Dementia is a neuropsychiatric disorder as a result of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, contributing to caregiver burden and premature institutionalization.
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Dementia is the loss of mental ability that is severe enough to interfere with people's every life.
Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.
Alzheimer's disease worsens over time and it is fatal.
American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetables which can lead to dementia and other kinds of diseases.
As the disease progression, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.
In the elderly, age-related changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulation of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.
In free radical theory, free radical overexpression causes the reduced levels of antioxidant enzymes produced by the elderly to initiate the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cell damage and development of AD.
β-amyloid (Aβ) accumulated in the neurons, the main component of the amyloid plaques in the brains have been found in patients with Alzheimer's disease.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of dementia, researchers investigated the cranberry extract (CBE) rich in polyphenols that delay paralysis induced by alleviating β-amyloid (Aβ) toxicity Alzheimer's disease (AD) in the C. elegans model.
According to the experimental results, researchers suggested that CBE showed a strong anti-AD activity by inhibiting the level of Aβ toxicity and promoting memory health, the two major pathological parameters in AD.
C. elegans AD model treated with CBE exerted significantly preventive and therapeutic protocols.
Based on the findings, researchers said, "CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals".
Taken altogether, cranberry may be considered a remedy for the management of AD, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease by Guo H1, Dong YQ2, Ye BP. (PubMed)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Wednesday, March 31, 2021
Thursday, March 25, 2021
Omega 3 Fatty Acid Inhibits the Onset of Acute Steatohepatitis in Vivos
Steatohepatitis is a fatty liver disease caused by inflammation of the liver tissue accompanied by fat accumulation.
The most common form of steatohepatitis is non-alcoholic steatohepatitis (NASH), an advanced form of non-alcoholic fatty liver disease (NAFLD) that is not caused by excessive alcohol drinking.
Most cases of NASH if untreated can lead to liver scars or building up of scar over time, a condition of liver cirrhosis, and one of the most common causes of liver cancer.
Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.
The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.
People with steatohepatitis have been associated with an increased risk of liver failure and liver cancer, due to excessive formation of liver scar tissues, epidemiologically.
According to the statistics, fatty liver affects approximately 25% of the general population worldwide. Non-alcoholic steatohepatitis (NASH), is very common in overweight persons.
Researchers do not know the exact cause of steatohepatitis. However, they do know certain medical conditions such as diabetes, being overweight or obese and people with metabolic syndrome, including high blood cholesterol are some most prevalent risks of the disease.
Some researchers suggested that people who are viral hepatitis carriers are also at risk of steatohepatitis.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of liver diseases, researchers examined the ω-3-acid ethyl ester prescription Lovaza effects on acute steatohepatitis.
According to the results of the study,
* In vivo, administration of CMPF to mice before or after high-fat diet feeding at exposures equivalent to those observed in humans increased whole-body lipid metabolism, improved insulin sensitivity, increased beta-oxidation, reduced lipogenic gene expression, and ameliorated steatosis.
* CMPF acutely inhibits Acetyl-CoA Carboxylase (Acc) activity in the monitoring of liver enzymatic activity and induces long-term loss of SREBP1c and ACC1/2 expression in lipid metabolism.
* CMPF upregulated the expression of FGF21, which is required for long-term steatosis protection.
Moreover, researchers said, "MPF treatment in mice parallels the effects of human Lovaza™ supplementation, revealing that CMPF may contribute to the improved metabolic effects observed with ω-3 fatty acid prescriptions".
Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of acute steatohepatitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis by Prentice KJ1, Wendell SG2, Liu Y1, Eversley JA1, Salvatore SR2, Mohan H1, Brandt SL1, Adams AC3, Serena Wang X1, Wei D1, FitzGerald GA4, Durham TB3, Hammond CD3, Sloop KW3, Skarke C5, Schopfer FJ6, Wheeler MB. (PubMed)
The most common form of steatohepatitis is non-alcoholic steatohepatitis (NASH), an advanced form of non-alcoholic fatty liver disease (NAFLD) that is not caused by excessive alcohol drinking.
Most cases of NASH if untreated can lead to liver scars or building up of scar over time, a condition of liver cirrhosis, and one of the most common causes of liver cancer.
Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.
The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.
People with steatohepatitis have been associated with an increased risk of liver failure and liver cancer, due to excessive formation of liver scar tissues, epidemiologically.
According to the statistics, fatty liver affects approximately 25% of the general population worldwide. Non-alcoholic steatohepatitis (NASH), is very common in overweight persons.
Researchers do not know the exact cause of steatohepatitis. However, they do know certain medical conditions such as diabetes, being overweight or obese and people with metabolic syndrome, including high blood cholesterol are some most prevalent risks of the disease.
Some researchers suggested that people who are viral hepatitis carriers are also at risk of steatohepatitis.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of liver diseases, researchers examined the ω-3-acid ethyl ester prescription Lovaza effects on acute steatohepatitis.
According to the results of the study,
* In vivo, administration of CMPF to mice before or after high-fat diet feeding at exposures equivalent to those observed in humans increased whole-body lipid metabolism, improved insulin sensitivity, increased beta-oxidation, reduced lipogenic gene expression, and ameliorated steatosis.
* CMPF acutely inhibits Acetyl-CoA Carboxylase (Acc) activity in the monitoring of liver enzymatic activity and induces long-term loss of SREBP1c and ACC1/2 expression in lipid metabolism.
* CMPF upregulated the expression of FGF21, which is required for long-term steatosis protection.
Moreover, researchers said, "MPF treatment in mice parallels the effects of human Lovaza™ supplementation, revealing that CMPF may contribute to the improved metabolic effects observed with ω-3 fatty acid prescriptions".
Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of acute steatohepatitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis by Prentice KJ1, Wendell SG2, Liu Y1, Eversley JA1, Salvatore SR2, Mohan H1, Brandt SL1, Adams AC3, Serena Wang X1, Wei D1, FitzGerald GA4, Durham TB3, Hammond CD3, Sloop KW3, Skarke C5, Schopfer FJ6, Wheeler MB. (PubMed)
Sunday, March 21, 2021
Herbal Ashwagandha, MayBe Used for Treatment of Infertility in Men, Studies Show
Infertility is a reproductive disease characterized by the failure to produce a pregnancy after 12 regular unprotected sexual intercourse, including pregnancy that can not be carried to term.
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such groups are seeking help from professionals.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financially stable before having children.
* Too young to be a parent, raising a child needs efforts, time, and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factor correlated to the increased infertile rate over the past few decades.
Dr. Nicole O. Palmer the lead scientist in the concern of obesity in the risk of men infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Recent data has shown that male obesity also impairs offspring metabolic and reproductive health suggesting that paternal health cues are transmitted to the next generation with the mediator mostly likely occurring via the sperm.".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of infertility, researchers examined beneficial effects induced by oral intake of the Withania sominifera (Ashwagandha) on semen quality of infertile men.
Based on the tested analysis, oral intake of Ashwagandha roots only improved sperm count and motility, and regulate reproductive hormone levels. but also inhibited the lipid peroxidation associated with the risk of infertility.
From a molecular perspective, oral intake of Ashwagandha roots inhibited the mitigation of oxidative stress and pathways involved in hormonal imbalance by enhancing the interaction of different endocrine glands to improve male fertility.
More precisely, Ashwagandha roots improved men's fertility by mitigating risk factor-that cause the onset of men's infertility.
In stress-induced male infertility on selected normozoospermic but infertile individuals (N = 60) that: divided into normozoospermic heavy smokers (N = 20), normozoospermic under psychological stress (N = 20), and normozoospermic with infertility of unknown etiology (N = 20).
Compared to Normozoospermic fertile men (N = 60), root powder of W. somnifera at a rate of 5 g/day for 3 months showed a strong effect in the treatment of stress-related infertility by improving the level of anti-oxidants and overall semen quality.
Root powder of W. somnifera treatment also resulted in pregnancy in the partners of 14% of the patients.
Taken altogether, Ashwagandha may be considered a functional herb for the treatment of male infertility, pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Withania somnifera (Ashwagandha) in the management of male infertility by Sengupta P1, Agarwal A2, Pogrebetskaya M3, Roychoudhury S4, Durairajanayagam D5, Henkel R. (PubMed)
(2) Withania somnifera Improves Semen Quality in Stress-Related Male Fertility by Mahdi AA1, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D. (PubMed)
(3) Impact of obesity on male fertility, sperm function and molecular composition by Nicole O. Palmer, Hassan W. Bakos, Tod Fullston, and Michelle Lane. (PMC)
Thursday, March 18, 2021
Omega-3 Fatty Acids May Process Anti Cardiovascular Diseases Activity
Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.
According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.
Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.
The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.
High blood pressure, high blood cholesterol, smoking, diabetes, weight, depression, and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.
In other words, anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. Here are some early indications of heart disease symptoms.
According to the statistics, cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.
The most common complications of heart diseases are heart failure, the condition that occurs when the heart cannot adequately pump blood throughout the body, and heart attack, which occurs when the coronary arteries narrow caused by the building up of plaques that block the blood supply to the heart.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effects of omega-3-fatty acids on cardiovascular diseases (CVD).
According to the tested analysis,* The administration of omega-3 fatty acids showed a significantly reduced risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with coronary heart disease.
* Furthermore, omega-3 fatty acids inhibited the expression of hyperlipidemia and hypertension.
* There are no significant drug interactions with oral administration of omega-3 fatty acids.
More profoundly, the American Heart Association recommends the consumption of two servings of fish per week for persons with no history of coronary heart disease and at least one serving of fish daily for those with known coronary heart disease.
Additionally, approximately 1 g/day of eicosapentaenoic acid plus docosahexaenoic acid is recommended for cardioprotection. Higher dosages of omega-3 fatty acids are found to ameliorate the elevated triglyceride levels (2-4 g/day).
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of CVD, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future by Watanabe Y1, Tatsuno I. (PubMed)
(2) Omega-3 fatty acids and cardiovascular disease by Jain AP1, Aggarwal KK, Zhang PY. (PubMed)
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.
According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.
Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.
The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.
High blood pressure, high blood cholesterol, smoking, diabetes, weight, depression, and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.
In other words, anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. Here are some early indications of heart disease symptoms.
According to the statistics, cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.
The most common complications of heart diseases are heart failure, the condition that occurs when the heart cannot adequately pump blood throughout the body, and heart attack, which occurs when the coronary arteries narrow caused by the building up of plaques that block the blood supply to the heart.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effects of omega-3-fatty acids on cardiovascular diseases (CVD).
According to the tested analysis,* The administration of omega-3 fatty acids showed a significantly reduced risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with coronary heart disease.
* Furthermore, omega-3 fatty acids inhibited the expression of hyperlipidemia and hypertension.
* There are no significant drug interactions with oral administration of omega-3 fatty acids.
More profoundly, the American Heart Association recommends the consumption of two servings of fish per week for persons with no history of coronary heart disease and at least one serving of fish daily for those with known coronary heart disease.
Additionally, approximately 1 g/day of eicosapentaenoic acid plus docosahexaenoic acid is recommended for cardioprotection. Higher dosages of omega-3 fatty acids are found to ameliorate the elevated triglyceride levels (2-4 g/day).
