Mitochondrial dysfunction is a condition that affects the organelles in the generated energy for the cell.
More precisely, mitochondria perform cellular respiration, by taking nutrients from the cell, breaking it down, and turning it into energy.
Mitochondria are the cells that convert food molecules into energy in the body. Mitochondria produce 90 percent of the energy for the body's function.
Furthermore, mitochondrial also play a critical role to induce the older or damaged cells to release cytochrome C, which activates enzymes involved in cell apoptosis.
Moreover, mitochondria also play an essential role in calcium absorption and calcium release that regulates cellular metabolism, steroid synthesis, and hormone signalings.
The genetic proposition that causes mitochondrial dysfunction has been found to alter the process of mitochondria in converting oxygen and food to energy in some people.
Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer.
Most common symptoms of mitochondrial dysfunction include poor growth, muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, and mental retardation depending on the location of the infected cells.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a natural compound for the protection of mitochondrial function, researchers examined the effect of lycopene on preventing mitochondrial dysfunction during the d Galactosamine/lipopolysaccharide (d-GalN/LPS)-induced fulminant hepatic failure (FHF).
Based on the tested analysis, administration of d-GalN/LPS (300 mg and 30 μg/kg body weight, respectively) to the experimental rats showed a significant effect on several disturbances in mitochondrial function.
In other words, d-GalN/LPS administration not only increased the levels of lipid peroxidation and hydrogen peroxidation but also decreased the levels of mitochondrial antioxidants, tricarboxylic acid (TCA) cycle that release stored energy through the oxidation, and electron transport chain enzymes associated with cellular detoxification and the cellular adenosine triphosphate (ATP) that provides energy to drive many processes in living cells,.
However, lycopene (10 mg/kg body weight for 6 days) pretreatment showed strong activity in attenuating the lipid peroxidation and prohibiting the excessive synthesis of hydrogen peroxide.
Furthermore, lycopene also inhibited the GalN/LPS-induced impairment in ATP production. Parameters associated with reduced mitochondrial function were effectively prevented by the lycopene administration.
More precisely, the mitochondrial protection of lycopene was mainly attributed to the strong antioxidant potential of its phytonutrient by preventing lipid peroxidation in the mitochondrial membrane.
Based on the results researchers said, "The carotenoid lycopene combatted oxidative stress, scavenged free radicals, prevented ROS generation, and inhibited the toxic effects of d-GalN/LPS during FHF".
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of mitochondrial dysfunction, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Prevents Mitochondrial Dysfunction during d-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Albino Rats by Sheriff SA1, Shaik Ibrahim S2, Devaki T1, Chakraborty S3, Agarwal S4, Pérez-Sánchez H. (PubMed)
(2) Lycopene induces apoptosis in Candida albicans through reactive oxygen species production and mitochondrial dysfunction by Choi H1, Lee DG. (PubMed)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Monday, May 23, 2022
Friday, May 13, 2022
Omega-3 Fatty Acids Improve the Symptoms of Rheumatoid Arthritis
Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many elders.
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.
A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.
There is no single cause of RA. Changes in the female hormonal environment such as in pregnancy, breastfeeding and the use of the oral contraceptive (OC) pill appear to have a role. Cigarette smoking has been associated with a consistently increased risk that might also apply to the passive inhalation of smoke. Occupation probably has a minor influence, although exposure to silica dust is of aetiological importance. Recent studies have highlighted the role of diet, with suggestions that diets high in caffeine, low in antioxidants, and high in red meat may contribute to an increased risk.
The most plausible environmental exposure is an infection and although several decades of study have produced few definitive candidate organisms, Epstein-Barr virus (EBV) remains an interesting target(22).
According to the CDC, Musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.
Patients with rheumatoid arthritis (RA) often associate with valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot.
The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, and joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...
Long-term bone damage and the prolonged onset of the disease can induce deformities of the hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.
The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.
Furthermore, rheumatoid nodules, lumps on the skin, and close to the joint have been found to affect the joints of patients with RA.
Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of rheumatoid arthritis, researchers evaluated the effects of omega -3 fatty acids on rheumatoid arthritis (RA).
