Scientists may have found a functional herb bioactive compound which processes anti-pancreatic cancer activity with no side effects, some scientists suggested.
Pancreatic cancer is a medical and chronic condition characterized by irregular cells growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obesity, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibit tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival
Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors and reduced eNOS phosphorylation in cell proliferation.
However, Emodin had no effect on VEGFR expression in vivo.
Dr. Lin SZ, the lead author said, "emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".
Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).
The combination therapy of gemcitabine plus emodin) are more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.
Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.
In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV) and tumor weight compared to monotherapy.
Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".
Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)
Ovarian Cyst Miracle (tm)
Permanently and Naturally, Eliminate All Types of Ovarian Cysts Within 2 Months
Thursday, February 28, 2019
Herbal Arnica, A Remedy Which Processes Anti-inflammatory Activity
Scientists may have herbal medicine which may reduce risk and treat diseases associated with inflammation, some studies suggested.
Inflammation is a natural defense that protects our body against the invasion of foreign stimuli, including damaged cells, irritants, pathogens.
In the body tissue damage caused by physical impact or other sources, macrophages, the immune first ile of defense, stimulating the production of proinflammatory cytokines to the site with an aim to protect our body by destroying possible bacteria or virus invasion.
However, in most cases, a prolonged period of overproduction of inflammatory cytokines can cause damage and death of the healthy cells leading to tissue damage and the formation of abnormal scars after healing. The liver scar is one of the examples.
Some cytokines process such as interleukin-6 (IL-6) a duo function of pro and anti-inflammatory activity. Under normal condition, the protein produces anti-inflammatory cytokines against substances that cause inflammation such as oxidative stress, however, in sensing of the bodily injury and damage, these proteins switch to produce proinflammatory cytokines.
Chronic inflammation is inflammation that lasts more than 3 months, occurred when the immune systematic response cannot destroy all pathogens in the acute phase of infection.
Chronic inflammation also can be caused by an autoimmune disorder in which the immune white blood cells mistakenly attack the body localized tissue, such as cancers and rheumatoid arthritis.
Symptoms associated with acute inflammation are depending on the location of the inflammation. including pain, swelling, redness, and heat.
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The herb has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Inflammation is a condition of the Immune system self-protection to remove harmful ... from our body.
The ingredients
Beside containing helenalin as it main ingredient used as an anti-inflammatory agent in herbal medicine, it also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative, etc.
In the study to reaffirm the traditional claim that herbal Arnica montana, in topical formulations process anti-inflammatory activity, researchers at the Pontificia Universidade Católica de Brasília, launched an investigation determine whether Arnica montana 6cH decreases acute and chronic inflammation in animal models.
In the acute, model, carrageenin-induced rat paw edema, the group treated with Arnica montana 6cH showed 30% inflammatory inhibition compared to control.
However, Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process.
In the chronic model, Nystatin-induced edema, Arnica montana 6cH treatment after 3 days of injection of Nystatin, exerts a significantly reduced inflammation 6 h after the last dose of the inflammatory agent was applied compared to insignificant result when treatment was given 6 h after Nystatin treatment.
In a model based on the histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.
These results suggested that Arnica montana 6cH induce the anti-inflammatory effects in a dose and time-dependent manner.
Additionally, in the study to compare two types of gels and microemulsions used to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica Montana extract, and aloin, an anthrone-C-glucosyls with antibacterial activity present in aloe vera extract, researchers found that microemulsion can be a good vehicle to increase the permeation of helenalin, while the gel formulation, containing Sepigel 305, proved able to reduce the release and permeation of aloin, with a consequent activity limited to the surface of application, without any permeation. in a modified Franz cell and a porcine skin membrane.
These results suggested Arnica montana gel may be a good choice in reduced skin inflammation if it is used combined with a microemulsion, which processes the function in increasing the permeation of helenalin.
Taken all together, Herbal Arnica may be considered a functional food for the prevention and an adjunct therapy combined with primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S.,(PubMed)
(2) Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals by Macêdo SB, Ferreira LR, Perazzo FF, Carvalho JC. (PubMed)
(3) Effect of vehicles on topical application of aloe vera and arnica Montana components by Bergamante V, Ceschel GC, Marazzita S, Ronchi C, Fini A.(PubMed)
Inflammation is a natural defense that protects our body against the invasion of foreign stimuli, including damaged cells, irritants, pathogens.
In the body tissue damage caused by physical impact or other sources, macrophages, the immune first ile of defense, stimulating the production of proinflammatory cytokines to the site with an aim to protect our body by destroying possible bacteria or virus invasion.
However, in most cases, a prolonged period of overproduction of inflammatory cytokines can cause damage and death of the healthy cells leading to tissue damage and the formation of abnormal scars after healing. The liver scar is one of the examples.
Some cytokines process such as interleukin-6 (IL-6) a duo function of pro and anti-inflammatory activity. Under normal condition, the protein produces anti-inflammatory cytokines against substances that cause inflammation such as oxidative stress, however, in sensing of the bodily injury and damage, these proteins switch to produce proinflammatory cytokines.
Chronic inflammation is inflammation that lasts more than 3 months, occurred when the immune systematic response cannot destroy all pathogens in the acute phase of infection.
Chronic inflammation also can be caused by an autoimmune disorder in which the immune white blood cells mistakenly attack the body localized tissue, such as cancers and rheumatoid arthritis.
Symptoms associated with acute inflammation are depending on the location of the inflammation. including pain, swelling, redness, and heat.
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The herb has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Inflammation is a condition of the Immune system self-protection to remove harmful ... from our body.
The ingredients
Beside containing helenalin as it main ingredient used as an anti-inflammatory agent in herbal medicine, it also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative, etc.
