Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Thursday, February 27, 2020

Bioactive Compound Sinigrin Protects Us Against Microbial Infection

Sinigrin may be used as a natural and bioactive compound against microbial infection before it can spread, according to studies.

Microbial infection is a disease caused by microorganisms, including viruses, bacteria, fungi, or parasites.

Microbial infection includes 4 different stages
* Stage 1 or incubation stage
In stage 1, harmful microorganisms after successfully entering the host start to incubate on the specific site by the multiplying organism to reach a population, leading to an early stage of symptoms.

* Stage 2 or prodromal stage
After successfully multiplying, the organisms start to show symptoms of illness, depending on the location of the infection.

* Stage 3 or acute stage
The numbers of microorganism have grown exponentially, leading to very pronounced symptoms, also depending on the location and organ being infected.

* Stage 4 or convalescence stage is the recovery stage. The microorganism starts to decrease or are wiped out from the host.


In most cases, the recovery stage is the result of the use of antibiotics. The length of the 4 stages of microbial infection can be vary depending on the host immune system.

Most healthy adults can be recovered quickly without using antibiotics.

However, if the immune system or antibiotics used cannot wipe off all the micro invader in a specific time, approximately 3 to 8 weeks, it will lead to the compromise of the immune system, leading to chronic infection, such as asthma, airway inflammation, pneumonia, and other respiratory diseases.


Dr. Garth L. Nicolson in the differentiation of diseases associated with chronic infection, said, "Some infections, such as those caused by certain Mycoplasma and Chlaymdiaspecies that are invasive and are found in respiratory epithelial cells are able to suppress immune responses by suppressing the ability of pulmonary macrophages to ingest and kill these infectious agents".
Researchers on seeking a natural compound for the prevention and treatment of antimicrobial infection examined the ability of Listeria (L.) monocytogenes to convert glucosinolates into antimicrobial isothiocyanates.


During both tests with deodorized (myrosinase-inactivated) mustard extracts (10 d at 20 °C) or with purified sinigrin (21 d at 20 °C) L. monocytogenes only inhibited when exogenous myrosinase was added.

Pure sinigrin, oriental or yellow mustard extracts incorporated in polyvinyl polyethylene glycol graft copolymer (PPG) films containing 3, 5 and 6% (w/w) of the corresponding glucosinolate showed a 100% of microbial inhibition at 70 days.

The yellow mustard extract was less inhibitory and the pure sinigrin showed a significantly lesser antimicrobial activity in the absence of L. monocytogenes.


These results strongly suggested that L. monocytogenes played a key role in enhancing the antimicrobial activity of pure sinigrin and the yellow mustard extract.

In the test of tested on Escherichia coli O157:H7 using the nanocomposite carboxymethyl cellulose films containing sinigrin (SNG), prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG), transparent nanoparticulate carboxymethyl cellulose (CMC) films containing sinigrin (SNG), an antimicrobial precursor, controlled surface contamination of packaged fresh beef by the pathogen Escherichia coli O157:H7 stored at 8°C.

Furthermore, the films with nanoparticulation that carried pure SNG or the naturally occurring SNG in Oriental mustard were significantly more antimicrobial compared to similar films without nanoparticulation.


Dr. Herzallah S, the lead scientist said, " films without sinigrin were not antimicrobial" and "nanoparticulation of the packaging film enhanced delivery of the antimicrobial incorporated within the film".

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of microbial infection pending to the confirmation of large sample size and multicenter human study.


However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Use of a nanoparticulate carboxymethyl cellulose film containing sinigrin as an antimicrobial precursor to kill Escherichia coli O157:H7 on fresh beef by Herzallah S1, Holley R. (PubMed)
(2) Inhibition of Listeria monocytogenes on bologna sausages by an antimicrobialfilm containing mustard extract or sinigrin by Lara-Lledó M1, Olaimat A, Holley RA. (PubMed)
(3) Infectious Disease Research, Chronic Infectious Diseases by Prof. Garth L. Nicolson

Cabbage Protects the Blood Vessel Against Vascular Inflammation

Blood vessels formed part of the circulatory system are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

Atherosclerosis is characterized by chronic inflammation of the vascular wall.

Chronic vascular inflammation has been found to cause historical changes in the blood vessel walls, leading to blood vessel wall thickening, weakening, narrowing or scarring on orchestrating blood flow restriction, resulting in organ and tissue damage.

Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.

Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage of the body through activating the protein associated with the production of pro-inflammatory cytokines.

The production of proinflammatory cytokines induced by the immune response is to kill the invasive pathogens, which try to enter the body through the wound.

In the acute phase of infection, the immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness and fever.