The meta-analysis includes reviewing the published randomized controlled trials (RCTs) associated with potential changes in RA disease activity, inflammation, and CVD risk.
According to the results of 20 RCTs, involving 717 patients with RA in the intervention group and 535 RA patients in the control group,* Consumption of ω-3 fatty acids was found to significantly improve eight disease-activity-related markers.
* Regarding inflammation, only leukotriene B4 was reduced compared to other pro-inflammatory markers.
* Omega 3 fatty acids were found to reduce blood triacylglycerol levels.
Collectively, researchers said, "The beneficial properties of ω-3 polyunsaturated fatty acids on RA disease activity confirm the results of previous meta-analyses. Among the five proinflammatory markers evaluated, only leukotriene B4 was found to be reduced. However, a positive effect on the blood lipid profile of patients with RA was evident".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis by Gioxari A1, Kaliora AC2, Marantidou F1, Panagiotakos DP. (PubMed)
(2) The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial by Rajaei E1, Mowla K, Ghorbani A, Bahadoram S, Bahadoram M, Dargahi-Malamir M. (PubMed)
(3) Risk factors for the development of rheumatoid arthritis by Oliver JE1, Silman AJ. (PubMed)
The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many elders.
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.
A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.
There is no single cause of RA. Changes in the female hormonal environment such as in pregnancy, breastfeeding and the use of the oral contraceptive (OC) pill appear to have a role. Cigarette smoking has been associated with a consistently increased risk that might also apply to the passive inhalation of smoke. Occupation probably has a minor influence, although exposure to silica dust is of aetiological importance. Recent studies have highlighted the role of diet, with suggestions that diets high in caffeine, low in antioxidants, and high in red meat may contribute to an increased risk.
The most plausible environmental exposure is an infection and although several decades of study have produced few definitive candidate organisms, Epstein-Barr virus (EBV) remains an interesting target(22).
According to the CDC, Musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.
Patients with rheumatoid arthritis (RA) often associate with valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot.
The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, and joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...
Long-term bone damage and the prolonged onset of the disease can induce deformities of the hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.
The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.
Furthermore, rheumatoid nodules, lumps on the skin, and close to the joint have been found to affect the joints of patients with RA.
Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of rheumatoid arthritis, researchers evaluated the effects of omega -3 fatty acids on rheumatoid arthritis (RA).
The meta-analysis includes reviewing the published randomized controlled trials (RCTs) associated with potential changes in RA disease activity, inflammation, and CVD risk.
According to the results of 20 RCTs, involving 717 patients with RA in the intervention group and 535 RA patients in the control group,* Consumption of ω-3 fatty acids was found to significantly improve eight disease-activity-related markers.
* Regarding inflammation, only leukotriene B4 was reduced compared to other pro-inflammatory markers.
* Omega 3 fatty acids were found to reduce blood triacylglycerol levels.
Collectively, researchers said, "The beneficial properties of ω-3 polyunsaturated fatty acids on RA disease activity confirm the results of previous meta-analyses. Among the five proinflammatory markers evaluated, only leukotriene B4 was found to be reduced. However, a positive effect on the blood lipid profile of patients with RA was evident".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis by Gioxari A1, Kaliora AC2, Marantidou F1, Panagiotakos DP. (PubMed)
(2) The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial by Rajaei E1, Mowla K, Ghorbani A, Bahadoram S, Bahadoram M, Dargahi-Malamir M. (PubMed)
(3) Risk factors for the development of rheumatoid arthritis by Oliver JE1, Silman AJ. (PubMed)
Thursday, May 5, 2022
Beta-Sitosterol Protects the Kidney Against Acute Nephrotoxicity
Kidneys are two bean-shaped organs located below the rib cage, one on each side of your spine with a function to filter out blood and remove waste through urinary secretion.
The kidney also plays a critical in maintaining the levels of fluids in the body, by removing extra fluids to make urine.
Furthermore, the kidney also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.
The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.
According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.
And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.