In the study to reaffirm the traditional claim that herbal Arnica montana, in topical formulations process anti-inflammatory activity, researchers at the Pontificia Universidade Católica de Brasília, launched an investigation determine whether Arnica montana 6cH decreases acute and chronic inflammation in animal models.
In the acute, model, carrageenin-induced rat paw edema, the group treated with Arnica montana 6cH showed 30% inflammatory inhibition compared to control.
However, Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process.
In the chronic model, Nystatin-induced edema, Arnica montana 6cH treatment after 3 days of injection of Nystatin, exerts a significantly reduced inflammation 6 h after the last dose of the inflammatory agent was applied compared to insignificant result when treatment was given 6 h after Nystatin treatment.
In a model based on the histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.
These results suggested that Arnica montana 6cH induce the anti-inflammatory effects in a dose and time-dependent manner.
Additionally, in the study to compare two types of gels and microemulsions used to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica Montana extract, and aloin, an anthrone-C-glucosyls with antibacterial activity present in aloe vera extract, researchers found that microemulsion can be a good vehicle to increase the permeation of helenalin, while the gel formulation, containing Sepigel 305, proved able to reduce the release and permeation of aloin, with a consequent activity limited to the surface of application, without any permeation. in a modified Franz cell and a porcine skin membrane.
These results suggested Arnica montana gel may be a good choice in reduced skin inflammation if it is used combined with a microemulsion, which processes the function in increasing the permeation of helenalin.
Taken all together, Herbal Arnica may be considered a functional food for the prevention and an adjunct therapy combined with primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S.,(PubMed)
(2) Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals by Macêdo SB, Ferreira LR, Perazzo FF, Carvalho JC. (PubMed)
(3) Effect of vehicles on topical application of aloe vera and arnica Montana components by Bergamante V, Ceschel GC, Marazzita S, Ronchi C, Fini A.(PubMed)
Wednesday, February 27, 2019
Tualang Honey Protects the Oral Cells Against Cancer With No Side Effects
Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.
Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.
According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.
The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.
Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at the increased risk of the disease.
The Canadian Cancer Society in the explanation of how a weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".
Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"
If you experience symptoms of a sore that does heal within a few days, a growth, lump or thickening of the skin or lining of your mouth, tongue and jaw pain that do not heal in weeks, persistent sore throat, difficult or chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effect compared to surgery followed by chemo and.or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.
The study procedures include several concentrations of Tualang honey (1% - 20%) were applied directly on OSCC cell lines for 3, 6, 12, 24, 48 and 72 hours.
The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit.to detect the cell apoptosis.
Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.
In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.
The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.
The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.
The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.
Dr. Ghashm AA the lead scientist at the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".
Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.
Due to the limitation of the above study, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.
According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.
The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.
Some researchers also suggested that people with immune system suppression due to the use of an immune suppressor are at the increased risk of the disease.
The Canadian Cancer Society in the explanation of how a weakened immune system can induce mouth cancer, wrote, "Your immune system can be weakened after an organ transplant or treatment for an immune system disease. and "People with a weakened immune system have a higher risk of developing oral cancer, especially lip cancer".
Also, " The higher risk may be due to taking drugs that suppress your immune system. People with weakened immune systems are also more likely to get an HPV infection, which increases the risk of oral cancer"
If you experience symptoms of a sore that does heal within a few days, a growth, lump or thickening of the skin or lining of your mouth, tongue and jaw pain that do not heal in weeks, persistent sore throat, difficult or chewing and swallowing, please check with your doctor to rule out the possibility of mouth cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the treatment of t inducing mouth cancer without inducing any side effect compared to surgery followed by chemo and.or radiotherapy researchers at the Universiti Sains Malaysia examine the antiproliferative activity of local honey (Tualang) on OSCC cell lines.
The study procedures include several concentrations of Tualang honey (1% - 20%) were applied directly on OSCC cell lines for 3, 6, 12, 24, 48 and 72 hours.
The study also used MTT assay to assess the cell viability and the Annexin V-FITC Apoptosis Detection Kit.to detect the cell apoptosis.
Application of Tualang honey induced cancer cells apoptosis observed by cell degradation and reduced in numbers.
In other words, the apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus were observed through MTT assay.
The MTT assay also suggested that Tualang honey exerts an inhibitory effect in a time and dose-dependent manner.
The efficacy was also found in the 50% inhibitory concentration (IC50) for OSCC of 4%.
The maximum inhibition of cell growth of ≥80% was observed in the concentration at 15%.
Dr. Ghashm AA the lead scientist at the final report wrote, "Tualang honey showed the antiproliferative effect on OSCC...cell lines by inducing early apoptosis".
Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary medicine for the treatment of mouth cancer.
Due to the limitation of the above study, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-mouth cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
Avocado, the Anti Inflammatory Diseases Functional Food
Intake avocado daily may have a strong effect in reducing the risk of acute and chronic inflammation, some researchers suggested.
Inflammation is a natural and systematic immune response with an aim to protect our body against the invasion of foreign pathogens.
Acute inflammation is caused by overproduction of proinflammatory cytokines which is activated the immune macrophages, a first line of the immune defense.
Chronic inflammation that lasts for several months and even year usually is the result of the immune system failing to eliminate all pathogenic invasion in the acute inflammation.
In some cases, chronic inflammation can also be caused by the immune white blood cells mistakenly attacks the body healthy tissue.
Some researchers suggested that long-term exposure to lower levels of irritants, such as industrial chemicals or polluted air may also cause chronic inflammation.
According to the statistic, in 2000, nearly 125 million Americans were living with chronic conditions and 61 million (21%) had more than one. And these numbers are expected to increase substantially,
More scarcely, 3 of 5 people die due to chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes, worldwide.
