Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Saturday, July 23, 2022

Omega 3 Fatty Acids Suppress Cancer Cachexia in Patients with Pancreatic Cancer

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.


Traditional Chinese medicine views the pancreas, as a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.


More precisely, the functions of the pancreas including
* Production of enzymes digest fat, protein, and
carbohydrates.

* production of juices combined with juices from the intestines helps to do the job of breaking down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even diagnosed early is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.

Researchers do not know what causes pancreatic cancer. They don't even know why people with the same health conditions in the same family, are susceptible to pancreatic cancer, while others do not.

The most common risk factors of pancreatic cancer are similar to those of common cancers, including age, family history, gender, ethnicity, smoking, being overweight or obese, and certain medical conditions such as diabetes.

Cancer cachexia is a condition a multifactorial syndrome associated with an ongoing loss of skeletal muscle mass.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers examined the effects of omega-3 fatty acids in patients with pancreatic and bile duct cancer.

According to the administration of Racol®, an enteral nutrient formulated with omega-3 fatty acids to patients with unresectable pancreatic and bile duct cancer at 4 and 8 weeks after, pre-administration and administration showed a strong activity that increases skeletal muscle mass at both 4 and 8 weeks.


In other words, Omega-3 fatty acid supplementation protects the skeletal muscle mass associated with cancer cachexia in patients with unresectable pancreatic cancer and may improve cancer.


Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the reduction of cancer cachexia in patients with pancreatic cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway by Ding Y1, Mullapudi B2, Torres C3, Mascariñas E4,5, Mancinelli G6, Diaz AM7, McKinney R8, Barron M9, Schultz M10,11, Heiferman M12, Wojtanek M13, Adrian K14, DeCant B15,16, Rao S17, Ouellette M18, Tsao MS19, Bentrem DJ20, Grippo PJ. (PubMed)
(2) Effects of ω-3 Fatty Acid Supplementation in Patients with Bile Duct or Pancreatic Cancer Undergoing Chemotherapy by Abe K1, Uwagawa T2, Haruki K2, Takano Y2, Onda S2, Sakamoto T2, Gocho T2, Yanaga K. (PubMed)

Saturday, July 9, 2022

Phytochemicals Omega-3 Fatty Acids, the Healthy Fat for the Treatment of Myocardial Infarction

Stroke is the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

Stroke is caused by the accumulation of cholesterol and other substances that build up the arterial walls.

In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, leading to the death of some cells in the brain.

According to the statistics, every year, more than 790,000 people suffer a stroke, 600,000 of these are first attacks, and 185,000 are recurrent attacks. Most cases of stroke occur in people over the age of 65.

Myocardial infarction (MI) is a medical condition known as a heart attack caused by the blood flow decreasing or stopping in a part of the heart, leading to damage to the heart muscle.

In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to reduced blood flow to the heart.

Prompt treatment can minimize brain damage and potential post-disease complications.


The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath, and dizziness.

Conventionally, the treatment of myocardial infarction is focused to reduce the damage to the heart muscle accomplished through medical or mechanical means.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of post-stroke, researchers examined the omega-3 eicosapentaenoic acid (EPA) EPA the infarct-limiting effect on experimental models.

The observational study was conducted in 100 patients with a reperfused anterior ST-elevation myocardial infarction (STEMI), at hospital admission who are quantified by gas-chromatography the red blood cell proportions of AA, EPA, and the AA: EPA ratio, a valid surrogate for cardiomyocyte membrane content.

According to the results of the tested analysis,* AA:EPA ratio directly related to acute infarct size (coefficient [95% CI]: 6.19 [1.68 to 10.69], P = 0.008) and inversely to long-term cardiac function (left ventricular ejection fraction [LVEF]) (coefficient [95% CI]: − 4.02 [− 7.15 to − 0.89], P = 0.012), comapred to uintreated control.

* EPA inversely related to acute infarct size (coefficient [95% CI]: − 6.58; [− 11.46 to − 1.70]; P = 0.009), while a direct association with LVEF at follow-up (coefficient [95% CI]: 3.67 [0.25 to 7.08]; P = 0.036) was observed.


In other words, both applications of omega 3 fatty acids demonstrated protective activity to preserve the neuron against damage immediately after the incidence of stroke.
Additionally, researchers also found, " A low AA: EPA ratio in red blood cells at the time of STEMI is associated with smaller acute infarct size and preserved long-term ventricular function".