According to the information provided by the WHO, each year, around 1.7 million people are thought to die from acute kidney injury. Overall, therefore, an estimated 5–10 million people die annually from kidney disease.
Furthermore, in 2010, an estimated 2.3–7.1 million people with end-stage kidney disease died without access to chronic dialysis.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of kidney diseases, researchers elucidated the effects of plant sterol β-sitosterol on acute nephrotoxicity.
In vivo, the male albino Wistar rats were randomly grouped into four:
* Group 1 was vehicle control rats (0.1% carboxymethyl cellulose [CMC]);
* Group 2 was rats treated with N-diethylnitrosamine (DEN) (200 mg/kg body weight [bw] i.p. on the 15th day) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg BW i.p. on 30th and 32nd days);
* Group 3 was rats that received β-sitosterol (20 mg/kg BW in 0.1% CMC, p.o. for 32 days) 2 weeks prior to the exposure to the nephrotoxins; and
* Group 4 was rats that received β-sitosterol alone.
According to the experimental results that were terminated after the 24 h of the last dosage of Fe-NTA, and all the animals were sacrificed,
* DEN and Fe-NTA treated animals induced the elevated parameters of stress markers, reduced antioxidant and increased lipid peroxidation and inflammatory markers in the kidney.
* However, the β-sitosterol pretreated group restored all altered biochemical parameters back to near normal by upregulating the function of antioxidant enzyme protein Nrf2 expression.
Based on the findings, researchers said, "Administration of β-sitosterol to nephrotoxicity induced rats showed significant positive changes in biochemical parameters, histopathological and immunohistochemical observations, and up-regulation of Nrf2 gene expression".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of acute nephrotoxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats by Sharmila R, Sindhu G, Arockianathan PM. (PubMed)
The kidney also plays a critical in maintaining the levels of fluids in the body, by removing extra fluids to make urine.
Furthermore, the kidney also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.
The disease is caused by a poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.
According to the American physician association, long term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.
And people with age over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.
According to the information provided by the WHO, each year, around 1.7 million people are thought to die from acute kidney injury. Overall, therefore, an estimated 5–10 million people die annually from kidney disease.
Furthermore, in 2010, an estimated 2.3–7.1 million people with end-stage kidney disease died without access to chronic dialysis.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.
On finding a potential phytochemical for the prevention and treatment of kidney diseases, researchers elucidated the effects of plant sterol β-sitosterol on acute nephrotoxicity.
In vivo, the male albino Wistar rats were randomly grouped into four:
* Group 1 was vehicle control rats (0.1% carboxymethyl cellulose [CMC]);
* Group 2 was rats treated with N-diethylnitrosamine (DEN) (200 mg/kg body weight [bw] i.p. on the 15th day) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg BW i.p. on 30th and 32nd days);
* Group 3 was rats that received β-sitosterol (20 mg/kg BW in 0.1% CMC, p.o. for 32 days) 2 weeks prior to the exposure to the nephrotoxins; and
* Group 4 was rats that received β-sitosterol alone.
According to the experimental results that were terminated after the 24 h of the last dosage of Fe-NTA, and all the animals were sacrificed,
* DEN and Fe-NTA treated animals induced the elevated parameters of stress markers, reduced antioxidant and increased lipid peroxidation and inflammatory markers in the kidney.
* However, the β-sitosterol pretreated group restored all altered biochemical parameters back to near normal by upregulating the function of antioxidant enzyme protein Nrf2 expression.
Based on the findings, researchers said, "Administration of β-sitosterol to nephrotoxicity induced rats showed significant positive changes in biochemical parameters, histopathological and immunohistochemical observations, and up-regulation of Nrf2 gene expression".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of acute nephrotoxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats by Sharmila R, Sindhu G, Arockianathan PM. (PubMed)
Sunday, May 1, 2022
Omega-3 Fatty Acids Induce Apoptosis in Mammary Cancer Cells in Vitro
Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
The mammary gland located in the breasts of females is responsible for lactation.
Both males and females have glandular tissue within the breasts; however, in females, the glandular tissue begins to develop after puberty in response to estrogen release.