If you experience symptoms of depression, anxiety and mood disorders, persistent gastrointestinal complications like constipation, diarrhea, and acid reflux, weight gain, and frequent infections, you may be at the early stage of the development of chronic inflammation. Please check with your doctor to rule out the possibility.
Dr. Roma Pahwa and Dr. Ishwarlal Jialal in the article of chronic inflammation suggested that many dietary and lifestyle changes may be helpful in removing inflammation triggers and reducing chronic inflammation as listed below. The most effective is weight loss.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
In the finding a natural ingredient for the treatment of skin inflammation caused by exposure to ultraviolet (UV) radiation without inducing side effects, researchers at the Granot Initiative Center conducted a study to test the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin.
Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6, and PGE(2), the proinflammatory cytokines and enhancing DNA repair.
In human skin explants, treating with PFA reduced significantly UV-induced cellular damage.
Furthermore, in the evaluation of the anti-inflammatory effect of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG) on cyclooxygenase-2 (COX-2) expression which is responsible for increase the inflammatory response and prostaglandin E(2) (PGE(2)) production in cytokine-activated equine chondrocytes, the cells harvested from normal or OA joints .
Before application of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG), equine chondrocytes responded to cytokine activation by up-regulated gene expression of COX-2 and increased PGE(2) production.
Application of ASU and EGCG marginally inhibited COX-2 expression and PGE(2) production in activated chondrocytes.
The combination of ASU and EGCG reduced COX-2 expression close to non-activated control levels and significantly inhibited PGE(2) production.
The inhibition of COX-2 expression and PGE(2) production was associated with the inhibition of NF-kappaB translocation in the regulation of cytokines and immune responses.
These results suggested that the combination may offer an attractive supplement or alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis, a chronic inflammatory disease.
Additional study on the effects of avocado soybean unsaponifiables (ASU) on proinflammatory mediators in chondrocytes and monocyte/macrophage-like cells, researchers also found that
* ASU reduced proinflammatory cytokines, TNF-alpha, IL-1beta, COX-2, and iNOS expression in LPS-activated chondrocytes to levels similar to nonactivated control levels.
* The suppression of COX-2 and iNOS expression was paralleled by a significant reduction in PGE(2) and nitrite, respectively.
Taken altogether, avocado processed a significant anti-inflammatory activity may be considered a functional food for the prevention of inflammatory disease and an adjunct therapy combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Polyhydroxylated fatty alcohols derived from avocado suppress the inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(2) Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate by Heinecke LF1, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG.(PubMed)
(3) Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages by Au RY1, Al-Talib TK, Au AY, Phan PV, Frondoza CG.(PubMed)
(4) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
Inflammation is a natural and systematic immune response with an aim to protect our body against the invasion of foreign pathogens.
Acute inflammation is caused by overproduction of proinflammatory cytokines which is activated the immune macrophages, a first line of the immune defense.
Chronic inflammation that lasts for several months and even year usually is the result of the immune system failing to eliminate all pathogenic invasion in the acute inflammation.
In some cases, chronic inflammation can also be caused by the immune white blood cells mistakenly attacks the body healthy tissue.
Some researchers suggested that long-term exposure to lower levels of irritants, such as industrial chemicals or polluted air may also cause chronic inflammation.
According to the statistic, in 2000, nearly 125 million Americans were living with chronic conditions and 61 million (21%) had more than one. And these numbers are expected to increase substantially,
More scarcely, 3 of 5 people die due to chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes, worldwide.
If you experience symptoms of depression, anxiety and mood disorders, persistent gastrointestinal complications like constipation, diarrhea, and acid reflux, weight gain, and frequent infections, you may be at the early stage of the development of chronic inflammation. Please check with your doctor to rule out the possibility.
Dr. Roma Pahwa and Dr. Ishwarlal Jialal in the article of chronic inflammation suggested that many dietary and lifestyle changes may be helpful in removing inflammation triggers and reducing chronic inflammation as listed below. The most effective is weight loss.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
In the finding a natural ingredient for the treatment of skin inflammation caused by exposure to ultraviolet (UV) radiation without inducing side effects, researchers at the Granot Initiative Center conducted a study to test the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin.
Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6, and PGE(2), the proinflammatory cytokines and enhancing DNA repair.
In human skin explants, treating with PFA reduced significantly UV-induced cellular damage.
Furthermore, in the evaluation of the anti-inflammatory effect of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG) on cyclooxygenase-2 (COX-2) expression which is responsible for increase the inflammatory response and prostaglandin E(2) (PGE(2)) production in cytokine-activated equine chondrocytes, the cells harvested from normal or OA joints .
Before application of the combination of avocado soybean unsaponifiables (ASU) and epigallocatechin gallate (EGCG), equine chondrocytes responded to cytokine activation by up-regulated gene expression of COX-2 and increased PGE(2) production.
Application of ASU and EGCG marginally inhibited COX-2 expression and PGE(2) production in activated chondrocytes.
The combination of ASU and EGCG reduced COX-2 expression close to non-activated control levels and significantly inhibited PGE(2) production.
The inhibition of COX-2 expression and PGE(2) production was associated with the inhibition of NF-kappaB translocation in the regulation of cytokines and immune responses.
These results suggested that the combination may offer an attractive supplement or alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis, a chronic inflammatory disease.
Additional study on the effects of avocado soybean unsaponifiables (ASU) on proinflammatory mediators in chondrocytes and monocyte/macrophage-like cells, researchers also found that
* ASU reduced proinflammatory cytokines, TNF-alpha, IL-1beta, COX-2, and iNOS expression in LPS-activated chondrocytes to levels similar to nonactivated control levels.
