The prevalence of extreme overweight and obesity has caused concerns of the scientific community in the South East Asian population, due unhealthy diet and lifestyle change over 2 decades of economic prosperity.
Overweight and obesity have reached epidemic proportions in many Asian countries, affecting even younger age than in Western populations with economic burden in the development of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).
One of six Malaysian is either extremely overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association.
And, according to global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of global DALYs are caused by overweight or obesity, worldwide(2).
Epidemiological studies, linking herbal medicine, foods, and vitamins in preventing and treating these diseases have been inconclusive(a)
Some researchers suggested that intake of certain herbal medicine may enhance appetite suppression.
However, according to the Georgetown University Medical Center, average daily food intake was decreased only with the herbal formulation, not the phenylpropanolamine (PPA) at the low and high doses, in comparison of the effectiveness among herbal formulation and a commonly available(3).
Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated with herbal products attributed with weight-reducing properties(4)(5)(6)(7).
The College of Medicine, The Ohio State University insisted that various dietary, lifestyle and psychologic factors are involved in the etiology of Prameha, particularly in relation to disturbances in fat and carbohydrate metabolism(8), without effective management, obtaining a workable weight loss plan may be extremely difficult.
Epidemiological studies, linking certain foods in reduced weight loss for the obese individual have produced certain positive results, but researchers emphasized that weight loss cannot be in the expenses of intake of nutrients(30a).
1. Oats
Oat is a species of cereal grain grown for its seed and was first cultivated in Europe but is now grown all over the world, especially in Scotland and England.
It is one of the good crop to plant in the poor soil after crops are harvested in the Fall(30).
Oat, rich in beta-glucan, may hold a magic power in the regulation of metabolism and liver-protecting effect.
According to Chung-Shan Medical University, consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions with no adverse effects(31).
Whole-grain ready-to-eat oat cereal, in a randomized study of 144 Free-living, overweight and obese adults (N=204, body mass index 25 to 45) with baseline LDL cholesterol levels 130 to 200 mg/dL, had favorable effects on fasting lipid levels and waist circumference(32).
Other study suggested that at-derived beta-glucan, combined with moderate exercise also improved the lipid profile and caused a decrease in weight(33).
2. Salmon
Salmon is the common name for Salmonidae. They are anadromous, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within to five years returning to the exacted location where they were born to reproduce and die(34).
Dietary salmon oil, in rat study, showed to reduced weight loss of CXB-E and -H tested mice, but induced with weight gain in recombinant inbred strains.
These findings may suggest that body weight response to salmon oil feeding is controlled by multiple genes(35).
A novel oral form of salmon calcitonin (sCT), according to the study at 1Nordic Bioscience, also showed to improve fasting and postprandial glycemic control and insulin sensitivity and may be considered as a promising agent for the treatment of obesity-related insulin resistance and type 2 diabetes patients(36)(37).
3. Brown rice
Brown rice or unpolished rice is a kind of whole, natural grain with the very brown color of which only the outermost layer of the rice kernel are removed, thus preventing the loss of nutrients(38).
The study of the weigh effect of brown rice on metabolic parameters in type 2 diabetes, showed a positive effect of consumption of the brown rice(LB) in association with a decreased waist circumference in type 2 diabetic patients(39).
Another randomized study of forty women between 20 and 35 years of age in the comparison of white rice and mixed rice of weight control, including brown rice, indicated that meal replacement with mixed rice was superior to replacement with white rice in weight control, improving antioxidant enzyme activity(40).
4. Chicken
Chicken are domesticated fowl belonging to the subspecies of Gallus domesticus and is raised all over the world for its delicious meats and eggs.
It can be roasted, broiled, grilled or poached into a very delicious, tasteful and nutritious meal(41).
In the comparison of weight loss and total lipid profile changes in overweight women consuming beef or chicken, researchers at 1Rippe Lifestyle Institute, Shrewsbury showed a interesting result of weight loss and improved lipid profile can be accomplished through diet and exercise, regardless to dietary protein source including lean beef or chicken(42).
But the study at University of Navarra showed an opposite result in the study of frequent consumption of selenium-enriched chicken meat(43), it may be the result of the presence of antioxidant selenium in the meat.
5. Water
According to Virginia Tech, consuming 500 ml water prior to each main meal may lead to greater weight loss than a hypocaloric diet alone in middle-aged and older adults, because of it acutely reduces meal energy intake(EI)(44) but not younger subjects(45).
The Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial, suggested that replacing caloric beverages with water or diet beverages induced 2% to 2.5% weight loss(46).
6. Nuts
Dietary consumption of nuts with rich sources of multiple nutrients is associated with health benefits and weight loss, epidemiologically. but in well-controlled nut-feeding trials, no changes in body weight were observed(47).
Pistachio nuts, a member of the cashew family, can be consumed as a portion-controlled snack for individuals restricting calories to lose weight without concern that pistachios will cause weight gain(48).
7. Green tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Green tea has been a precious drink in traditional Chinese culture and used exceptionally in socialization for more than 4000 thousand years.
Because of their health benefits, they have been cultivated for commercial purposes all over the world.
According to Maastricht University, caffeine intake and green tea supplementation are associated to improved weight maintenance, partly through thermogenesis and fat oxidation, in a randomized placebo-controlled double-blind parallel trial in 76 overweight and moderately obese subjects(49).
Catechins the antioxidants found abundantly in green tea, significantly decreased body weight and significantly maintained body weight after a period of weight loss, depending to the moderators of habitual caffeine intake and ethnicity(50).
In a high-protein diet, green tea-caffeine mixture failed to exert the same effect on body weight maintenance(51).
8. Coffee
Coffee made from the roasted seeds of the genus Coffee, belongings to the family Rubiaceae native to southern Arabia.
In a randomized, double-blind, placebo-controlled, linear dose, crossover study, green coffee extract, consistent with human and animal studies and a meta-analysis may be an effective nutraceutical in reducing weight in preobese adults(52).
Mannooligosaccharides (MOS), extracted from coffee, exhibited a potential functional use for weight management and improvement in adipose tissue distribution, but varying in gender(53).
Unfortunately, green coffee extract (GCE), according to University of Exeter, in reviews of the effect against weight loss of existed data, showed a significant poor methodological quality and suggested that more rigorous trials are needed to assess the usefulness of GCE as a weight loss tool(54).
Another study, reported a case of Brazil Potent Slimming Coffee and possibly also other weight-loss products may be contaminated with sibutramine and as a result, cause severe adverse reactions after stabbing herself in the stomach with a knife(55).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(30) #Healthy #Foods - Oats ((Avena sativa) (Health tips for better living and living health)
(31a) Association between mood and diet quality in subjects with metabolic syndrome participating in a behavioural weight-loss programme: A cross-sectional assessment by Perez-Cornago A, Zulet MA, Martinez JA.(PubMed)
(31b) Dietary quality-adherence to the dietary guidelines in Tehranian adolescents: Tehran Lipid and Glucose Study by Mirmiran P1, Azadbakht L, Azizi F.(PubMed)
(31) Oat prevents obesity and abdominal fat distribution, and improves liver function in humans by Chang HC1, Huang CN, Yeh DM, Wang SJ, Peng CH, Wang CJ.(PubMed)
(32) Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods by Maki KC1, Beiseigel JM, Jonnalagadda SS, Gugger CK, Reeves MS, Farmer MV, Kaden VN, Rains TM.(PubMed)
(33) Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia, Reyna-Villasmil N1, Bermúdez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili ZH, Hernández-Hernández R, Valasco M, Arraiz N.(PubMed)
(34) #Healthy #Foods - Seafoods - Salmon (Healthy tips for better living and living health)
(35) Genetically determined body weight loss in mice fed diets containing salmon oil by LeBoeuf RC1, Veldee MS.(PubMed)
(36) Oral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats by Feigh M1, Nielsen RH, Hansen C, Henriksen K, Christiansen C, Karsdal MA.(PubMed)
(37) A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats by Feigh M1, Henriksen K, Andreassen KV, Hansen C, Henriksen JE, Beck-Nielsen H, Christiansen C, Karsdal MA.(PubMed)
(38) #Healthy #Foods - Whole Grain - Brown rice or Hulled rice's(Health tips for beter living and living health)
(39) Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes by Kim TH1, Kim EK, Lee MS, Lee HK, Hwang WS, Choe SJ, Kim TY, Han SJ, Kim HJ, Kim DJ, Lee KW.(PubMed)
(40) Meal replacement with mixed rice is more effective than white rice in weight control, while improving antioxidant enzyme activity in obese women by Kim JY1, Kim JH, Lee da H, Kim SH, Lee SS.(PubMed)
(41) #Healthy #Foods - Chicken (Gallus gallus domesticus)(Health tips for btter living and living health)
(42) Weight loss and total lipid profile changes in overweight women consuming beef or chicken as the primary protein source by Melanson K1, Gootman J, Myrdal A, Kline G, Rippe JM.(PubMed)
(43) Frequent consumption of selenium-enriched chicken meat by adults causes weight loss and maintains their antioxidant status by Navas-Carretero S1, Cuervo M, Abete I, Zulet MA, Martínez JA.(PubMed)
(44) Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults by Dennis EA1, Dengo AL, Comber DL, Flack KD, Savla J, Davy KP, Davy BM(PubMed)
(45) Pre-meal water consumption reduces meal energy intake in older but not younger subjects by
Van Walleghen EL1, Orr JS, Gentile CL, Davy BM.(PubMed)
(46) Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial by Tate DF1, Turner-McGrievy G, Lyons E, Stevens J, Erickson K, Polzien K, Diamond M, Wang X, Popkin B.(PubMed)
(47) Nut consumption and body weight by Sabaté J.(PubMed)
(48) Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight lossprogram by Li Z1, Song R, Nguyen C, Zerlin A, Karp H, Naowamondhol K, Thames G, Gao K, Li L, Tseng CH, Henning SM, Heber(PubMed)
(48) Impact of peanuts and tree nuts on body weight and healthy weight loss in adults by Mattes RD1, Kris-Etherton PM, Foster GD.(PubMed)
(49) Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation by Westerterp-Plantenga MS1, Lejeune MP, Kovacs EM.(PubMed)
(50) The effects of green tea on weight loss and weight maintenance: a meta-analysis by Hursel R1, Viechtbauer W, Westerterp-Plantenga MS.(PubMed)
(51) Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss by Hursel R1, Westerterp-Plantenga MS.(PubMed)
(52) Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects by Vinson JA1, Burnham BR, Nagendran MV.(PubMed)
(53) A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women, by St-Onge MP1, Salinardi T, Herron-Rubin K, Black RM.(PubMed)
(54) The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials by Onakpoya I1, Terry R, Ernst E.(PubMed)
(55) [Life-threatening psychosis caused by using sibutramine-contaminated weight-loss coffee].