A mammary tumor is a medical and chronic condition that originated from the milk-producing gland.
The mammary gland located in the breasts of females is responsible for lactation.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases that which breast cancer starts in other areas of the breast.
In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of mammary cancer are first found in the cell on the surface of the inner lining of the milk-producing gland, before penetrating deeper into the layers.
At the advanced stage, the malignant cancer cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
Epidemiologically, mammary cancer has been found to spread to the colon and the liver.
Most common risk factors of mammary cancer are similar to those of breast cancer, including, aging, physical inactivity, being obese or overweight, family and personal history, having a dense breast, radiation therapy, pregnancy history, genetic proposition, particularly in women who had used drug diethylstilbestrol (DES).
Conventionally, treatment of mammary gland cancer is totally dependent on the stage and grade of cancer, including surgery, radiation therapy, chemotherapy, or a combination.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of breast cancer, researchers examined the effects of omega 3 on the signaling pathway impacted by syndecan-1 (SDC-1) induced apoptosis in vitro and Vivo.
According to the tested analysis,* In MCF-7 cells and SK-BR-3 cells, DHA and an SDC-1 ectodomain impaired signaling of the p44/42 mitogen-activated protein kinase (MAPK) pathway associated with mitogens, and growth factors and pro-apoptotic protein to induce apoptosis.
* In Fat-1 mice that is a genetic model able to convert n-6 to n-3 PUFA to result in higher SDC-1 levels in Fat-1 mammary tissue compared with that of wild-type (wt) mice, which showed a lower level of apoptosis compared to elevated signaling of the p44/42 mitogen-activated protein kinase (MAPK) in MCF-7 cells and SK-BR-3 cells.
* Moreover, SDC-1(-/-) mice demonstrated markedly higher levels of mitogens, growth factors, and pro-apoptotic protein in mammary gland tissue compared with those of SDC(+/+) mice.
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway by Sun H1, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. (PubMed)
The mammary gland located in the breasts of females is responsible for lactation.
Both males and females have glandular tissue within the breasts; however, in females, the glandular tissue begins to develop after puberty in response to estrogen release.
A mammary tumor is a medical and chronic condition that originated from the milk-producing gland.
The mammary gland located in the breasts of females is responsible for lactation.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases that which breast cancer starts in other areas of the breast.
In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of mammary cancer are first found in the cell on the surface of the inner lining of the milk-producing gland, before penetrating deeper into the layers.
At the advanced stage, the malignant cancer cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
Epidemiologically, mammary cancer has been found to spread to the colon and the liver.
Most common risk factors of mammary cancer are similar to those of breast cancer, including, aging, physical inactivity, being obese or overweight, family and personal history, having a dense breast, radiation therapy, pregnancy history, genetic proposition, particularly in women who had used drug diethylstilbestrol (DES).
Conventionally, treatment of mammary gland cancer is totally dependent on the stage and grade of cancer, including surgery, radiation therapy, chemotherapy, or a combination.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of breast cancer, researchers examined the effects of omega 3 on the signaling pathway impacted by syndecan-1 (SDC-1) induced apoptosis in vitro and Vivo.
According to the tested analysis,* In MCF-7 cells and SK-BR-3 cells, DHA and an SDC-1 ectodomain impaired signaling of the p44/42 mitogen-activated protein kinase (MAPK) pathway associated with mitogens, and growth factors and pro-apoptotic protein to induce apoptosis.
* In Fat-1 mice that is a genetic model able to convert n-6 to n-3 PUFA to result in higher SDC-1 levels in Fat-1 mammary tissue compared with that of wild-type (wt) mice, which showed a lower level of apoptosis compared to elevated signaling of the p44/42 mitogen-activated protein kinase (MAPK) in MCF-7 cells and SK-BR-3 cells.
* Moreover, SDC-1(-/-) mice demonstrated markedly higher levels of mitogens, growth factors, and pro-apoptotic protein in mammary gland tissue compared with those of SDC(+/+) mice.
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway by Sun H1, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. (PubMed)
Friday, April 22, 2022
Phytochemical Tocopherol, A Potential Ingredient for the Treatment of Hyperlipidemia
Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, and produces vitamin D and steroid hormones.
Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.
In other words, hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.
High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.
Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.
There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.
Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent causes of hyperlipidemia in the Western world.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.
On finding a potential phytochemical for the treatment of chronic diseases, researchers compared the effect of consumption of virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complimentary ones from thyme (FVOOT) could improve HDL status and function. Thirty-three hypercholesterolemic individuals ingested (25 ml/day, 3 weeks) (a) VOO (80 ppm), (b) FVOO (500 ppm), and (c) FVOOT (500 ppm) on HDL-related markers.
According to the results of the randomized, double-blind, controlled, crossover trial, α-tocopherol, the main HDL antioxidant, was only augmented after FVOOT versus its baseline.
In other words, the complementary phenol-enriched olive oil is the one that increased the main HDL antioxidant, α-tocopherol.
Long-term consumption of phenol-enriched olive oils showed a strong implication on the improvement of HDL antioxidant content.
Therefore, complementary phenol-enriched olive oil could be a useful dietary tool for improving HDL richness in antioxidants.
Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial by Farràs M1, Fernández-Castillejo S2, Rubió L3, Arranz S4, Catalán Ú2, Subirana I5, Romero MP6, Castañer O7, Pedret A8, Blanchart G9, Muñoz-Aguayo D7, Schröder H10, Covas MI11, de la Torre R12, Motilva MJ6, Solà R2, Fitó M. (PubMed)
Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.
In other words, hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.
High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.
Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.
There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.
Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent causes of hyperlipidemia in the Western world.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.
On finding a potential phytochemical for the treatment of chronic diseases, researchers compared the effect of consumption of virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complimentary ones from thyme (FVOOT) could improve HDL status and function. Thirty-three hypercholesterolemic individuals ingested (25 ml/day, 3 weeks) (a) VOO (80 ppm), (b) FVOO (500 ppm), and (c) FVOOT (500 ppm) on HDL-related markers.
According to the results of the randomized, double-blind, controlled, crossover trial, α-tocopherol, the main HDL antioxidant, was only augmented after FVOOT versus its baseline.
In other words, the complementary phenol-enriched olive oil is the one that increased the main HDL antioxidant, α-tocopherol.
Long-term consumption of phenol-enriched olive oils showed a strong implication on the improvement of HDL antioxidant content.
Therefore, complementary phenol-enriched olive oil could be a useful dietary tool for improving HDL richness in antioxidants.
Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial by Farràs M1, Fernández-Castillejo S2, Rubió L3, Arranz S4, Catalán Ú2, Subirana I5, Romero MP6, Castañer O7, Pedret A8, Blanchart G9, Muñoz-Aguayo D7, Schröder H10, Covas MI11, de la Torre R12, Motilva MJ6, Solà R2, Fitó M. (PubMed)
Friday, April 15, 2022
Low Levels of Omega-3 Fatty Acids Are Associated with Increased Risk of Atherosclerosis
Cardiovascular disease refers to heart diseases, affecting millions of people in the world.
According to statistics, over 17.7 million people died from CVDs in 2015.
The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.
Most cases of heart disease in the Western world are associated with atherosclerosis.
In other words, atherosclerosis is a leading cause of coronary heart disease (CHD).
According to the 2016 Heart Disease and Stroke Statistics, 15.5 million people in the USA. have CHD. The lifetime risk of developing CHD with ≥2 major risk factors is 37.5% for men and 18.3% for women.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of EPA and DHA on the early-onset of coronary atherosclerosis.
According to the results of 71 participant groups included 51 were below and 20 were above the 75th AS-percentile.
* A significantly lower value for EPA (0.77%[0.63; 0.97] vs. 0.93%[0.72; 1.21]; p = 0.045), DHA (4.90%[4.12; 5.57] vs. 5.50%[4.58; 6.52]; p = 0.038) and the Omega-3 Index (5.73%[4.75; 6.35] vs. 6.22%[5.46; 7.71]; p = 0.034) were seen in patients above the 75th AS-percentile was found to associated with the onset of coronary atherosclerosis.