Collectively, they said, "Our results are consistent with prior work in experimental models and add to the notion of omega-3 fatty acids as a healthy fat".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of myocardial infarction, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nutritional preconditioning by marine omega-3 fatty acids in patients with ST-segment elevation myocardial infarction: A METOCARD-CNIC trial substudy by Sala-Vila A1, Fernández-Jiménez R2, Pizarro G3, Calvo C1, García-Ruiz JM4, Fernández-Friera L5, Rodriguez MD4, Escalera N4, Palazuelos J6, Macías A4, Pérez-Asenjo B4, Fernández-Ortiz A2, Ros E1, Fuster V7, Ibáñez B. (PubMed)

Sunday, July 3, 2022

Beta-Sitosterol Protects the Pancreatic Islets functioning Against the Risk of Type 2 Diabetes

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, as a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

More precisely, the functions of the pancreas including the
* Production of enzymes digest fat, protein, and
carbohydrates.

* Production of juices combined with juices from the intestines to break down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic islets are groups of hormones producing cells, including insulin and glucagon, that work together to maintain the proper level of sugar (glucose) in the blood.

Profound distortion of islet organization in the pancreas has been found to induce account abnormal secretory behavior of the glucagon-secreting A cells in insulin-dependent juvenile-onset diabetes.

Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, is the most common form of diabetes found in children and is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

In finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers elucidated the anti-diabetic effects of the extract of A. tenuifolia underground parts and β-sitosterol on rat pancreatic islets.

According to the results of the analysis,* The root extract of the plant and compound β-sitosterol isolated from the root extracts showed moderate α-amylase inhibitory activity.

* Furthermore, the herb root extract was able to increase the secretion of insulin in high concentrations (10 mg/mL) and improved the cell viability with no toxicity in all doses.

* The herbal extract could reduce the levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) associated with the onset of oxidative stress in orchestrating damage to the pancreatic islets.

* Moreover, the plant extract also significantly decreased the enzyme activity associated with pro-apoptotic expression by increasing the antioxidant capacity of the isolated cells.


In other words, all compounds found in the extract work synergistically to protect the pancreatic islets by inhibiting all parameters involved in pancreatic damage, particularly, the compound β-sitosterol

Taken altogether, beta-Sitosterol combined with other phytochemicals found in A. tenuifolia underground parts may be considered a supplement for the protection of pancreatic islets-induced diabetes, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Investigation of β-Sitosterol and Prangol Extracted from Achillea Tenoifolia Along with Whole Root Extract on Isolated Rat Pancreatic Islets by Rahimifard M1,2, Manayi A3,2, Baeeri M1, Gholami M4, Saeidnia S3, Abdollahi M. (PubMed)

Sunday, June 26, 2022

Oleanolic Acid Cures Diarrhea in Vivo



Diarrhea is a condition of frequent bowel movements with three loose or liquid each day. A prolonged period of diarrhea may result in dehydration due to fluid loss.


Acute diarrhea, healing on its own is a common problem caused by viruses that may last a few days. The most common causes of acute diarrhea are rotavirus in children and norovirus in adults.

Persistent diarrhea that lasts more than 4 weeks is considered chronic diarrhea.

Chronic diarrhea is a medical condition caused by impaired digestion of fats due to low production of the pancreatic enzymes and impaired absorption of fats due to small intestinal diseases, including lactose, sorbitol, and fructose intolerance and irritable bowel syndrome (IBS).

Certain medications such as antibiotics, dietary changes, infected with bacteria or viruses are some of the most common factors associated with an increased risk of diarrhea.

Infections by bacteria such as Salmonella or Escherichia coli are the most common causes of acute diarrhea. Patients with acute diarrhea usually are recovered within a week or 2 with or without medication.

However, patients with some bowel diseases such as irritable bowel syndrome or inflammatory bowel disease also frequently experience chronic conditions, which can not be cured unless the diseases are treated.

In some cases, chronic frequent and severe diarrhea can be a sign of intestinal disease or a functional bowel disorder.

The most common symptoms of diarrhea include loose, watery stools. abdominal pain and gastrointestinal discomforts. In severe cases, patients may also experience symptoms of fever and blood in the stool.