[Article in Dutch] by Bertholee D1, ter Horst PG, Wieringa A, Smit JP.(PubMed)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Friday, November 30, 2018
Thursday, November 29, 2018
Unripe Papaya Whole Food Which Averts The Onset of Diabetes
Papaya may be used as a functional food to inhibit early onset and treatment of diabetes, some scientists suggested.
Diabetes is a medical and chronic condition characterized by abnormally high levels of sugar (glucose) in the blood caused by pancreas inability in produced insulin.
In other words, diabetes is a result of absence or insufficient production of insulin by the pancreas. The condition is also caused by the inability of the body to properly use of insulin, leading to insulin resistance.
According to the statistic produced by the Canadian Diabetes Association, approximately, 17%
of Canadian, over 12 years of age are diagnosed with diabetes.
Interestingly, diabetes affects both genders up to age 64. The prevalence does not increase significantly for those aged 65 and older.
Unlike type 1 diabetes which is caused by the immune system attacking the cells in the pancreas that make insulin, leading to the body without enough insulin to function normally, type 2 diabetes is caused by unhealthy diet and lifestyle.
Obesity and increasing age are 2 of many risk factors that can elevate the risk of type 2 diabetes.
Symptoms of type 1 and 2 diabetes, according to Medicine Net include increased urine output, excessive thirst, weight loss, hunger, fatigue, skin problems slow-healing wounds, yeast infections,..... and tingling or numbness in the feet or toes(6).
If you experience some of the above symptoms, please see your doctor to rule out the possibility.
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries
Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a).
Water extract from papaya isolated from unripe pawpaw (Carica papaya Linn) fruit, exerted a significant effect in inhibition of enzymes, α-amylase and α-glucosidase that linked to type 2 diabetes, in sodium nitroprusside (SNP)-induced lipid peroxidation mice model and a dose-dependent manner(1).
Combination of the flesh, seed, and peel in equal amounts produced the highest inhibitory effect on α-amylase and α-glucosidase activities compared to other preparations.
Dr. Oboh G, the lead authors in the study said, "Strong inhibitory activities of the unripe pawpaw fruit against key enzymes linked to type 2 diabetes and SNP-induced lipid peroxidation in rat pancreas could be part of the mechanism by which unripe pawpaw is used in the management/prevention of diabetes mellitus in folk medicine"(1).
Truly, in the preparation of individual aqueous extract of the unripe pawpaw fruit parts; peel (PG), seed (SG), flesh (FG), flesh with peel (FPG) and a combination of equal amount of all parts (CG), the Federal University of Technology at the end of experiment indicated that on Fe²⁺-induced lipid peroxidation in rat pancreas, application of the prepared extracts phenolic compounds inhibited oxidative stress through their antioxidant activities(2).
According to Universidad Juárez Autónoma de Tabasco (UJAT), unripe papaya preparations not only exert hypoglycemic effects in both animals and humans studies but also help islet regeneration, preservation of cell size and prevented hepatocyte disruption(3).
In fact, the aqueous extract of Carica papaya also significantly decreased blood glucose levels in diabetic rats and decreased cholesterol, triacylglycerol, and amino-transferases blood levels without changing the levels of plasma insulin levels in diabetic rats(4).
In short-term supplementation of a fermented papaya, showed to exhibit its effect in the management of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(5).
These findings suggested that all parts of unripe papaya have a strong and profound effect in inhibition of diabetic onset and treatment of type 2 diabetes.
However, a large sample size and a multi-center clinical trial on human consumption on the course of the disease onset are necessary to confirm the unripe papaya anti-diabetes possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya). by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(2) Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe²⁺-induced oxidative stress in rat pancreas in vitro by Oboh G1, Olabiyi AA, Akinyemi AJ.(PubMed)
(3) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(4) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y1, Bhixavatimath P(PubMed)
(5) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Diabetes Symptoms, (Type 1 and Type 2) by Medicine Net
Diabetes is a medical and chronic condition characterized by abnormally high levels of sugar (glucose) in the blood caused by pancreas inability in produced insulin.
In other words, diabetes is a result of absence or insufficient production of insulin by the pancreas. The condition is also caused by the inability of the body to properly use of insulin, leading to insulin resistance.
According to the statistic produced by the Canadian Diabetes Association, approximately, 17%
of Canadian, over 12 years of age are diagnosed with diabetes.
Interestingly, diabetes affects both genders up to age 64. The prevalence does not increase significantly for those aged 65 and older.
Unlike type 1 diabetes which is caused by the immune system attacking the cells in the pancreas that make insulin, leading to the body without enough insulin to function normally, type 2 diabetes is caused by unhealthy diet and lifestyle.
Obesity and increasing age are 2 of many risk factors that can elevate the risk of type 2 diabetes.
Symptoms of type 1 and 2 diabetes, according to Medicine Net include increased urine output, excessive thirst, weight loss, hunger, fatigue, skin problems slow-healing wounds, yeast infections,..... and tingling or numbness in the feet or toes(6).
If you experience some of the above symptoms, please see your doctor to rule out the possibility.
Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries
Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a).
Water extract from papaya isolated from unripe pawpaw (Carica papaya Linn) fruit, exerted a significant effect in inhibition of enzymes, α-amylase and α-glucosidase that linked to type 2 diabetes, in sodium nitroprusside (SNP)-induced lipid peroxidation mice model and a dose-dependent manner(1).
Combination of the flesh, seed, and peel in equal amounts produced the highest inhibitory effect on α-amylase and α-glucosidase activities compared to other preparations.
Dr. Oboh G, the lead authors in the study said, "Strong inhibitory activities of the unripe pawpaw fruit against key enzymes linked to type 2 diabetes and SNP-induced lipid peroxidation in rat pancreas could be part of the mechanism by which unripe pawpaw is used in the management/prevention of diabetes mellitus in folk medicine"(1).
Truly, in the preparation of individual aqueous extract of the unripe pawpaw fruit parts; peel (PG), seed (SG), flesh (FG), flesh with peel (FPG) and a combination of equal amount of all parts (CG), the Federal University of Technology at the end of experiment indicated that on Fe²⁺-induced lipid peroxidation in rat pancreas, application of the prepared extracts phenolic compounds inhibited oxidative stress through their antioxidant activities(2).
According to Universidad Juárez Autónoma de Tabasco (UJAT), unripe papaya preparations not only exert hypoglycemic effects in both animals and humans studies but also help islet regeneration, preservation of cell size and prevented hepatocyte disruption(3).
In fact, the aqueous extract of Carica papaya also significantly decreased blood glucose levels in diabetic rats and decreased cholesterol, triacylglycerol, and amino-transferases blood levels without changing the levels of plasma insulin levels in diabetic rats(4).
In short-term supplementation of a fermented papaya, showed to exhibit its effect in the management of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(5).
These findings suggested that all parts of unripe papaya have a strong and profound effect in inhibition of diabetic onset and treatment of type 2 diabetes.
However, a large sample size and a multi-center clinical trial on human consumption on the course of the disease onset are necessary to confirm the unripe papaya anti-diabetes possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya). by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(2) Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe²⁺-induced oxidative stress in rat pancreas in vitro by Oboh G1, Olabiyi AA, Akinyemi AJ.(PubMed)
(3) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(4) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y1, Bhixavatimath P(PubMed)
(5) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Diabetes Symptoms, (Type 1 and Type 2) by Medicine Net
Wednesday, November 28, 2018
Green tea Protects Against Retinal Degeneration, US National Library of Medicine Studies Show
Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, in compared to potent medicine Trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease of photoreceptor-specific markers (RET-P1, rhodopsin kinase), an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness.
Also, the application reduced an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
Caspase 3 is an important marker of apoptosis and one of side effect of sodium nitroprusside (SNP) is cyanide toxicity, that can induce overexpression ROS in facilitated free radical chain reaction.
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
In the examine the retinal structure and function after LD, according to the optical coherence tomography (OCT) and electroretinography (ERG), application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors in compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in the study to evaluate green tea EGCG effect in reduced glutamate and induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly assigned into
*. A normal control group (n = 9);
*. A saline control group with intravitreal saline injections (n = 54);
*. NMDA control group with an intravitreal NMDA injection;
*. Intraperitoneal saline injections (n = 54); and
*. NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections.
Observation of the groups at 2 weeks after additional injection of NMDA, showed that group treated with intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through
* Inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors.
These results were observed by differentiation of Thy-1 immunoreactivity in several areas of the immature and adult human brain in an expression of retinal ganglion cell damage.
Thy-1 is mostly is expressed by the ganglion cells within the retina and used to index ganglion cell death after ischemia and excitotoxicity.
And NMDA excitotoxicity is associated with the death of retinal ganglion cells (RGCs).
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be used the combination with standard therapy for protection and treatment of retinal degenerative disease
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, in compared to potent medicine Trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease of photoreceptor-specific markers (RET-P1, rhodopsin kinase), an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness.
Also, the application reduced an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
Caspase 3 is an important marker of apoptosis and one of side effect of sodium nitroprusside (SNP) is cyanide toxicity, that can induce overexpression ROS in facilitated free radical chain reaction.
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
In the examine the retinal structure and function after LD, according to the optical coherence tomography (OCT) and electroretinography (ERG), application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors in compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in the study to evaluate green tea EGCG effect in reduced glutamate and induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly assigned into
*. A normal control group (n = 9);
*. A saline control group with intravitreal saline injections (n = 54);
*. NMDA control group with an intravitreal NMDA injection;
*. Intraperitoneal saline injections (n = 54); and
*. NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections.
Observation of the groups at 2 weeks after additional injection of NMDA, showed that group treated with intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through
* Inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors.
These results were observed by differentiation of Thy-1 immunoreactivity in several areas of the immature and adult human brain in an expression of retinal ganglion cell damage.