* The suppression of COX-2 and iNOS expression was paralleled by a significant reduction in PGE(2) and nitrite, respectively.
Taken altogether, avocado processed a significant anti-inflammatory activity may be considered a functional food for the prevention of inflammatory disease and an adjunct therapy combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Polyhydroxylated fatty alcohols derived from avocado suppress the inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(2) Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate by Heinecke LF1, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG.(PubMed)
(3) Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages by Au RY1, Al-Talib TK, Au AY, Phan PV, Frondoza CG.(PubMed)
(4) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
Tuesday, February 26, 2019
Asparagus, The Miracle Anti Diabetes and Diabetes Complications Functional Food, Scientists Say
Asparagus may have a potential and profound effect in reduced risk of diabetes in patients with no diabetes and diabetic complications in patients with diabetes, some studies suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.
The actual causes of diabetes are debatable. As researchers do not know why some people without genetic mutations are susceptible to disease development, while others do not.
Researchers believed that the onset of diabetes type 2 is associated with a set of risk factors. According to the retrospective cohort study, using the data of 8337 adolescent respondents from Add Health (1994-2008) including 5131 non-Hispanic Whites, 1651 non-Hispanic Blacks, 1223 Hispanics, and 332 American Indians/Alaska Natives lead by College of Medicine, Washington State University,
* Pre-diabetes and diabetes were more prevalent in non-Hispanic Blacks (55% and 12%, respectively) than in American Indians/Alaska Natives (43% and 11%),
* Higher body mass index and family history of diabetes were associated with higher risk of pre-diabetes and diabetes.
* Female sex was associated with lower risk of pre-diabetes in compared to the male counterpart.
Furthermore
* Physical inactivity, sedentary behaviors, or fast food consumption are associated with independent and preventive risk factors that induce early onset of prediabetes and diabetes.
Most people with prediabetes do not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may lead to serious complications of cardiovascular diseases, kidney damage, nerve, foot and eye damage, skin wound that can heal,....... and dementia such as Alzheimer's disease.
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.
The vegetable has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
In Streptozotocin (90 mg/kg) injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes, researchers found that rats treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg per d) expressed lowering fasting blood glucose, improved serum insulin, total antioxidant status and qualitative and quantitative in β-cell function(1) is compared to placebo group.
Additional observation also discovered that the methanolic extract also exerts a significant effect in reduced complications of kidney disease by inhibiting renal hypertrophy, polyuria, hyperfiltration, microalbuminuria and abnormal changes in the renal tissue(1).
Furthermore, asparagus extract enhanced production of antioxidants from the host in neutralizing the unbalanced ratio of antioxidants and free radical in initiated oxidative stress(1) induced by injection of Streptozotocin (90 mg/kg) effectively.
Moreover, according to the study by Smt. Kashibai Navale College of Pharmacy, oral administration of ethanolic extract of Asparagus racemosus (EEAR) at a dose level of 100 and 250 mg/kg daily for 4 weeks, significantly reduced the expression of streptozotocin-induced early diabetic nephropathy in compared with control group(2).
Dr. Somania R, the lead researcher said, " A. racemosus treatment significantly decreased plasma glucose, creatinine, ..... total cholesterol and triglyceride levels. Renal hypertrophy,....and abnormal changes in the renal tissue".
These effects can be attributed to the extract's anti-diabetic effects by improving insulin secretion and β-cell function(2).
Interestingly, the 21 days continuous administration of aqueous extract of asparagus by-product (AEA) to examine the hypoglycemic effect in a streptozotocin (STZ)-induced diabetic rat model indicated(3), found
* Rat treated with the extract showed to decrease fasting serum glucose and triglyceride levels but markedly increased body weight and hepatic glycogen level.
* In an oral glucose tolerance test, both the blood glucose level measured at 30, 60 and 120 min after glucose loading and the area under the glucose curve showed a significant decrease after AEA treatment.
* The extract also exhibited the hypoglycaemic and hypotriglyceridaemic effects in preventing diabetic complications associated with hyperglycemia and hyperlipidemia (3).
Taking all together, there is no doubt that many aspects have contributed to the effectiveness of asparagus in reduced risk of diabetic complications and treatment of diabetes, but a large amount of asparagus extract intake should only be prescribed by related field specialist.
However, further data collection on large example size and multi-center clinical studies and trials performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Asparagus racemosus Willd (Liliaceae) ameliorates early diabetic nephropathy in STZ induced diabetic rats by Somania R1, Singhai AK, Shivgunde P, Jain D.(PubMed)
(2) Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats by Hafizur RM1, Kabir N, Chishti S.(PubMed)
(3) The aqueous extract of Asparagus officinalis L. by-product exerts hypoglycaemic activity in streptozotocin-induced diabetic rats by Zhao J1, Zhang W, Zhu X, Zhao D, Wang K, Wang R, Qu W.(PubMed)
(4) Risk factors for pre-diabetes and diabetes in adolescence and their variability by race and ethnicity by Zamora-Kapoor A1, Fyfe-Johnson A2, Omidpanah A2, Buchwald D2, Sinclair K(PubMed)
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.
The actual causes of diabetes are debatable. As researchers do not know why some people without genetic mutations are susceptible to disease development, while others do not.
Researchers believed that the onset of diabetes type 2 is associated with a set of risk factors. According to the retrospective cohort study, using the data of 8337 adolescent respondents from Add Health (1994-2008) including 5131 non-Hispanic Whites, 1651 non-Hispanic Blacks, 1223 Hispanics, and 332 American Indians/Alaska Natives lead by College of Medicine, Washington State University,
* Pre-diabetes and diabetes were more prevalent in non-Hispanic Blacks (55% and 12%, respectively) than in American Indians/Alaska Natives (43% and 11%),
* Higher body mass index and family history of diabetes were associated with higher risk of pre-diabetes and diabetes.