Some researchers suggested that symptoms of diarrhea accompanied by blood in the stool are also a sign of colon cancer.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that improves the digestive functioning, researchers examined the effect of oleanolic acid (OA) on Salmonella typhimurium (S.T), a common cause of acute, self-limiting food-borne diarrhea with severe intestinal inflammation and intestinal barrier damage.


The study included a total of eighty BALB/c mice (4-week-old) that were randomly divided into the control group (no S.T, no OA), the S.T group (S.T only), the S.T + OA group (S.T plus 100 mg kg-1 OA) and the OA group (100 mg kg-1 OA only).

According to the results of the analysis,
* Compared with the S.T group, OA administration significantly reduced clinical symptoms and weight loss, and the severity of diarrhea and intestinal structural damage was significantly alleviated observed by a decrease in the diarrhea index (DI) and jejunal histological damage.

* In the infected jejunum, OA maintained the expression and localization of occludin, claudin-1, and ZO-1 to protect the jejunal barrier.

* OA treatment not only reduced the levels of COX-2 and iNOS but also inhibited the secretion of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α.

* A treatment significantly inhibited IκB phosphorylation and degradation against the intestinal tissues.


* OA also decreased the level of TLR4 associated with inflammatory cytokines and the activation of the MAPK pathway in the production of anti-inflammatory cytokines.

Collectively, researchers said, "OA can maintain the intestinal tight junction barrier and prevent diarrhea caused by S.T.".


Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of liver diarrhea, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway by Dong N1, Xue C1, Zhang L1, Zhang T1, Wang C1, Bi C1, Shan A. (PubMed).

Sunday, June 19, 2022

Omega-3 Fatty Acids Improve Oral Mucositis and Body Weight Loss in Chemoradiotherapy Patients with Head and Neck Cancer



Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.


Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer, at the early stage, start with the cell growth irregularly and disorderly on the surface of the inner lining of the head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck, or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia), and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

The most common head and neck cancer metastases are secondary skin cancer.

The exact causes of head and neck cancer are unknown. Researchers cannot explain why people with similar health conditions and the same risk factors, are susceptible to the onset of the disease, while others do not.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

mitted virus.


According to the statistics, head and neck cancer account only for about 4% of all cancers in the US. In 2019, an estimated 65,410 people (48,000 men and 17,410 women) were funded to develop head and neck cancer.


Most people diagnosed with head and neck cancer are older than 50.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.


The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effect of a nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®) on body weight loss, and oral mucositis in patients with head and neck cancer.

The study included 17 patients with oropharyngeal and hypopharyngeal cancer who were treated with concomitant cisplatin and 70 Gy of radiotherapy with or without 2 packs of Prosure®per day during chemoradiotherapy.


According to the final results,* The reduction in body weight was significantly improved compared with that in the historical control group that did not receive Prosure®(7.3% vs 10.3%, p<0.01),

* The rate of Grade 3-4 oral mucositis was significantly reduced for the patient groups that received Prosure®(CTCAE v3.0 GradeB3; 24% vs 58%, p<0.05).

Most importantly, the completion rate of chemoradiotherapy was not significantly different between both groups(77% vs 60%, NS).


Based on the evidence, researchers said, "A nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®)had effects on oral mucositis and body weight loss in head and neck cancer patients treated with chemoradiotherapy".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer by reducing the breast density, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®) Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treated with Chemoradiotherapy].[Article in Japanese] by Mizumachi T1, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C, Kumagai S, Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y, Onimaru R, Shirato H, Fukuda S. (PubMed)
(2) A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients by de Luis DA1, Izaola O, Cuellar L, Terroba MC, de la Fuente B, Cabezas G. (PubMed)

Saturday, June 11, 2022

Lycopene in the Promotion of Lung Function Against Obstructive Lung Functioning



The lungs formed part of the respiratory system are a pair of spongy, air-filled organs located on either side of the chest with the main function to process of gas exchange during breathing.

In other words, the lungs transfer life-giving oxygen into the blood supply and remove carbon dioxide produced by cells' metabolism from the blood.

Additionally, the lung is also the first-line defense against inhaled particles and prevent the circulation of emboli such as blood clot (thrombus), a fat globule (fat embolism), a bubble of air or other gas (gas embolism), or foreign material.