Thy-1 is mostly is expressed by the ganglion cells within the retina and used to index ganglion cell death after ischemia and excitotoxicity.
And NMDA excitotoxicity is associated with the death of retinal ganglion cells (RGCs).
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be used the combination with standard therapy for protection and treatment of retinal degenerative disease
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--
Tuesday, November 27, 2018
The Root Vegetable That Prevents Macular Degeneration (AMD), Biomedical Literature Suggest
Carrots may have a profound and positive effect on the prevention of mascular degeneration, some scientists suggested.
Macular degeneration is a condition characterized by deterioration of the macula, the small central area of the retina of the eye that controls visual acuity.
Symptoms of early signs of AMD include central vision shadows or unusually fuzzy or distorted vision.
According to statistic, approximately 6 percent of Americans age 40 and older have some forms of macular degeneration.
There are 2 types of macular degeneration, the dry and wet form.
The dry form is one of most common of macula degeneration accounted for over 85 to 90 % of the disease.
Dry macular degeneration also known as non-neovascular is an early stage of the disease caused by aging and thinning of macular tissues, leading to gradual central vision loss.
In compared to the dry form, wet macular degeneration (neovascular) is a severe and advanced stage of the disease caused by new blood vessels grow beneath the retina and leak blood and fluid causing permanent damage to light-sensitive retinal cells in the induction of blind spots in central vision.
Untreated or advanced stage of wet form AMD is also complicated by complete vision loss.
Dr. Ikram MK the lead author at the Singapore National Eye Centre study, said, "Persons with AMD are (regardless of treatment or not) at an increased risk of both cerebral infarction and intracerebral hemorrhage" and "These data (the study) provide further insight into common pathophysiological processes between AMD and stroke subtypes"(4).
Conventional medicine used for the treatment of AMD, such as Lucentis approved by FDA in 2006 can increase the risk of heart attack and stroke.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigated the effect of major bioactive phytochemicals lutein and zeaxanthin isolated from orange pigment vegetables, including carrot in eye health, researchers at the Guelph Food Research Centre, found that application of indicated compounds exert a significantly protective effect of the yellow spot of the human retina which protects the macula from damage by blue light and improves visual acuity and scavenges harmful reactive oxygen species.
Long-term exposure to the blue light may cause structural, thermal and photochemical damage to the retina, particularly, an the aging population.
Further analysis also suggested that application of lutein and zeaxanthin increased antioxidants and stimulated natural antioxidants produced by the body tissue in inhibited overexpression of free radicals and their chain of domino's effects caused by sunlight exposure in the induction of oxidative stress.
The restoration of balance of the ratio of reactive oxygen species and antioxidants not only prevented oxidative damage to the cells of retina but also reduced risk of age-related macular degeneration (AMD) and cataracts, according to the research over the past decade is focused on the development of carotenoid-rich foods to boost their intake especially in the elderly population
Dr. Abdel-Aal el-SM, after taking into account other co and confounders said, "The review also lists major dietary sources of lutein and zeaxanthin and refers to newly developed foods, daily intake, bioavailability and physiological effects in relation to eye health".
These suggestion not only addressed a strong protective effect of bioactive compound carotenoids found abundantly in carrot in improved eye health but also recommended daily and regular intake of a moderate amount of carrot in aging risk of macular degeneration.
Additionally, in the evaluation of the possibility of macular carotenoids, lutein (L), and zeaxanthin (Z) in ameliorated the retardation of age-related changes in the eye and prevention of the eye diseases such as cataract and macular degeneration, researchers at the University of Georgia suggested that intake of carotenoids rich food, such as carrot in the early life may be the best to protect against eye diseases due to aging.
The benefits of early carotenoids consumption in protected against retard age-related changes in the eye and the eye diseases were associated to influence of the development of the visual system through
* Altered input during a critical/sensitive period of visual development and/or
* Influenced maturation and/or
*Protected the retina during a period when it was particularly vulnerable.
Interestingly, in the differentiation of lutein and zeaxanthin accumulated throughout the tissues of the eye, especially in the central retina, researchers once again strongly found that circulated pigments' antioxidants serve a variety of roles in the specialized human vision, including all aspects of visual performance.
Taken together, Carrot with a high amount of carotenoids ( lutein (L), and zeaxanthin) may be considered as functional food in the prevention of eye diseases, particularly in the older adult.
People with a higher risk of eye diseases may want to add a portion of carrot into their daily diet for preventive measure. And intake of carrot extracts should be taken as acute liver toxicity has been reported in numbers of supplement.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health by Abdel-Aal el-SM1, Akhtar H, Zaheer K, Ali R.(PubMed)
(2) Possible role for dietary lutein and zeaxanthin in visual development by Hammond BR Jr1(PubMed)
(3) Dietary lutein and zeaxanthin: possible effects on visual function by Stringham JM1, Hammond BR Jr.(PubMed)
(4) Age-related macular degeneration and long-term risk of stroke subtypes by Ikram MK1, Mitchell P, Klein R, Sharrett AR, Couper DJ, Wong TY(PubMed)
Macular degeneration is a condition characterized by deterioration of the macula, the small central area of the retina of the eye that controls visual acuity.
Symptoms of early signs of AMD include central vision shadows or unusually fuzzy or distorted vision.
According to statistic, approximately 6 percent of Americans age 40 and older have some forms of macular degeneration.
There are 2 types of macular degeneration, the dry and wet form.
The dry form is one of most common of macula degeneration accounted for over 85 to 90 % of the disease.
Dry macular degeneration also known as non-neovascular is an early stage of the disease caused by aging and thinning of macular tissues, leading to gradual central vision loss.
In compared to the dry form, wet macular degeneration (neovascular) is a severe and advanced stage of the disease caused by new blood vessels grow beneath the retina and leak blood and fluid causing permanent damage to light-sensitive retinal cells in the induction of blind spots in central vision.
Untreated or advanced stage of wet form AMD is also complicated by complete vision loss.
Dr. Ikram MK the lead author at the Singapore National Eye Centre study, said, "Persons with AMD are (regardless of treatment or not) at an increased risk of both cerebral infarction and intracerebral hemorrhage" and "These data (the study) provide further insight into common pathophysiological processes between AMD and stroke subtypes"(4).
Conventional medicine used for the treatment of AMD, such as Lucentis approved by FDA in 2006 can increase the risk of heart attack and stroke.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigated the effect of major bioactive phytochemicals lutein and zeaxanthin isolated from orange pigment vegetables, including carrot in eye health, researchers at the Guelph Food Research Centre, found that application of indicated compounds exert a significantly protective effect of the yellow spot of the human retina which protects the macula from damage by blue light and improves visual acuity and scavenges harmful reactive oxygen species.
Long-term exposure to the blue light may cause structural, thermal and photochemical damage to the retina, particularly, an the aging population.
Further analysis also suggested that application of lutein and zeaxanthin increased antioxidants and stimulated natural antioxidants produced by the body tissue in inhibited overexpression of free radicals and their chain of domino's effects caused by sunlight exposure in the induction of oxidative stress.
The restoration of balance of the ratio of reactive oxygen species and antioxidants not only prevented oxidative damage to the cells of retina but also reduced risk of age-related macular degeneration (AMD) and cataracts, according to the research over the past decade is focused on the development of carotenoid-rich foods to boost their intake especially in the elderly population
Dr. Abdel-Aal el-SM, after taking into account other co and confounders said, "The review also lists major dietary sources of lutein and zeaxanthin and refers to newly developed foods, daily intake, bioavailability and physiological effects in relation to eye health".
These suggestion not only addressed a strong protective effect of bioactive compound carotenoids found abundantly in carrot in improved eye health but also recommended daily and regular intake of a moderate amount of carrot in aging risk of macular degeneration.
Additionally, in the evaluation of the possibility of macular carotenoids, lutein (L), and zeaxanthin (Z) in ameliorated the retardation of age-related changes in the eye and prevention of the eye diseases such as cataract and macular degeneration, researchers at the University of Georgia suggested that intake of carotenoids rich food, such as carrot in the early life may be the best to protect against eye diseases due to aging.
The benefits of early carotenoids consumption in protected against retard age-related changes in the eye and the eye diseases were associated to influence of the development of the visual system through
* Altered input during a critical/sensitive period of visual development and/or
* Influenced maturation and/or
*Protected the retina during a period when it was particularly vulnerable.
Interestingly, in the differentiation of lutein and zeaxanthin accumulated throughout the tissues of the eye, especially in the central retina, researchers once again strongly found that circulated pigments' antioxidants serve a variety of roles in the specialized human vision, including all aspects of visual performance.
Taken together, Carrot with a high amount of carotenoids ( lutein (L), and zeaxanthin) may be considered as functional food in the prevention of eye diseases, particularly in the older adult.
People with a higher risk of eye diseases may want to add a portion of carrot into their daily diet for preventive measure. And intake of carrot extracts should be taken as acute liver toxicity has been reported in numbers of supplement.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health by Abdel-Aal el-SM1, Akhtar H, Zaheer K, Ali R.(PubMed)
(2) Possible role for dietary lutein and zeaxanthin in visual development by Hammond BR Jr1(PubMed)
(3) Dietary lutein and zeaxanthin: possible effects on visual function by Stringham JM1, Hammond BR Jr.(PubMed)
(4) Age-related macular degeneration and long-term risk of stroke subtypes by Ikram MK1, Mitchell P, Klein R, Sharrett AR, Couper DJ, Wong TY(PubMed)
Sunday, November 25, 2018
Cayenne, A Spice Which Blocks Airway Inflammation, Scientists Reveal
Scientists in numbers of institute suggested that cayenne, a kitchen spice may process a significant effect in inhibited airway inflammation, an important component of asthma, chronic obstructive pulmonary disease (COPD), and the various cough syndromes.
Conventional medicine has synthesized the effect of many of herbal plants' secondary metabolites, since the discovery of penicillin, the first antibiotic extracted from a very primitive plant, the fungus Penicillium, in 1928, used for the treatment of infection.
In years, herbalist is suspicious that these plants must contain some substances used together for healing purposes, without knowing the existence of every single ingredient.
Today, under microscopes of new technology, scientists discovered that effectiveness of herbal plants in the treatment of conditions and diseases are attributed to their's secondary metabolites.