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of CVD, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future by Watanabe Y1, Tatsuno I. (PubMed)
(2) Omega-3 fatty acids and cardiovascular disease by Jain AP1, Aggarwal KK, Zhang PY. (PubMed)
Tuesday, March 16, 2021
Tocopherols, the Potential and Natural Anti-hypercholesterolemic Phytochemicals
The liver is a large internal organ of the human body that protects us by filtering the blood that comes from the digestive system before passing to other parts of the body.
In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.
The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build upon the arterial wall, the major cause of heart disease and stroke.
More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.
In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).
According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of diseases associated with high blood cholesterol, researchers examined the antioxidant defense activity of alpha-tocopherol in familial hypercholesterolemia and the effects of lipoprotein apheresis.
The study included a group of hypercholesterolemic patients (n = 14) that were treated by lipoprotein apheresis was compared to healthy adult normolipidemic controls to induce the decrease of tocopherol in serum and lipoprotein fractions with no change of the content of in membrane alpha-tocopherol.
According to the analysis of a simple isocratic reversed-phase HPLC method that has been developed and validated for the determination of alpha-tocopherol in human erythrocytes in a clinical setting, alpha-tocopherol significantly decreased lipoperoxidation as revealed by serum TBARS, representing end products of lipid peroxidation which increased from third day afterward and remained significantly higher in comparison to controls until the next LDL-apheresis.
More precisely, the phytochemical demonstrated an aggressive lipid-lowering procedure with lipoprotein apheresis associated with a favorable transient decrease of lipoperoxidation.
In other words, alpha-tocopherol inhibited the lipoperoxidation in the induction of hypercholesterolemia in the tested patients through its antioxidant activity.
After talking about other factors into account, researchers said, "Simultaneously the cell membrane-bound antioxidative defense mechanisms as reflected by the content of alpha-tocopherol in human erythrocyte membrane were not depressed in spite of its decreased plasma lipid carrier".
Taken altogether, tocopherols may be considered an adjunct therapy in the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant defense system in familial hypercholesterolemia and the effects of lipoprotein apheresis by Blaha V1, Blaha M2, Solichová D3, Krčmová LK3, Lánská M2, Havel E3, Vyroubal P3, Zadák Z3, Žák P2, Sobotka L. (PubMed)
In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.
The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build upon the arterial wall, the major cause of heart disease and stroke.
More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.
In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).
According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of diseases associated with high blood cholesterol, researchers examined the antioxidant defense activity of alpha-tocopherol in familial hypercholesterolemia and the effects of lipoprotein apheresis.
The study included a group of hypercholesterolemic patients (n = 14) that were treated by lipoprotein apheresis was compared to healthy adult normolipidemic controls to induce the decrease of tocopherol in serum and lipoprotein fractions with no change of the content of in membrane alpha-tocopherol.
According to the analysis of a simple isocratic reversed-phase HPLC method that has been developed and validated for the determination of alpha-tocopherol in human erythrocytes in a clinical setting, alpha-tocopherol significantly decreased lipoperoxidation as revealed by serum TBARS, representing end products of lipid peroxidation which increased from third day afterward and remained significantly higher in comparison to controls until the next LDL-apheresis.
More precisely, the phytochemical demonstrated an aggressive lipid-lowering procedure with lipoprotein apheresis associated with a favorable transient decrease of lipoperoxidation.
In other words, alpha-tocopherol inhibited the lipoperoxidation in the induction of hypercholesterolemia in the tested patients through its antioxidant activity.
After talking about other factors into account, researchers said, "Simultaneously the cell membrane-bound antioxidative defense mechanisms as reflected by the content of alpha-tocopherol in human erythrocyte membrane were not depressed in spite of its decreased plasma lipid carrier".
Taken altogether, tocopherols may be considered an adjunct therapy in the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant defense system in familial hypercholesterolemia and the effects of lipoprotein apheresis by Blaha V1, Blaha M2, Solichová D3, Krčmová LK3, Lánská M2, Havel E3, Vyroubal P3, Zadák Z3, Žák P2, Sobotka L. (PubMed)
Friday, March 12, 2021
Herbal Angelica Sinensis, A Promising Anti-Glioblastoma Remedy
Cancers are the class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effect".
Taken altogether, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effect".
Taken altogether, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
Thursday, March 11, 2021
Antioxidant Lycopene in the Prevention of Acute Pancreatitis
Pancreatitis is a condition associated with the inflammation of the pancreas.
Most cases of pancreatitis are involved in the abnormal activation of digestive enzymes in the small intestine that attacks the pancreas.
According to the statistics, in the Western world, the incidence of chronic pancreatitis rate is 5-12/100,000.
Epidemiologically, the chronic condition is found mostly in patients between the ages of 30 and 40 and more common in men than women.
Acute pancreatitis is an inflammation that starts rapidly and lasts for a short time. The condition can be mild or severe. In mild cases, most patients are recovered quickly if the cause is found.
In severe cases, acute pancreatitis can be life-threatening. The condition has been found to induce bleeding into the gland, serious tissue damage, infection, and cyst formation.
In some patients, the condition also can cause damage to vital organs such as the heart, lungs, and kidney
The most common symptoms of acute pancreatitis are upper abdominal pain, swollen and tender abdomen, nausea and vomiting, fever, and increased heart rate.
If you have some of the aforementioned symptoms that persistently with no signs of healing. Please check with your doctor to rule out the possibility of acute pancreatitis.
The exact causes of acute pancreatitis are unknown. The most common factors associated with the prevalent risk of acute pancreatitis are gallstones or heavy alcohol use.
Dr. Parimal Chowdhury, the lead scientist wrote, "Use of alcohol is a worldwide habit regardless of socio-economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis".