* All other fatty acids showed no significant differences.
* In multivariable analysis, the Omega-3 Index showed a significant inverse association with early onset of CAC (OR: 0.533 (95%CI: 0.303-0.938; p = 0.029)), independent of age, gender, statin use, and creatinine level (all p > 0.05).
Collectively, researchers said, "Low levels of EPA and DHA (Omega-3 Index) are associated with early-onset coronary atherosclerosis. This finding needs to be validated in larger cohorts and might help understand the beneficial cardiovascular effects of omega-3 fatty acids".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Early-onset coronary atherosclerosis in patients with low levels of omega-3 fatty acids by Bittner DO1, Goeller M2, Zopf Y3, Achenbach S2, Marwan M. (PubMed)
(2) The Impact of Omega 3 Fatty Acids in Atherosclerosis and Arterial Stiffness: An Overview of their Actions by Verveniotis A1, Siasos G1,2, Oikonomou E1, Tsigkou V1, Papageorgiou N1, Zaromitidou M1,2, Psaltopoulou T1, Marinos G1, Deftereos S1, Vavuranakis M1, Stefanadis C3, Papavassiliou AG4, Tousoulis D. (PubMed)
According to statistics, over 17.7 million people died from CVDs in 2015.
The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.
Most cases of heart disease in the Western world are associated with atherosclerosis.
In other words, atherosclerosis is a leading cause of coronary heart disease (CHD).
According to the 2016 Heart Disease and Stroke Statistics, 15.5 million people in the USA. have CHD. The lifetime risk of developing CHD with ≥2 major risk factors is 37.5% for men and 18.3% for women.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is made of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of EPA and DHA on the early-onset of coronary atherosclerosis.
According to the results of 71 participant groups included 51 were below and 20 were above the 75th AS-percentile.
* A significantly lower value for EPA (0.77%[0.63; 0.97] vs. 0.93%[0.72; 1.21]; p = 0.045), DHA (4.90%[4.12; 5.57] vs. 5.50%[4.58; 6.52]; p = 0.038) and the Omega-3 Index (5.73%[4.75; 6.35] vs. 6.22%[5.46; 7.71]; p = 0.034) were seen in patients above the 75th AS-percentile was found to associated with the onset of coronary atherosclerosis.
* All other fatty acids showed no significant differences.
* In multivariable analysis, the Omega-3 Index showed a significant inverse association with early onset of CAC (OR: 0.533 (95%CI: 0.303-0.938; p = 0.029)), independent of age, gender, statin use, and creatinine level (all p > 0.05).
Collectively, researchers said, "Low levels of EPA and DHA (Omega-3 Index) are associated with early-onset coronary atherosclerosis. This finding needs to be validated in larger cohorts and might help understand the beneficial cardiovascular effects of omega-3 fatty acids".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Early-onset coronary atherosclerosis in patients with low levels of omega-3 fatty acids by Bittner DO1, Goeller M2, Zopf Y3, Achenbach S2, Marwan M. (PubMed)
(2) The Impact of Omega 3 Fatty Acids in Atherosclerosis and Arterial Stiffness: An Overview of their Actions by Verveniotis A1, Siasos G1,2, Oikonomou E1, Tsigkou V1, Papageorgiou N1, Zaromitidou M1,2, Psaltopoulou T1, Marinos G1, Deftereos S1, Vavuranakis M1, Stefanadis C3, Papavassiliou AG4, Tousoulis D. (PubMed)
Saturday, April 9, 2022
Tocopherols Induce Cytotoxicity in Cancer Cells
Cytotoxicity is the process of the induction of cell death through toxins.
In other words, cell cytotoxicity is the process in which certain chemicals or mediator cells are used to destroy living cells.
In cancers, cytotoxicity can be benefits humans by destroying the cancer cells and preventing them from proliferation.
Most cases of cytotoxicity used by a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.
But, before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and Vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.
In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.