* Female sex was associated with lower risk of pre-diabetes in compared to the male counterpart.
Furthermore
* Physical inactivity, sedentary behaviors, or fast food consumption are associated with independent and preventive risk factors that induce early onset of prediabetes and diabetes.
Most people with prediabetes do not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may lead to serious complications of cardiovascular diseases, kidney damage, nerve, foot and eye damage, skin wound that can heal,....... and dementia such as Alzheimer's disease.
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.
The vegetable has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
In Streptozotocin (90 mg/kg) injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes, researchers found that rats treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg per d) expressed lowering fasting blood glucose, improved serum insulin, total antioxidant status and qualitative and quantitative in β-cell function(1) is compared to placebo group.
Additional observation also discovered that the methanolic extract also exerts a significant effect in reduced complications of kidney disease by inhibiting renal hypertrophy, polyuria, hyperfiltration, microalbuminuria and abnormal changes in the renal tissue(1).
Furthermore, asparagus extract enhanced production of antioxidants from the host in neutralizing the unbalanced ratio of antioxidants and free radical in initiated oxidative stress(1) induced by injection of Streptozotocin (90 mg/kg) effectively.
Moreover, according to the study by Smt. Kashibai Navale College of Pharmacy, oral administration of ethanolic extract of Asparagus racemosus (EEAR) at a dose level of 100 and 250 mg/kg daily for 4 weeks, significantly reduced the expression of streptozotocin-induced early diabetic nephropathy in compared with control group(2).
Dr. Somania R, the lead researcher said, " A. racemosus treatment significantly decreased plasma glucose, creatinine, ..... total cholesterol and triglyceride levels. Renal hypertrophy,....and abnormal changes in the renal tissue".
These effects can be attributed to the extract's anti-diabetic effects by improving insulin secretion and β-cell function(2).
Interestingly, the 21 days continuous administration of aqueous extract of asparagus by-product (AEA) to examine the hypoglycemic effect in a streptozotocin (STZ)-induced diabetic rat model indicated(3), found
* Rat treated with the extract showed to decrease fasting serum glucose and triglyceride levels but markedly increased body weight and hepatic glycogen level.
* In an oral glucose tolerance test, both the blood glucose level measured at 30, 60 and 120 min after glucose loading and the area under the glucose curve showed a significant decrease after AEA treatment.
* The extract also exhibited the hypoglycaemic and hypotriglyceridaemic effects in preventing diabetic complications associated with hyperglycemia and hyperlipidemia (3).
Taking all together, there is no doubt that many aspects have contributed to the effectiveness of asparagus in reduced risk of diabetic complications and treatment of diabetes, but a large amount of asparagus extract intake should only be prescribed by related field specialist.
However, further data collection on large example size and multi-center clinical studies and trials performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Asparagus racemosus Willd (Liliaceae) ameliorates early diabetic nephropathy in STZ induced diabetic rats by Somania R1, Singhai AK, Shivgunde P, Jain D.(PubMed)
(2) Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats by Hafizur RM1, Kabir N, Chishti S.(PubMed)
(3) The aqueous extract of Asparagus officinalis L. by-product exerts hypoglycaemic activity in streptozotocin-induced diabetic rats by Zhao J1, Zhang W, Zhu X, Zhao D, Wang K, Wang R, Qu W.(PubMed)
(4) Risk factors for pre-diabetes and diabetes in adolescence and their variability by race and ethnicity by Zamora-Kapoor A1, Fyfe-Johnson A2, Omidpanah A2, Buchwald D2, Sinclair K(PubMed)
Honey, the Potential Anti-Colon Cancer Functional Food
Scientists may have found a sweet functional food that processes a potential for the prevention and treatment of cancer, some studies suggested.
Cancers are the group of chronic diseases, caused by cell growth disorderly and uncontrollably in some specific tissue and organs.
Most primary cancers start in the cells on the surface of the inner lining of tissue caused the alternation of DNA.
At the later stage, after penetrating deep in the tissue of the infected organs, most primary cancer can travel a distance away from the original site to damage other healthy tissue and organs.
As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.
Researchers do not know the exact causes of colon cancer. Neither they know why some people with the same health conditions, diet pattern and ethnicity and family history, some are susceptible to the early onset of the diseases, while many others do not.
Most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.
In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".
What are the age-related factors that contribute to cancer be changed? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:
These results furtherly emphasized the needs to prevent chronic diseases and support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are most important factors that can reduce substantially the risk of cancer.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.
Combined ginger and Gelam honey treatment stimulated the early cell death response through enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes and inhibiting the function of proteins associated with cells proliferation.
The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated a similar efficacy as of the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.
These results suggest ginger and Gelam honey used alone or combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.
Further differentiation of the anti-proliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than the Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam honey to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.
* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.
Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.
These results once against suggested that Gelam honey and ginger extract used alone or combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)
Monday, February 25, 2019
Herbal Cascara Sagrada's Emodin Kills Non-small Cell Lung Cancer (NSCLC) Cells, in Vivo and Vitro
Herbal Cascara sagrada may be the next pharmaceutical target to identify the single ingredient for the treatment of non-small cell lung cancer (NSCLC), some scientists suggested.
Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancers is derived from epithelial cells.
According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.
In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.
Most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.
Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.
The most common risk factors of non-small cell lung cancer (NSCLC) are long term smoking and people exposed to long-term second-hand smoke.