Chronic inflammation is a serious condition caused by the immune system to adapt to the new change due to its inability to kill all the invasion within a set of times.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find natural food that inhibits inflammation, researchers examined the anti-inflammatory activities of an anthocyanin-rich extract from red Chinese cabbage (ArCC).

According to the inhibitory effects in cultured endothelial cells and hyperlipidemic apolipoprotein E-deficient mice, ArCC treatment suppressed monocyte adhesion to tumor necrosis factor-α, the pro-inflammatory cytokines -stimulated endothelial cells.

Furthermore, ArCC's also processed the ability to downregulate the expression and transcription of endothelial adhesion molecules associated with the increased response to cytokines and other inflammatory mediators.

Moreover, the regulation of adhesion molecules was accompanied by transcriptional inhibition of nuclear factor-κB, which restricted cytoplasmic localization in triggering inflammation.

Additionally, Administration of ArCC (150 or 300 mg/kg/day) inhibited aortic inflammation in hyperlipidemic apolipoprotein E-deficient mice,

More precisely, ArCC markedly lower leukocyte infiltration, reduced plaque formation and lowered concentrations of blood inflammatory cytokines compared to control mice.

Based on the results, researchers wrote, " ...the consumption of anthocyanin-rich red Chinese cabbage is closely correlated with lowering the risk of vascular inflammatory diseases.".
Taken altogether, Korean cabbage kimchi may be used for the treatment of vascular inflammation, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular Inflammation in Endothelial Cells and Apo E-/- Mice by Joo HK1, Choi S2, Lee YR3, Lee EO4, Park MS5, Park KB6, Kim CS7, Lim YP8, Park JT9, Jeon BH. (PubMed)

Wednesday, February 26, 2020

Lycopene, the Anti-Gastroesophageal Reflux Disease (GERD) Phytochemical

Acid Reflux or heartburn is a condition characterized by the going back up of acidic stomach contents to the esophagus.

Most cases of acid reflux are happened immediately after eating causing a burning sensation or pain in the lower chest area.

According to the statistics, in the US, approximately, 20% of people with acid reflux will develop gastroesophageal reflux disease (GERD).

More than 65% of people who suffer from acid reflux are 40 years old or older. And, 15 to 30 5 of the U.S. population has GERD.

There is no single cause of GERD. Epidemiologically, eating large meals or lying down right after a meal, snacking close to bedtime, smoking, being overweight or obese, overeating certain foods such as citrus, tomato, chocolate, mint, garlic, onions, or spicy or fatty foods are some prevalent factors associated with the risk of GERD.

Furthermore, long-term intake of certain medications such as bronchodilators for asthma, progestin for birth control or to treat abnormal menstrual bleeding, sedatives for insomnia and anxiety, calcium channel blockers for high blood pressure.


First-time pregnancy women may also experience GERD caused by increasing levels of hormones combined with pressure from the growing fetus.


Dr. P J Kahrilas and colleagues in examing the smoking risk associated with the onset of GERD wrote, "Studies were done to evaluate the lower oesophageal sphincter function of chronic smokers compared with non-smokers and to ascertain the acute effects of smoking on the sphincter and the occurrence of acid reflux".

And, "The mechanisms of acid reflux during cigarette smoking were mainly dependent upon the coexistence of diminished lower oesophageal sphincter pressure. Fewer than half of reflux events occurred by transient lower oesophageal sphincter relaxations. The majority of acid reflux occurred with coughing or deep inspiration during which abrupt increases in intra-abdominal pressure overpowered a feeble sphincter".

Therefore, if you currently a smoker, your risk GERD is substantially higher compared to non-smokers.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of gastroesophageal reflux disease (GERD), researchers examined the role of lycopene on experimental reflux esophagitis.

Selected rats included in the study groups of rats induced esophagitis treated by lycopene (50 and 100 mg/kg, po) and pantoprazole (30 mg/kg, po).

Based on the tested analysis, treatment with lycopene showed physiological protection when scrutinized for pH, acidity (total and free), the volume of gastric juices and esophagitis index.

Furthermore, lycopene also protected the esophagus tissue by inhibiting the expression of oxidative stress against lipid and protein peroxidation and enhancing the production of the enzymatic activity of SOD and catalase.

Moreover, levels of pro-inflammatory cytokines were also diminished observed in the lycopene treatment group.

The efficacy of lycopene in the protection of gastroesophageal reflux disease (GERD) was dose-dependent.

Based on the findings, researchers said, "lycopene can impart momentous protection against experimental esophagitis by wrapping up the reactive oxygen species and through dual inhibition of the arachidonic acid pathway".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of gastroesophageal reflux disease (GERD), pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of lycopene against gastroesophageal reflux disease in experimental animals by Giri AK1, Rawat JK2, Singh M3, Gautam S4, Kaithwas G. (PubMed)
(2) Mechanisms of acid reflux associated with cigarette smoking by P J Kahrilas and R R Gupta. (PMC)

Green-Plant Membrane inhibits the Onset of Hypertriglyceridemia

Triglycerides are accumulated in the blood for future use by converting any unused calories.