And, "The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol-induced pancreatitis".
Other risk factors found in patients with acute pancreatitis are long-term use of some medications such as Azathioprine, Thiazide, and Valproic acid, autoimmune disease, infections, trauma, metabolic disorders, and surgery.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of pancreatic disease, researchers examined the anti-oxidative and anti-inflammatory effects of lycopene on severe acute pancreatitis (SAP) in both in vivo and in vitro models.
According to the tested differentiation, lycopene administration protected against SAP by decreasing the levels of serum amylase and C-reactive protein associated with the inflammatory pancreas.
Lycopene also inhibited the overexpression of pro-inflammatory proteins such as The serum levels of tumor necrosis factor-α, interleukin-6, macrophage inflammatory protein-1α.
Free radicals overexpression such as lipid peroxidase and antioxidant enzyme production such as myeloperoxidase and superoxide dismutase associated with oxidative stress was also modulated by the injection of lycopene against acinar cells in the pancreas against cells apoptosis.
In other words, lycopene protected the pancreas against the onset of acute pancreatitis in a simulated SAP model in a rat acinar cell line by inhibiting ROS.induction.
Based on the findings, researchers said, "Lycopene exerts protective effects against SAP in rats that may be related to its anti-inflammatory property through inhibiting the expression of damage-associated molecular patterns, and anti-oxidative property".
Taken altogether, lycopene found in tomato may be considered a remedy for the prevention and treatment of acute pancreatitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis by El-Ashmawy NE1, Khedr NF2, El-Bahrawy HA3, Hamada OB. (PubMed)
(2) Lycopene protects pancreatic acinar cells against severe acute pancreatitis by abating the oxidative stress through JNK pathway by Lv JC1, Wang G, Pan SH, Bai XW, Sun B. (PubMed)
(3) Pathophysiology of alcoholic pancreatitis: An overview by Parimal Chowdhury and Priya Gupta. (PMC)
Most cases of pancreatitis are involved in the abnormal activation of digestive enzymes in the small intestine that attacks the pancreas.
According to the statistics, in the Western world, the incidence of chronic pancreatitis rate is 5-12/100,000.
Epidemiologically, the chronic condition is found mostly in patients between the ages of 30 and 40 and more common in men than women.
Acute pancreatitis is an inflammation that starts rapidly and lasts for a short time. The condition can be mild or severe. In mild cases, most patients are recovered quickly if the cause is found.
In severe cases, acute pancreatitis can be life-threatening. The condition has been found to induce bleeding into the gland, serious tissue damage, infection, and cyst formation.
In some patients, the condition also can cause damage to vital organs such as the heart, lungs, and kidney
The most common symptoms of acute pancreatitis are upper abdominal pain, swollen and tender abdomen, nausea and vomiting, fever, and increased heart rate.
If you have some of the aforementioned symptoms that persistently with no signs of healing. Please check with your doctor to rule out the possibility of acute pancreatitis.
The exact causes of acute pancreatitis are unknown. The most common factors associated with the prevalent risk of acute pancreatitis are gallstones or heavy alcohol use.
Dr. Parimal Chowdhury, the lead scientist wrote, "Use of alcohol is a worldwide habit regardless of socio-economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis".
And, "The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol-induced pancreatitis".
Other risk factors found in patients with acute pancreatitis are long-term use of some medications such as Azathioprine, Thiazide, and Valproic acid, autoimmune disease, infections, trauma, metabolic disorders, and surgery.
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of pancreatic disease, researchers examined the anti-oxidative and anti-inflammatory effects of lycopene on severe acute pancreatitis (SAP) in both in vivo and in vitro models.
According to the tested differentiation, lycopene administration protected against SAP by decreasing the levels of serum amylase and C-reactive protein associated with the inflammatory pancreas.
Lycopene also inhibited the overexpression of pro-inflammatory proteins such as The serum levels of tumor necrosis factor-α, interleukin-6, macrophage inflammatory protein-1α.
Free radicals overexpression such as lipid peroxidase and antioxidant enzyme production such as myeloperoxidase and superoxide dismutase associated with oxidative stress was also modulated by the injection of lycopene against acinar cells in the pancreas against cells apoptosis.
In other words, lycopene protected the pancreas against the onset of acute pancreatitis in a simulated SAP model in a rat acinar cell line by inhibiting ROS.induction.
Based on the findings, researchers said, "Lycopene exerts protective effects against SAP in rats that may be related to its anti-inflammatory property through inhibiting the expression of damage-associated molecular patterns, and anti-oxidative property".
Taken altogether, lycopene found in tomato may be considered a remedy for the prevention and treatment of acute pancreatitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis by El-Ashmawy NE1, Khedr NF2, El-Bahrawy HA3, Hamada OB. (PubMed)
(2) Lycopene protects pancreatic acinar cells against severe acute pancreatitis by abating the oxidative stress through JNK pathway by Lv JC1, Wang G, Pan SH, Bai XW, Sun B. (PubMed)
(3) Pathophysiology of alcoholic pancreatitis: An overview by Parimal Chowdhury and Priya Gupta. (PMC)
Sunday, March 7, 2021
Omega-3 Fatty Acids Show to Reduce Cancer-Related Complications
Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
Most common cancer complications, depending on the types of cancer are
* Pain can be caused by cancer or by cancer treatment
* Fatigue.
* Difficulty breathing.
*Nausea.
*Diarrhea or constipation.
* Weight loss.
*Chemical changes in your body.
* Brain and nervous system problems.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the improvement of quality of life in cancer patients, researchers examined the omega-3 polyunsaturated fatty acids (PUFAs) effects on cancer complications
According to the medical literature* A systematic review demonstrated that a nutritional supplement enriched with fish oil decreased the symptoms of fatigue and pain in patients during chemo- and/or radiotherapy, probably due to reduced inflammatory status.
