Phytochemical Tocopherol, A Potential Ingredient for the Treatment of Hyperlipidemia

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, and produces vitamin D and steroid hormones.

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.


In other words, hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.


There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.

Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent causes of hyperlipidemia in the Western world.


Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers compared the effect of consumption of virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complimentary ones from thyme (FVOOT) could improve HDL status and function. Thirty-three hypercholesterolemic individuals ingested (25 ml/day, 3 weeks) (a) VOO (80 ppm), (b) FVOO (500 ppm), and (c) FVOOT (500 ppm) on HDL-related markers.

According to the results of the randomized, double-blind, controlled, crossover trial, α-tocopherol, the main HDL antioxidant, was only augmented after FVOOT versus its baseline.

In other words, the complementary phenol-enriched olive oil is the one that increased the main HDL antioxidant, α-tocopherol.

Long-term consumption of phenol-enriched olive oils showed a strong implication on the improvement of HDL antioxidant content.

Therefore, complementary phenol-enriched olive oil could be a useful dietary tool for improving HDL richness in antioxidants.


Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial by Farràs M1, Fernández-Castillejo S2, Rubió L3, Arranz S4, Catalán Ú2, Subirana I5, Romero MP6, Castañer O7, Pedret A8, Blanchart G9, Muñoz-Aguayo D7, Schröder H10, Covas MI11, de la Torre R12, Motilva MJ6, Solà R2, Fitó M. (PubMed)

Low Levels of Omega-3 Fatty Acids Are Associated with Increased Risk of Atherosclerosis

Cardiovascular disease refers to heart diseases, affecting millions of people in the world.
According to statistics, over 17.7 million people died from CVDs in 2015.

The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.

Most cases of heart disease in the Western world are associated with atherosclerosis.

In other words, atherosclerosis is a leading cause of coronary heart disease (CHD).

According to the 2016 Heart Disease and Stroke Statistics, 15.5 million people in the USA. have CHD. The lifetime risk of developing CHD with ≥2 major risk factors is 37.5% for men and 18.3% for women.


Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.

In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of EPA and DHA on the early-onset of coronary atherosclerosis.

According to the results of 71 participant groups included 51 were below and 20 were above the 75th AS-percentile.
* A significantly lower value for EPA (0.77%[0.63; 0.97] vs. 0.93%[0.72; 1.21]; p = 0.045), DHA (4.90%[4.12; 5.57] vs. 5.50%[4.58; 6.52]; p = 0.038) and the Omega-3 Index (5.73%[4.75; 6.35] vs. 6.22%[5.46; 7.71]; p = 0.034) were seen in patients above the 75th AS-percentile was found to associated with the onset of coronary atherosclerosis.

* All other fatty acids showed no significant differences.

* In multivariable analysis, the Omega-3 Index showed a significant inverse association with early onset of CAC (OR: 0.533 (95%CI: 0.303-0.938; p = 0.029)), independent of age, gender, statin use, and creatinine level (all p > 0.05).

Collectively, researchers said, "Low levels of EPA and DHA (Omega-3 Index) are associated with early-onset coronary atherosclerosis. This finding needs to be validated in larger cohorts and might help understand the beneficial cardiovascular effects of omega-3 fatty acids".


Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Early-onset coronary atherosclerosis in patients with low levels of omega-3 fatty acids by Bittner DO1, Goeller M2, Zopf Y3, Achenbach S2, Marwan M. (PubMed)
(2) The Impact of Omega 3 Fatty Acids in Atherosclerosis and Arterial Stiffness: An Overview of their Actions by Verveniotis A1, Siasos G1,2, Oikonomou E1, Tsigkou V1, Papageorgiou N1, Zaromitidou M1,2, Psaltopoulou T1, Marinos G1, Deftereos S1, Vavuranakis M1, Stefanadis C3, Papavassiliou AG4, Tousoulis D. (PubMed)

Tocopherols Induce Cytotoxicity in Cancer Cells

Cytotoxicity is the process of the induction of cell death through toxins.
In other words, cell cytotoxicity is the process in which certain chemicals or mediator cells are used to destroy living cells.

In cancers, cytotoxicity can be benefits humans by destroying the cancer cells and preventing them from proliferation.