In other words, triglycerides are an ester derived from glycerol and three fatty acids (from tri- and glyceride).

Overexpression of hyperglyceridemia is found to patients with atherosclerosis even without the presence of high cholesterol levels, and predispose.

Hypertriglyceridemia is a condition characterized by high levels of triglycerides in the blood.

Hypertriglyceridemia can also be accumulated to the arterial wall or combined with other substances to form plaque that narrows the arteries in transporting rich oxygenated blood to the heart and other parts of the body, leading to the onset of atherosclerosis.

Primary hypertriglyceridemia is found in 5% of patients associated with genetic preposition compared to 95% of secondary hypertriglyceridemia found in obese metabolic syndrome, diabetes,... patients.

Treating hypertriglyceridemia is difficult, as the condition is frequent coexistence with other conditions that affect cardiovascular disease risks, such as high levels of low-density lipoprotein, obesity, metabolic syndrome, and type 2 diabetes.

In severe cases of hypertriglyceridemia, patients may also experience the complication of acute pancreatitis, independent of the risk of CVD.


On finding a potential wholefood for the treatment of diabetes, researchers examined the effects of the once-daily intake of the green-plant membrane with dietary oil on postprandial hypertriglyceridemia in vitro and in vivo.

In vitro, green-plant membrane-bound hydrophobic bile acids but did not inhibit pancreatic lipase activity.

The green-plant membrane in rats, oral fat tolerance tests, increased serum triglycerides levels were significantly reduced.

Moreover, fecal total lipid and bile acid volumes were significantly increased in rats that administered 200 mg/mL green-plant membrane.

Based on the evidence, researchers said, "...green-plant membrane with dietary oil inhibits dietary fat absorption via promotion of bile acid excretion in feces and the effectiveness of eating green-plant membrane, such as green leafy vegetables, with meals".


Taken altogether, the green-plant membrane may be considered a functional food for the prevention of hypertriglyceridemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Intake of green-plant membrane with dietary oil suppresses postprandial hypertriglyceridemia in rats via promoting excretion of bile acids by Matsuda H1, Ooi S1, Otokozawa R1, Kumazaki K1, Udagawa E1, Asakura M1, Suzuki D1, Shirai T. (PubMed)

Tuesday, February 25, 2020

Oleanolic Acid Gobbles Up Liver Cancer Cells in Vitro

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction partly or completely the function of the liver, including liver failure.

Liver disease is a process of reduced function of the liver acutely or gradually.

Liver cancer is a chronic liver disease associated with irregular cell growth that starts in the cells on the surface of the liver's inner lining tissue, before penetrating into deeper layers to form tumors through cell proliferation.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some form of liver disease.

Believe it or not, 95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

The most common signs and symptoms of liver disease are jaundice, abdominal pain, and swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool and tendency to bruise easily.

Primary liver cancer is a medical condition caused by irregular cell growth in the liver tissue as a result of the alternation of cell DNA.

According to the statistics, in 2019, approximately, 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with primary liver cancer is increased by approximately 3% annually.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that processes anti-cancer activity researchers examined the anti liver cancer effects of a natural compound oleanolic acid.


The study included human HepG2 liver cancer cells that were treated with various concentrations of oleanolic acid for 24 h.

According to the results of the analysis,
* Oleanolic acid decreased the viability of the liver cancer HepG2 cells and exhibited an IC50 of 30 µM.
* Oleanolic acid exerted very low toxic effects on normal liver cells AML12 cells and exhibited an IC50 of 120 µM.

* Furthermore, oleanolic acid also caused remarkable changes in the morphology of the HepG2 cells and inhibited their colony formation potential.

* Moreover, oleanolic acid triggered G2/M arrest and prompted apoptosis of the HepG2 cells.

* Additionally, oleanolic acid also increased the apoptotic cells from 2.2% in control to around 35% at 30 µM concentration.

* Oleanolic acid also suppressed the migration and invasion of the liver cancer cells.
Collectively, researchers said, "The results of the current research revealed that oleanolic acid can be a molecule that may be utilized in the treatment of liver cancer in the future".

Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of cancer cell growth by oleanolic acid in multidrug resistant liver carcinoma is mediated via suppression of cancer cell migration and invasion, mitochondrial apoptosis, G2/M cell cycle arrest and deactivation of JNK/p38 signalling pathway by Gao C1, Li X, Yu S, Liang L. (PubMed

Herbal Dandelion(Taraxacum officinale) Promotes Gastric Emptying and Smooth Muscle Motility

The digestive system including the gastrointestinal (GI) tract, the liver, pancreas, and gallbladder processes the function to digest foods and transfer the nutrients and fluids to the body's needs.

There is no single cause of the gastrointestinal disorder. Researchers suggested that the cause of the disorder can be attributed directly to the digestive system, or other systemic problems that facilitate the onset of disease.

However, according to the epidemiological studies, bacterial infection, viral infection, inflammation, muscle dysfunction, gallstones, stress, and intake of certain anti-inflammatory drugs are associated with the onset of the acute and chronic digestive disorders.

Dietary factors also play an important in the reduction and promotion of digestive dysfunction. People who are overeating, eating too much fatty food, not consuming enough fiber, and consuming too much alcohol and smoking are at a higher risk of digestive diseases, including ulcers and gastric acid reflux.

Gastric emptying is a test that measures the time that takes for food to empty from the stomach and enter the small intestine. The test is used to find out why your child is vomiting, having stomach pain or not gaining weight.

Gastrointestinal motility is the contraction of the smooth muscles of the gastrointestinal tract.

The gastroprotective effect is a process involved enhancing the function of the digestive system against the harmful organisms in induced chronic digestive disorder.

People with digestive problems may experience certain stomach discomfort, including bloating. constipation. diarrhea. heartburn, nausea and vomiting,.......and belly pain.

Untreated digestive problems over the long term can induce serious ailments of chronic illnesses, as the digestive system no longer performs its functions in provided nutrients and fluids to the needs of the body's cells and tissue.

The results of malnutriments over a long period of time can lead to weakened immune defense and reduced levels of antioxidants produced by tissues of the body in fighting against pathogens,


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the improvement of digestive functioning, scientists examined the effects of Taraxacum officinale (TO) is a traditional herbal medicine on gastric emptying (GE) and smooth muscle motility.

According to the administration of ethyl acetate fraction (EA), n-butanol fraction (BF), and aqueous fraction (AF) prepared in succession from 70% ethanol extract (EE) of TO in phenol red meal adopt mice,
* The percentage of GE was 48.8 ± 6.1% (vehicle control), 75.3 ± 6.5% (cisapride positive control), 68.0±6.7% (EE), 53.3±6.0% (EA), 54.1±6.3% (AF), and 86.0±6.5% (BF).

* Furthermore, BF was most effective in accelerating GE, compared to others.


* Moreover, the stimulatory effect of BF on GE was also supported by the observation that BF increased spontaneous contraction of gastric fundus and antrum and decreased the spontaneous motility of pyloric sphincter in vitro.

Based on the findings, researchers said, "BF seems to be a promising prokinetic agent. BF-induced increase in the contraction of fundus and antrum contributes to an increase in the intra-gastric pressure. BF-induced decrease in the motility of pyloric sphincter contributes to a decrease in the resistance of food from the stomach to the small intestine"

And "The acceleration of GE by BF is likely to be exerted through cholinergic stimulation".

Taken altogether, Dandelion that processed the aforementioned chemical compounds may be considered a gastric emptying and smooth muscle motility remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents by Jin YR1, Jin J, Piao XX, Jin NG. (PubMed)

Monday, February 24, 2020

Cranberry in the Promotion of Digestive Health

The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.


Digestion is a process of the digestive system by breaking down food for nutrients through mechanical and enzymatic action.

Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.

Under normal conditions, gut microbiota plays a critical role in overall health, including improving the absorption of the dietary nutrients of the digestive system, protecting the body against xenobiotics and drug toxicity through facilitating the excretion.

Furthermore, the gut microbiota also involved in the maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

In immunomodulation, gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.

Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".

And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of digestive health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function.

According to the tested differentiation, cranberry anthocyanidins only interfered with the colonization of the gut by Escherichia coli in vitro but also attenuated gut barrier dysfunction caused by dietary insults in vivo.

The efficacy of cranberry anthocyanidins in the promotion of gut microbiota in the flavor of the good bacterias was attributed by the synergic activity between these proanthocyanidins, other cranberry components such as isoprenoids and xyloglucans.


Moreover, cranberry constituents and their bioactive catabolites also have a strong effect on bacterial adhesion, coaggregation, and biofilm formation that may contribute clinical benefits on gastrointestinal and urinary tract infections,

Additionally, cranberry constituents and their bioactive catabolites also processed strong anti-inflammatory actions by mediating the gut microbiome.

Taken altogether, cranberry may be considered a remedy for the improvement of the digestive health, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MeseaNeto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(2) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang, Sha Li and Ren-You Gan. (Research Gate)