* A recent systematic review evaluated the effects of fish oil for cachexia in advanced cancer, concluding that clinical evidence is still uncertain due to a weak methodology and a large variation of fish oil dosages. However, fish oil supplementation could benefit postoperative recovery and reduce complications, such as impaired wound healing and infections.
* The plasmatic contents of omega-6/omega-3 and ALA/EPA were associated with muscle atrophy in cachectic cancer patients, indicating that these molecules may participate in the development of cancer cachexia.
* Regarding the participation of omega-3 in cancer-associated depression, it was observed that, in newly diagnosed Japanese lung cancer patients, the ALA and total omega-3 consumption was inversely associated with the development of depression.
* The application of omega-3 supplementation could be beneficial for hypercalcemia-associated bone resorption because it was observed that, in an animal model of apical periodontitis, omega-3 supplementation reduced bone resorption by the downregulation of the inflammatory cells influx.
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of cancer-related complications, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications by Freitas RDS1,2, Campos MM. (PubMed)
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
Most common cancer complications, depending on the types of cancer are
* Pain can be caused by cancer or by cancer treatment
* Fatigue.
* Difficulty breathing.
*Nausea.
*Diarrhea or constipation.
* Weight loss.
*Chemical changes in your body.
* Brain and nervous system problems.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the improvement of quality of life in cancer patients, researchers examined the omega-3 polyunsaturated fatty acids (PUFAs) effects on cancer complications
According to the medical literature* A systematic review demonstrated that a nutritional supplement enriched with fish oil decreased the symptoms of fatigue and pain in patients during chemo- and/or radiotherapy, probably due to reduced inflammatory status.
* A recent systematic review evaluated the effects of fish oil for cachexia in advanced cancer, concluding that clinical evidence is still uncertain due to a weak methodology and a large variation of fish oil dosages. However, fish oil supplementation could benefit postoperative recovery and reduce complications, such as impaired wound healing and infections.
* The plasmatic contents of omega-6/omega-3 and ALA/EPA were associated with muscle atrophy in cachectic cancer patients, indicating that these molecules may participate in the development of cancer cachexia.
* Regarding the participation of omega-3 in cancer-associated depression, it was observed that, in newly diagnosed Japanese lung cancer patients, the ALA and total omega-3 consumption was inversely associated with the development of depression.
* The application of omega-3 supplementation could be beneficial for hypercalcemia-associated bone resorption because it was observed that, in an animal model of apical periodontitis, omega-3 supplementation reduced bone resorption by the downregulation of the inflammatory cells influx.
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of cancer-related complications, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications by Freitas RDS1,2, Campos MM. (PubMed)
Friday, March 5, 2021
Omega -3 Fatty Acids Induce Weight Loss Naturally in Obese with Type 2 Diabetes
Today, the prevalence of extremely overweight and obese children caused by an unhealthy diet and lifestyle change over 2 decades of economic prosperity, in the southeast Asian population has raised concerns of the scientific community,
Overweight and obesity have reached epidemic proportions in many countries, affecting even younger age populations inducing an economic burden in the health care system for treatment of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).
Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.
Weight loss is a process that intentionally reduces the total body mass, through the decrease of fluid, body fat or adipose tissue or lean mass.
Due to the widespread obesity in North America (over 68% of the US population is either overweight or obese), many weight loss products were created by manufacturers.
The weight loss products is a 66 billion business in the US, according to the statistic provided by the Marketdata LLC research firm. And the business continues to grow at a rapid rate.
Are the weight loss products work? I don't think so. Otherwise, the percentage of the overweight population in the US should be decreased substantially.
In other words, all weight loss products may have a complex structure or a long-term commitment before the results can be seen.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of chronic diseases associated with obesity, researchers examined the relationship between levels of serum eicosapentaenoic acid (EPA), arachidonic acid (AA), as well as EPA/AA ratio and weight loss during hospitalization in participants considered to be overweight, with type 2 diabetes.
The study included 142 patients who were hospitalized for treatment of type 2 diabetes divided into two groups depending on the achievement in the reduction of body weight by 3% or more during hospitalization.
According to the tested analysis,
* After the adjustment was made for several confounders, the hazard ratio of effective weight loss for logarithmical serum EPA was 1.59 (95% CI 1.02-2.49, P = 0.04) and for logarithmical EPA/AA ratio 1.64 (1.03-2.61, P = 0.04), whereas the hazard ratio for effective weight loss for logarithmical serum AA was 1.11 (0.45-2.78, P = 0.82).
* Furthermore, after dividing EPA/AA ratio and serum EPA into quartiles based on participant number, the hazard ratio for the highest quartile of EPA/AA ratio was 2.33 for the highest quartile of serum EPA 1.60 (0.80-3.19, P = 0.18) compared with the lowest quartile.
More precisely, EPA is involved in body weight change under a caloric-restriction regimen.
In other words, a high serum level of EPA, relative to the level of AA, can lead to a reduction of adipose tissue weight through the anti-inflammatory effects of EPA.
Based on the finding, researchers said, " EPA/AA ratio was found to be a better predictor of medical intervention for weight loss among overweight patients with type 2 diabetes, compared with serum EPA level".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for inducing weight loss, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Eicosapentaenoic acid/arachidonic acid ratio and weight loss during hospitalization for glycemic control among overweight Japanese patients with type 2 diabetes: a retrospective observational study by Nakanishi S1, Hirukawa H2, Shimoda M2, Tatsumi F2, Kohara K2, Obata A2, Okauchi S2, Kinoshita T2, Sanada J2, Fushimi Y2, Nishioka M2, Kan Y2, Tomita A2, Mashiko A2, Horiya M2, Iwamoto Y2, Mune T2, Kaku K3, Kaneto H. (PubMed)
(2) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
Overweight and obesity have reached epidemic proportions in many countries, affecting even younger age populations inducing an economic burden in the health care system for treatment of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).
Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.
Weight loss is a process that intentionally reduces the total body mass, through the decrease of fluid, body fat or adipose tissue or lean mass.
Due to the widespread obesity in North America (over 68% of the US population is either overweight or obese), many weight loss products were created by manufacturers.
The weight loss products is a 66 billion business in the US, according to the statistic provided by the Marketdata LLC research firm. And the business continues to grow at a rapid rate.
Are the weight loss products work? I don't think so. Otherwise, the percentage of the overweight population in the US should be decreased substantially.
In other words, all weight loss products may have a complex structure or a long-term commitment before the results can be seen.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of chronic diseases associated with obesity, researchers examined the relationship between levels of serum eicosapentaenoic acid (EPA), arachidonic acid (AA), as well as EPA/AA ratio and weight loss during hospitalization in participants considered to be overweight, with type 2 diabetes.
The study included 142 patients who were hospitalized for treatment of type 2 diabetes divided into two groups depending on the achievement in the reduction of body weight by 3% or more during hospitalization.
According to the tested analysis,
* After the adjustment was made for several confounders, the hazard ratio of effective weight loss for logarithmical serum EPA was 1.59 (95% CI 1.02-2.49, P = 0.04) and for logarithmical EPA/AA ratio 1.64 (1.03-2.61, P = 0.04), whereas the hazard ratio for effective weight loss for logarithmical serum AA was 1.11 (0.45-2.78, P = 0.82).
* Furthermore, after dividing EPA/AA ratio and serum EPA into quartiles based on participant number, the hazard ratio for the highest quartile of EPA/AA ratio was 2.33 for the highest quartile of serum EPA 1.60 (0.80-3.19, P = 0.18) compared with the lowest quartile.
More precisely, EPA is involved in body weight change under a caloric-restriction regimen.
In other words, a high serum level of EPA, relative to the level of AA, can lead to a reduction of adipose tissue weight through the anti-inflammatory effects of EPA.
Based on the finding, researchers said, " EPA/AA ratio was found to be a better predictor of medical intervention for weight loss among overweight patients with type 2 diabetes, compared with serum EPA level".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for inducing weight loss, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Eicosapentaenoic acid/arachidonic acid ratio and weight loss during hospitalization for glycemic control among overweight Japanese patients with type 2 diabetes: a retrospective observational study by Nakanishi S1, Hirukawa H2, Shimoda M2, Tatsumi F2, Kohara K2, Obata A2, Okauchi S2, Kinoshita T2, Sanada J2, Fushimi Y2, Nishioka M2, Kan Y2, Tomita A2, Mashiko A2, Horiya M2, Iwamoto Y2, Mune T2, Kaku K3, Kaneto H. (PubMed)
(2) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
Thursday, March 4, 2021
Healthy Foods Brassica rapa Suppresses Oxidative Nephrotoxicity in Vitro and Vivo
Kidneys are 2 bean-shaped organs found on the left and right side in the retroperitoneal space in the body.
The function of kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.
Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.
The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.
According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.
And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.
Oxidative nephrotoxicity is a condition of kidney damage caused by overexpression of free radicals compared to levels of antioxidants.
Dr. Keiko Hosohata in the examining "Role of Oxidative Stress in Drug-Induced Kidney Injury",
Said, "Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury".
And "In fact, drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20% of cases of acute kidney injury (AKI) among hospitalized patients".
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of kidney diseases, researchers examined nephroprotective effects of 6-hydroxy-1-methylindole-3-acetonitrile (6-HMA), which was isolated from the roots of B. rapa, on cisplatin-induced toxicity in renal epithelial LLC-PK1 cells and in rats with acute renal injury
The study included 16subjects that were randomized, and fifteen subjects completed all visits.
According to the tested analysis, in vitro and Vivo
* The pretreatment of LLC-PK1 cells with 6-HMA ameliorated cisplatin-induced cytotoxicity caused by oxidative stress.
* The pretreatment also decreased the levels of reactive oxygen species (ROS) and kidney stress marker malondialdehyde (MDA) and increased levels of glutathione (GSH).
* Furthermore, 6-HMA inhibited cisplatin-induced heme oxygenase-1 (HO-1) expression involved in oxidation and inflammation by the binding activity of NF-E2-related factor 2 (Nrf2), the antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
* Moreover, 6-HMA administered rats showed lower levels of blood urea nitrogen (BUN), creatinine, and urinary lactate dehydrogenase (LDH) associated with kidney damage than cisplatin alone-treated rats in cisplatin-induced renal injury model.
* Additionally, 6-HMA inhibited the cisplatin-induced formation of MDA and GSH depletion and increased the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR).
Based on the results, researchers wrote, " these findings indicate 6-HMA is a major active constituent from the roots of B. Rapa to have a protective effect against cisplatin-induced nephrotoxicity by attenuating oxidative stress.".
Taken altogether, Brassica rapa processed abundantly 6-HMA may be considered supplements for the prevention of oxidative nephrotoxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation by Moon JH1, Shin JS, Kim JB, Baek NI, Cho YW, Lee YS, Kay HY, Kim SD, Lee KT. (PubMed)
(2) Role of Oxidative Stress in Drug-Induced Kidney Injury by Keiko Hosohata. (PMC)
The function of kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.
Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.
The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.
According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.
And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.
Oxidative nephrotoxicity is a condition of kidney damage caused by overexpression of free radicals compared to levels of antioxidants.