Secondary metabolites are organic compounds, according to Massachusetts Institute of Technology that serve(7)
* As competitive weapons used against other bacteria, fungi, amoebae, plants, insects, and large animals.
* As metal transporting agents.
* As agents of symbiosis between microbes and plants, nematodes, insects, and higher animals.
* As sexual hormones; and
* As differentiation effectors.
for the survival of the plants producing them,
Following the herbalist food step and used herbal medicine as a fundamental source, conventional medicine has discovered numbers of single-ingredient medication, including quinine (from cinchona bark), and morphine (from the opium poppy)......
According to the Dr. Stanley F. Malamed, the lead author in the study of causative factors for acute asthma suggestion, "(In acute airway inflammation) Inflammation may occur as a result of either immunologic or nonimmunologic airway insults, which produce airway edema and cause the immigration of inflammatory cells into the lumen through the epithelium "(5)
Chronic airway inflammation can lead to chronic obstructive pulmonary disease (COPD), a progressive syndrome caused by expiratory airflow limitation as a result of airway remodeling, including an increase in airway smooth muscle (hyperplasia and hypertrophy),......
More importantly, the longer duration of airway inflammation may lower the lung function in induction of the worse of the bronchial hyperresponsiveness and symptoms(6)
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.
The herb or food has been used in traditional medicine to increase metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, ......., particularly, in treatment of inflammation caused by invasion of microbial organisms and allergens.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases, including inflammation.
Red pepper (Capsicum baccatum) extracts, according to the study by the Federal University of Rio Grande do Sul (UFRGS), exerted its anti-inflammatory properties through in inhibiting the neutrophil migration induced by carrageenan (Cg).
In animal study, the ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity through their antioxidant phenolic and flavonoid compounds against oxidative and inflammation-related pathological processes, including airway inflammation.
β-Defensin, members of the antimicrobial peptide found in cayenne inhibited the expression of the mRNA of anti-inflammatory cytokine during the bacterial invasion, through stimulating immunomodulatory effects.
Other research suggested that anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory sites, such as upper airway.
Regular intake of Cayenne pepper can improve immune system against microbial infection and reduced risk of airway inflammation but overdose is found to induce toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro by Allemand A1,2, Leonardi BF1, Zimmer AR1, Moreno S3, Romão PR2, Gosmann G1. (PubMed)
(2) Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation by Spiller F1, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR. (PubMed)
(3) Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach by Zimmer AR1, Leonardi B, Miron D, Schapoval E, Oliveira JR, Gosmann G.(PubMed)
(4) Defensin γ-thionin from Capsicum chinense has immunomodulatory effects on bovine mammary epithelial cells during Staphylococcus aureus internalization by Díaz-Murillo V1, Medina-Estrada I1, López-Meza JE1, Ochoa-Zarzosa A2. (PubMed)
(5) Learn more about Airway Inflammation(Science Direct)
(6) Why Does Airway Inflammation Persist? Is It Failure to Treat Early? by SØREN PEDERSEN(ATS Journals)
(7) The natural functions of secondary metabolites by Demain AL1, Fang A(PubMed)
Conventional medicine has synthesized the effect of many of herbal plants' secondary metabolites, since the discovery of penicillin, the first antibiotic extracted from a very primitive plant, the fungus Penicillium, in 1928, used for the treatment of infection.
In years, herbalist is suspicious that these plants must contain some substances used together for healing purposes, without knowing the existence of every single ingredient.
Today, under microscopes of new technology, scientists discovered that effectiveness of herbal plants in the treatment of conditions and diseases are attributed to their's secondary metabolites.
Secondary metabolites are organic compounds, according to Massachusetts Institute of Technology that serve(7)
* As competitive weapons used against other bacteria, fungi, amoebae, plants, insects, and large animals.
* As metal transporting agents.
* As agents of symbiosis between microbes and plants, nematodes, insects, and higher animals.
* As sexual hormones; and
* As differentiation effectors.
for the survival of the plants producing them,
Following the herbalist food step and used herbal medicine as a fundamental source, conventional medicine has discovered numbers of single-ingredient medication, including quinine (from cinchona bark), and morphine (from the opium poppy)......
According to the Dr. Stanley F. Malamed, the lead author in the study of causative factors for acute asthma suggestion, "(In acute airway inflammation) Inflammation may occur as a result of either immunologic or nonimmunologic airway insults, which produce airway edema and cause the immigration of inflammatory cells into the lumen through the epithelium "(5)
Chronic airway inflammation can lead to chronic obstructive pulmonary disease (COPD), a progressive syndrome caused by expiratory airflow limitation as a result of airway remodeling, including an increase in airway smooth muscle (hyperplasia and hypertrophy),......
More importantly, the longer duration of airway inflammation may lower the lung function in induction of the worse of the bronchial hyperresponsiveness and symptoms(6)
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.
The herb or food has been used in traditional medicine to increase metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, ......., particularly, in treatment of inflammation caused by invasion of microbial organisms and allergens.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases, including inflammation.
Red pepper (Capsicum baccatum) extracts, according to the study by the Federal University of Rio Grande do Sul (UFRGS), exerted its anti-inflammatory properties through in inhibiting the neutrophil migration induced by carrageenan (Cg).
In animal study, the ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity through their antioxidant phenolic and flavonoid compounds against oxidative and inflammation-related pathological processes, including airway inflammation.
β-Defensin, members of the antimicrobial peptide found in cayenne inhibited the expression of the mRNA of anti-inflammatory cytokine during the bacterial invasion, through stimulating immunomodulatory effects.
Other research suggested that anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory sites, such as upper airway.
Regular intake of Cayenne pepper can improve immune system against microbial infection and reduced risk of airway inflammation but overdose is found to induce toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro by Allemand A1,2, Leonardi BF1, Zimmer AR1, Moreno S3, Romão PR2, Gosmann G1. (PubMed)
(2) Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation by Spiller F1, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR. (PubMed)
(3) Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach by Zimmer AR1, Leonardi B, Miron D, Schapoval E, Oliveira JR, Gosmann G.(PubMed)
(4) Defensin γ-thionin from Capsicum chinense has immunomodulatory effects on bovine mammary epithelial cells during Staphylococcus aureus internalization by Díaz-Murillo V1, Medina-Estrada I1, López-Meza JE1, Ochoa-Zarzosa A2. (PubMed)
(5) Learn more about Airway Inflammation(Science Direct)
(6) Why Does Airway Inflammation Persist? Is It Failure to Treat Early? by SØREN PEDERSEN(ATS Journals)
(7) The natural functions of secondary metabolites by Demain AL1, Fang A(PubMed)
Saturday, November 24, 2018
Green Tea, The Beverage Will Protect Your Lung Injury and Damage Caused by Second Hand Cigarette Smokes, Suggested by Health Model Studies
Green tea may have a therapeutic and positive effect in protecting your lung damage caused by cigarette smoking, some scientists suggested.
The results of these research were conducted by several respectable institutions such as J American University of Madaba and Policlinico Universitario and published on the online medical literature.
According to the statistic, cigarette smoking is the leading cause of preventable disease and death, accounting for more than 480,000 deaths every year, or about 1 in 5 deaths in the US alone.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In the study to investigate outcome of cigarette smoking-induced oxidative stress in alternated the cellular antioxidant defense system in facilitated apoptosis in lung tissue, inflammation and damage in rat model random assigned to into four groups, sham air (SA), cigarette smoke (CS), CGT 2% plus SA or plus CS, through an experiment carried out as a single daily dose (1 cigarette/rat) for a period of 90 days, using an electronically controlled smoking machine, researchers found that
* Long-term exposure to cigarette smoking catalyzed the balance of ratio of free radicals and antioxidant defense in the tested body, leading to overexpression ROS in precipitated cytotoxicity to lung tissue and induced production of proinflammatory cytokines.
* Lung injury and damage due to smoking are observed through the 24 hr collection after last CS exposure from histology and all enzyme assays.
* Lung cells apoptosis are evidenced by the fragmentation of DNA in TUNEL assay.
Application of green tea CGT demonstrated a significant recovery of all pathophysiological and biochemical events expressed from above, particularly, in the treatment group given CGT infusion as a drink instead of water.
After taking into account of other co and confounders Dr. Al-Awaida W, the lead researcher said, " Exposure of albino rat model to cigarette smoke caused oxidative stress, altered the cellular antioxidant defense system, induced apoptosis in lung tissue, inflammation and tissues damage, which could be prevented by supplementation of CGT".
Moreover, oral administration of green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG)
in tested Sprague-Dawley rats randomly divided into four groups, sham air (SA), 4% CS, 2% Lung Chen tea plus SA or 4% CS with SA or 4% CS carried out for 1h/day for 56 days in ventilated smoking chambers, exerted
* A significant effect in reduced airspace enlargement and goblet cell hyperplasia associated with asthma caused by 56-day CS exposure alone
* A strong effect in restored the balance of antioxidants produced by EGCG and the host natural defense and reactive oxygen species, through suppressing levels of oxidative stress caused by CS.
Additionally, according to the Policlinico Universitario in the study to evaluate the green tea extract in risk of pleurisy, a lung disease caused inflammation of the tissue layers (pleura) lining the lungs and inner chest wall induced by carrageenan, application of green tea extract reduced fluid accumulation in the pleural cavity containing many neutrophils (PMNs), an indication of inflammation.
These results were attributed to green tea property in reduced immune response in initiated and increased production of proinflammatory cytokines such as nitrite/nitrate, tumor necrosis factor alpha and ICAM-1 inactivated NF-κB in cellular response to stimuli and increased the expression of adhesion molecules as well as overexpression of and poly (ADP-ribose) synthetase (PARS) and nitrotyrosine formation.
Nitrite/nitrate are food preservatives added to food to prevent bacteria from growing. Dietary consumption of nitrates is associated with an increased risk of cancer(4).
The chemical compounds may induce cell cytotoxicity if taking in some amounts.
Truly, serum of nitrite/nitrate is in high levels in patients with inflammatory diseases, such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis, according to BMJ journals(5).
Tumor necrosis factor is a cell signaling protein (cytokine) plays an important role in systemic inflammation of the acute phase reaction. Overexpression of tumor necrosis factor can result of tissue damage and apoptosis to nearby healthy cells.
