Fennel may have a potential and positive effect in reduced negative stress impact on daily living, some scientists suggested.
Stress is a natural response of our brain against any kinds of threat and demand. People responded to stress differently, some can cope with stress that no one else can.
However, if stress is overwhelming, caused over productions of certain hormones that can induce strong implications in interfered one's daily activity.
Prolonged stress is found to exert physically, emotionally and mentally negative expression in various aspects, including sleep disturbance, digestive disorders,...
Some researchers suggested that people with chronic stress not only increases the risk of heart attack and stroke, speeds up the aging process but also are susceptible to the risk of mental conditions, such as anxiety, depression, and other mental health problems.
If you experience some abnormal cognitive, emotional, physical,....... and behavior symptoms, you may be in the early stage of chronic stress. Please check with your health service providers.
Causes of stress can be external and internal,
* External stress includes difficulty in a relationship, at work stress, financial problem, loss of a loved one,...... and financial problems.
* Internal stress includes pessimism, rigid thinking, lack of flexibility,........and negative thinking.
Chronic stress if untreated can lead to the development of some serious ailments, including mental disorders, abnormal endocrine functions, cardiovascular disease,.......... and respiratory problems.
Some researchers suggested that people with untreated chronic stress also are likely to increase the risk of infections, digestive problems, and muscular pains, particularly headaches and migraine attack.
Furthermore, society and the environment also have significant impacts on stress conditions.
According to the widely validated Holmes and Rahe Stress Scale, the top ten stressful life events for adults, including
Death of a spouse
Divorce
Marriage separation
Imprisonment
Death of a close family member
Injury or illness
Marriage
Job loss
Marriage reconciliation
Retirement
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb or food also is used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In the study to evaluate the anti-stress and memory-enhancing properties of F. vulgare extract in experimentally stress rats at doses of 50, 100 and 200 mg/kg body weight administered orally with an orogastric tube, researchers found that rats treated with all doses exert significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.
Further analysis of fennel rat treated group with an additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41 and 125.82 μg/kg within the same period on doses of 50, 100 and 200 mg/kg body weight respectively in compared to untreated control group.
These results indicated that fennel has a stronger impact in reduced chronic stress connotation in compared to both ascorbic acid and control groups.
Moreover, the treated group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in the induction of ROS production and reduction of natural antioxidant defense in compared to rat group treated with ascorbic acid.
Dr. S Koppula,, the lead author, after taking into account of other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".
Additionally, in the review literature of a number of such drugs mostly in the form of their extracts (holistic approach) or in some, of active principles isolated from them for their antistress activity by a number of tests, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association to stress in the induction of anxiety.
* Fennel inhibits the production of level stress hormone corticosterone produced in the cortex of the adrenal gland.
* Fennel increases production antioxidant and enhancing the antioxidant defense of hosts such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibited overexpression of ROS in an initiated chain reaction caused by chronic stress.
* Fennel inhibits levels of MAO in association to the alternation of mood and mental conditions.
Finally, application of fennel also reduced the tension of the central nervous system in response to stress impact, thus reducing neurotransmitter levels in the stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......
The above illustration was supported by the application of fennel oil in exerted significant anti psychiatric disorders caused by chronic stress such as depressive and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg) and fennel oil (0.5 ml/day) conducted by the Aga Khan University
Repeated administration of fennel oil for 3 weeks demonstrated significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in elevated plus maze (EPM) incomparable to fluoxetine treatment group.
Interestingly, rats treated group also exhibited high levels of antioxidant in inhibited ROS in the facilitated production of free radicals through lipid peroxidation.
Taken together, fennel with abundant phytochemicals may be considered as a functional food in reduced stress implication in the initiation of related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Untreated Stress Can Lead To Serious Problems(Aarogya)
(4) Stress Symptoms, Signs, and Causes(Help guide)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Wednesday, October 31, 2018
Monday, October 29, 2018
Losing Weight By Restricting Fat and Glucose Absorption of GI, Scientists Say
Green tea may have a therapeutic and positive effect in the induction of weight loss through reduced GI absorption of glucose and lipid, some scientists suggested.
The absorption of too much sugar too quickly may depress the pancreas in produced extra insulin to neutralize glucose transport in the body.
A prolonged period of too much sugar in the bloodstream not only increases the risk of diabetes but also puts pressure of liver in converted triglycerides to fat to tissue
Blocking fat absorption also plays an important role in weight loss and weight management. According to Dr. Ying Sun and Dr. Jiande Chen, reducing fat absorption may be a therapeutic potential for obesity"(4).
The GI tract plays an essential role in our body well being and lifelong health.
Some researchers suggested that a poor functioning of GI may induce occurrence of many chronic health problems.
There are many causes of digestive dysfunction. It can be the digestive system itself due to bacterial infection, viral infection, inflammation, lactase deficiency, difficulty digesting certain foods, poor circulation to the intestines or symptoms of the wider systemic disease, such perforated organs, muscle dysfunction, gallstones, stress, and anxiety.
Dysfunction GI if untreated may interfere with daily activities and induce poor quality of life.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the Agriculture and Agri-Food Canada, native catechins found in green tea were not absorbed by the digestive system after intake.
The polyphenol catechins were accumulated in the intestinal lumen inside space of a tubular structure where they exhibited a significant activity in ameliorated cellular glucose and cholesterol uptake that reduced risk in overexpression of fasting glucose and lipid accumulation entering the bloodstream in the induction of syndromes of abnormally high blood sugar and cholesterol.
The pervaded catechins found approximately, 2-15% in the intestinal levels significantly bound to 37% to plasma HDLs through inhibiting the key enzymes involved in lipid biosynthesis and reduced intestinal lipid absorption, thus improving blood lipid profile.action of cholesterol metabolism.
Further analysis of the unstable condition of polyphenols in intestinal environment, also found that transition from the gastric phase to the intestinal phase of green tea extract shows a 50% decrease in the antioxidant activity due to the degradation of polyphenols but the deceased extract still exerts a strong effect in the gastrointestinal environment.
However, intake of whole food milk and cheese in the definition of dairy matrices displayed a significant improvement of polyphenol stability in the intestinal phase and increase of the antioxidant activity by 29% (cheese) to 42% (milk) in compared to nongreen tea injection control.
Additionally, administration of green tea also demonstrated a strong activity in decreased expression of stomach secretes pepsinogen, in breaking down milk and cheese protein and fat intake in degraded into their component polypeptide or amino acid and glycerol and fatty acids, respectively in the gastric phase but had no effect in the intestinal phase, thus reducing glucose and fat being absorbed and presented in the bloodstream.
The findings showed that green tea polyphenols intake after certain times of intake of dairy products improved antioxidant activity and enhanced the integrity of polyphenols in the intestinal phase of digestion, but have a serious effect in the stomach if it is taken together with milk.
Interestingly, in the evaluated rats fed with selenium-containing green tea (Se-GTE, 1.44 mg selenium/kg dry leaves) and China green tea(CH-GTE, 0.13 mg selenium/kg leaves) and China green tea(CH-GTE) effect in the intestinal micro bacterial activity, researchers indicated that oral administration of rat group fed with Se-GTE extract for 6 days
* Exerts a significant increase in caecal counts of lactobacilli and bifidobacteria while significantly reducing the caecal counts of Bacteroides and clostridial bacteria in compared to
* CH-GTE rat group exerts insignificant increase in the numbers of caecal lactobacilli and bifidobacteria but decreased significantly the numbers of Bacteroides (p < 0.05) and clostridia.
Moreover, rats fed with CH-GTE and Se-GTE showed a 17.2% and 21.3% reduction in the activity of the bacterial enzyme β-glucuronidase, which has been found in the contribution of biliary sludge, stone formation and increased risk for colorectal cancer, respectively.
More promisingly, treatment of both CH-GTE and Se-GTE also resulted in 19% and 25.5% increments in the activity of β-glucosidase, an enzyme presented in cellulase with function in completed the final step in converting cellobiose (a reducing sugar) to glucose.
Taken together, green tea with abundantly major bioactive polyphenols may be considered a functional food in weight loss and weight management by reduced absorption of glucose and lipid in the induction of abnormal high fasting blood sugar and cholesterol levels through binding to fat and protein in the gastric phase of digestion.
However, further data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of digestion will be necessary to complete the picture of green tea effects in gastrointestinal phases in the absorption of glucose and lipid possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Interaction of green tea polyphenols with dairy matrices in a simulated gastrointestinal environment by Lamothe S1, Azimy N, Bazinet L, Couillard C, Britten M.(PubMed)
(2) Simulated gastrointestinal digestion, intestinal permeation and plasma protein interaction of white, green, and black tea polyphenols by Tenore GC1, Campiglia P2, Giannetti D3, Novellino E3.(PubMed)
(3) The ability of green tea to positively modulate key markers of gastrointestinal function in rats by Molan AL1, Liu Z, Tiwari R.(PubMed)
(4) Intestinal Electric Stimulation Decreases Fat Absorption in Rats: Therapeutic Potential for Obesity by Ying Sun and Jiande Chen(PMC)
Green Tea, The Anti Allergic Inflammatory Diseases' Beverage, Scientists Say
Green tea may have a particular and special effect in ameliorated autoimmunity in precipitation of allergic diseases, some scientists opinionated.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
Allergic diseases are a class of conditions characterized by an overreaction of the immune system to substances which cause little or no harm to the body.
Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate to certain mechanisms.
According to the statistic, approximately 60 million Americans suffer from allergic diseases. affecting all age groups.
Most common allergic diseases include hay fever, food allergy, respiratory diseases such as asthma and eczema.
In the rare case, allergies can trigger also a life-threatening anaphylaxis.
Most common symptoms include itch, redden, Hives Itchy skin Rash Facial swelling Wheezing, sneezing Itching of the nose, eyes or roof of the mouth, runny and stuffy nose....and swelling of the lips, tongue, face or throat.
However, if you experience some the severe symptoms of a drop in blood pressure, any form of shortness of breath, skin rash, lightheadedness, .... and a rapid, weak pulse, you may already be infected by life-threatening anaphylaxis, please visit the nearest hospital right the way.
According to the Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibited the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in the expression of immunoglobulin E (IgE), an antibody isotype involved allergy disorder through 67 kDa laminin receptor in mediation of the suppressive effect by epigallocatechin-3-O-gallate.
Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cell by suppressing the myosin light chain phosphorylation in regulated immune response to eosinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signalling by modulation of inflammatory cytokines expression.
A double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed significantly relieved allergic symptoms induced by pollen such as nose blowing, eye itching in compared with the placebo group without affecting the normal immune responses.
More interestingly, in mouse bone marrow-derived mast cells activated by antigens, bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell signaling protein (cytokine) in response to systemic inflammation in the acute phase infection. and macrophage Inflammatory Proteins(MIP-1α), a chemokine involved host response to invading bacteria and virus.
In compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited a much stronger anti-allergic activity than 43.5 mg of EGCG, observed by the area under curve AUC (area under the drug concentration-time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.
Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered as a functional food for protection against autoimmune response stimulated by unharmful allergens.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antiallergic possibilities.
Intake of green tea extracts, such as EGCG should be taken with extreme care, as overdoses induced acute liver toxicity have been reported by some medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or lifestyle-related diseases by Maeda-Yamamoto M1.(PubMed)(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,
1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
Allergic diseases are a class of conditions characterized by an overreaction of the immune system to substances which cause little or no harm to the body.
Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate to certain mechanisms.
According to the statistic, approximately 60 million Americans suffer from allergic diseases. affecting all age groups.
Most common allergic diseases include hay fever, food allergy, respiratory diseases such as asthma and eczema.
In the rare case, allergies can trigger also a life-threatening anaphylaxis.
Most common symptoms include itch, redden, Hives Itchy skin Rash Facial swelling Wheezing, sneezing Itching of the nose, eyes or roof of the mouth, runny and stuffy nose....and swelling of the lips, tongue, face or throat.
However, if you experience some the severe symptoms of a drop in blood pressure, any form of shortness of breath, skin rash, lightheadedness, .... and a rapid, weak pulse, you may already be infected by life-threatening anaphylaxis, please visit the nearest hospital right the way.
According to the Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibited the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in the expression of immunoglobulin E (IgE), an antibody isotype involved allergy disorder through 67 kDa laminin receptor in mediation of the suppressive effect by epigallocatechin-3-O-gallate.
Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cell by suppressing the myosin light chain phosphorylation in regulated immune response to eosinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signalling by modulation of inflammatory cytokines expression.
A double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed significantly relieved allergic symptoms induced by pollen such as nose blowing, eye itching in compared with the placebo group without affecting the normal immune responses.
More interestingly, in mouse bone marrow-derived mast cells activated by antigens, bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell signaling protein (cytokine) in response to systemic inflammation in the acute phase infection. and macrophage Inflammatory Proteins(MIP-1α), a chemokine involved host response to invading bacteria and virus.
In compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited a much stronger anti-allergic activity than 43.5 mg of EGCG, observed by the area under curve AUC (area under the drug concentration-time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.
Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered as a functional food for protection against autoimmune response stimulated by unharmful allergens.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antiallergic possibilities.
Intake of green tea extracts, such as EGCG should be taken with extreme care, as overdoses induced acute liver toxicity have been reported by some medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or lifestyle-related diseases by Maeda-Yamamoto M1.(PubMed)(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,
1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)
Sunday, October 28, 2018
11 Fruits That Inhibit Prostate Cancer Cells, Scientist Suggested
In South East Asian, prostate cancer is considered a disease of aging male, now has become major concerns of governments and scientific community, because of its tendency to affect even younger age population.
Some researchers that the disease is the result of over-consumption of bad fats accompanied by an unhealthy diet and lifestyle, linking directly to the economic prosperity over 3 decades.
Some people who have made a lot of money.in that region in the past 3 decades are Western diet followers. Therefore, they are also susceptible to the diseases of the Western world.
Dr. Salinas CA, the lead author at the joint studies led by the University of Michigan Medical School, said, "Prostate cancer is considered a disease of older men (aged >65 years), but today over 10% of new diagnoses in the USA occur in young men aged ≤55 years"(1).
Most of the younger age patients who have prostate cancer are diagnosed with low-risk of the disease. Although early diagnosis may increase the chance of survival, these people may expose to long-term effects of treatment-related morbidities and risk of disease progression that can lead to death from prostate cancer(1).
Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.
Besides inherited genes such as RNASEL and BRCA1 and BRCA2 that increase the risk of prostate cancer, researchers do not know what causes prostate cancer. However, there are numbers of risk factor which may increase the risk of prostate cancer onset, including age, family history, obesity,...unhealthy diet.
Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during physical (rectum) exams.
According to a statistic in Canada, prostate cancer is a 3rd leading cause of death from cancer in men. in Canada.
In 2017(2)
* 21,300 men were diagnosed with prostate cancer. This represents 21% of all new cancer cases in men in 2017.
* 4,100 men died from prostate cancer. This represents 10% of all cancer deaths in men in 2017.
* On average, 58 Canadian men were diagnosed with prostate cancer every day.
* On average, 11 Canadian men died from prostate cancer every day.
People in the early stage of prostate cancer may experience no symptoms. However, as the cancer progress, patient may encounter problems of urinating, blood in the urine or semen, trouble getting an erection (erectile dysfunction or ED), pain in the hips, back (spine), chest (ribs), or other areas from cancer that has spread to bones.... and numbness in the legs or feet(3)
In some serious cases, patients may also lose bladder or bowel control if the tumor is pressing on the spinal cord.
If you have suffered from some of the above symptoms, please check with your doctor right the way.
11 Fruits that Kills Prostate cancer Cells include
1. Mangosteen fruit
Mangosteen fruit, a tropical fruit grown in South East Asia is an evergreen tree originated in the Sunda Islands and the Moluccas of Indonesia.
In 22Rv1, LNCaP, and prostate epithelial cells (PrECs), standardized mangosteen fruit extract (MFE), suppressed tumor growth in a xenograft tumor model without causing damage to non-tumorigenic prostate epithelial cell through induction of toxicity(46).
Polyphenols, the main chemical constituent of the fruit extract also targeted multiple signaling pathways involved cell cycle arrest and apoptosis in prostate cancer(47).
rate
α-Mangostin, a xanthone derived from Polyphenols of mangosteen fruit, demonstrated a significant effect in exhibited cell cycle-related proteins involved in prostate carcinogenesis(48).
2. Long Pepper or Indian long pepper
Used as a spice and seasoning, Long Pepper or Indian long pepper is a flowering vine in the family Piperaceae.
Piperlongumine (PL), a natural alkaloid presented in the fruit inhibited prostate cancer through downregulation of Akt downstream signaling of cell proliferation, resulting in decrease mTORC1 (nutrient/energy)activity and autophagy (cell degradation)stimulation(49).
Application of PL also induced rapid depletion of the Androgen receptor (AR) in prostate cancer (PC) cells which is an early indication of prostate cancer(50).
In human prostate cancer DU145, PC-3 and LNCaP cells, piperine, another an alkaloid from black and long peppers, also exhibited an anti-proliferative effect in human prostate cancer cells by inducing cell cycle arrest and autophagy(51).
3. Pomegranate
Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.
POMx, a pomegranate (PE) formula currently approved for clinical trials, effectively inhibited survivin (baculoviral inhibitor), induced apoptosis, retarded the rate of tumor growth in the skeleton(52).
Polyphenols, main chemical compounds from pomegranate fruit extracts (PFEs), slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 (expression usually seen in invasive and highly tumorigenic cancers) from prostate cancer cell lines(53).
Another polyphenol derivative, ellagic acid (EA) converted from Ellagitannins (ETs) from pomegranate juice (PJ), significantly decreased cell proliferation by exhibiting synergism in PC-3 cells(54).
4. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.
Application of berry juice study, including strawberry, inhibited prostate cancer cell proliferation, not involve caspase-dependent apoptosis, but in cell-cycle arrest, by down-regulation of the expression of cdk4, cdk6, cyclin D1 and cyclin D3(Decrease the proliferative activity (55).
In fact, major classes of berry phenolics, including anthocyanins, flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic acids are found to be effective in attenuated growth of many human cancer cell lines, including prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro g/mL.(56).
Crude extracts (250 microg/mL) from strawberry and its pure compounds (100 microg/mL) also induced apoptosis of prostate (LNCaP, DU145) cancer cells(57).
5. Grapes
Grape is a woody vine of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Fisetin, a chemical compound found in grape inhibited prostate cancer cell lines through downregulation of the PI3K/Akt (anti-apoptosis and increased cell proliferation)and the mTOR(energy sources) pathways(58).
Another chemical constituent pterostilbene, in dose-dependent, ameliorated cellular proliferation, through activation of expression of AMPK(cellular energy homeostasis) and the p53(antigens).
But in p53 positive LNCaP cells, pterostilbene blocked the progression of the cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression and in p53 negative, induced apoptosis in PC3 cells(59).
Piceatannol found in grape, exhibited potential anticancer properties by suppressing proliferation of a wide variety of tumor cells, through cell-cycle arrest, upregulation of antibody antigens and apoptotic activity and down-regulation of cancer cell proliferation(60).
6. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, cultivated tree fruits. The tree is originated in Central Asia.
Apple peel extract (APE), exerted its anti-cancer effects by significant decrease growth and enhanced clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells, through a G0-G1(Cell cycle) phase arrest(61).
In the study of Does an apple a day keep the oncologist away? showed an inverse association of apple intake and incidence of cancer(62).
7. Papaya
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, first cultivated in Mexico and several centuries.
Benzylisothiocyanate (BITC), a solvent of papaya fruit inhibited cancer cell line through induced apoptosis by converging two major pathways: the death receptor-mediated extrinsic and the mitochondrial intrinsic pathway(63).
In the role of diet, papaya is effectively (more than 22.7 g/d (50th percentile) reduced prostate cancer risk by 7.4 (Adjusted OR 7.4 (95% CI 1.17-46.8)(64).
Lycopene, a major chemical constituent in tomato, also in papaya, in prospective and retrospective epidemiological studies showed an inverse relationship between lycopene intake and prostate cancer risk in vitro and in vivo(65).
8. Apricot
Apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongings to the family Rosaceae.
Ethanolic extracts (30%) of apricot inhibited the growth of PC-3 and LNCaP (Prostate cancer cell lines) cells through induction of apoptosis via down-regulating ERalpha (estrogen receptor α), ) and PKC-alpha(interaction with the cell membrane) protein, and binding of both mouse uterine estrogen receptors and LNCaP human androgen receptors(66).