Dr. Ryo Maeda MD, the lead scientists in the study to investigate the association between cigarette smoking and clinicopathological characteristics of patients with non-small cell lung cancer (NSCLC) and to evaluate its significance as a predictor of recurrence after resection showed that
* The 5 years of the survival rate of never and ever smokers in patients with stage I is 92%, compared to 76%, in smokers.
* The 5-year recurrence-free proportions (RFPs) for never and ever smokers were 89% compared to 80%, in smokers.
At the final report, the doctors wrote, "Smoking history showed the different impact on postoperative recurrence in patients with NSCLC between stage I and stages II and III, and depending on histology in stage I patients" and "Disease stages should be considered while evaluating smoking history as a predictor of recurrence".
These results not only indicated smoking has a strong impact on the increased incidence of non-small cell lung cancer (NSCLC) and but also reduces years of survival.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, Cascara sagrada also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
On finding a natural ingredient for the treatment of nonsmall cell lung cancer, researchers examined the effect of Emodin, a tyrosine kinase inhibitor is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants including herbal Cascara Sagrada.
Compared to the effect of cisplatin, a chemo drug, Emodin, exposure to the human NSCLC cells to emodin decreased cisplatin-elicited in the inhibition of the metaplasia and tumor development and increased the inability of a protein associated to cell DNA repaired.
Application of emodin alone or combined with cisplatin significantly decreased expression of cell repaired protein in carrying a portion of the code to other parts of the cell for processing.
Furthermore, the combination of Emodine and cisplatin decreased the proliferation and enhanced cisplatin-induced cytotoxicity in non-small cell lung cancer (NSCLC).
Although the study did not mention the effect of Emodin used combined with cisplatin have elicited the side effect caused by cisplatin, Emodin may lead to novel therapy in the future for NSCLC through the down-regulating expression of proteins associated to tumor spreading.
Further analysis of the Emodin effect on the non-small cell lung cancer (NSCLC) scientists at the Hsinchu Hospital investigates the role of ERCC1 and Rad51 in emodin-mediated cytotoxicity in human non-small cell lung cancer (NSCLC) cells.
Where ERCC1 is a protein associated with cells repair and DNA recombination and RAD51 is a protein associated with the assists in repair of DNA double-strand breaks.
Injection of Emodin showed a reduction of the expression of ERCC1 and Rad51 protein levels as well as mRNA levels in four different NSCLC cell lines correlated with the inactivation of the MKK1/2-ERK1/2 pathway involving cells proliferation.
The result suggested that application of Emodin exerts the similar effect as those of U0126, an MKK1/2 inhibitor used in conventional medicine for the inhibition of cellular ERCC1 and Rad51 protein and mRNA levels.
Combination of Emodin and U0126 could enhance emodin cytotoxic activity against the tested cell lines.
Dr. the lead scientist suggested these results showed that Emodin isolated from herbal Cascara Sagrada inhibited the nonsmall lung cancer through cytotoxic effect by blocking the protein associated with cell proliferation to induce apoptosis.
Taken altogether, herbal Cascara Sagrada processed the bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of non-small cell lung cancer (NSCLC)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2 by Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Chiu YF, Kuo YH, Tsai MS, Lin YW. (PubMed)
(2). Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells by Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Lin YW. (PubMed)
(3) The Prognostic Impact of Cigarette Smoking on Patients with Non-small Cell Lung Cancer. (Research Gate)
Sunday, February 24, 2019
Ginger, The Alternative Painkiller With No Side Effect
Ginger is one of the natural whole food recommended by many scientists for the treatment of muscle pain and soreness.
Muscle pain is a common condition can arise by a number of factors including injury or overexertion, infections of soft tissues, or inflammation.
Another factor such as the flu may also cause muscle pain.
Medication used for the treatment of cholesterol such as statins, fibromyalgia and under active thyroidism is also associated with the onset of muscle pain.
Swelling, redness, or fever are also most common symptoms accompanied by muscle pain.
Acute pain triggered by the nervous system, alerting you to possible injury.
Chronic muscle pain is a pain that lasts more than 3 months. Most cases of chronic muscle are caused by a syndrome of chronic myofascial pain (CMP), a painful condition that affects the muscles and the sheath of the tissue that surround the muscles.
The syndrome processes a most highly sensitive and notable symptom associated with the areas within the muscles that can also stimulate the pain in the other area of the body.
In contrast to the chronic myofascial pain (CMP), fibromyalgia syndrome (FMS) also cause chronic muscle pain due to brain disorder in processing pain signalings
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the reaffirming the ginger root pain-relief properties, researchers at the Old Dominion University launched a randomized, double-blind, placebo-controlled trial to determine whether ginger root supplementation reduces muscle soreness and dysfunction from downhill running.
Thirty-two runners (10 women, 22 men) included in the trial were pair-matched and randomized to 1.425 g/day of ginger root or placebo for 5 days.
Ang a 40-minute downhill (-7.5%) run was completed on day 3. Before supplementation and at various points throughout a 5-day protocol, muscle soreness, pain-pressure threshold, vertical jump, and 1.5-mile run performance.
Soreness while jogging likely increased to a lesser degree with ginger root from baseline. Ginger root had a possible small benefit on the vertical jump from baseline to day 5 but no meaningful impact on 1.5-mile run performance.
No significant differences in adverse events were observed during the experiment between treatments.
The results suggested that ginger root possibly has moderate beneficial effects on running-induced soreness but irrelevant effects on recovery of physical performance.
Dr. Wilson PB, said, "Ginger represents one option for runners looking to temporarily reduce pain".
Furthermore, in the findings, a natural ingredient for the treatment of inflammation and pain induced by delayed onset muscle soreness (DOMS), a joint study led by the Shiraz University, was launched to examine the effect of ginger extract on the biochemical and functional symptom of delayed onset muscle soreness.