ICAM-1 (Intercellular Adhesion Molecule 1) plays an essential role in the immune response in facilitated directly inflammatory expression.
Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes. Overexpression of PARP may alter cellular DNA in the induction of early stage of carcinogenesis(6).
An increase of nitrotyrosine and impairment of antioxidant defense systems are associated patients with inflammatory diseases such as diabetes. But in smoke exposure, nitrotyrosine formation is an indication of lung cell apoptosis.
D. Chan KH, the lead author at the final phase of analysis, suggested that green tea extract exerts a protective effect and offers a novel therapeutic approach for the management of lung injury.
The findings suggested that green tea, its extract, and bioactive polyphenols EGCG may be considered as functional foods in the protection of lung tissue injury, damage and cell death due to long-term exposure to cigarette smoking.
However, further data collection on studies performed with human consumption during the course of the investigation will be necessary to complete the picture of its protective effect of the lung in exposure to cigarette smoking.
Intake of green tea supplement should be taken with extreme care as acute liver toxicity was reported in numbers of the case in the medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chinese green tea consumption reduces oxidative stress, inflammation, and tissues damage in smoke exposed rats by Al-Awaida W1, Akash M2, Aburubaiha Z1, Talib WH3, Shehadeh H4(PubMed)
(2) Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice by Di Paola R1, Mazzon E, Muià C, Genovese T, Menegazzi M, Zaffini R, Suzuki H, Cuzzocrea S.(PubMed)
(3) Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats by Chan KH1, Ho SP, Yeung SC, So WH, Cho CH, Koo MW, Lam WK, Ip MS, Man RY, Mak JC. (PubMed)
(4) Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis by Peng Song,1,† Lei Wu,2,† and Wenxian Guan1(PMC)
(5) Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis by Ersoy1, E Özerol2, Ö Baysal1, I Temel2, R S MacWalter3, Ü Meral1, Z E Altay. (BMJ Journals)
(6) Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis by Nosho K1, Yamamoto H, Mikami M, Taniguchi H, Takahashi T, Adachi Y, Imamura A, Imai K, Shinomura Y. (PubMed)
The results of these research were conducted by several respectable institutions such as J American University of Madaba and Policlinico Universitario and published on the online medical literature.
According to the statistic, cigarette smoking is the leading cause of preventable disease and death, accounting for more than 480,000 deaths every year, or about 1 in 5 deaths in the US alone.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In the study to investigate outcome of cigarette smoking-induced oxidative stress in alternated the cellular antioxidant defense system in facilitated apoptosis in lung tissue, inflammation and damage in rat model random assigned to into four groups, sham air (SA), cigarette smoke (CS), CGT 2% plus SA or plus CS, through an experiment carried out as a single daily dose (1 cigarette/rat) for a period of 90 days, using an electronically controlled smoking machine, researchers found that
* Long-term exposure to cigarette smoking catalyzed the balance of ratio of free radicals and antioxidant defense in the tested body, leading to overexpression ROS in precipitated cytotoxicity to lung tissue and induced production of proinflammatory cytokines.
* Lung injury and damage due to smoking are observed through the 24 hr collection after last CS exposure from histology and all enzyme assays.
* Lung cells apoptosis are evidenced by the fragmentation of DNA in TUNEL assay.
Application of green tea CGT demonstrated a significant recovery of all pathophysiological and biochemical events expressed from above, particularly, in the treatment group given CGT infusion as a drink instead of water.
After taking into account of other co and confounders Dr. Al-Awaida W, the lead researcher said, " Exposure of albino rat model to cigarette smoke caused oxidative stress, altered the cellular antioxidant defense system, induced apoptosis in lung tissue, inflammation and tissues damage, which could be prevented by supplementation of CGT".
Moreover, oral administration of green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG)
in tested Sprague-Dawley rats randomly divided into four groups, sham air (SA), 4% CS, 2% Lung Chen tea plus SA or 4% CS with SA or 4% CS carried out for 1h/day for 56 days in ventilated smoking chambers, exerted
* A significant effect in reduced airspace enlargement and goblet cell hyperplasia associated with asthma caused by 56-day CS exposure alone
* A strong effect in restored the balance of antioxidants produced by EGCG and the host natural defense and reactive oxygen species, through suppressing levels of oxidative stress caused by CS.
Additionally, according to the Policlinico Universitario in the study to evaluate the green tea extract in risk of pleurisy, a lung disease caused inflammation of the tissue layers (pleura) lining the lungs and inner chest wall induced by carrageenan, application of green tea extract reduced fluid accumulation in the pleural cavity containing many neutrophils (PMNs), an indication of inflammation.
These results were attributed to green tea property in reduced immune response in initiated and increased production of proinflammatory cytokines such as nitrite/nitrate, tumor necrosis factor alpha and ICAM-1 inactivated NF-κB in cellular response to stimuli and increased the expression of adhesion molecules as well as overexpression of and poly (ADP-ribose) synthetase (PARS) and nitrotyrosine formation.
Nitrite/nitrate are food preservatives added to food to prevent bacteria from growing. Dietary consumption of nitrates is associated with an increased risk of cancer(4).
The chemical compounds may induce cell cytotoxicity if taking in some amounts.
Truly, serum of nitrite/nitrate is in high levels in patients with inflammatory diseases, such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis, according to BMJ journals(5).
Tumor necrosis factor is a cell signaling protein (cytokine) plays an important role in systemic inflammation of the acute phase reaction. Overexpression of tumor necrosis factor can result of tissue damage and apoptosis to nearby healthy cells.
ICAM-1 (Intercellular Adhesion Molecule 1) plays an essential role in the immune response in facilitated directly inflammatory expression.
Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes. Overexpression of PARP may alter cellular DNA in the induction of early stage of carcinogenesis(6).
An increase of nitrotyrosine and impairment of antioxidant defense systems are associated patients with inflammatory diseases such as diabetes. But in smoke exposure, nitrotyrosine formation is an indication of lung cell apoptosis.
D. Chan KH, the lead author at the final phase of analysis, suggested that green tea extract exerts a protective effect and offers a novel therapeutic approach for the management of lung injury.
The findings suggested that green tea, its extract, and bioactive polyphenols EGCG may be considered as functional foods in the protection of lung tissue injury, damage and cell death due to long-term exposure to cigarette smoking.
However, further data collection on studies performed with human consumption during the course of the investigation will be necessary to complete the picture of its protective effect of the lung in exposure to cigarette smoking.
Intake of green tea supplement should be taken with extreme care as acute liver toxicity was reported in numbers of the case in the medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chinese green tea consumption reduces oxidative stress, inflammation, and tissues damage in smoke exposed rats by Al-Awaida W1, Akash M2, Aburubaiha Z1, Talib WH3, Shehadeh H4(PubMed)
(2) Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice by Di Paola R1, Mazzon E, Muià C, Genovese T, Menegazzi M, Zaffini R, Suzuki H, Cuzzocrea S.(PubMed)
(3) Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats by Chan KH1, Ho SP, Yeung SC, So WH, Cho CH, Koo MW, Lam WK, Ip MS, Man RY, Mak JC. (PubMed)
(4) Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis by Peng Song,1,† Lei Wu,2,† and Wenxian Guan1(PMC)
(5) Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis by Ersoy1, E Özerol2, Ö Baysal1, I Temel2, R S MacWalter3, Ü Meral1, Z E Altay. (BMJ Journals)
(6) Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis by Nosho K1, Yamamoto H, Mikami M, Taniguchi H, Takahashi T, Adachi Y, Imamura A, Imai K, Shinomura Y. (PubMed)
Friday, November 23, 2018
How to Improve Your Body Cells Integrity and Viability in Expression of Cytoprotection and Antitumor Activity
Fennel may have a potential and positive effect of induction of cytoprotection and antitumor activity against cancer expression, some scientists suggested.
The results were reported by several respectable institutes including the National Cancer Institute and National Institute of Health.
Cytoprotection is a natural process by which certain chemical compounds isolated exhibited protection to cells against harmful agents, including bacteria, virus, toxicity,...
Antitumor activity is also a process in inhibited cell growth irregularly and uncontrollably. Tumors can be benign or invasive.
Malignant tumors have the ability to travel outside of the original site to infect the nearby tissue or organs. Depending on the stage of invasive cancer, early discovered is one most important factor in the increased chance of survival.
According to a statistic from Canary Foundation, cancer strikes about 1 in 3 women and 1 in 2 men in the U.S and more than 560,000 die each year due to cancers.
The five years of the survival rate of breast and prostate in the early stage of discovery is closed to 100%.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
In an aim to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector, researchers at the National Cancer Institute, Cairo, launched an investigation in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation.
During the 30 days of experiment, researchers found that application of fennel seed methanolic extract (FSME) exerts a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at dose of 50 μg/mL and 48 μg/mL in inhibited the proliferation of the MCF7 breast cancer cell line and Hep-2 liver cancer cell line, respectively.
The treatment group also displayed a decreased level of MDA and improved natural antioxidants produced by the tissues of the host in compared to an elevation of MDA and significantly reduced levels of catalase and Glutathione (GSH) contents in control.
Malondialdehyde (MDA) is a highly oxidative compound and considered as a marker of oxidative stress.
Catalase is a common enzyme and antioxidants produced by the host with function in inhibited free radical expression through de-composited hydrogen peroxide to water and oxygen.
Glutathione (GSH) is also an antioxidant enzyme with function in inhibited overexpression of reactive oxygen species and theirs' chain reaction.
Reduced levels of natural antioxidants produced by the host tissue show a strong effect in the imbalance of the ratio of antioxidants and free radical expression in the induction of early development of oxidative related diseases.
These results suggested that fennel seed methanolic extract (FSME) ameliorated overproduction of ROS caused by ingestion of doses of gamma irradiation through its antioxidants and enhanced antioxidants production of the mice tissue via the ratio of ROS and Antioxidants.
In other words, application of the fennel extract may have a potential in
* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.
* Improved natural antioxidants and oxidative stability of fatty foods during storage.
* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.
Further illustration of the effect of whole food fennel in treatment of cancers and examination of the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.
According to the results of the experiment,
* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
* In CWR22R tumors, application of all supplements exerted a similar effect in suppression of the cancer cells proliferation.
* All applications did not show an inhibitory activity against levels of testosterone in compared to untreated mice.
