#Antioxidant Beta-Sitosterol Exhibits a Protective Effect on Alzheimer's, Scientists Suggest

Neurological diseases are the medical conditions of brain disorders. Anything that involves structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves, including brain damage is considered neuro disease.

The most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunctional, dementia can be Parkinson's, Alzheimer's,... or Huntington's disease.

Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant cause of stroke and vascular dementia.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Dementia is a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition and medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.


The most common form of neurodegenerative disease in North America is Alzheimer's disease (AD).

Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas through the destruction of brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.

According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of neurodegenerative diseases, researchers elucidated the effects of sterol β-Sitosterol on the production of platelet Aβ in Alzheimer's disease (AD).

According to the results in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice which were treated with β-Sitosterol for four weeks, * β-Sitosterol treatment improved spatial learning and recognition memory ability, and reduced plaque load in APP/PS1 mice.

* β-Sitosterol treatment reversed dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency.

In other words, β-Sitosterol demonstrated a neuroprotective effect that may offer a novel pharmaceutical agent for the treatment of AD.

Based on the findings, researchers said, " these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition".

Beta-Sitosterol may be considered a remedy for the prevention and treatment of AD, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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How To Get Rid Of Eye Floaters
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice by Ye JY1, Li L1, Hao QM1, Qin Y1, Ma CS. (PubMed)

#Antioxidant Beta-Sitosterol Reduces the Risk and Onset of Tuberculosis

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.



Chronic respiratory diseases are medical conditions related to abnormal function of the airways and other parts of the lung.

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Commonly, the bacterium attacked the lung tissue but in some cases, it also can cause major damage to other parts of the body.

The disease is very contagious, as types of bacteria that cause TB can spread from person to person through microscopic droplets released into the air.

In other words, people can be infected by TB if they can to close contact with TB patients through tuberculosis coughs, speaks, sneezes, spits,.... and laughs.

The disease is rare in the Western world, however, according to the report of WHO of the region including 36 countries in the Western Pacific Region, approximately 1.4 million notified cases of all forms of TB in 2011 (75 per 100 000 population), corresponding to 23% of the total cases notified globally.

There were 0.6 million new smear-positive cases notified in 2011 (32 per 100 000 population), corresponding to 22% of the total smear-positive cases notified globally.


The most common TB complications has been recorded are spinal pain, back pain, and stiffness, joint damage.


Furthermore, depending on the diseases associated with the complication induced by tuberculous, patients may also experience hip and knee malformation, swelling of the membranes that cover the brain, liver or kidney problems, and heart disorders.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers examined the adjuvant effect of beta-sitosterol and its glucoside in the treatment of culture-proven pulmonary tuberculosis (PTB).

The blinded randomized placebo-controlled trial was conducted by using the culture-proven drug-sensitive PTBs from patients hospitalized for the duration of treatment.

According to the chemical analysis,
* Weight gain was significantly greater in the sitosterol group (mean weight gain 8.9 kg) compared to the placebo.

* However, the speed of achieving culture negativity, radiological improvement, and induration on Mantoux testing was similar in the two groups.

* Most importantly, the sitosterol treatment group demonstrated a significant increase in lymphocyte counts and eosinophil counts from baseline compared to the placebo.

Collectively, scientists suggested, "The study has shown significantly improved weight gain and higher lymphocyte and eosinophil counts in PTB patients receiving sitosterols in addition to an efficacious antituberculosis regimen".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of tuberculosis, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis by Donald PR1, Lamprecht JH, Freestone M, Albrecht CF, Bouic PJ, Kotze D, van Jaarsveld PP. (PubMed)

Ursolic Acid Suppresses the Diseases Associated with Chronic Lung Inflammation in Vivo

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air and then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Lung inflammation is a class of diseases associated with the inflammation of the lung tissues.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.


In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, and smoking are some of the most prevalent factors associated with the onset of the disease.

Inflammation is a natural defense of the immune system that protects the body against the insult from foreign invasion.

Acute inflammation occurs quickly or within hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.


Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

In finding a potential phytochemical for the treatment of lung diseases, researchers examined the effect of synthesized ursolic acid derivatives on mice models of PM2.5-induced COPD in vivo.

According to the analysis of mice-induced COPD by the administration of 25 μL of PM2.5 suspension through the intranasal route daily for 1 week,
* COPD mice showed elevated levels of oxidative stress markers and inflammatory cytokines like tumor necrosis factors-α and interleukin-6 in the mice bronchoalveolar fluids.

* The administration of ursolic acid derivative caused significant suppression of aforementioned parameters including oxidative stress markers and inflammatory cytokines in COPD mice in a dose-dependent manner.

* Furthermore, the inflammatory cell infiltration in COPD mice was inhibited by the treatment of ursolic acid derivative.

* More importantly, The ursolic acid derivative treatment also increased the level of antioxidant enzymes such as superoxide dismutase and inhibited lung injury in mice with COPD.

After taking other factors into account, researchers said, " ursolic acid derivative inhibits pulmonary tissue damage in mice through suppression of inflammatory cytokine and oxidative enzymes. Therefore, ursolic acid derivative can be of therapeutic importance for the treatment of PM2.5-induced COPD".