Some of the cancer drugs with cytotoxic activity have been found to induce cancer cell death accompanied by serious health problems, including weakened immune functioning such as low blood counts causing an increased possibility of developing infection or anemia, tiredness, mouth soreness, nausea, vomiting, loss of appetites, constipation or diarrhea, skin changes or reactions. particularly hair loss.
However, the combination used of chemo drug and herbal medicine and plant-based antioxidants that can also stimulate the ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.
Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of cancer, researchers examined the cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells.
According to the tested analysis,
* Among tocopherols, only delta-T exhibited cytotoxicity.
* Among para quinones, alpha-TQ showed no cytotoxicity, while gamma-TQ and delta-TQ were highly cytotoxic in both CEM and CEM/VLB100 cell lines (LD50 < 10 muM).
* Delta-TQ and gamma-TQ were more cytotoxic than the widely studied chemotherapeutic agent doxorubicin, which also showed selective cytotoxicity to CEM cells.
* Compared to doxorubicin, the orthoquinone Tocored was less cytotoxic than doxorubicin in drug-sensitive cells but more cytotoxic than doxorubicin in multidrug-resistant cells.
* Cytotoxicity was not a function of the phytyl side-chain since both TMCQ and PR were cytotoxic in leukemia cells.
* Cytotoxicity was enhanced when the glutathione pool was depleted by preincubation with buthionine-[S,R]-sulfoximine, but cytotoxicity was diminished by the addition of N-acetylcysteine to cultures. alpha-T also diminished the cytotoxicity of para- and orthoquinones.
Collectively, researchers said, "tocopheryl quinones represent a new class of alkylating electrophilic quinones that function as highly cytotoxic agents and escape multidrug resistance in acute lymphoblastic leukemia cell lines".
Taken altogether, tocopherols may process cytotoxic activity against cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells by Cornwell DG1, Jones KH, Jiang Z, Lantry LE, Southwell-Keely P, Kohar I,
Thornton DE. (PubMed)
In other words, cell cytotoxicity is the process in which certain chemicals or mediator cells are used to destroy living cells.
In cancers, cytotoxicity can be benefits humans by destroying the cancer cells and preventing them from proliferation.
Most cases of cytotoxicity used by a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.
But, before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and Vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.
In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.
Some of the cancer drugs with cytotoxic activity have been found to induce cancer cell death accompanied by serious health problems, including weakened immune functioning such as low blood counts causing an increased possibility of developing infection or anemia, tiredness, mouth soreness, nausea, vomiting, loss of appetites, constipation or diarrhea, skin changes or reactions. particularly hair loss.
However, the combination used of chemo drug and herbal medicine and plant-based antioxidants that can also stimulate the ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.
Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of cancer, researchers examined the cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells.
According to the tested analysis,
* Among tocopherols, only delta-T exhibited cytotoxicity.
* Among para quinones, alpha-TQ showed no cytotoxicity, while gamma-TQ and delta-TQ were highly cytotoxic in both CEM and CEM/VLB100 cell lines (LD50 < 10 muM).
* Delta-TQ and gamma-TQ were more cytotoxic than the widely studied chemotherapeutic agent doxorubicin, which also showed selective cytotoxicity to CEM cells.
* Compared to doxorubicin, the orthoquinone Tocored was less cytotoxic than doxorubicin in drug-sensitive cells but more cytotoxic than doxorubicin in multidrug-resistant cells.
* Cytotoxicity was not a function of the phytyl side-chain since both TMCQ and PR were cytotoxic in leukemia cells.
* Cytotoxicity was enhanced when the glutathione pool was depleted by preincubation with buthionine-[S,R]-sulfoximine, but cytotoxicity was diminished by the addition of N-acetylcysteine to cultures. alpha-T also diminished the cytotoxicity of para- and orthoquinones.
Collectively, researchers said, "tocopheryl quinones represent a new class of alkylating electrophilic quinones that function as highly cytotoxic agents and escape multidrug resistance in acute lymphoblastic leukemia cell lines".
Taken altogether, tocopherols may process cytotoxic activity against cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells by Cornwell DG1, Jones KH, Jiang Z, Lantry LE, Southwell-Keely P, Kohar I,
Thornton DE. (PubMed)
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