Research Attributed to Kyle J. Norton, The Curable Smoothie of Blueberry, Grape and Green tea Prevention and Treatment of Anxiety

Kyle J. Norton(Scholar, Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of anxiety
Yield: 2 serving (about 8 ounce each)
1 cup organic mulberry fruit juice or Blueberry Juice
1/2 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Anxiety is the psychocological disorder characterized by a feeling of excessive uneasiness and worriness. Blueberry(1), grape(2) and green tea(3) due to theirs antioxidants anthocyanins(1), resveratrol(2) and catechins(3) respectively, may be the next generation of therapeutic ingredients for reduced risk and treatment of anxiety.

In adult rats study, consumed approximately 3.2 mg kg(-1)day (oral), of the anthocyanins found in fruits especially in blueberry, significantly reduced the memory deficits, anxiety and improved locomotion(3).Dr. Valcheva-Kuzmanova S and, Zhelyazkova-Savova M. in the classification of aronia melanocarpa fruit juice rich with anthocyanin suggested that the juice exhibited neither an anxiolytic-like effect with no changed significantly horizontal and vertical locomotor activity, nor did it adversely affect working memory(4)

Grape, containing high amount of resveratrol, is a woody vines of the genus Vitis, belonginjgs to the family Vitaceae, native to southern Turkey. Epidemiological studies, strong evidences through the accumulated data suggested that dietary supplements rich in important phytochemicals resveratrol significantly decreases anxiety/depressive behaviours(6).
Pterostilbene, a natural analog of resveratrol, exhibited anxiolytic-like activity without effecting locomotor activity, through regulating cellular processes(7).
Dr.Sönmez U and the research team at the Dokuz Eylul University Inciralti, in the study of traumatic brain injury in immature rats said," resveratrol decreased anxiety and increased cortex/hippocampus dependent memory of animals subjected to blunt head trauma"(8).

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Flavanols, a natural products found in green tea, inhibited anxiety like symptoms in adult male C57BL/6 mice, through mood-modulating effects(9).
Dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis has found to associate to depression and anxiety, chronic administration of catechin (CTN) significantly alleviated of the complex symptoms associated with depression and anxiety disorders, on chronic CORT-induced behavioral alterations using the forced swimming test (FST), according to the Acupuncture and Meridian Science Research Center(10).
Furthermore, "(-)-epigallocatethin-3-O-gallate (EGCG) (another catechins phytochemical found in green tea),... reverses caffeine-induced anxiogenic-like effects" and "exhibited anxiolytic effects in an animal model" Dr. Park KS and the research team at the Chungbuk National University said.

Taking altogether, people who are at increased risk of anxiety due to family history, gene mutation .....should drink at least one serving daily and people with chronic anxiety should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.


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References
(1) Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B by Dreiseitel A1, Korte G, Schreier P, Oehme A, Locher S, Domani M, Hajak G, Sand PG.(PubMed)
(2) Effect of resveratrol on behavioral performance of streptozotocin-induced diabetic mice in anxiety tests by Damián JP1, Acosta V, Da Cuña M, Ramírez I, Oddone N, Zambrana A, Bervejillo V, Benech JC.(PubMed)
(3) Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children by Richards G1, Smith A2.(PubMed)
(4) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT.(PubMed)
(5) Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats by Valcheva-Kuzmanova S1, Zhelyazkova-Savova M.(PubMed)
(6) Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review by Nabavi SM, Daglia M, Braidy N, Nabavi SF.(PubMed)
(7) Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation by Al Rahim M1, Rimando AM, Silistreli K, El-Alfy AT.(PubMed)
(8) Neuroprotective effects of resveratrol against traumatic brain injury in immature rats by Sönmez U1, Sönmez A, Erbil G, Tekmen I, Baykara B.(PubMed)
(9) Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice by Stringer TP1, Guerrieri D1, Vivar C1, van Praag H1.(PubMed)