Most cases of cytotoxicity used by a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.


But, before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and Vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.

In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.


Some of the cancer drugs with cytotoxic activity have been found to induce cancer cell death accompanied by serious health problems, including weakened immune functioning such as low blood counts causing an increased possibility of developing infection or anemia, tiredness, mouth soreness, nausea, vomiting, loss of appetites, constipation or diarrhea, skin changes or reactions. particularly hair loss.


However, the combination used of chemo drug and herbal medicine and plant-based antioxidants that can also stimulate the ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.


Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancer, researchers examined the cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells.

According to the tested analysis,
* Among tocopherols, only delta-T exhibited cytotoxicity.

* Among para quinones, alpha-TQ showed no cytotoxicity, while gamma-TQ and delta-TQ were highly cytotoxic in both CEM and CEM/VLB100 cell lines (LD50 < 10 muM).

* Delta-TQ and gamma-TQ were more cytotoxic than the widely studied chemotherapeutic agent doxorubicin, which also showed selective cytotoxicity to CEM cells.


* Compared to doxorubicin, the orthoquinone Tocored was less cytotoxic than doxorubicin in drug-sensitive cells but more cytotoxic than doxorubicin in multidrug-resistant cells.


* Cytotoxicity was not a function of the phytyl side-chain since both TMCQ and PR were cytotoxic in leukemia cells.


* Cytotoxicity was enhanced when the glutathione pool was depleted by preincubation with buthionine-[S,R]-sulfoximine, but cytotoxicity was diminished by the addition of N-acetylcysteine to cultures. alpha-T also diminished the cytotoxicity of para- and orthoquinones.


Collectively, researchers said, "tocopheryl quinones represent a new class of alkylating electrophilic quinones that function as highly cytotoxic agents and escape multidrug resistance in acute lymphoblastic leukemia cell lines".


Taken altogether, tocopherols may process cytotoxic activity against cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells by Cornwell DG1, Jones KH, Jiang Z, Lantry LE, Southwell-Keely P, Kohar I,
Thornton DE. (PubMed)

Omega-3 Fatty Acids Induce the Death of Ovarian Cancer Cells In Vitro

Cancer is the class of chronic disease caused by irregular cell growth in the tissue or specific organ in the body due to the alternation of cell DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.

The ovaries are oval-shaped ovum-producing reproductive organs formed as part of women's reproductive system that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovaries take a turn to release an egg every month.


In other words, the main functions of the ovary play a critical role in producing oocytes (eggs) for fertilization and reproductive growth hormones, estrogen, and progesterone.

According to the statistics, ovarian cancer is one of the fifth most common cancer, accounting for more deaths than any other cancer of the female reproductive system in the US.

The lifetime risk of getting ovarian cancer in a woman is about 1 in 78. compared to the lifetime of dying from ovarian cancer risk of 1 in 108.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, and acquired genetic mutation such as the TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.

Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvic area, and changes in bowel habits, such as constipation. and a frequent need to urinate.


According to the statistics provided by the Canadian Cancer Society, in Canada, the 5-year net survival for ovarian cancer is 45%.

In other words, on average, 45% of women diagnosed with ovarian cancer will survive for at least 5 years.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effect of OM-3FAs on epithelial ovarian cancer cell lines.

According to the results of 3 epithelial ovarian cancer cell lines (SKOV-3 [p53 null], TOV-21G [wt p53], and OVCAR-3 [mutant p53]) and one immortalized ovarian surface epithelial cell line (IOSE-29 [wt p53]) treated with OM-3FAs, OM-3FAs showed a statistically significant inhibitory effect in all four cell lines.

Furthermore, in the p53 null and mutant cell lines, SKOV-3 and OVCAR-3, the application of OM-3FAs showed inhibitory activity without inducing apoptosis and down-regulated expression of VEGF.

However, the apoptosis and/or VEGF down-regulation was strongly evident in the wt p53 cell lines TOV-21G and IOSE-29.

Collectively, researchers said, "under the influence of OM-3FAs, there are definitive growth-suppressive mechanisms at work and that the biologic effects of OM-3FAs may in part be mediated by the p53 status".


Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of Omega-3 fatty acids on growth regulation of epithelial ovarian cancer cell lines by Sharma A1, Belna J, Logan J, Espat J, Hurteau JA. (PubMed)
(2) Intake of omega-3 and omega-6 fatty acids and risk of ovarian cancer by Ibiebele TI1, Nagle CM, Bain CJ, Webb PM. (PubMed)

Antioxidant Tocopherols Protect the Skin Against UVB-Induced Skin Damage

Skin is the largest organ in the body with the function to protect the internal organs and tissue against foreign organisms infection, leading organs and tissue injury and damage.
It also is the third organ behind the liver and kidney to eliminate body toxins if the first 2 fail to cleanse them all.

Skin diseases are conditions of skin damage and are classified according to each pathogenic cause.

Most cases of skin disease are involved in allergens, irritants. However certain medical conditions such as irritable bowel disease, autoimmune diseases, and genetic preposition can also cause r skin diseases.

Recent studies suggested that a poor diet is also associated with the onset of skin diseases such as dermatological disease which may be linked to systemic disease, and dietary changes which may affect health outcomes, as in psoriasis.


Photodamage is a type of skin damage caused by long-term exposure to the sunlight or tanning bed.

Photodamage skin is one most common forms of skin damage in the US, due to misunderstanding the benefits and adverse effects of light exposure.

Believe it or not, a quarter of lifetime sun exposure occurs before the end of the teenage years. Most cases of photo skin damage can also stimulate some unwanted skin conditions, including advanced aging or wrinkling, uneven skin, hyperpigmentation, telangiectasias, actinic keratoses liver, and age spots.

In severe cases, long-term photodamaged skin can also lead to skin cancer. More people in the US are diagnosed with skin cancer each year than all other cancers combined.
According to the statistic, 1 in 5 Americans will develop skin cancer by the age of 70.

Conventionally, most cases of early-stage and mild damage of skin are treated by topical Levulan that removes scaly patches of actinic keratoses from your skin.

UVB-induced skin damage is a condition of skin damage caused by overexposure to UVB.


Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of skin diseases, researchers examined the protective capacity of alpha-tocopherol and beta-carotene during UVA and UVB irradiation of human melanocytes in vitro.

According to the primary cultures of normal human melanocytes irradiated by different wavelengths within the UV spectrum (UVA 6 J cm(-2), UVB 60 mJ cm(-2)),* UVA and UVB irradiation decreased the intracellular concentration of reduced glutathione associated with an antioxidant enzyme produced by the host and activated the transcription factor nuclear factor (NF)-kappaB, involved in the production of pro-inflammatory cytokines.


Furthermore, UVA and UVB irradiation increased the level of the p65 subunit in the activation of the potential of NF-kappa Band translocation to the nucleus.

Moreover, UVA and UVB caused apoptotic cell death as detected by nuclear fragmentation and caspase activation 24 h postirradiation.

Pretreatment with alpha-tocopherol prevented UVA- and UVB-induced glutathione loss, NF-kappaB translocation, and diminished apoptosis. However, beta-carotene did not show a similar protective capacity. Further, exposure to alpha-tocopherol by itself reduced cell proliferation rate.


Based on the results, researchers said, "UVA and UVB irradiation affected the intracellular redox state and increased the frequency of apoptosis in human melanocytes in vitro. alpha-Tocopherol might be a useful substance in protecting melanocytes from UV-induced damage".


Taken altogether, tocopherols may be considered a supplement for the treatment of UVB-induced skin damage, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ultraviolet (UV)A- and UVB-induced redox alterations and activation of nuclear factor-kappaB in human melanocytes-protective effects of alpha-tocopherol by Larsson P1, Ollinger K, Rosdahl I. (PubMed)

Tocopherols Destroy Oral Cancer Cells in Vitro

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissues of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that lines the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die because of these cancers in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection, and genetic mutation is the most common prevalent risk factors found in people with mouth cancer.