However, supplements PP and FBL101 exerted a significantly reduced VEGF level, a potent angiogenic factor with function in the stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.
* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, the lead author said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
The above differentiation was supported by the Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multi-drug resistant (MDR) pathogens and anticancer effect against MCF-7 cell line.
According to the results of the report, application of whole food fennel and fennel ethanol extract exhibited significant inhibition of cancer cells proliferation, induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens and Methicillin-resistant S. aureus. Pseudomonas aeruginosa
Taken together, fennel and its extracts may be used as functional food in the exertion of cytoprotection and antitumor activity.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its cytoprotection and antitumor possibilities.
Intake of fennel extracts should be taken with extreme care, as overdoses may cause acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM. (PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD. (PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda, and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2. (PubMed)
The results were reported by several respectable institutes including the National Cancer Institute and National Institute of Health.
Cytoprotection is a natural process by which certain chemical compounds isolated exhibited protection to cells against harmful agents, including bacteria, virus, toxicity,...
Antitumor activity is also a process in inhibited cell growth irregularly and uncontrollably. Tumors can be benign or invasive.
Malignant tumors have the ability to travel outside of the original site to infect the nearby tissue or organs. Depending on the stage of invasive cancer, early discovered is one most important factor in the increased chance of survival.
According to a statistic from Canary Foundation, cancer strikes about 1 in 3 women and 1 in 2 men in the U.S and more than 560,000 die each year due to cancers.
The five years of the survival rate of breast and prostate in the early stage of discovery is closed to 100%.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
In an aim to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector, researchers at the National Cancer Institute, Cairo, launched an investigation in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation.
During the 30 days of experiment, researchers found that application of fennel seed methanolic extract (FSME) exerts a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at dose of 50 μg/mL and 48 μg/mL in inhibited the proliferation of the MCF7 breast cancer cell line and Hep-2 liver cancer cell line, respectively.
The treatment group also displayed a decreased level of MDA and improved natural antioxidants produced by the tissues of the host in compared to an elevation of MDA and significantly reduced levels of catalase and Glutathione (GSH) contents in control.
Malondialdehyde (MDA) is a highly oxidative compound and considered as a marker of oxidative stress.
Catalase is a common enzyme and antioxidants produced by the host with function in inhibited free radical expression through de-composited hydrogen peroxide to water and oxygen.
Glutathione (GSH) is also an antioxidant enzyme with function in inhibited overexpression of reactive oxygen species and theirs' chain reaction.
Reduced levels of natural antioxidants produced by the host tissue show a strong effect in the imbalance of the ratio of antioxidants and free radical expression in the induction of early development of oxidative related diseases.
These results suggested that fennel seed methanolic extract (FSME) ameliorated overproduction of ROS caused by ingestion of doses of gamma irradiation through its antioxidants and enhanced antioxidants production of the mice tissue via the ratio of ROS and Antioxidants.
In other words, application of the fennel extract may have a potential in
* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.
* Improved natural antioxidants and oxidative stability of fatty foods during storage.
* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.
Further illustration of the effect of whole food fennel in treatment of cancers and examination of the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.
According to the results of the experiment,
* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
* In CWR22R tumors, application of all supplements exerted a similar effect in suppression of the cancer cells proliferation.
* All applications did not show an inhibitory activity against levels of testosterone in compared to untreated mice.
However, supplements PP and FBL101 exerted a significantly reduced VEGF level, a potent angiogenic factor with function in the stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.
* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, the lead author said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
The above differentiation was supported by the Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multi-drug resistant (MDR) pathogens and anticancer effect against MCF-7 cell line.
According to the results of the report, application of whole food fennel and fennel ethanol extract exhibited significant inhibition of cancer cells proliferation, induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens and Methicillin-resistant S. aureus. Pseudomonas aeruginosa
Taken together, fennel and its extracts may be used as functional food in the exertion of cytoprotection and antitumor activity.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its cytoprotection and antitumor possibilities.
Intake of fennel extracts should be taken with extreme care, as overdoses may cause acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM. (PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD. (PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda, and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2. (PubMed)
Thursday, November 22, 2018
The Impact of Hormones On The Onset Of Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetable which can lead to dementia and other kinds of diseases.
As we age, productions of hormone decrease gradually that can affect the cognitive function, leading to dementia.
According to Eric R. Braverman, MD in the article of Hormones Dementia, numerous studies have linked hormone supplementation as protective in the development of dementia regardless of whether or not these hormones are deficient but more so when they are deficient.
Growth hormone beginning from age 30 in both men and women, estrogen loss beginning at age 40 in women, testosterone loss beginning at age 40 in men and DHEA loss beginning in both men and women at age 50.
The loss of luteinizing and sex binding globulin hormones may also be associated with the development of dementia with age(1)
Hormone Causes of Dementia
1. Growth hormone
A report at the Universidad de Barcelona, Barcelona showed that there is a physiological decline of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis with aging, and the possibility that the GH/IGF-I axis is involved in cognitive deficits has been recognized for several years.
The results of several studies addressing the deficiency of growth hormone (GH) in the induction of dementia include
* Superimposable response of GH to GHRH than the response of GH to GHRH in healthy individuals.
* Blunted GH to GHRH response in AD patients
* Higher GH concentrations in the morning; a greater increase of GH to GHRH in AD patients than in controls(2).
Other reported that evidence favoring this idea stems from the ability of both hormones to stimulate beta-amyloid release from neurons as well as by the stimulatory effect that IGF-I exerts on brain amyloid clearance.
In addition, insulin and IGF-I levels are altered in Alzheimer's patients and, probably in close association to these changes, cell sensitivity towards insulin--and possibly also IGF-I--is decreased in these patients. (3)
2. Estrogen
In the research of the association of decreased levels of estrogen and dementia, the scientists at the Kings College London suggested that the positive effects of estrogen are most robust in young women and in older women who had initiated ET around the time of menopause(4).
Other study supported the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease in postmenopausal women.
Prospective clinical trials are required to enable women and their physicians to weigh the risks and benefits of estrogen replacement therapy for the prevention of dementia(5)
3. Testosterone
In a study of a group of 28 older men with either subjective memory loss or dementia, researchers found that serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40.
According to the Fremantle Hospital study, lower androgen levels are associated with increased plasma Abeta40 in older men with memory loss or dementia.
These results suggested that subclinical androgen deficiency enhances the expression of Alzheimer's disease-related peptides in vivo(6).
4. DHEA
Kyushu University, in the study of a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD), found that patients with AD and patients with CVD were found to have a lower concentration of serum DHEA-S and a lower DHEA-S/DHEA ration compared to normal control individuals.
Also, according to the final report, no significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with the AD and those with CVD.
These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases(7).
Another study in the assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72) showed that Plasma DHEA concentrations are significantly lower in AD patients compared to control (4.24+/-0.4 ng/ml for the AD; 3.38+/-0.3 ng/ml for control, p=0.027, Mann-Whitney 1-tailed)
And DHEA levels are significantly correlated to DHEAS levels in both control and AD conditions (Spearman's rho correlation coefficient=0.635 in controls and 0.467 in the AD, p<or=0.01)(8).
Spearman's rho correlation coefficient is a method used to measure the relationship between two variables using a monotonic function.
5. Sex-hormone binding globulin
There is evidence in the literature suggests that gonadotropins may be involved in processes in contribution to the etiology/pathogenesis of AD such as inflammation, cholesterol homeostasis, and insulin status.
Here we examine the potential mechanisms by which gonadotropins could influence neurodegenerative processes. (9)
6. Luteinizing hormone (LH)
Some researchers suspected that another hormone of the hypothalamic-pituitary-gonadal axis, luteinizing hormone (LH), may be a major factor in AD parthenogenesis.
In cell culture, LH increased amyloidogenic processing of amyloid-beta protein precursor, and in animal models of the AD, pharmacologic suppression of LH and FSH reduced plaque formation.
Given the evidence supporting a pathogenic role for LH in the AD, a trial of leuprolide acetate, which suppresses LH release, has been initiated in patients. (10)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, Ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) http://www.pathmed.com/faq/?p=409
(2) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(3) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(4) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(5) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(6) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(7) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(8) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(9) http://www.ncbi.nlm.nih.gov/pubmed/16785601
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetable which can lead to dementia and other kinds of diseases.
As we age, productions of hormone decrease gradually that can affect the cognitive function, leading to dementia.
According to Eric R. Braverman, MD in the article of Hormones Dementia, numerous studies have linked hormone supplementation as protective in the development of dementia regardless of whether or not these hormones are deficient but more so when they are deficient.
Growth hormone beginning from age 30 in both men and women, estrogen loss beginning at age 40 in women, testosterone loss beginning at age 40 in men and DHEA loss beginning in both men and women at age 50.
The loss of luteinizing and sex binding globulin hormones may also be associated with the development of dementia with age(1)
Hormone Causes of Dementia
1. Growth hormone
A report at the Universidad de Barcelona, Barcelona showed that there is a physiological decline of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis with aging, and the possibility that the GH/IGF-I axis is involved in cognitive deficits has been recognized for several years.
The results of several studies addressing the deficiency of growth hormone (GH) in the induction of dementia include
* Superimposable response of GH to GHRH than the response of GH to GHRH in healthy individuals.
* Blunted GH to GHRH response in AD patients
* Higher GH concentrations in the morning; a greater increase of GH to GHRH in AD patients than in controls(2).
Other reported that evidence favoring this idea stems from the ability of both hormones to stimulate beta-amyloid release from neurons as well as by the stimulatory effect that IGF-I exerts on brain amyloid clearance.
In addition, insulin and IGF-I levels are altered in Alzheimer's patients and, probably in close association to these changes, cell sensitivity towards insulin--and possibly also IGF-I--is decreased in these patients. (3)
2. Estrogen
In the research of the association of decreased levels of estrogen and dementia, the scientists at the Kings College London suggested that the positive effects of estrogen are most robust in young women and in older women who had initiated ET around the time of menopause(4).
Other study supported the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease in postmenopausal women.
Prospective clinical trials are required to enable women and their physicians to weigh the risks and benefits of estrogen replacement therapy for the prevention of dementia(5)
3. Testosterone
In a study of a group of 28 older men with either subjective memory loss or dementia, researchers found that serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40.