Additionally, the lung also processes other abilities of
* Balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.


* Removing small blood clots in the lung protects the body against the forming air embolisms.


* Protecting lung infection through the secretion of immunoglobulin A.

Any part of the lung injury can reduce the lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.


Obstructive lung diseases are condition in which the lungs are unable to expel air properly during exhalation. Diseases associated with obstruction lung diseases such as asthma, bronchiectasis, COPD, and emphysema.

Besides smoking, second-hand smoke is the most common cause of obstructive lung disease. Dr.Mark D. Eisner said, "Secondhand smoke (SHS) has been extensively studied as a risk factor for obstructive lung disease, including decreased lung function, asthma, and chronic obstructive pulmonary disease (COPD) (1–5)".

And, "Epidemiologic studies have played a key role in evaluating the respiratory health effects of SHS because they are the only feasible method for studying the impact of exposure, as it occurs naturally, on large numbers of the subject".


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of lung disease researchers examined the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C, and α-tocopherol and all-cause mortality among US adults with obstructive lung function.

The study included a total of 1492 adults aged 20-79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988-94) that cause 629 deaths during a median follow-up period of 14 years.

α-carotene (P= 0·037); β-carotene (P= 0·022); cryptoxanthin (P= 0·022); lutein/zeaxanthin (P= 0·004); total carotenoids (P= 0·001) vitamin C (P< 0·001) concentration were invesely associated with all-cause mortality among adults with obstructive lung function.

However, in maximally adjusted models, only the concentrations of lycopene (P= 0·013) and vitamin C (P= 0·046) were found to be significantly and inversely associated with all-cause mortality compared to other tested antioxidants.


Additionally, lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status were associated with lutein/zeaxanthin concentrations.


Based on the findings, researchers said, "The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function".

Taken altogether, lycopene found in tomatoes may be considered a remedy for the improvement of obstructive lung function, pending the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Associations between antioxidants and all-cause mortality among US adults with obstructive lung function by Ford ES1, Li C2, Cunningham TJ1, Croft JB. (PubMed)
(2) Secondhand Smoke and Obstructive Lung Disease, A Causal Effect? by Mark D. Eisner. (ATS Journals)

Sunday, June 5, 2022

Antioxidant Beta-Sitosterol Inhibits the Parameters Associated with the Risk of Diabetes

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

There are 2 major types of diabetes,

* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, is the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

The most common symptoms of type 2 diabetes are an increased thirst that won't stop with water intake, and increased hunger.


Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.

By managing your blood glucose properly and daily, the risk of diabetic complications can be reduced in diabetics by
*Taking your medication as directed.

*Keeping tight control of your blood sugar or managing the blood glucose in the required range

* Eating healthy with moderate exercise to protect your weight, blood pressure, and cholesterol. Being overweight, blood pressure and cholesterol are some of the conditions associated with an increased risk of diabetes complications.

* Get regular checkups

* Quit smoking


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention of chronic diseases involved in oxidative stress, researchers investigated the anti-diabetes activity of beta-sitosterol (β-sitosterol) on insulin signaling molecules and glucose oxidation.

According to the differentiation of the adipose tissue of a high-fat diet and sucrose-induced type-2 diabetic experimental rats given the dose of β-sitosterol (20 mg/kg b.wt, orally for 30 days), β-sitosterol normalized the altered levels of blood glucose, serum insulin in the tested rats.

Furthermore, the hormone testosterone, lipid profile, oxidative stress markers, antioxidant enzymes, insulin receptor (IR), and glucose transporter 4 (GLUT4) proteins associated with glucose uptake were also inhibited by the application of beta-sitosterol.

In other words, most parameters associated with the characteristics of diabetes were inhibited by the injection of the bioactive compound.

Based on the findings, researchers aid, "β-sitosterol improves glycemic control through activation of IR and GLUT4 in the adipose tissue of high fat and sucrose-induced type-2 diabetic rats".

Taken altogether, beta-Sitosterol may be considered a supplement for the treatment of diabetes, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In silico and in vivo analysis to identify the antidiabetic activity of beta sitosterol in adipose tissue of high fat diet and sucrose induced type-2 diabetic experimental rats by Ponnulakshmi R1, Shyamaladevi B2, Vijayalakshmi P3, Selvaraj J. (PubMed).