P, Kohar I,
Thornton DE. (PubMed)