According to the Fremantle Hospital study, lower androgen levels are associated with increased plasma Abeta40 in older men with memory loss or dementia.
These results suggested that subclinical androgen deficiency enhances the expression of Alzheimer's disease-related peptides in vivo(6).
4. DHEA
Kyushu University, in the study of a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD), found that patients with AD and patients with CVD were found to have a lower concentration of serum DHEA-S and a lower DHEA-S/DHEA ration compared to normal control individuals.
Also, according to the final report, no significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with the AD and those with CVD.
These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases(7).
Another study in the assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72) showed that Plasma DHEA concentrations are significantly lower in AD patients compared to control (4.24+/-0.4 ng/ml for the AD; 3.38+/-0.3 ng/ml for control, p=0.027, Mann-Whitney 1-tailed)
And DHEA levels are significantly correlated to DHEAS levels in both control and AD conditions (Spearman's rho correlation coefficient=0.635 in controls and 0.467 in the AD, p<or=0.01)(8).
Spearman's rho correlation coefficient is a method used to measure the relationship between two variables using a monotonic function.
5. Sex-hormone binding globulin
There is evidence in the literature suggests that gonadotropins may be involved in processes in contribution to the etiology/pathogenesis of AD such as inflammation, cholesterol homeostasis, and insulin status.
Here we examine the potential mechanisms by which gonadotropins could influence neurodegenerative processes. (9)
6. Luteinizing hormone (LH)
Some researchers suspected that another hormone of the hypothalamic-pituitary-gonadal axis, luteinizing hormone (LH), may be a major factor in AD parthenogenesis.
In cell culture, LH increased amyloidogenic processing of amyloid-beta protein precursor, and in animal models of the AD, pharmacologic suppression of LH and FSH reduced plaque formation.
Given the evidence supporting a pathogenic role for LH in the AD, a trial of leuprolide acetate, which suppresses LH release, has been initiated in patients. (10)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, Ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) http://www.pathmed.com/faq/?p=409
(2) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(3) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(4) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(5) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(6) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(7) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(8) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(9) http://www.ncbi.nlm.nih.gov/pubmed/16785601
Wednesday, November 21, 2018
Would Yoga Practice Be The Best for Letting Go of Anxiety Naturally?
People who participated in yoga class are likely to experience less or lower levels of anxiety and in some cases, may have the best chance in letting go of anxiety through reduction of stress implications, some studies suggested.
Yoga, the ancient technique for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture..... has been best known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
Anxiety is a mental disorder characterized by worry about future events and fear of current events.
People experience anxiety differently. Some people feel a sudden moment of anxiety just a bad feeling, it comes and goes, only lasting a short time. Depending on how people cope with the moments of anxiety, the events can be brief or last a few days.
However, in some persons, if anxiety does not go away, they may require treatment from the related field specialists.
If you are frequently experiencing symptoms of nervousness, restlessness, or being tense feelings of danger, panic, or dread rapid heart rate rapid breathing, or hyperventilation,..... you may have developed an anxiety disorder.
In the evaluate yoga effect in reduced levels of anxiety, Dr. Bernardi ML and colleagues launched an investigation of 45 mastectomized women treated at the Ilza Bianco outpatient service of Santa Rita de Cássia Hospital in the Brazilian state of Espírito Santo from March to November 2010.
Selected women were assigned to 6 yoga-applied sessions.
At the end of the experiment periods, researchers found that yoga treatment group shows a statistically significant in decreased anxiety levels measured by Anxiety Trait and State Test.
Anxiety Trait and State Test is a psychological inventory 40 self-report items used for testing of anxiety effect with an aim to measure anxiety at both poles of the normal effect curve known as state vs. trait.
Further analysis also suggested that the reduced level of anxiety in participants was attributed to decreasing physiological and psychological arousal such as the heart rate, blood pressure, relaxation and calmness and easing respiration.
Moreover, women in yoga group at the end of the lessons also found less stressful in compared to the beginning of the class.
In other words, yoga participants have successfully learned how to manage stress, thus reducing the risk of anxiety in response to mental or emotional strain.
Truly, regular yoga exercise including breathing technique, meditation not only provides participants the positive mind in the maintained state of calmness and relaxation in the deal with such events without getting restless and confusion but also enhances recovery from anxiety.
Some yoga instructors suggested that the technique of yoga practice including mindfulness also reduces production of stress hormone cortisol and brought back the present moment while letting them go or dealing them in a profound way.
Indeed, yoga postures and deep breathing have shown to ameliorate overexpression of nerve neurons in the transmitted information of sensation, stress, and suffering, thus reducing the risk of anxiety.
Dr. Bernardi ML, the lead author of the study said, "hatha yoga exercises decrease stress and anxiety in the experimental group. No connection between confounding variables and anxiety and stress levels was found".
Hatha yoga is one form of yoga practice containing physical exercises and breathing control.
More importantly, according to the data collection period and meditation program between January 9 and August 31, 2009, in 46 women who were pregnant following IVF, and were between 12-20 weeks gestation, participated in the study (23 experimental group, 23 control group), women pregnant after IVF participated in yoga class showed statistically significant improvements in stress, anxiety, labor pain, and labor confidence.
In fact, yoga in improvements of stress, anxiety, labor pain, and labor confidence, decreasing physiological and psychological arousal also enhanced women's sense of control and confidence in giving birth as well as stay away from negative thinking of the pregnancy outcome.
IVF is a medical procedure characterized by egg fertilized outside the mother womb.
Interestingly, in a total of 46 participants completed both a resistance exercise class and yoga class in a counterbalanced order, researchers suggested that in compared to measurement of body satisfaction and social physique anxiety completed immediately before and after each class, yoga participated group displays a greater improvements of body image and reduces state of social physique anxiety.
In other words, by focusing on breathing, the connection of the mind and body, yoga participants were found to associate with decreased state social physique anxiety by increased in body satisfaction.
According to the differentiation of the Journal of Clinical Research & Bioethics of a group of patients suffered from chronic diseases participated in yoga class, yoga attendees benefited from stimulation of immune functions in reduced physical symptoms by improving expression of human β-defensin 2 (HBD-2), a potent antimicrobial peptide forms part of the innate immune response, .natural killer (NK) cells, and anti-inflammatory cytokines, decreasing stress and/or anxiety symptoms and improving quality of life.
Taking together, yoga may be the best treatment for people with anxiety through improvement of social, mental and body confidence in the reduced state of over worries, particularly in people with frequent stress. People continued yoga practice daily may have the best chance of letting go of anxiety forever.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [The effects of hatha yoga exercises on stress and anxiety levels in mastectomized women].[Article in Portuguese]by Bernardi ML, Amorim MH, Zandonade E, Santaella DF, Barbosa Jde A.(PubMed)
(2) [Effects of a yoga-focused prenatal program on stress, anxiety, self confidence and labor pain in pregnant women with in vitro fertilization treatment].[Article in Korean] by Shim CS1, Lee YS(PubMed)
Yoga, the ancient technique for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture..... has been best known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
Anxiety is a mental disorder characterized by worry about future events and fear of current events.
People experience anxiety differently. Some people feel a sudden moment of anxiety just a bad feeling, it comes and goes, only lasting a short time. Depending on how people cope with the moments of anxiety, the events can be brief or last a few days.
However, in some persons, if anxiety does not go away, they may require treatment from the related field specialists.
If you are frequently experiencing symptoms of nervousness, restlessness, or being tense feelings of danger, panic, or dread rapid heart rate rapid breathing, or hyperventilation,..... you may have developed an anxiety disorder.
In the evaluate yoga effect in reduced levels of anxiety, Dr. Bernardi ML and colleagues launched an investigation of 45 mastectomized women treated at the Ilza Bianco outpatient service of Santa Rita de Cássia Hospital in the Brazilian state of Espírito Santo from March to November 2010.
Selected women were assigned to 6 yoga-applied sessions.
At the end of the experiment periods, researchers found that yoga treatment group shows a statistically significant in decreased anxiety levels measured by Anxiety Trait and State Test.
Anxiety Trait and State Test is a psychological inventory 40 self-report items used for testing of anxiety effect with an aim to measure anxiety at both poles of the normal effect curve known as state vs. trait.
Further analysis also suggested that the reduced level of anxiety in participants was attributed to decreasing physiological and psychological arousal such as the heart rate, blood pressure, relaxation and calmness and easing respiration.
Moreover, women in yoga group at the end of the lessons also found less stressful in compared to the beginning of the class.
In other words, yoga participants have successfully learned how to manage stress, thus reducing the risk of anxiety in response to mental or emotional strain.
Truly, regular yoga exercise including breathing technique, meditation not only provides participants the positive mind in the maintained state of calmness and relaxation in the deal with such events without getting restless and confusion but also enhances recovery from anxiety.
Some yoga instructors suggested that the technique of yoga practice including mindfulness also reduces production of stress hormone cortisol and brought back the present moment while letting them go or dealing them in a profound way.
Indeed, yoga postures and deep breathing have shown to ameliorate overexpression of nerve neurons in the transmitted information of sensation, stress, and suffering, thus reducing the risk of anxiety.
Dr. Bernardi ML, the lead author of the study said, "hatha yoga exercises decrease stress and anxiety in the experimental group. No connection between confounding variables and anxiety and stress levels was found".
Hatha yoga is one form of yoga practice containing physical exercises and breathing control.
More importantly, according to the data collection period and meditation program between January 9 and August 31, 2009, in 46 women who were pregnant following IVF, and were between 12-20 weeks gestation, participated in the study (23 experimental group, 23 control group), women pregnant after IVF participated in yoga class showed statistically significant improvements in stress, anxiety, labor pain, and labor confidence.
In fact, yoga in improvements of stress, anxiety, labor pain, and labor confidence, decreasing physiological and psychological arousal also enhanced women's sense of control and confidence in giving birth as well as stay away from negative thinking of the pregnancy outcome.
IVF is a medical procedure characterized by egg fertilized outside the mother womb.
Interestingly, in a total of 46 participants completed both a resistance exercise class and yoga class in a counterbalanced order, researchers suggested that in compared to measurement of body satisfaction and social physique anxiety completed immediately before and after each class, yoga participated group displays a greater improvements of body image and reduces state of social physique anxiety.
In other words, by focusing on breathing, the connection of the mind and body, yoga participants were found to associate with decreased state social physique anxiety by increased in body satisfaction.