Taken altogether, Ursolic acid may be considered adjunct therapy in the treatment of lung diseases associated with chronic inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preventive effect of ursolic acid derivative on particulate matter 2.5-induced chronic obstructive pulmonary disease involves suppression of lung inflammation by Li C1, Chen J2, Yuan W3, Zhang W4, Chen H3, Tan H. (PubMed)

The Healthy and Weight loss recipe: Shallot and grapefruit dressing

The Healthy and Weight loss recipe: Shallot and grapefruit dressing
Recipe by Cooking light, the complete Quick Cook, (A practical Guide to Smart, Fast home Cooking) by Bruce Weinstein and Mark Scarborough, Publisher Oxmoor House.

Drizzle this zesty dressing over mixed salad green topped with goat cheese. Squeeze the juice from juicy grapefruit or look for fresh grapefruit juice in a produce section of the grocery store.
1 tsp. olive oil
1/2 cup chopped shallots
2 cups fresh grapefruit juice (about 3 grapefruit)
2 tsp. chopped fresh cilantro
2 tsp. sugar
1/4 tsp. freshly ground black pepper
2 tsp. olive oil
Bloat 1 tsp. oil in a large nonstick skillet over medium heat. Add shallots, and cook for 5 minutes or until golden brown. Stir in juice. Bring to a boil over medium-high heat, and cook until reduced to 1 cup, about 6 minutes. Removed from heat cool to room temperature.
Place grapefruit mixture, cilantro, sugar, and pepper in a food processor, and process until smooth. With the processor on, slowly pour 2 tsp. oil through the food chute, and process until smooth. Store, covered in the refrigerator for up to 1 week. Yield 1 cup (Serving size: 1 tsp.)

 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

The Healthy and Weight loss recipe: New age Succotash

The Healthy and Weight loss recipe:  New age Succotash

Recipe contributed by eat well and lose weight by better Holmes and Gardens (more than 500 deliciously satisfying recipes), published by Houghton Mifflin Harcourt. You can view its website at www.hmhbooks.com.

In a small bowl gently tops together 1/2 cup cooked brown rice; 1/3 cup chopped red sweet pepper; 1/4 cup canned no-salt-added black bean, rinsed and drained; 1/4 cup frozen corn, thawed; and 2 tablespoons light lime vinaigrette salad dressing. Top with 1/2 cup shredded cooked chicken seasoned with 1/2 teaspoon salt-free fiesta lime seasoning.
Per serving; 403 cal., 22 fat(3 g sat. fat), 62 mg chol., 356 mg sodium, 47g carb., 6g sugar, 7 g fiber, 28g pro.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

Vitamin B2 Effects on Liver Cancer

Intake of vitamin B2 supplements regularly may reduce the risk of Vitamin B2 deficiency in the induction of early onset of liver cancer.

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, and enriched fever cells, increased proliferation is caused by oxidative damage to proteins and DNA, and prevents cell cycle arrest.

In fact, vitamin B2 deficiency is also associated with greater than 183% in riboflavin-deficient cells of that induced abundance of pro-apoptotic pleiomorphic adenoma gene-like 1 gene in inducing liver cancer in compared with riboflavin-sufficient controls.

Taking together, riboflavin deficiency is associated with oxidative damage to proteins and DNA in liver cells, causing liver disease through many aspects of protein functioning.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Kyle J. Norton, all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells by Xin Z1,2, Pu L1, Gao W1, Wang Y1,2, Wei J1, Shi T1, Yao Z1, Guo C1.(PubMed)

Omega-3 Fatty Acids, the Potential Lipid Inflammatory Mediators in Vitro and Vivo

Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.

Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat in the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.

In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.

Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.

However, in people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.


Lipids mediators, derived from the omega-6 polyunsaturated fatty acids (PUFA) are potent enhancers of innate and adaptive immune activation in numerous inflammatory disorders.

Dr. Bennett M, the lead scientist in the examing "Lipid Mediators in Inflammation" wrote, "Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA".

In other words, each individual acid arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties which are derived from polyunsaturated fatty acids (PUFAs), plays a selective role in maintaining cellular process depending on the types of fatty acid.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of inflammatory diseases, researchers examined the effects of n3-PUFA DHA and its derived specialized pro-resolving lipid mediators (SPMs) MaR1, RvD1, and RvD2, on TNF-α inhibition of intestinal sugar and glutamine uptake.


Based on the differentiation,* DHA blocked TNF-α-induced inhibition of α-methyl-D-glucose (αMG) uptake, an analog of glucose, and SGLT1, a glucose transporter, expression in the apical membrane of Caco-2 cells.

* Compared to DHA, SPMs showed the same preventive effect at concentrations 1000 times lower.

* In diet-induced obese (DIO) mice, oral gavage of SPMs, MaR1 reversed the up-regulation of pro-inflammatory cytokines found in the intestinal mucosa of these mice without inducing a reduced intestinal transport of αMG and SGLT1 expression in the DIO mice.

* In Caco-2 cells, EPA, DHA, and the DHA-derived SPMs. also prevent the TNF-α in the inhibition of glutamine uptake.

Collectively, scientists said, " DHA and its SPMs as promising biomolecules to restore intestinal nutrients transport during intestinal inflammation".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of diseases associated with impaired lipid inflammatory mediators, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DHA and its derived lipid mediators MaR1, RvD1 and RvD2 block TNF-α inhibition of intestinal sugar and glutamine uptake in Caco-2 cells by Castilla-Madrigal R1, Gil-Iturbe E1, López de Calle M2, Moreno-Aliaga MJ3, Lostao MP. (PubMed)