9. Avocado
Avocado, a commercially valuable fruit cultivated in tropical climates throughout the world is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America.
Whole-blood fatty acids testing indicated that higher intakes of dietary MUFA(monounsaturated fatty) with the principal source of dietary avocado intake was inversely related to prostate cancer(67).
Acetone extract of avocado, containing carotenoids and tocopherols decreased the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro.
Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27(cell cycle inhibitor) protein expression(68).
10. Citrus fruits
The fruit is the genus Citrus, native to southern and southeast Asia, include grapefruit, lemon, orange, etc.
Study of incidence of prostate cancer in North India compared to South India showed a positive decreased risk of prostate cancer in increasing dietary consumption of tea, citrus fruits and melon(69).
Citrus consumption is associated with reduced all-cancer incidences, according to the study of cancer incidence among 42,470 Japanese adults in the Ohsaki National Health Insurance Cohort(70).
Oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoid, showed the deduction of both the weights (57%-100% inhibition) and volumes (78%-94% inhibition) of the tumors without inducing any adverse toxicity, accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS and cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and proliferative molecules, as well as inducing apoptosis in prostate tumors(71).
Unfortunately, some studies did not show an association between the intake of citrus fruits and the risk of prostate cancer(72).
11. Bitter melon
Bitter melon, an extremely bitter fruit, is a tropical and subtropical vine belongings to the family Cucurbitaceae, native in Asia, Africa, and the Caribbean.
Treatment of bitter melon extract (BME) in prostate cancer, enhanced Bax expression(involved in p53-mediated apoptosis) and induced PARP(a nuclear protein implicated in DNA repair) cleavage(during apoptosis), delayed the progression to high-grade prostatic intraepithelial neoplasia (precede the development of prostate adenocarcinoma) and displayed approximately 51% reduction of proliferating cell nuclear antigen expression in mice(73).
MCP30, from bitter melon seeds induced apoptosis in PIN and PCa cell lines in vitro and suppressed PC-3 growth in vivo with no effect on normal prostate cells(74).
Bitter melon leaf extract (BMLE) inhibited the secretion of MMP-2, MMP-9(metastasis) and urokinase plasminogen activator (uPA)(invasion and metastasis) from rat prostate cancer cell line (PLS10)(75).
Taken altogether, the findings suggested that certain fruits and their bioactive compound may have a strong impact on reduced risk, progression, and treatment of prostate cancer. However, due to the limitation of the sample, a large cohort study with a larger sample size is necessary to reconfirm their viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Prostate cancer in young men: an important clinical entity by Salinas CA1, Tsodikov A2, Ishak-Howard M1, Cooney KA(PubMed)
(2) Prostate cancer statistics(Canadian Cancer Society)
(3) Signs and Symptoms of Prostate Cancer(US Cancer Society)
(46) Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson J(PubMed)
(47) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer by Li G, Thomas S, Johnson JJ.(PubMed)
(48) α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth by Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.(PubMed)
(49) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death by Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM.(PubMed)
(50) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells by Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM.(PubMed)
(51) Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy by Ouyang DY, Zeng LH, Pan H, Xu LH, Wang Y, Liu KP, He XH.(PubMed)
(52) Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy by Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K, Ritenour C, Kucuk O, Wu D.(PubMed)
(53) Ellagic acid inhibits migration and invasion by prostate cancer cell lines by Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.(PubMed)
(54) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis by Vicinanza R, Zhang Y, Henning SM, Heber D.(PubMed)
(55) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice by in D, Blanchette M, Barrette S, Moghrabi A, Béliveau R.(PubMed)
(56)Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(57)Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(58) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management by Adhami VM, Syed DN, Khan N, Mukhtar H.(PubMed)
(59) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancercells by Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.(PubMed)
(60) Biological activity of piceatannol: leaving the shadow of resveratrol by Piotrowska H, Kucinska M, Murias M.(PubMed)
(61) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(62) Does an apple a day keep the oncologist away by Gallus S, Talamini R, Giacosa A, Montella M, Ramazzotti V, Franceschi S, Negri E, La Vecchia C.(PubMed)
(63) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(64) Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia by Shahar S, Shafurah S, Hasan Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, Zainuddin ZM.(PubMed)
(65) Multitargeted therapy of cancer by lycopene by van Breemen RB, Pajkovic N.(PubMed)
(66) Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo by Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.(PubMed)
(67)Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(68)Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances by Lu QY, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D(PubMed)
(69) A case control study on prostate cancer in Delhi by Tyagi B, Manoharan N, Raina V.(PubMed)
(70) Citrus consumption and cancer incidence: the Ohsaki cohort study by Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(71) Potent anti-cancer effects of citrus peel flavonoids in human prostatexenograft tumors by Lai CS, Li S, Miyauchi Y, Suzawa M, Ho CT, Pan MH.(PubMed)
(72) Citrus fruits intake and prostate cancer risk: a quantitative systematic review by Bae JM, Lee EJ, Guyatt G.(PubMed)
(73) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model by Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.(PubMed)
(74) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells by Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC.(PubMed)
(75) Momordica charantia leaf extract suppresses rat prostate cancerprogression in vitro and in vivo by Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.(PubMed)
Some researchers that the disease is the result of over-consumption of bad fats accompanied by an unhealthy diet and lifestyle, linking directly to the economic prosperity over 3 decades.
Some people who have made a lot of money.in that region in the past 3 decades are Western diet followers. Therefore, they are also susceptible to the diseases of the Western world.
Dr. Salinas CA, the lead author at the joint studies led by the University of Michigan Medical School, said, "Prostate cancer is considered a disease of older men (aged >65 years), but today over 10% of new diagnoses in the USA occur in young men aged ≤55 years"(1).
Most of the younger age patients who have prostate cancer are diagnosed with low-risk of the disease. Although early diagnosis may increase the chance of survival, these people may expose to long-term effects of treatment-related morbidities and risk of disease progression that can lead to death from prostate cancer(1).
Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.
Besides inherited genes such as RNASEL and BRCA1 and BRCA2 that increase the risk of prostate cancer, researchers do not know what causes prostate cancer. However, there are numbers of risk factor which may increase the risk of prostate cancer onset, including age, family history, obesity,...unhealthy diet.
Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during physical (rectum) exams.
According to a statistic in Canada, prostate cancer is a 3rd leading cause of death from cancer in men. in Canada.
In 2017(2)
* 21,300 men were diagnosed with prostate cancer. This represents 21% of all new cancer cases in men in 2017.
* 4,100 men died from prostate cancer. This represents 10% of all cancer deaths in men in 2017.
* On average, 58 Canadian men were diagnosed with prostate cancer every day.
* On average, 11 Canadian men died from prostate cancer every day.
People in the early stage of prostate cancer may experience no symptoms. However, as the cancer progress, patient may encounter problems of urinating, blood in the urine or semen, trouble getting an erection (erectile dysfunction or ED), pain in the hips, back (spine), chest (ribs), or other areas from cancer that has spread to bones.... and numbness in the legs or feet(3)
In some serious cases, patients may also lose bladder or bowel control if the tumor is pressing on the spinal cord.
If you have suffered from some of the above symptoms, please check with your doctor right the way.
11 Fruits that Kills Prostate cancer Cells include
1. Mangosteen fruit
Mangosteen fruit, a tropical fruit grown in South East Asia is an evergreen tree originated in the Sunda Islands and the Moluccas of Indonesia.
In 22Rv1, LNCaP, and prostate epithelial cells (PrECs), standardized mangosteen fruit extract (MFE), suppressed tumor growth in a xenograft tumor model without causing damage to non-tumorigenic prostate epithelial cell through induction of toxicity(46).
Polyphenols, the main chemical constituent of the fruit extract also targeted multiple signaling pathways involved cell cycle arrest and apoptosis in prostate cancer(47).
rate
α-Mangostin, a xanthone derived from Polyphenols of mangosteen fruit, demonstrated a significant effect in exhibited cell cycle-related proteins involved in prostate carcinogenesis(48).
2. Long Pepper or Indian long pepper
Used as a spice and seasoning, Long Pepper or Indian long pepper is a flowering vine in the family Piperaceae.
Piperlongumine (PL), a natural alkaloid presented in the fruit inhibited prostate cancer through downregulation of Akt downstream signaling of cell proliferation, resulting in decrease mTORC1 (nutrient/energy)activity and autophagy (cell degradation)stimulation(49).
Application of PL also induced rapid depletion of the Androgen receptor (AR) in prostate cancer (PC) cells which is an early indication of prostate cancer(50).
In human prostate cancer DU145, PC-3 and LNCaP cells, piperine, another an alkaloid from black and long peppers, also exhibited an anti-proliferative effect in human prostate cancer cells by inducing cell cycle arrest and autophagy(51).
3. Pomegranate
Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.
POMx, a pomegranate (PE) formula currently approved for clinical trials, effectively inhibited survivin (baculoviral inhibitor), induced apoptosis, retarded the rate of tumor growth in the skeleton(52).
Polyphenols, main chemical compounds from pomegranate fruit extracts (PFEs), slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 (expression usually seen in invasive and highly tumorigenic cancers) from prostate cancer cell lines(53).
Another polyphenol derivative, ellagic acid (EA) converted from Ellagitannins (ETs) from pomegranate juice (PJ), significantly decreased cell proliferation by exhibiting synergism in PC-3 cells(54).
4. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.
Application of berry juice study, including strawberry, inhibited prostate cancer cell proliferation, not involve caspase-dependent apoptosis, but in cell-cycle arrest, by down-regulation of the expression of cdk4, cdk6, cyclin D1 and cyclin D3(Decrease the proliferative activity (55).
In fact, major classes of berry phenolics, including anthocyanins, flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic acids are found to be effective in attenuated growth of many human cancer cell lines, including prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro g/mL.(56).
Crude extracts (250 microg/mL) from strawberry and its pure compounds (100 microg/mL) also induced apoptosis of prostate (LNCaP, DU145) cancer cells(57).
5. Grapes
Grape is a woody vine of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Fisetin, a chemical compound found in grape inhibited prostate cancer cell lines through downregulation of the PI3K/Akt (anti-apoptosis and increased cell proliferation)and the mTOR(energy sources) pathways(58).
Another chemical constituent pterostilbene, in dose-dependent, ameliorated cellular proliferation, through activation of expression of AMPK(cellular energy homeostasis) and the p53(antigens).