36 healthy female subjects included in the study were recruited by intra dormitory calls and randomly divided into 3 groups, including ginger intake 1 hour before exercise (GIBE), ginger intake immediately after exercise (GIAE) and placebo group (PL).
Participants consumed capsules contain 60 mg of ginger extract (the equivalent of 2 g dried ginger powder) or placebo before and after exercise. The exercise protocol consisted of a 20-minute step test using a 46cm step at a rate of 15 steps per minute.
Ginger intake immediately after exercise (GIAE) showed a significant reduction of pain compared to GIAE after 24 and 48h of EE and GIAE compared to PL.
The inflammatory cytokine IL-6 changed significantly in GIBE compared to PL (p<0.05) after 1, 24, and 48h after EE.
These results indicated that 2 grams of ginger may have anti-inflammation and analgesic effect on DOMS.
Taken altogether, ginger root may be considered a functional painkiller kitchen spice for the deduction of muscle pain and soreness if it is intake 1 hour before exercise.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners.
Wilson PB. (PubMed)
(2) Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness by Hoseinzadeh K1, Daryanoosh F2, Baghdasar PJ3, Alizadeh H. (PubMed)
Saturday, February 23, 2019
Herbal Arctostaphylos uva-ursi, the Free Radicals Scavenger Functional Herb
Herbal Arctostaphylos uva-ursi may have a potential effect in reducing the risk and treatment of oxidative stress-related diseases, some studies suggested.
Oxidative stress is a production of the imbalance of ratio of free radicals and antioxidant in the bost body.
The imbalance of the ratio of free radicals and antioxidant in the bost body can be caused either by the overproduction of free radicals or antioxidant enzymes are suppressed by the outside sources.
However, most outside sources that suppress the levels of antioxidant enzymes also play an important role in stimulating the overexpression of free radicals, such as chemical toxins
Free radicals are unstable atoms with the unpaired electron in the outer ring. Therefore, in order for them to become stable, free radical either donates or steals an electron from stable molecules, leading to a chain of reaction that facilitates the onset of oxidative stress.
The chain once starts, it can not stop until the electron on the outer ring is paired or inhibited by antioxidant.
Free radical has been known to cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA.
Antioxidants are stable molecules found abundantly in fruits, vegetable, and herbal medicine.
If oxidative stress-related diseases are associated with the overproduction of free radicals, then long-term intake of a healthy diet high in fruits, vegetable and less in red meat and saturated and trans fat and processed foods can reduce the risk of the diseases in the healthy individuals.
Dr. Halliwell B, in the study to reaffirm the effect of healthy dietary patterns against the onset of oxidative stress said, " diet-derived antioxidants may be particularly important in protecting against these diseases" and
"The physiological relevance of these effects is uncertain, as is the optimal intake of most diet-derived antioxidants. In principle, these questions could be addressed by examining the effects of dietary composition and/or antioxidant supplementation upon parameters of oxidative damage in vivo".
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the examining the Dr. Bol'shakova IV, the lead author at the Emanuel Institute of Biochemical Physics claim, that Arctostaphylos uva.processes a significant antioxidant property in the inhibition of free radicals generation, researchers launched an investigation to evaluate the concentration of compound that inhibited cell growth by 50% (IC(50)) of a range of phytochemicals and plant extracts.
All selected extracts were differentiated according to the antioxidant and genoprotective effects under conditions of oxidative stress in U937 cells.
Two phytochemicals-resveratrol and citroflavan-3-ol isolated from the herbal Arctostaphylos uva-ursi demonstrated the highest IC50 value of 13.7 microg/mL, compared to the lowest at 9,400 microg/mL. of Echinacea.
Extract of herbal Arctostaphylos uva-ursi displayed a significant attenuation of the oxidative stress induced by the etoposide injection by inhibiting the expression of H2O2- and tBOOH-induced DNA damage.
These result reconfirmed the findings of Dr. Bol'shakova IV team that herbal Arctostaphylos uva-ursi as a non-nutrient dietary constituent may act as significant bioactive compounds in enhancing the antioxidants activity and stimulating the production of antioxidant enzymes if the herb is administrated in an animal model.
Moreover, Dr.Matsuda H the antioxidant team leader at the Kinki University, Osaka in the finding the natural compounds or whole food with potential antioxidant effects evaluated the inhibitory effect of 50% ethanol extracts obtained from the leaves of six Arctostaphylos plants (A. patula, A. viscida, A. canescens, A. Columbiana, A. nevadensis and A. uva-ursi) (Ericaceae).
Injection of the extracts of A. patula showed potent inhibition against tyrosinase, the enzyme that cause oxidation of the skin pigment.
Also, Arctostaphylos uva-ursi not only inhibited the production of melanin from dopachrome by autoxidation and but reduced the over exhibited SOD (superoxide dismutase, free radical)-like activity.
Additionally, Arctostaphylos uva-ursi processed a moderate absorbance in the UV-B area.
The results not only reaffirm the claim of Dr. Bol'shakova IV suggestion but also introduce a new herbal whitening medicine for the skin.
Taken all together, Herbal Arctostaphylos uva-ursi may be considered a functional food for the prevention and an adjunct therapy combine with primary medicine for the treatment of oxidative-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Antioxidant properties of plant extracts].[Article in Russian] by Bol'shakova IV, Lozovskaia EL, Sapezhinskiĭ II. (PubMed)
(2) Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells by O'Brien NM, Carpenter R, O'Callaghan YC, O'Grady MN, Kerry JP. (PubMed)
(3) Studies of cuticle drugs from natural sources. IV. Inhibitory effects of some Arctostaphylos plants on melanin biosynthesis. by Matsuda H, Higashino M, Nakai Y, Iinuma M, Kubo M, Lang FA. (PubMed)
Friday, February 22, 2019
Herbal Butcher's broom, the Functional Remedy for the Treatment of Varicose Veins, with No Side Effects
Scientists may have a natural herb for the treatment of varicose vein without inducing any side effects, some studies found.