According to the differentiation of the Journal of Clinical Research & Bioethics of a group of patients suffered from chronic diseases participated in yoga class, yoga attendees benefited from stimulation of immune functions in reduced physical symptoms by improving expression of human β-defensin 2 (HBD-2), a potent antimicrobial peptide forms part of the innate immune response, .natural killer (NK) cells, and anti-inflammatory cytokines, decreasing stress and/or anxiety symptoms and improving quality of life.
Taking together, yoga may be the best treatment for people with anxiety through improvement of social, mental and body confidence in the reduced state of over worries, particularly in people with frequent stress. People continued yoga practice daily may have the best chance of letting go of anxiety forever.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [The effects of hatha yoga exercises on stress and anxiety levels in mastectomized women].[Article in Portuguese]by Bernardi ML, Amorim MH, Zandonade E, Santaella DF, Barbosa Jde A.(PubMed)
(2) [Effects of a yoga-focused prenatal program on stress, anxiety, self confidence and labor pain in pregnant women with in vitro fertilization treatment].[Article in Korean] by Shim CS1, Lee YS(PubMed)
Tuesday, November 20, 2018
9 Natural Remedies with Potential to Cure Non-Alcoholic Fatty Liver Disease (NALFD), Suggested by Scientists
Non-alcoholic Fatty Liver Disease is a liver disease characterized by fat accumulated in the liver, not caused by abusive alcohol consumption.
The disease is also manifested by steatosis, steatohepatitis, cirrhosis.
Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in the US due to increasing obesity in the adult population.
Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).
In conventional medicine, treatments of NAFLD are mainly focused on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.
As of today, there is no effective pharmacologic therapy approved specifically and directly for treatment of nonalcoholic fatty liver disease (NAFLD).
Finding the natural treatments for less or no side effects have become an urgency in many scientific communities, including researchers at the Universities.
Alternative medicines for the treatment of NAFLD have been expressed in numbers of successful histories.
1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
Turmeric has long been used in herbal medicine in treating numbers of disease.
Today, its curcuminoid, curcumin has attracted interests from researchers in many parts of the world.
Curcumin, as an antihyperlipidemic agent, has been found to lower the “bad cholesterol” low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver.
In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in the liver, researchers found that the derivative not only significantly alleviates fibrosis but also decreases the grade of liver steatosis.
2. Hawthorn
Hawthorn is shrubs and trees of the genus Crataegus, belongings to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia, and North America.
The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.
Out of 246 kinds of Chinese herb, hawthorn fruit is found in the list of many formulas for treatments of Nonalcoholic fatty liver disease (NAFLD).
3. Phytochemical Berberine and 4. Resveratrol
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well as herbs and herbal formulas such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet.
According to studies, these formulas not only improved a biochemical and histological change in nonalcoholic fatty liver disease, but also inhibited lipid accumulation by up-regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines.
In such instance, Berberine and resveratrol may be considered as a potential treatment for the nonalcoholic fatty liver disease in the future.
5. Phytochemical Triterpenoid
Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex, hainanensis Merr.
In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) fed with a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, then orally administrated TF (250 mg/kg) for another two weeks, researchers showed that TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation, levels of inflammation and infection and apoptosis response in the liver.
Of these results, TF is effective in protecting the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.
6. Peony
Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony.
The acrid, bitter and mild cool herb has been used in TCM as anti microorganism, anti-inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.
Peony, a very popular Chinese herb is emerging as in many studies for its anti-inflammatory, anticoagulative, anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma.
In the study of the effects of peony in non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of peony group, scientists at end of experiment showed that oral administration of total glucosides not only inhibit hyperinsulinemia but also decrease levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C).
Further analysis also found that peony also raises levels of high-density lipoprotein cholesterol (HDL-C)] and ameliorates the overexpression of activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) and superoxide dismutase (SOD) as well as contents of malondialdehyde (MDA).
These results suggested that paeony may consist of a potential effect in protecting liver function by modulating serum lipid and decreasing oxidative stress caused by lipid peroxidation in the induction of fatty liver.
7. Bayberry
Bayberry is a species of Myrica gale, genus Myrica, belongings to the family Myricaceae.
The herbal medicine contains numbers of bioactive chemical constituents, including gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins.
In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, researchers found that intake of bay berry juice decreases inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reducing risk of steatosis progression in precipitated NALFD.
8. Green Tea
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with the nonalcoholic fatty liver disease is associated to its antioxidant compound polyphenolic catechins in the induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.
These chemical compounds are also found to mitigate the occurrence and progression of NAFLD.
Dr. Masterjohn C(7), the lead author said, “(The phytochemical compounds are) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD”.
In mice fed on a high-fat diet for 24 weeks, then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice show a significant improvement in body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation, and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance caused by high-fat diet.
The phytochemicals EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.
In fact, EGCG not only promoted weight loss but also attenuated symptoms of mice with the nonalcoholic fatty liver disease.
Administration of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, not only decreased weight gain and visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides out flux from liver.
9. Herbal Anise
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries in the treatment of strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.
In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an study of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO).
At the end of the experiment, researchers found that both applications exert significantly reverse activities in increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decreased in high-density lipoprotein level caused by choline-deficient diet in a dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injury or damage caused by the acute inflammation.
Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significant lower overexpression of ROS in an exhibited free radical chain reaction in the induction of oxidative stress to precipitated liver toxicity.
According to the histological findings, researchers concluded that both AE and AO display a substantial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Taken together, remedies indicated may be considered as functional foods for the treatment of non-alcoholic fatty liver disease (NAFLD).
However, additional data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of diseases will be necessary to complete the picture of above natural remedies’ effects in complete the treatment possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD. (PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH. (PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH. (PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS. (PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1. (PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1. (PubMed)
(14) Pimpinella anisum L. fruit: Chemical composition and effect on a rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
The disease is also manifested by steatosis, steatohepatitis, cirrhosis.
Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in the US due to increasing obesity in the adult population.
Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).
In conventional medicine, treatments of NAFLD are mainly focused on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.
As of today, there is no effective pharmacologic therapy approved specifically and directly for treatment of nonalcoholic fatty liver disease (NAFLD).
Finding the natural treatments for less or no side effects have become an urgency in many scientific communities, including researchers at the Universities.
Alternative medicines for the treatment of NAFLD have been expressed in numbers of successful histories.
1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
Turmeric has long been used in herbal medicine in treating numbers of disease.
Today, its curcuminoid, curcumin has attracted interests from researchers in many parts of the world.
Curcumin, as an antihyperlipidemic agent, has been found to lower the “bad cholesterol” low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver.
In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in the liver, researchers found that the derivative not only significantly alleviates fibrosis but also decreases the grade of liver steatosis.
2. Hawthorn
Hawthorn is shrubs and trees of the genus Crataegus, belongings to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia, and North America.
The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.
Out of 246 kinds of Chinese herb, hawthorn fruit is found in the list of many formulas for treatments of Nonalcoholic fatty liver disease (NAFLD).
3. Phytochemical Berberine and 4. Resveratrol
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well as herbs and herbal formulas such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet.
According to studies, these formulas not only improved a biochemical and histological change in nonalcoholic fatty liver disease, but also inhibited lipid accumulation by up-regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines.
In such instance, Berberine and resveratrol may be considered as a potential treatment for the nonalcoholic fatty liver disease in the future.
5. Phytochemical Triterpenoid
Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex, hainanensis Merr.
In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) fed with a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, then orally administrated TF (250 mg/kg) for another two weeks, researchers showed that TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation, levels of inflammation and infection and apoptosis response in the liver.
Of these results, TF is effective in protecting the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.
6. Peony
Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony.
The acrid, bitter and mild cool herb has been used in TCM as anti microorganism, anti-inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.
Peony, a very popular Chinese herb is emerging as in many studies for its anti-inflammatory, anticoagulative, anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma.
In the study of the effects of peony in non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of peony group, scientists at end of experiment showed that oral administration of total glucosides not only inhibit hyperinsulinemia but also decrease levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C).
Further analysis also found that peony also raises levels of high-density lipoprotein cholesterol (HDL-C)] and ameliorates the overexpression of activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) and superoxide dismutase (SOD) as well as contents of malondialdehyde (MDA).
These results suggested that paeony may consist of a potential effect in protecting liver function by modulating serum lipid and decreasing oxidative stress caused by lipid peroxidation in the induction of fatty liver.
7. Bayberry
Bayberry is a species of Myrica gale, genus Myrica, belongings to the family Myricaceae.
The herbal medicine contains numbers of bioactive chemical constituents, including gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins.
In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, researchers found that intake of bay berry juice decreases inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reducing risk of steatosis progression in precipitated NALFD.
8. Green Tea
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with the nonalcoholic fatty liver disease is associated to its antioxidant compound polyphenolic catechins in the induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.
These chemical compounds are also found to mitigate the occurrence and progression of NAFLD.
Dr. Masterjohn C(7), the lead author said, “(The phytochemical compounds are) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD”.
In mice fed on a high-fat diet for 24 weeks, then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice show a significant improvement in body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation, and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance caused by high-fat diet.
The phytochemicals EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.
In fact, EGCG not only promoted weight loss but also attenuated symptoms of mice with the nonalcoholic fatty liver disease.
Administration of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, not only decreased weight gain and visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides out flux from liver.
9. Herbal Anise
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries in the treatment of strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.
In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an study of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO).
At the end of the experiment, researchers found that both applications exert significantly reverse activities in increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decreased in high-density lipoprotein level caused by choline-deficient diet in a dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injury or damage caused by the acute inflammation.
Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significant lower overexpression of ROS in an exhibited free radical chain reaction in the induction of oxidative stress to precipitated liver toxicity.
According to the histological findings, researchers concluded that both AE and AO display a substantial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Taken together, remedies indicated may be considered as functional foods for the treatment of non-alcoholic fatty liver disease (NAFLD).
However, additional data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of diseases will be necessary to complete the picture of above natural remedies’ effects in complete the treatment possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD. (PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH. (PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH. (PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS. (PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1. (PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1. (PubMed)
(14) Pimpinella anisum L. fruit: Chemical composition and effect on a rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
Subscribe to:
Posts (Atom)