But in p53 positive LNCaP cells, pterostilbene blocked the progression of the cell cycle at G1 phase by inducing p53 expression and further up-regulating p21 expression and in p53 negative, induced apoptosis in PC3 cells(59).
Piceatannol found in grape, exhibited potential anticancer properties by suppressing proliferation of a wide variety of tumor cells, through cell-cycle arrest, upregulation of antibody antigens and apoptotic activity and down-regulation of cancer cell proliferation(60).
6. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, cultivated tree fruits. The tree is originated in Central Asia.
Apple peel extract (APE), exerted its anti-cancer effects by significant decrease growth and enhanced clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells, through a G0-G1(Cell cycle) phase arrest(61).
In the study of Does an apple a day keep the oncologist away? showed an inverse association of apple intake and incidence of cancer(62).
7. Papaya
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, first cultivated in Mexico and several centuries.
Benzylisothiocyanate (BITC), a solvent of papaya fruit inhibited cancer cell line through induced apoptosis by converging two major pathways: the death receptor-mediated extrinsic and the mitochondrial intrinsic pathway(63).
In the role of diet, papaya is effectively (more than 22.7 g/d (50th percentile) reduced prostate cancer risk by 7.4 (Adjusted OR 7.4 (95% CI 1.17-46.8)(64).
Lycopene, a major chemical constituent in tomato, also in papaya, in prospective and retrospective epidemiological studies showed an inverse relationship between lycopene intake and prostate cancer risk in vitro and in vivo(65).
8. Apricot
Apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongings to the family Rosaceae.
Ethanolic extracts (30%) of apricot inhibited the growth of PC-3 and LNCaP (Prostate cancer cell lines) cells through induction of apoptosis via down-regulating ERalpha (estrogen receptor α), ) and PKC-alpha(interaction with the cell membrane) protein, and binding of both mouse uterine estrogen receptors and LNCaP human androgen receptors(66).
9. Avocado
Avocado, a commercially valuable fruit cultivated in tropical climates throughout the world is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America.
Whole-blood fatty acids testing indicated that higher intakes of dietary MUFA(monounsaturated fatty) with the principal source of dietary avocado intake was inversely related to prostate cancer(67).
Acetone extract of avocado, containing carotenoids and tocopherols decreased the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro.
Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27(cell cycle inhibitor) protein expression(68).
10. Citrus fruits
The fruit is the genus Citrus, native to southern and southeast Asia, include grapefruit, lemon, orange, etc.
Study of incidence of prostate cancer in North India compared to South India showed a positive decreased risk of prostate cancer in increasing dietary consumption of tea, citrus fruits and melon(69).
Citrus consumption is associated with reduced all-cancer incidences, according to the study of cancer incidence among 42,470 Japanese adults in the Ohsaki National Health Insurance Cohort(70).
Oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoid, showed the deduction of both the weights (57%-100% inhibition) and volumes (78%-94% inhibition) of the tumors without inducing any adverse toxicity, accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS and cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and proliferative molecules, as well as inducing apoptosis in prostate tumors(71).
Unfortunately, some studies did not show an association between the intake of citrus fruits and the risk of prostate cancer(72).
11. Bitter melon
Bitter melon, an extremely bitter fruit, is a tropical and subtropical vine belongings to the family Cucurbitaceae, native in Asia, Africa, and the Caribbean.
Treatment of bitter melon extract (BME) in prostate cancer, enhanced Bax expression(involved in p53-mediated apoptosis) and induced PARP(a nuclear protein implicated in DNA repair) cleavage(during apoptosis), delayed the progression to high-grade prostatic intraepithelial neoplasia (precede the development of prostate adenocarcinoma) and displayed approximately 51% reduction of proliferating cell nuclear antigen expression in mice(73).
MCP30, from bitter melon seeds induced apoptosis in PIN and PCa cell lines in vitro and suppressed PC-3 growth in vivo with no effect on normal prostate cells(74).
Bitter melon leaf extract (BMLE) inhibited the secretion of MMP-2, MMP-9(metastasis) and urokinase plasminogen activator (uPA)(invasion and metastasis) from rat prostate cancer cell line (PLS10)(75).
Taken altogether, the findings suggested that certain fruits and their bioactive compound may have a strong impact on reduced risk, progression, and treatment of prostate cancer. However, due to the limitation of the sample, a large cohort study with a larger sample size is necessary to reconfirm their viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Prostate cancer in young men: an important clinical entity by Salinas CA1, Tsodikov A2, Ishak-Howard M1, Cooney KA(PubMed)
(2) Prostate cancer statistics(Canadian Cancer Society)
(3) Signs and Symptoms of Prostate Cancer(US Cancer Society)
(46) Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson J(PubMed)
(47) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer by Li G, Thomas S, Johnson JJ.(PubMed)
(48) α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth by Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.(PubMed)
(49) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death by Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM.(PubMed)
(50) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells by Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM.(PubMed)
(51) Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy by Ouyang DY, Zeng LH, Pan H, Xu LH, Wang Y, Liu KP, He XH.(PubMed)
(52) Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy by Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K, Ritenour C, Kucuk O, Wu D.(PubMed)
(53) Ellagic acid inhibits migration and invasion by prostate cancer cell lines by Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.(PubMed)
(54) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis by Vicinanza R, Zhang Y, Henning SM, Heber D.(PubMed)
(55) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice by in D, Blanchette M, Barrette S, Moghrabi A, Béliveau R.(PubMed)
(56)Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(57)Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(58) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management by Adhami VM, Syed DN, Khan N, Mukhtar H.(PubMed)
(59) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancercells by Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.(PubMed)
(60) Biological activity of piceatannol: leaving the shadow of resveratrol by Piotrowska H, Kucinska M, Murias M.(PubMed)
(61) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(62) Does an apple a day keep the oncologist away by Gallus S, Talamini R, Giacosa A, Montella M, Ramazzotti V, Franceschi S, Negri E, La Vecchia C.(PubMed)
(63) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(64) Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia by Shahar S, Shafurah S, Hasan Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, Zainuddin ZM.(PubMed)
(65) Multitargeted therapy of cancer by lycopene by van Breemen RB, Pajkovic N.(PubMed)
(66) Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo by Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.(PubMed)
(67)Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(68)Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances by Lu QY, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D(PubMed)
(69) A case control study on prostate cancer in Delhi by Tyagi B, Manoharan N, Raina V.(PubMed)
(70) Citrus consumption and cancer incidence: the Ohsaki cohort study by Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(71) Potent anti-cancer effects of citrus peel flavonoids in human prostatexenograft tumors by Lai CS, Li S, Miyauchi Y, Suzawa M, Ho CT, Pan MH.(PubMed)
(72) Citrus fruits intake and prostate cancer risk: a quantitative systematic review by Bae JM, Lee EJ, Guyatt G.(PubMed)
(73) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model by Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.(PubMed)
(74) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells by Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC.(PubMed)
(75) Momordica charantia leaf extract suppresses rat prostate cancerprogression in vitro and in vivo by Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.(PubMed)
Saturday, October 27, 2018
The Veggies That Inhibit Advanced Glycation End Products in Induction of Diabetic Vascular Complications
Conventional medicine has tried for years to synthesize the effect of many herbal plants' for treatment of diseases since the discovery of penicillin the first antibiotic extracted from a very primitive plant, the fungus Penicillium, in 1928, used for the treatment of infection.
However, the findings have drawn many criticisms, as single ingredient isolated from herb through synthetic version for patent right and commercial profit has induced some serious side effect.
Some researchers suggested that by using the single ingredient to treat one ailment, conventional medicine may exhibit several side effect and conditions if such medications are taken in the long term.
According to traditional Chinese medicine, the single and synthetic version of conventional medicine is so powerful, long-term intake may cause damage to the kidney such as antibiotics, diuretics,...
and liver, such as statins, antibiotics......
According to Fred Hutchinson Cancer Research Center, long-term use of some high blood pressure drugs associated with increased risk of breast cancer in postmenopausal women(8).
But many researchers have raised the question of herbal quality, because geographic differences, time of grown and harvest, etc. may affect their's potency.
Cruciferous vegetable consumption regularly may be beneficiary in reduced risk of diabetic vascular complications, some scientists suggested.
Cruciferous vegetables are the group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy,.... and broccoli.
Diabetic vascular complications are caused by a diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.
Patients with diabetes are associated with intense levels of advanced glycation end products. The toxic substance accumulated over time may have significant damage effect in host organs and tissue, as aging progress.
In some cases, the toxins can cause death to the host.
Some researchers suggested that accumulated advanced glycation end products also consisted of a strong implication in escalated the aging process.
According to the Dr. JAIME URIBARRI, MD and colleagues at the Mount Sinai School of Medicine, "The formation of new dAGEs during cooking was prevented by the AGE inhibitory compound aminoguanidine and significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar".
Due to its complex association to oxidative stress in the aging population, advanced glycation end-products (AGEs) have also strong implication in the induction of many neurodegenerative diseases, including Huntington disease, amyotrophic lateral sclerosis, and Alzheimer disease.
Diabetes is a condition caused by insufficient insulin entering the bloodstream in the regulation of glucose.
The disease is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Long-term uncontrolled diabetes may cause complications that can lead to renal failure and cardiovascular events.
Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"
Advanced glycation end-products (AGEs) interaction with RAGE stimulate the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases, a membrane-bound enzyme with function in induction of ROS expression.
Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end products aggravated diabetic vascular complications can be modulated via the RAGE receptors in the removal of AGE.
According to the Kurume University School of Medicine, sulforaphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference of proinflammatory reaction, reduction of oxidate stress.
In other words, application of sulforaphane exerted an inhibition of RAGE function in decreased DNA synthesis, apoptotic cell death in the host by increased monocyte chemoattractant protein 1 messenger RNA levels in protection against pro-inflammatory exertion in pericytes, the endothelial cells that line the capillaries and venules.
This efficacy was found in cultured cells and experimental animals.
In vivo and vitro, sulforaphane suppressed inflammatory activation of vascular cells, induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.
Also. intake of cruciferous vegetables may reduce the risk of diabetic vascular complication as sulforaphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling of over 500 genes expression of cellular defense mechanisms.
The nuclear factor E2-related factor 2 (Nrf2) is a transcription factor with a function that activates the natural antioxidant enzymes found in the host tissue in response to oxidative stress.