Dr. Keiko Hosohata in the examining "Role of Oxidative Stress in Drug-Induced Kidney Injury",
Said, "Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury".
And "In fact, drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20% of cases of acute kidney injury (AKI) among hospitalized patients".
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of kidney diseases, researchers examined nephroprotective effects of 6-hydroxy-1-methylindole-3-acetonitrile (6-HMA), which was isolated from the roots of B. rapa, on cisplatin-induced toxicity in renal epithelial LLC-PK1 cells and in rats with acute renal injury
The study included 16subjects that were randomized, and fifteen subjects completed all visits.
According to the tested analysis, in vitro and Vivo
* The pretreatment of LLC-PK1 cells with 6-HMA ameliorated cisplatin-induced cytotoxicity caused by oxidative stress.
* The pretreatment also decreased the levels of reactive oxygen species (ROS) and kidney stress marker malondialdehyde (MDA) and increased levels of glutathione (GSH).
* Furthermore, 6-HMA inhibited cisplatin-induced heme oxygenase-1 (HO-1) expression involved in oxidation and inflammation by the binding activity of NF-E2-related factor 2 (Nrf2), the antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
* Moreover, 6-HMA administered rats showed lower levels of blood urea nitrogen (BUN), creatinine, and urinary lactate dehydrogenase (LDH) associated with kidney damage than cisplatin alone-treated rats in cisplatin-induced renal injury model.
* Additionally, 6-HMA inhibited the cisplatin-induced formation of MDA and GSH depletion and increased the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR).
Based on the results, researchers wrote, " these findings indicate 6-HMA is a major active constituent from the roots of B. Rapa to have a protective effect against cisplatin-induced nephrotoxicity by attenuating oxidative stress.".
Taken altogether, Brassica rapa processed abundantly 6-HMA may be considered supplements for the prevention of oxidative nephrotoxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation by Moon JH1, Shin JS, Kim JB, Baek NI, Cho YW, Lee YS, Kay HY, Kim SD, Lee KT. (PubMed)
(2) Role of Oxidative Stress in Drug-Induced Kidney Injury by Keiko Hosohata. (PMC)
Wednesday, March 3, 2021
Lycopene Inhibits Pulmonary Emphysema in Vivo
The lung formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
Lung diseases are a group of medical conditions that cause the reduced function of the lung inhaling oxygen to the blood and exhaling carbon dioxide from the blood.
Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The most common pulmonary diseases are asthma, a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood; pneumothorax, a condition of collection of air within the pleural cavity, from either the outside or from the lung, and bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.
Emphysema is a type of COPD with a long-term and progressive condition that causes shortness of breath, depending on the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.
Most common causes of pulmonary emphysema, smoking, exposure to air pollution, such as chemical fumes, dust, and other substances, and irritating fumes and dust at work.
Dr. Stephen I. Rennard, the lead scientist wrote, "Emphysema is characterized by enlargement of alveolar spaces together with destruction of alveolar walls in the absence of obvious fibrosis (1). Far and away, the most common cause of pulmonary emphysema is cigarette smoking".
And, "Cigarette smoke causes an inflammatory response in the lower respiratory tract characterized by the accumulation of pigment-laden alveolar macrophages together with the recruitment of smaller numbers of neutrophils (1, 2)".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of colitis researchers examined the effects of lycopene on antioxidant and anti-inflammatory properties on emphysema.
Mice selected for the study were treated by two different doses of lycopene (25 or 50 mg/kg/day, diluted in sunflower oil by orogastric gavage before exposing to 60 days of CS or not (CG).
According to the tested analysis, lycopene not only promoted a reduction in the number of total leukocyte counts and improved patients with pulmonary emphysema.
Furthermore, lycopene promotes the balanced ratio of free radical and antioxidant enzymes by decreasing lipid peroxidation and DNA damage and increasing the activities of SOD, CAT, and GSH content.
Levels of TNF-α, IFN-γ, and IL-10. which were elevated by the injection of CS were also decreased by the application of lycopene.
Additionally, the decrease in myeloperoxidase activity and nitrite content. associated with overexpression of free radicals induced inflammation was also inhibited by the lycopene.
Based on the findings, researchers said, " our data elucidated the role of lycopene as an antioxidant and anti-inflammatory agent in mice exposed to CS".
Taken altogether, lycopene found in tomato may be considered a remedy for the prevention and treatment of pulmonary emphysema, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model by Campos KKD1, de Oliveira Ramos C1, Martins TL1, Costa GP2, Talvani A2, Garcia CCM3, Oliveira LAM4, Cangussú SD1, Costa DC5, Bezerra FS. (PubMed)
(2) Cigarette Smoke Inhibits Alveolar Repair. A Mechanism for the Development of Emphysema by Stephen I. Rennard , Shinsaku Togo , and Olaf Holz. (ATS Journals)
Tuesday, March 2, 2021
Angelica Sinensis Protects the liver Against Toxicity
The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.
The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins, including detoxification which is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs and weaken the immune system, leading to hormone imbalance and much chronic illness consequently.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
On finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the hepatoprotective effects of polysaccharides-enriched fractions from the root of Angelica sinensis in rodents.
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis,
* Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration.
* AP inhibited the liver stress markers alanine transferase (ALT), malondialdehyde (MDA) and hepatic nitric oxide synthase (NOS) activities and glutathione level in the liver.
* In the carbon tetrachloride (CCl4) induced liver damage animals, AP showed weak protective activity.
* However, a higher dose of AP inhibited the MDA level without affecting the serum ALT level, the hepatic glutathione level instead while the NOS activity in CCl4 induced liver damage in rats.
Based on the results, researchers suggest, "These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver".
