Omega-3 Fatty Acids Improve Oral Mucositis and Body Weight Loss in Chemoradiotherapy Patients with Head and Neck Cancer

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.


Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer, at the early stage, start with the cell growth irregularly and disorderly on the surface of the inner lining of the head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck, or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia), and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

The most common head and neck cancer metastases are secondary skin cancer.

The exact causes of head and neck cancer are unknown. Researchers cannot explain why people with similar health conditions and the same risk factors, are susceptible to the onset of the disease, while others do not.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

mitted virus.


According to the statistics, head and neck cancer account only for about 4% of all cancers in the US. In 2019, an estimated 65,410 people (48,000 men and 17,410 women) were funded to develop head and neck cancer.


Most people diagnosed with head and neck cancer are older than 50.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effect of a nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®) on body weight loss, and oral mucositis in patients with head and neck cancer.

The study included 17 patients with oropharyngeal and hypopharyngeal cancer who were treated with concomitant cisplatin and 70 Gy of radiotherapy with or without 2 packs of Prosure®per day during chemoradiotherapy.


According to the final results,* The reduction in body weight was significantly improved compared with that in the historical control group that did not receive Prosure®(7.3% vs 10.3%, p<0.01),

* The rate of Grade 3-4 oral mucositis was significantly reduced for the patient groups that received Prosure®(CTCAE v3.0 GradeB3; 24% vs 58%, p<0.05).

Most importantly, the completion rate of chemoradiotherapy was not significantly different between both groups(77% vs 60%, NS).


Based on the evidence, researchers said, "A nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®)had effects on oral mucositis and body weight loss in head and neck cancer patients treated with chemoradiotherapy".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer by reducing the breast density, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®) Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treated with Chemoradiotherapy].[Article in Japanese] by Mizumachi T1, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C, Kumagai S, Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y, Onimaru R, Shirato H, Fukuda S. (PubMed)
(2) A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients by de Luis DA1, Izaola O, Cuellar L, Terroba MC, de la Fuente B, Cabezas G. (PubMed)