Oxidative stress is an indication imbalance of the ratio of the levels of antioxidants and free radical in the host body.
Therefore, in the prevention of diabetic vascular complications, people with diabetes may want to add a portion of cruciferous vegetables into their daily diet.
Intake of sulforaphane supplement should be taken with extreme care, as acute liver toxicity may be induced if overdose.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective role of sulforaphane against vascular complications in diabetes by Yamagishi S1, Matsui T1. (PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, Xu HQ3. (PubMed)
(5) Advanced glycation end product Key players in skin aging? by Paraskevi Gkogkolou and Markus Böhm(PMC)
(6) Advanced glycation end products in foods and a practical guide to their reduction in the diet by Uribarri J1, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H.(PubMed)
(7) Neuronal cell death and regeneration in diseases associated with advanced glycation end-products accumulation by Bikbova G1, Oshitari T1, Yamamoto S(PubMed)
(8) Long-term use of some high blood pressure drugs associated with increased risk of breast cancer in postmenopausal women by Fred Hutchinson Cancer Research Center
However, the findings have drawn many criticisms, as single ingredient isolated from herb through synthetic version for patent right and commercial profit has induced some serious side effect.
Some researchers suggested that by using the single ingredient to treat one ailment, conventional medicine may exhibit several side effect and conditions if such medications are taken in the long term.
According to traditional Chinese medicine, the single and synthetic version of conventional medicine is so powerful, long-term intake may cause damage to the kidney such as antibiotics, diuretics,...
and liver, such as statins, antibiotics......
According to Fred Hutchinson Cancer Research Center, long-term use of some high blood pressure drugs associated with increased risk of breast cancer in postmenopausal women(8).
But many researchers have raised the question of herbal quality, because geographic differences, time of grown and harvest, etc. may affect their's potency.
Cruciferous vegetable consumption regularly may be beneficiary in reduced risk of diabetic vascular complications, some scientists suggested.
Cruciferous vegetables are the group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy,.... and broccoli.
Diabetic vascular complications are caused by a diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.
Patients with diabetes are associated with intense levels of advanced glycation end products. The toxic substance accumulated over time may have significant damage effect in host organs and tissue, as aging progress.
In some cases, the toxins can cause death to the host.
Some researchers suggested that accumulated advanced glycation end products also consisted of a strong implication in escalated the aging process.
According to the Dr. JAIME URIBARRI, MD and colleagues at the Mount Sinai School of Medicine, "The formation of new dAGEs during cooking was prevented by the AGE inhibitory compound aminoguanidine and significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar".
Due to its complex association to oxidative stress in the aging population, advanced glycation end-products (AGEs) have also strong implication in the induction of many neurodegenerative diseases, including Huntington disease, amyotrophic lateral sclerosis, and Alzheimer disease.
Diabetes is a condition caused by insufficient insulin entering the bloodstream in the regulation of glucose.
The disease is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.
Long-term uncontrolled diabetes may cause complications that can lead to renal failure and cardiovascular events.
Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"
Advanced glycation end-products (AGEs) interaction with RAGE stimulate the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases, a membrane-bound enzyme with function in induction of ROS expression.
Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end products aggravated diabetic vascular complications can be modulated via the RAGE receptors in the removal of AGE.
According to the Kurume University School of Medicine, sulforaphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference of proinflammatory reaction, reduction of oxidate stress.
In other words, application of sulforaphane exerted an inhibition of RAGE function in decreased DNA synthesis, apoptotic cell death in the host by increased monocyte chemoattractant protein 1 messenger RNA levels in protection against pro-inflammatory exertion in pericytes, the endothelial cells that line the capillaries and venules.
This efficacy was found in cultured cells and experimental animals.
In vivo and vitro, sulforaphane suppressed inflammatory activation of vascular cells, induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.
Also. intake of cruciferous vegetables may reduce the risk of diabetic vascular complication as sulforaphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling of over 500 genes expression of cellular defense mechanisms.
The nuclear factor E2-related factor 2 (Nrf2) is a transcription factor with a function that activates the natural antioxidant enzymes found in the host tissue in response to oxidative stress.
Oxidative stress is an indication imbalance of the ratio of the levels of antioxidants and free radical in the host body.
Therefore, in the prevention of diabetic vascular complications, people with diabetes may want to add a portion of cruciferous vegetables into their daily diet.
Intake of sulforaphane supplement should be taken with extreme care, as acute liver toxicity may be induced if overdose.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective role of sulforaphane against vascular complications in diabetes by Yamagishi S1, Matsui T1. (PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, Xu HQ3. (PubMed)
(5) Advanced glycation end product Key players in skin aging? by Paraskevi Gkogkolou and Markus Böhm(PMC)
(6) Advanced glycation end products in foods and a practical guide to their reduction in the diet by Uribarri J1, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H.(PubMed)
(7) Neuronal cell death and regeneration in diseases associated with advanced glycation end-products accumulation by Bikbova G1, Oshitari T1, Yamamoto S(PubMed)
(8) Long-term use of some high blood pressure drugs associated with increased risk of breast cancer in postmenopausal women by Fred Hutchinson Cancer Research Center
Friday, October 26, 2018
Fennel May Alleviate Daily Stress Automatically and Naturally, Scientists Discover
Fennel may have a potential and positive effect in reduced negative stress impact on daily living, some scientists suggested.
Stress is a natural response of our brain against any kinds of threat and demand. People responded to stress differently, some can cope with stress that no one else can.
However, if stress is overwhelming, caused over productions of certain hormones that can induce strong implications in interfered one's daily activity.
Prolonged stress is found to exert physically, emotionally and mentally negative expression in various aspects, including sleep disturbance, digestive disorders,...
Some researchers suggested that people with chronic stress not only increases the risk of heart attack and stroke, speeds up the aging process but also are susceptible to the risk of mental conditions, such as anxiety, depression, and other mental health problems.
If you experience some abnormal cognitive, emotional, physical,....... and behavior symptoms, you may be in the early stage of chronic stress. Please check with your health service providers.
Causes of stress can be external and internal,
* External stress includes difficulty in the relationship, at work stress, financial problem, loss of a loved one,...... and financial problems.
* Internal stress includes pessimism, rigid thinking, lack of flexibility,........and negative thinking.
Chronic stress if untreated can lead to the development of some serious ailments, including mental disorders, abnormal endocrine functions, cardiovascular disease,.......... and respiratory problems.
Some researchers suggested that people with untreated chronic stress also are likely to increase the risk of infections, digestive problems, and muscular pains, particularly headaches and migraine attack.
Furthermore, society and the environment also have significant impacts on stress conditions.
According to the widely validated Holmes and Rahe Stress Scale, the top ten stressful life events for adults, are
Death of a spouse
Divorce
Marriage separation
Imprisonment
Death of a close family member
Injury or illness
Marriage
Job loss
Marriage reconciliation
Retirement
,
Fennel (Foeniculum vulgare) is a plant species of genus Foeniculum belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb or food also is used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In the study to evaluate the anti-stress and memory-enhancing properties of F. vulgare extract in experimentally stress rats at doses of 50, 100 and 200 mg/kg body weight administered orally with an orogastric tube, researchers found that rats treated with all doses exert significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.
Further analysis of fennel rat treated group with an additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41 and 125.82 μg/kg within the same period on doses of 50, 100 and 200 mg/kg body weight respectively in compared to untreated control group.
These results indicated that fennel has a stronger impact in reduced chronic stress connotation in compared to both ascorbic acid and control groups.
Moreover, the treated group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in the induction of ROS production and reduction of natural antioxidant defense in compared to rat group treated with ascorbic acid.
Dr. S Koppula,, the lead author, after taking into account of other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".
Additionally, in the review literature of a number of such drugs mostly in the form of their extracts (holistic approach) or in some, of active principles isolated from them for their antistress activity by a number of tests, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association to stress in the induction of anxiety.
* Fennel inhibits the production of level stress hormone corticosterone produced in the cortex of the adrenal gland.
* Fennel increases production antioxidant and enhancing the antioxidant defense of hosts such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibited overexpression of ROS in an initiated chain reaction caused by chronic stress.
* Fennel inhibits levels of MAO in association to the alternation of mood and mental conditions.
Finally, application of fennel also reduced the tension of the central nervous system in response to stress impact, thus reducing neurotransmitter levels in the stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......
The above illustration was supported by the application of fennel oil in exerted significant anti psychiatric disorders caused by chronic stress such as depressive and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg) and fennel oil (0.5 ml/day) conducted by the Aga Khan University
Repeated administration of fennel oil for 3 weeks demonstrated significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in elevated plus maze (EPM) incomparable to fluoxetine treatment group.
Interestingly, rats treated group also exhibited high levels of antioxidant in inhibited ROS in the facilitated production of free radicals through lipid peroxidation.
Taken together, fennel with abundant phytochemicals may be considered as a functional food in reduced stress implication in the initiation of related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Untreated Stress Can Lead To Serious Problems(Aarogya)
(4) Stress Symptoms, Signs, and Causes(Help guide)
Thursday, October 25, 2018
The Inter Relation of Free Radicals, Antioxidant Enzymes and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))
Dementia is a condition of neurodegeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 millions of worldwide population are affected by the disease, mostly in the West.
The evaluation of the diseases by holistic medicine has been lacking, especially through conventional medicine research and studies.
Maintaining a balanced ratio of antioxidant and free radicals is essential for our body to perform daily physiological function properly.
Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including dementia.
* Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donated an electron to or accept an electron from other molecules to exhibit chain and domino's effects.
Most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, including hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.
According to the University of Texas Medical Branch, observation of patients with amyotrophic lateral sclerosis (ALS) indicated that free radicals play a role in the expression of amyotrophic lateral sclerosis (ALS) through the alternation of \gene containing Cu,Zn superoxide dismutase (Cu,Zn-SOD).
Dr. Liu D said, "The selective degeneration of motor neurons in ALS may be caused by the high level of Cu,Zn-SOD present in and a large number of glutamatergic synapses projecting to these neurons"(b).
These selections of free radical in degeneration of motor neurons in ALS were attributed to free radical(mutation of Cu,Zn superoxide dismutase (Cu,Zn-SOD)) in long-term induction of oxidative stress, according to the study involved167 ALS patients (aged 59+/-13 years), treated or not with riluzole, compared with 62 age-matched healthy control subjects (aged 60+/-11 years) simultaneously, conducted by Hôpital de la Salpêtrière(c).