Taken altogether, Dandelion may be considered a remedy for the protection against liver damage, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury by Ye YN1, Liu ES, Li Y, So HL, Cho CC, Sheng HP, Lee SS, Cho CH. (PubMed)
(2) Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism by Niu C1, Wang J, Ji L, Wang Z. (PubMed)
The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.
The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins, including detoxification which is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs and weaken the immune system, leading to hormone imbalance and much chronic illness consequently.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
On finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the hepatoprotective effects of polysaccharides-enriched fractions from the root of Angelica sinensis in rodents.
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis,
* Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration.
* AP inhibited the liver stress markers alanine transferase (ALT), malondialdehyde (MDA) and hepatic nitric oxide synthase (NOS) activities and glutathione level in the liver.
* In the carbon tetrachloride (CCl4) induced liver damage animals, AP showed weak protective activity.
* However, a higher dose of AP inhibited the MDA level without affecting the serum ALT level, the hepatic glutathione level instead while the NOS activity in CCl4 induced liver damage in rats.
Based on the results, researchers suggest, "These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver".
Taken altogether, Dandelion may be considered a remedy for the protection against liver damage, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury by Ye YN1, Liu ES, Li Y, So HL, Cho CC, Sheng HP, Lee SS, Cho CH. (PubMed)
(2) Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism by Niu C1, Wang J, Ji L, Wang Z. (PubMed)
Monday, March 1, 2021
Devil's club (Oplopanax horridus) influences on Gut Microbiota and Colorectal Cancer Cells
Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.
Gut microbiota or gastrointestinal microbiota, the complex community of microorganisms play a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
In a healthy individual, the levels of gut microbiota are balanced that allows the body to function in an optimal way.
Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.
However, alterations in gut microbiota composition have been found in patients with a low-grade inflammatory state, leading to an increased risk of several diseases, including type 2 diabetes mellitus and cardiovascular disease.
Overexpression of certain harmful bacterias in the gut such as E. coli can utilize a complex arsenal of virulence factors to colonize and persist in the intestine.
In other words, although the digestive tract can adapt to change, the loss of balance in gut microbiota may induce dysbiosis., leading to health problems of functional bowel disorders, inflammatory bowel disease, allergies, obesity, and diabetes.
The are many risk factors associated with gut microbiota imbalance. Some researchers suggested that the major causes of the condition may be a result of the promotion of a high-fat diet over the past few decades.
From the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.
Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America.
The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.
On finding a potential compound for improvement of digestive functioning, scientists examined the polyyne-enriched fraction (PEFO) from Devil's club effects on gut microbiota and colorectal cancer cells after oral administration.
According to the tested analysis,* The antiproliferative effects of PEFO incubated with human gut microbiota for 72 h (PEFO I) was much lower than that of PEFO on HCT-116, SW-480, and HT-29 cells.
* PEFO possessed better anti-CRC activity in vivo, and significantly induced apoptosis of the CRC cells, which was associated with activation of caspase-3 in the induction of apoptosis.
More precisely, the anti-colorectal cancer activity of polyynes might be antagonized by some bio-converted metabolites after incubation with human gut microbiota.
Collectively, researchers said, "Therefore, it might be better for CRC prevention if the polyynes could be orally administrated as purified compounds".
Taken altogether, coltsfoot may be considered a remedy for the protection of gut functioning in patients with colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemo-Preventive Potential of Falcarindiol-Enriched Fraction from Oplopanax elatus on Colorectal Cancer Interfered by Human Gut Microbiota by Wang J1,2, Shao L3, Rao T1,2, Zhang W1,2, Huang WH. (PubMed)
Gut microbiota or gastrointestinal microbiota, the complex community of microorganisms play a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
In a healthy individual, the levels of gut microbiota are balanced that allows the body to function in an optimal way.
Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.
However, alterations in gut microbiota composition have been found in patients with a low-grade inflammatory state, leading to an increased risk of several diseases, including type 2 diabetes mellitus and cardiovascular disease.
Overexpression of certain harmful bacterias in the gut such as E. coli can utilize a complex arsenal of virulence factors to colonize and persist in the intestine.
In other words, although the digestive tract can adapt to change, the loss of balance in gut microbiota may induce dysbiosis., leading to health problems of functional bowel disorders, inflammatory bowel disease, allergies, obesity, and diabetes.
The are many risk factors associated with gut microbiota imbalance. Some researchers suggested that the major causes of the condition may be a result of the promotion of a high-fat diet over the past few decades.
From the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.
Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America.
The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.
On finding a potential compound for improvement of digestive functioning, scientists examined the polyyne-enriched fraction (PEFO) from Devil's club effects on gut microbiota and colorectal cancer cells after oral administration.
According to the tested analysis,* The antiproliferative effects of PEFO incubated with human gut microbiota for 72 h (PEFO I) was much lower than that of PEFO on HCT-116, SW-480, and HT-29 cells.
* PEFO possessed better anti-CRC activity in vivo, and significantly induced apoptosis of the CRC cells, which was associated with activation of caspase-3 in the induction of apoptosis.
More precisely, the anti-colorectal cancer activity of polyynes might be antagonized by some bio-converted metabolites after incubation with human gut microbiota.
Collectively, researchers said, "Therefore, it might be better for CRC prevention if the polyynes could be orally administrated as purified compounds".
Taken altogether, coltsfoot may be considered a remedy for the protection of gut functioning in patients with colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemo-Preventive Potential of Falcarindiol-Enriched Fraction from Oplopanax elatus on Colorectal Cancer Interfered by Human Gut Microbiota by Wang J1,2, Shao L3, Rao T1,2, Zhang W1,2, Huang WH. (PubMed)
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