The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

Stages
1. Stage O
Benign tumor
2. Stage I
The cancer is < 2 cm in size (about 1 inch), with no lymph nodes spreading found in the area.
3. Stage II
The cancer is ≥ 2 cm in size, but < 4 cm (less than 2 inches), with no lymph nodes spreading found in the area.4. Stage III

The cancer is ≥ cm in size or any size with only one lymph node on the same side of the neck as of cancer. The cancerous node is ≤ 3 cm (about one inch).
5. Stage IV
Cancer has spread to tissues around the lip and oral cavity with lymph nodes in the area may or may be infected. The cancer of any size has spread to more than one lymph node on the same side of the neck or lymph nodes on one or both sides of the neck, or to any lymph node that measures ≥ 6 cm (over 2 inches) in size or to distant parts of the body.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases associated with inflammation, researchers examined the effects of α-tocopherol on the oral squamous carcinoma cells ORL-48.

According to the experimental results,
* In vitro study, α-tocopherol exhibited effective antitumor activity on ORL-48 at 2.5 ± 0.42 µg/mL.


* Although Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL, compared to α-tocopherol which exhibited cytotoxicity on normal human epidermal keratinocytes at very low concentration (<0.1 µg/mL).

* Despite the lower potency of α-tocopherol, signs of apoptosis such as the shrinkage of cells and appearance of apoptotic bodies were observed much earlier than cisplatin in time-lapse microscopy.

* Both applications increased the number of cell accumulation in the G0/G1 phase with ultrastructural changes of the cellular structures verified the apoptotic mode of cell death by both agents.

Based on the findings, researchers said, " Both cisplatin and α-tocopherol displayed cell cycle arrest at the Sub G0 phase. α-tocopherol thus showed potential as an antitumor agent for the treatment of oral cancer and merits further research".

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48 by Zulkapli R1,2, Abdul Razak F1, Zain RB. (PubMed)

Antioxidant Lycopene Protects the Kidney Cell Integrity Against Damage

The kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.

Besides being accompanied by the liver and skin to form a detox system in the body, the kidneys also process significant effects that maintain the body fluid balance, regulate the production of red blood cell and high blood pressure.

Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.

Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.

CKD can cause dangerous levels of fluid, electrolytes, and wastes to build up in the body.

According to statistics, approximately 14 percent of the US general population suffers from CKD. More than 661,000 Americans are living with kidney failure, including 468,000 individuals on dialysis.

People with reduced kidney function do not experience any symptoms until the advanced stage. In other words, kidney disease in the advanced stage can lead to dangerous levels of fluid, electrolytes, and building toxins in the body.

Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent factors found in most patients.

In this advanced stage, patients also experience symptoms of gastrointestinal discomforts, weakness,
sleep problems, changes of urination, decreased mental sharpness, muscle twitches and cramps, and swelling of feet and ankles, particularly the persistent itching.


Some researchers suggested high blood pressure is one of the major causes of CKD.

The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"

And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".


Lycopene is a phytochemical found in tomatoes in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potent ingredient for the protection of kidney damage, researchers examined the effect of lycopene on the nephrotoxicity of deltamethrin.

The study included male albino rats that were divided into four groups with10 animals each: group I served as control, which received standard diet; group II received oral administration of deltamethrin (1.28 mg/kg per day) for 30 days; group III received both deltamethrin and lycopene (1 mg/kg per day); group IV received lycopene (1 mg/kg per day).

According to the results of the end of the experiment, the deltamethrin-treated group not only showed significantly increased expression of the pro-inflammatory cytokine, TNF-α but also caused mild necrotic changes of the kidney associated with localized cell death due to interruption of the blood supply.

Renal proximal tubules in the deltamethrin treated group also showed an increased number and irregular shape of mitochondria causing the reduced function of the cell in the kidney to take nutrients from the cell breaks it down and turn it into energy.


Vacuolar degeneration in the epithelial cells, increased number of lysosomes, and loss of apical microvilli associated with the reduced function of kidney cells in the absorptive and secretory function, may lead to the decrease of the detoxed function of the kidney.


Moreover, focal segmental thickening and the duplication of the glomerular basement membrane and podocyte changes are involved in kidney damage. were also found in the deltamethrin treated group.

Pretreatment of lycopene demonstrated a strong effect either restored the kidney tissue damage or inhibited the parameters that cause the kidney disease.

Based on the findings, researchers said, "Histopathological and ultrastructural study showed some protective effect of lycopene on kidney tissues".


Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats by El-Gerbed MS. (PubMed)
(3) High Blood Pressure & Kidney Disease. What is high blood pressure? the Natural Kidney Foundation. (NIH)