Some researchers suggested that cell damage and homeostatic disruption caused by free radicals can be inhibited by targeting free radicals of all kinds of molecules in the body(a), including lipids, nucleic acids, and proteins, through improving antioxidant status in the body.
* Antioxidants is a natural compound with function in inhibited molecules that cause oxidation before they can induce chains of domino's reaction.
* Antioxidants include those are produced by body tissue enzymes and externally dietary antioxidants intake from functional food sources.
Here is the summary of "The Battles of Free Radicals, Antioxidant Enzymes, and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))"
Free radicals and Dementia (Lou Gehrig's disease)
Researchers found that glutamate in the synapses enhances the production of free radicals(77), due to its excitotoxicity, only in motor nerve cells but spares other nerve cells(74)(75) such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels(76).
Antioxidants and Dementia (Lou Gehrig's disease)
1. Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).
2. Vitamin E
Vitamin E protected against cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane cause of ALS(81).
3. Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).
4. Cerebral cortex
Oxidative stress and DNA alternation triggered neurons damage(84) were found in elevated levels in mice with ALS(85).
5. Amino acids
Diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Free radicals, antioxidants and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra(PMC)
(b) The roles of free radicals in amyotrophic lateral sclerosis by Liu D(PubMed)
(c) Blood oxidative stress in amyotrophic lateral sclerosis by Bonnefont-Rousselot D1, Lacomblez L, Jaudon M, Lepage S, Salachas F, Bensimon G, Bizard C, Doppler V, Delattre J, Meininger V(PubMed)
(74) System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice by Mesci P1, Zaïdi S1, Lobsiger CS1, Millecamps S1, Escartin C2, Seilhean D1, Sato H3, Mallat M1, Boillée S4.(PubMed)
(75) Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase by Lewis KE, Rasmussen AL, Bennett W, King A, West AK, Chung RS, Chuah MI1.(PubMed)
(76) Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism by Abazyan S1, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M.(PubMed)
(77) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia by Globus MY1, Alonso O, Dietrich WD, Busto R, Ginsberg MD.(PubMed)
(78) Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. by Hemendinger RA1, Armstrong EJ 3rd, Brooks BR.(PubMed)
(79) [Clinical trials of ultra-high-dose methylcobalamin in ALS].[Article in Japanese] by Izumi Y1, Kaji R.(PubMed)
(80) Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers. by Fernandes KS1, Silva AH, Mendanha SA, Rezende KR, Alonso A.(PubMed)
(81) Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis by Michal Freedman D1, Kuncl RW, Weinstein SJ, Malila N, Virtamo J, Albanes D.(PubMed)
(82) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt AJ1, Shin DS1, Merz GE2, Rambo RP3, Lancaster WA4, Dyer KN3, Borbat PP5, Poole FL 2nd4, Adams MW4, Freed JH5, Crane BR2, Tainer JA6, Getzoff ED7. (PubMed)
(83) Hydrogen peroxide induce modifications of human extracellular superoxide dismutase that results in enzyme inhibition by Gottfredsen RH1, Larsen UG, Enghild JJ, Petersen SV. (PubMed)
(84) Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult. by An SJ1, Kang TC, Park SK, Hwang IK, Cho SS, Chung MH, Won MH. (PubMed)
(85) Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.by Matus S1, Lopez E, Valenzuela V, Nassif M, Hetz C.(PubMed)
(86) Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.by Bame M1, Grier RE, Needleman R, Brusilow WS. (PubMed)
(87) Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.[No authors listed](PubMed)
Wednesday, October 24, 2018
The Pungent Spice That Inhibits Breast Cancer Cells, Scientists Reveal
The finding of whole food medication by scientists all over the world to replace the single ingredient of the Western medicine for treatment of breast cancer with little or no side effect has been difficult due to no commercial benefits and patent right to producers.
Breast cancer is a medical and chronic condition characterized by irregular cells growth in the breast tissue.
In most cases, breast cancer (malignant breast neoplasm) starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases that breast cancer starts in other areas of the breast.
According to statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Depending to the stage of cancer, women in the very early stage (increased risk of breast cancer) may only experience rusting at the nipple, bloody nipple drainage, a retracted, flattened nipple, particularly in those symptoms that do not go away in 2 weeks.
In the early stage of breast cancer, the tumor is smaller than the approximate size of a peanut (2 centimeters or smaller) and localized.
The survival rate of women diagnosed at this early stage is 100%.
In the breast cancer stage, according to the American Cancer Society, any of the following unusual changes in the breast can be a symptom of breast cancer such as swelling of all or part of the breast, skin irritation or dimpling. breast pain, nipple pain or the nipple turning inward. redness, scaliness, or thickening of the nipple or breast skin.
Therefore, regardless of breast cancer risk, self-examination is one of the best method to detect early breast cancer. All woman should be herself looking at and feeling each breast for possible lumps, distortions or swelling monthly,
Some researchers suggested that women with alternated genes and family history of breast cancers might be required to have their mammogram taken annually.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.
The food or herb has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
According to the study, administration of fresh Garlic Extract only exerted a significant effect in the inhibited colon and gastric cancer, but also stimulated cancer cell cycle arrest and alternated the morphology of MCF7 breast cancer cells.
In MCF7 human breast cancer cells, garlic constituent diallyl trisulfide have highly effective antitumor effects by suppressing viability of cultured MCF-7 and MCF-12a cells, through decreased the percent of cells in G(2)/M and induced apoptotic cell death.
According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless of the state of estrogen in the tumors.
In a total of in 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables has a negative association between the consumption of raw onion and risk of breast cancer.
Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".
These results suggested that the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb.
Adding garlic intake to your daily diet can ameliorate the risk of breast cancer substantially.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR. (PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2. (PubMed)
Breast cancer is a medical and chronic condition characterized by irregular cells growth in the breast tissue.
In most cases, breast cancer (malignant breast neoplasm) starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases that breast cancer starts in other areas of the breast.
According to statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Depending to the stage of cancer, women in the very early stage (increased risk of breast cancer) may only experience rusting at the nipple, bloody nipple drainage, a retracted, flattened nipple, particularly in those symptoms that do not go away in 2 weeks.
In the early stage of breast cancer, the tumor is smaller than the approximate size of a peanut (2 centimeters or smaller) and localized.
The survival rate of women diagnosed at this early stage is 100%.
In the breast cancer stage, according to the American Cancer Society, any of the following unusual changes in the breast can be a symptom of breast cancer such as swelling of all or part of the breast, skin irritation or dimpling. breast pain, nipple pain or the nipple turning inward. redness, scaliness, or thickening of the nipple or breast skin.
Therefore, regardless of breast cancer risk, self-examination is one of the best method to detect early breast cancer. All woman should be herself looking at and feeling each breast for possible lumps, distortions or swelling monthly,
Some researchers suggested that women with alternated genes and family history of breast cancers might be required to have their mammogram taken annually.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.
The food or herb has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
According to the study, administration of fresh Garlic Extract only exerted a significant effect in the inhibited colon and gastric cancer, but also stimulated cancer cell cycle arrest and alternated the morphology of MCF7 breast cancer cells.
In MCF7 human breast cancer cells, garlic constituent diallyl trisulfide have highly effective antitumor effects by suppressing viability of cultured MCF-7 and MCF-12a cells, through decreased the percent of cells in G(2)/M and induced apoptotic cell death.
According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless of the state of estrogen in the tumors.
In a total of in 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables has a negative association between the consumption of raw onion and risk of breast cancer.
Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".
These results suggested that the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb.
Adding garlic intake to your daily diet can ameliorate the risk of breast cancer substantially.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR. (PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2. (PubMed)
Tuesday, October 23, 2018
11 Fruits and Veggies That Program Cervical Cancer Cells Death
The cervix is the lower part of the uterus that opens at the top of the vagina.
Cervix acts as a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
At the later stage, the cancerous cells may travel a distance away from the cervix to infect other healthy organs and tissue.
According to the statistic, every year, approximately,13,000 women in the United States are diagnosed with invasive cervical cancer and 4,170 die from the disease.
Women in the ages of 35 and 44.are associated to substantially increase the risk of cervical cancer in compared to only 15% in women over age 65.
According to cancer.net, in the early stage of cervical cancer, patients may experience some mild symptoms of blood spots or light bleeding between or following periods, longer and heavier menstrual bleeding.
If you experience some of the symptoms above, please let your family doctor knows. Early diagnosed
is associated closely to 100% of survival rate.
In the later stage, patients may experience symptoms of bleeding after intercourse, douching, or a pelvic examination...........and unexplained, persistent pelvic and/or back pain. If you develop the above symptoms, please see your doctor immediately.
The American cancer associate suggested that women with genetic mutation and infected by human papillomavirus (HPV) that becomes aggressively in the induced production of proteins known as E6 and E7 which turn off some tumor suppressor genes, may be the causes of cervical cancer.
Please note that most women with HPV don’t get cervical cancer
Risk factors besides HPV also include immune system deficiency, herpes, smoking, age.group ... use of oral contraceptives and exposure to diethylstilbestrol (DES).
The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).
Depending on the stage and grade of cancer, if the cancer is found in the early stage, hysterectomy may not be needed.
Others, after surgery, may require chemotherapy including Cisplatin, Fluorouracil (5-FU), Mitomycin, Paclitaxel, Ifosfamide, Carboplatin, Bevacizumab, and radiotherapy if necessary,
All these chemo-drugs have been known to induce serious side effects
Epidemiological studies strongly suggested that a healthy and balanced diet improved serum levels of antioxidants may reduce cervical neoplasia risk(b)(c)
Foods have been found effective in reduced risk and treatment of cervical cancer., include
1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Isothiocyanates, a major chemical constituent found in Cruciferous vegetables, inhibited the cell viability of human cervical cancer cells, through improvement of antioxidant status(1).
β-Phenylethyl isothiocyanate (PEITC). induced apoptosis to inhibit cell proliferation in human cervical cancer cell lines (HEp-2 and KB), through increased the expression of the death receptors (DR4 and DR5) and cleaved caspase-3(2).
Other chemical compounds, such as I3C (indole-3-carbinol) and DIM (diindolylmethane) found in all types of cruciferous vegetables, demonstrated exceptional anti-cancer effects against hormone responsive cancers such as ovarian cancers(3).
Some researchers suggested that isothiocyanates and indoles through the intake of cruciferous vegetable may decrease cancer risk, but the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body.
And in some instances, long-term exposure to sulforaphane and indole-3-carbinol (I3C), may have a negative implication in the treatment of a variety of anticarcinogenic mechanisms(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purpose and often in the greenhouse.
Glycoalkaloid-rich green tomato extracts, according to the Seowon University inhibited proliferation of HeLa in cervical carcinoma cells through inactivation(5).
Dr. Ferguson LR, in the study of prospects for cancer prevention, suggested that fruit and vegetable servings with total a minimum of five each day, particularly in some specific fruits and vegetables (e.g., tomato, broccoli, onions) may have strong benefits against individual cancer types(6).
But, the reviews of FDA in 2004 studies which indicated an inverse association between tomato and/or lycopene intake and the risk of some types of cancer, suggested that there are no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer(7).
3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties.
Diallyl sulfide (DAS), a chemical component of garlic-induced mitochondrial dysfunction, caused the release of cytochrome c for causing apoptosis in human cervical cancer Ca Ski cells(8) and cell cycle arrest and apoptosis through the p53, caspase- and mitochondria-dependent pathways in HeLa human cervical cancer cells(9).
The Defense Food Research Laboratory study indicated that garlic exerted its anticarcinogenic effect(including cervical cancer) through a number of mechanisms, including scavenging of radicals, increasing glutathione levels, increasing the activities of enzymes(10).
In 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice study, researchers found that there is a significant decline in the incidence of carcinoma with oral administration of garlic at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion(11).
4. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Crude methanol and fractionated extract of the rhizomes of Alpinia pahangensis, a wild ginger distributed in the lowlands of Pahang, Malaysia, showed a potent cytotoxic effect against certain cancer cell lines, including human cervical cancer cell line, Ca Ski(12).
In human cervical epithelial carcinoma (HeLa), aqueous extract of ginger (GAE) induced apoptosis of cancer cells through interacted directly with cellular microtubules and disrupts its structure(13).
Other study indicated that Benjakul [BEN], a composition of five plants: Piper Chaba fruit [PC], Piper sarmentosum root [PS], Piper interruptum stem [PI], Plumbago indica root [PL] and Zingiber officinale rhizome [ZO] in Thai herbal medicine, exerted potential cytotoxic activity against certain types of cancer cell line including cervical cancer cell line Hela(14).
5. Carrot
Carrot can grow to 3ft tall. It is root vegetable with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
According to Aichi Cancer Center, frequent intakes of carrot are associated with decreased risk of cervical cancer(15).
The Shandong University study in assessing the risk of cervical cancer association of vitamin A, found abundantly in carrot (retinol, carotene and other carotenoids) indicated that vitamin A intake and blood vitamin A levels are inversely associated with the risk of cervical cancer(16).
Others in the testing of concentrations of retinol and beta carotene in serum samples taken from 113 women with cervical cancer, 32 with invasive and 81 with pre-invasive disease, and compared with those from 226 age-matched control women, scientists after taking into account of other confounders suggested that there is a significantly reduced concentration of beta carotene levels in women with pre-invasive disease compared to the control(17).
6. Dulse
Dulse is a red seaweed of genus Palmaria, belongings to Family Palmariaceae that grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific.
The seaweed is commonly used in Ireland and Atlantic Canada both as food and medicine. Today, dulses are now shipped around the globe for commercial benefits because of its health benefits
And fried dulses can be found in many health food stores or fish markets or can be ordered directly from local distributors.
Ryerson University study of the extracts from a variety of edible seaweeds, showed a positive effect of dulse polyphenols in inhibited on cell proliferation on human cervical adenocarcinoma cell line (HeLa cells) through its antioxidant activity(18)(19).
Fucoxanthin found abundantly in dulse, in the study by Henan University, displayed aautophagy-dependent cytotoxic effect in cervical cancer cell lines HeLa cells via inhibition of Akt/mTOR signaling pathway(20).
8. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae.
The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The studies of the effects of a variety of berry extracts in human cervical cancer (HeLa) cells, indicated that
* Tannin-rich fraction of procyanidins of the strawberry extract are most potent in comparison with other berries(21).
* The extract of Strawberry, Blueberry, and Raspberry Extracts. showed a positive effect in inhibited CaSki and SiHa cervical cancer cell lines(22).
9. Grape and Red wine
Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Grape extracts was found to interact effectively with decaffeinated green tea extracts both in the inhibition of tNOX activity and in the inhibition of cancer cell growth(23).
Red and white winepolyphenols and resveratrol exerted higher cytotoxic activity against HeLabut white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract(24).
10. Cactus pear
Cactus pear also known as Prickly pear is a genus Opuntia, belongings to the family Cactaceae, native to Mexico.
Cactus pear extracts, in the study of immortalized ovarian and ovarian cancer cells (OVCA420, SKOV3), exhibited anti proliferative effect through a dramatic increase of reactive oxygen species (ROS),(25).
Study from the University of Arizona, indicated that aqueous extracts of cactus pear significantly increased apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner through cell cycle arrest(26).
11. Vitis coignetiae Pulliat
Vitis coignetiae Pulliat also known as Yamabudo, Crimson Glory Vine, is the genus Viti, belongings to the family Vitaceae, native to the temperate climes of Asia.
It has been used as a health juice and wine because of the abundant polyphenols and anthocyanins.
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat (AIMs), inhibited the invasion of HeLa cell in a dose-dependent manner,(26).
The stem extracts from Greek Vitis vinifera varieties of the total polyphenolic content (TPC) inhibited at low concentrations, the growth of HepG2 and HeLa cancer cells comparable to those of seed extracts(27)(28).
Taken altogether, without going into reviews, the list of foods above may be potent in reduced risk and treatment of cervical cancer. But further studies with large sample sizes and multi centers are necessary to improve the validation of these claims.
However, some researchers argued that the role of diet and nutrition in the etiology of cervical cancer is not yet resolved(d).
And, the Catalan Institute of Oncology study showed statistically nonsignificant inverse associations were observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for invasive squamous cervical cancer (ISC)(e).
As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Cerical cancer (Amerrican cancer society)
(b) Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women by Tomita LY1, Longatto Filho A, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team.(PubMed)
(c) Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking by Tomita LY1, Roteli-Martins CM, Villa LL, Franco EL, Cardoso MA; BRINCA Study Team.(PubMed)
(d) Diet and the risk of in situ cervical cancer among white women in the United States by Ziegler RG1, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, et al.(PubMed)
(e) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(2) Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5 by Huong le D1, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD(PubMed)
(3) Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis by Acharya A1, Das I, Singh S, Saha T.(PubMed)
(4) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis by Higdon JV1, Delage B, Williams DE, Dashwood RH.(PubMed)
(5) Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts by Choi SH1, Lee SH, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(PubMed)
(6) Prospects for cancer prevention by Ferguson LR.(PubMed)
(7) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC.(PubMed)
(8) Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells by Chiu TH1, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG.(PubMed)
(9) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways by Wu PP1, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(PubMed)
(10) Anticarcinogenic properties of garlic: a review by Khanum F1, Anilakumar KR, Viswanathan KR.(PubMed)
(11) Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice by Hussain SP1, Jannu LN, Rao AR.(PubMed)
(12) Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes by Phang CW1, Malek SN, Ibrahim H.(PubMed)
(13) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells by Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.(PubMed)
(14) In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells by Ruangnoo S1, Itharat A, Sakpakdeejaroen I, Rattarom R, Tappayutpijam P, Pawa KK.(PubMed)
(15) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].
[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)
(16) Vitamin A and risk of cervical cancer: a meta-analysis by Zhang X1, Dai B, Zhang B, Wang Z.(PubMed)
(17) Cancer of the cervix uteri and vitamin A by Harris RW, Forman D, Doll R, Vessey MP, Wald NJ.(PubMed)
(18) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds by Yuan YV1, Walsh NA.(PubMed)
(19) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(20) Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells by Hou LL1, Gao C, Chen L, Hu GQ, Xie SQ.(PubMed)
(21) Berry extracts exert different antiproliferative effects against cervicaland colon cancer cells grown in vitro by McDougall GJ1, Ross HA, Ikeji M, Stewart D.(PubMed)
(22) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells. by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(23) Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions by Morré DM1, Morré DJ.(PubMed)
(24) Cytotoxic effect of wine polyphenolic extracts and resveratrol against human carcinoma cells and normal peripheral blood mononuclear cells by Matić I1, Zizak Z, Simonović M, Simonović B, Godevac D, Savikin K, Juranić Z.(PubMed)
(25) Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells by Feugang JM1, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, Zou C.(PubMed)
(26) Cactus pear: a natural product in cancer chemoprevention by Zou DM1, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C.(PubMed)
(27) Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells by Lu JN1, Lee WS, Yun JW, Kim MJ, Kim HJ, Kim DC, Jeong JH, Choi YH, Kim GS, Ryu CH, Shin SC.(PubMed)
(28) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts by Apostolou A1, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D.
Cervix acts as a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
At the later stage, the cancerous cells may travel a distance away from the cervix to infect other healthy organs and tissue.
According to the statistic, every year, approximately,13,000 women in the United States are diagnosed with invasive cervical cancer and 4,170 die from the disease.
Women in the ages of 35 and 44.are associated to substantially increase the risk of cervical cancer in compared to only 15% in women over age 65.
According to cancer.net, in the early stage of cervical cancer, patients may experience some mild symptoms of blood spots or light bleeding between or following periods, longer and heavier menstrual bleeding.
If you experience some of the symptoms above, please let your family doctor knows. Early diagnosed
is associated closely to 100% of survival rate.
In the later stage, patients may experience symptoms of bleeding after intercourse, douching, or a pelvic examination...........and unexplained, persistent pelvic and/or back pain. If you develop the above symptoms, please see your doctor immediately.
The American cancer associate suggested that women with genetic mutation and infected by human papillomavirus (HPV) that becomes aggressively in the induced production of proteins known as E6 and E7 which turn off some tumor suppressor genes, may be the causes of cervical cancer.
Please note that most women with HPV don’t get cervical cancer
Risk factors besides HPV also include immune system deficiency, herpes, smoking, age.group ... use of oral contraceptives and exposure to diethylstilbestrol (DES).
The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).
Depending on the stage and grade of cancer, if the cancer is found in the early stage, hysterectomy may not be needed.
Others, after surgery, may require chemotherapy including Cisplatin, Fluorouracil (5-FU), Mitomycin, Paclitaxel, Ifosfamide, Carboplatin, Bevacizumab, and radiotherapy if necessary,
All these chemo-drugs have been known to induce serious side effects
Epidemiological studies strongly suggested that a healthy and balanced diet improved serum levels of antioxidants may reduce cervical neoplasia risk(b)(c)
Foods have been found effective in reduced risk and treatment of cervical cancer., include
1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Isothiocyanates, a major chemical constituent found in Cruciferous vegetables, inhibited the cell viability of human cervical cancer cells, through improvement of antioxidant status(1).
β-Phenylethyl isothiocyanate (PEITC). induced apoptosis to inhibit cell proliferation in human cervical cancer cell lines (HEp-2 and KB), through increased the expression of the death receptors (DR4 and DR5) and cleaved caspase-3(2).
Other chemical compounds, such as I3C (indole-3-carbinol) and DIM (diindolylmethane) found in all types of cruciferous vegetables, demonstrated exceptional anti-cancer effects against hormone responsive cancers such as ovarian cancers(3).
Some researchers suggested that isothiocyanates and indoles through the intake of cruciferous vegetable may decrease cancer risk, but the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body.
And in some instances, long-term exposure to sulforaphane and indole-3-carbinol (I3C), may have a negative implication in the treatment of a variety of anticarcinogenic mechanisms(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purpose and often in the greenhouse.
Glycoalkaloid-rich green tomato extracts, according to the Seowon University inhibited proliferation of HeLa in cervical carcinoma cells through inactivation(5).
Dr. Ferguson LR, in the study of prospects for cancer prevention, suggested that fruit and vegetable servings with total a minimum of five each day, particularly in some specific fruits and vegetables (e.g., tomato, broccoli, onions) may have strong benefits against individual cancer types(6).
But, the reviews of FDA in 2004 studies which indicated an inverse association between tomato and/or lycopene intake and the risk of some types of cancer, suggested that there are no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer(7).
3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties.
Diallyl sulfide (DAS), a chemical component of garlic-induced mitochondrial dysfunction, caused the release of cytochrome c for causing apoptosis in human cervical cancer Ca Ski cells(8) and cell cycle arrest and apoptosis through the p53, caspase- and mitochondria-dependent pathways in HeLa human cervical cancer cells(9).
The Defense Food Research Laboratory study indicated that garlic exerted its anticarcinogenic effect(including cervical cancer) through a number of mechanisms, including scavenging of radicals, increasing glutathione levels, increasing the activities of enzymes(10).
In 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice study, researchers found that there is a significant decline in the incidence of carcinoma with oral administration of garlic at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion(11).
4. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Crude methanol and fractionated extract of the rhizomes of Alpinia pahangensis, a wild ginger distributed in the lowlands of Pahang, Malaysia, showed a potent cytotoxic effect against certain cancer cell lines, including human cervical cancer cell line, Ca Ski(12).
In human cervical epithelial carcinoma (HeLa), aqueous extract of ginger (GAE) induced apoptosis of cancer cells through interacted directly with cellular microtubules and disrupts its structure(13).
Other study indicated that Benjakul [BEN], a composition of five plants: Piper Chaba fruit [PC], Piper sarmentosum root [PS], Piper interruptum stem [PI], Plumbago indica root [PL] and Zingiber officinale rhizome [ZO] in Thai herbal medicine, exerted potential cytotoxic activity against certain types of cancer cell line including cervical cancer cell line Hela(14).
5. Carrot
Carrot can grow to 3ft tall. It is root vegetable with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
According to Aichi Cancer Center, frequent intakes of carrot are associated with decreased risk of cervical cancer(15).
The Shandong University study in assessing the risk of cervical cancer association of vitamin A, found abundantly in carrot (retinol, carotene and other carotenoids) indicated that vitamin A intake and blood vitamin A levels are inversely associated with the risk of cervical cancer(16).
Others in the testing of concentrations of retinol and beta carotene in serum samples taken from 113 women with cervical cancer, 32 with invasive and 81 with pre-invasive disease, and compared with those from 226 age-matched control women, scientists after taking into account of other confounders suggested that there is a significantly reduced concentration of beta carotene levels in women with pre-invasive disease compared to the control(17).
6. Dulse
Dulse is a red seaweed of genus Palmaria, belongings to Family Palmariaceae that grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific.
The seaweed is commonly used in Ireland and Atlantic Canada both as food and medicine. Today, dulses are now shipped around the globe for commercial benefits because of its health benefits
And fried dulses can be found in many health food stores or fish markets or can be ordered directly from local distributors.
Ryerson University study of the extracts from a variety of edible seaweeds, showed a positive effect of dulse polyphenols in inhibited on cell proliferation on human cervical adenocarcinoma cell line (HeLa cells) through its antioxidant activity(18)(19).
Fucoxanthin found abundantly in dulse, in the study by Henan University, displayed aautophagy-dependent cytotoxic effect in cervical cancer cell lines HeLa cells via inhibition of Akt/mTOR signaling pathway(20).
8. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae.
The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The studies of the effects of a variety of berry extracts in human cervical cancer (HeLa) cells, indicated that
* Tannin-rich fraction of procyanidins of the strawberry extract are most potent in comparison with other berries(21).
* The extract of Strawberry, Blueberry, and Raspberry Extracts. showed a positive effect in inhibited CaSki and SiHa cervical cancer cell lines(22).
9. Grape and Red wine
Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Grape extracts was found to interact effectively with decaffeinated green tea extracts both in the inhibition of tNOX activity and in the inhibition of cancer cell growth(23).
Red and white winepolyphenols and resveratrol exerted higher cytotoxic activity against HeLabut white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract(24).
10. Cactus pear
Cactus pear also known as Prickly pear is a genus Opuntia, belongings to the family Cactaceae, native to Mexico.
Cactus pear extracts, in the study of immortalized ovarian and ovarian cancer cells (OVCA420, SKOV3), exhibited anti proliferative effect through a dramatic increase of reactive oxygen species (ROS),(25).
Study from the University of Arizona, indicated that aqueous extracts of cactus pear significantly increased apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner through cell cycle arrest(26).
11. Vitis coignetiae Pulliat
Vitis coignetiae Pulliat also known as Yamabudo, Crimson Glory Vine, is the genus Viti, belongings to the family Vitaceae, native to the temperate climes of Asia.
It has been used as a health juice and wine because of the abundant polyphenols and anthocyanins.
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat (AIMs), inhibited the invasion of HeLa cell in a dose-dependent manner,(26).
The stem extracts from Greek Vitis vinifera varieties of the total polyphenolic content (TPC) inhibited at low concentrations, the growth of HepG2 and HeLa cancer cells comparable to those of seed extracts(27)(28).
Taken altogether, without going into reviews, the list of foods above may be potent in reduced risk and treatment of cervical cancer. But further studies with large sample sizes and multi centers are necessary to improve the validation of these claims.
However, some researchers argued that the role of diet and nutrition in the etiology of cervical cancer is not yet resolved(d).
And, the Catalan Institute of Oncology study showed statistically nonsignificant inverse associations were observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for invasive squamous cervical cancer (ISC)(e).
As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Cerical cancer (Amerrican cancer society)
(b) Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women by Tomita LY1, Longatto Filho A, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team.(PubMed)
(c) Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking by Tomita LY1, Roteli-Martins CM, Villa LL, Franco EL, Cardoso MA; BRINCA Study Team.(PubMed)
(d) Diet and the risk of in situ cervical cancer among white women in the United States by Ziegler RG1, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, et al.(PubMed)
(e) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(2) Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5 by Huong le D1, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD(PubMed)
(3) Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis by Acharya A1, Das I, Singh S, Saha T.(PubMed)
(4) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis by Higdon JV1, Delage B, Williams DE, Dashwood RH.(PubMed)
(5) Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts by Choi SH1, Lee SH, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(PubMed)
(6) Prospects for cancer prevention by Ferguson LR.(PubMed)
(7) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC.(PubMed)
(8) Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells by Chiu TH1, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG.(PubMed)
(9) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways by Wu PP1, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(PubMed)
(10) Anticarcinogenic properties of garlic: a review by Khanum F1, Anilakumar KR, Viswanathan KR.(PubMed)
(11) Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice by Hussain SP1, Jannu LN, Rao AR.(PubMed)
(12) Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes by Phang CW1, Malek SN, Ibrahim H.(PubMed)
(13) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells by Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.(PubMed)
(14) In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells by Ruangnoo S1, Itharat A, Sakpakdeejaroen I, Rattarom R, Tappayutpijam P, Pawa KK.(PubMed)
(15) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].
[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)
(16) Vitamin A and risk of cervical cancer: a meta-analysis by Zhang X1, Dai B, Zhang B, Wang Z.(PubMed)
(17) Cancer of the cervix uteri and vitamin A by Harris RW, Forman D, Doll R, Vessey MP, Wald NJ.(PubMed)
(18) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds by Yuan YV1, Walsh NA.(PubMed)
(19) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(20) Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells by Hou LL1, Gao C, Chen L, Hu GQ, Xie SQ.(PubMed)
(21) Berry extracts exert different antiproliferative effects against cervicaland colon cancer cells grown in vitro by McDougall GJ1, Ross HA, Ikeji M, Stewart D.(PubMed)
(22) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells. by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(23) Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions by Morré DM1, Morré DJ.(PubMed)
(24) Cytotoxic effect of wine polyphenolic extracts and resveratrol against human carcinoma cells and normal peripheral blood mononuclear cells by Matić I1, Zizak Z, Simonović M, Simonović B, Godevac D, Savikin K, Juranić Z.(PubMed)
(25) Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells by Feugang JM1, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, Zou C.(PubMed)
(26) Cactus pear: a natural product in cancer chemoprevention by Zou DM1, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C.(PubMed)
(27) Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells by Lu JN1, Lee WS, Yun JW, Kim MJ, Kim HJ, Kim DC, Jeong JH, Choi YH, Kim GS, Ryu CH, Shin SC.(PubMed)
(28) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts by Apostolou A1, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D.
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