The varicose veins are conditions characterized by the enlarged and twisted veins caused by blood flowing backward, most commonly found in the leg.
The causes of varicose vein in most cases are associated with the weak or damaged valves in the veins which prevent blood from flowing backward.
Third to the arteries and capillaries delivering oxygen-rich blood to your body, veins return the blood to the heart and lungs to be oxygenated,
In some cases, the presence of varicose veins may be an indication of other health issues, including heart disease.
Some researchers at the University of Tampere found that people with varicose veins are associated to a higher risk of congestive heart failure than those without, the odds ratio for the disease onset is 2.9% compared to 1.9 of those without.
After adjustment to the body mass index, arterial disease and hypertension; multi-adjusted indicine odd ration (IOR) for the incidence of CHF by varicose veins was 2.1.
Other risk factors may accelerate the onset of varicose veins, including genetic preposition, gender, occupation involved long-term standing and sitting, the increase in age and people who are overweight and obese.
In the study to compare the genetic preposition of patients with Chronic venous insufficiency (CVI) and those without, researchers at the Duke University School of Medicine, showed that
* Relative gene expression profiles analyzed by the study significantly differed between patients with CVI and patients unaffected by CVI.
* Regulatory genes of mediators of the inflammatory reaction and collagen production were up-regulated and down-regulated, respectively in CVI patients, compared to those without.
* Some unanalyzed relative gene expression of multiple genes were significantly different in CVI patients compared to those without, according to the DNA microarray analysis.
These results suggested that people who carry these genes are more likely associated with the substantial risk of varicose veins compared to people who do not.
Butcher's broom is a low evergreen shrub, a species of Ruscus aculeatus, belonging to the family Asparagaceae, native to Eurasia.
The medical plant has been used in herbal medicine to treat reduce inflammation, Peripheral vascular disease, Hemorrhoids Bronchial asthma, Varicose veins, Hypotension, Jaundice, functional disorders of the heart, kidney disorder, venotonic and anti-oedematous properties, etc..
The chemical ingredients of Butcher's broom include rutin, sitosterol, sparteine, spirostanol saponins, steroidal sapogenins, sterols, stigmasterol, sulfated steroidal saponins, sweet broom, tetracosanoic acid, triterpenes, triterpenes, tyramine, etc.
On finding, the natural ingredient or whole food for the treatment of varicose vein without inducing any side effects, researchers at the Thorne Research examine the effects of oral dietary supplementation and the traditional treatment of hemorrhoids and varicose veins.
Application of traditional medicine such as herbal Butcher's boom exerted a strong effect in the restoration of the loss of vascular integrity associated with the pathogenesis of both hemorrhoids and varicose veins.
Butcher's broom and other tested botanical plant extracts also improved microcirculation, capillary flow, and vascular tone, and to strengthen the connective tissue of the perivascular amorphous substrate.
These plant may be the alternative by preventing time-consuming, painful, and expensive complications of varicose veins and hemorrhoids induced by conventional surgery. suggested by Dr. MacKay D.
Additionally, the Mayo Clinic and Foundation experiments to evaluate the effect of an extract of Butcher's broon and to characterize pharmacologically adrenergic receptors in human varicose veins to the natural transmitter norepinephrine showed the application of Norepinephrine and Ruscus extract at the concentration-dependent inhibits the contractions in all veins.
Contractions to the extract were greater in varicose tributaries than in greater saphenous veins from varicose patients compared to the injection of Norepinephrine.
Interestingly, unlike Norepinephrine, contractions to Butcher's broom extract were not reduced by the alpha-adrenergic blocker, which is conventional medicine for the treatment of hypertension that relaxes certain muscles and helps small blood vessels remain open in control veins but were reduced by the alpha2-adrenergic blocker, an immobilizing an anesthetic drug in varicose veins.
These results strongly suggested that patients who used alpha-adrenergic blockers medicine for treatment of high blood pressure should switch to the alpha2-adrenergic blockade, before applying butcher's broom extract for the treatment of varicose veins.
Taken altogether, herbal Butcher's broom may be considered a functional herb for the treatment of varicose veins without inducing side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hemorrhoids and varicose veins: a review of treatment options by MacKay D.(PubMed)
(2) Pharmacological assessment of adrenergic receptors in human varicose veins by Miller VM, Rud KS, Gloviczki P.(PubMed)
(4) Genomics of varicose veins and chronic venous insufficiency by Markovic JN1, Shortell CK. (PubMed)
The varicose veins are conditions characterized by the enlarged and twisted veins caused by blood flowing backward, most commonly found in the leg.
The causes of varicose vein in most cases are associated with the weak or damaged valves in the veins which prevent blood from flowing backward.
Third to the arteries and capillaries delivering oxygen-rich blood to your body, veins return the blood to the heart and lungs to be oxygenated,
In some cases, the presence of varicose veins may be an indication of other health issues, including heart disease.
Some researchers at the University of Tampere found that people with varicose veins are associated to a higher risk of congestive heart failure than those without, the odds ratio for the disease onset is 2.9% compared to 1.9 of those without.
After adjustment to the body mass index, arterial disease and hypertension; multi-adjusted indicine odd ration (IOR) for the incidence of CHF by varicose veins was 2.1.
Other risk factors may accelerate the onset of varicose veins, including genetic preposition, gender, occupation involved long-term standing and sitting, the increase in age and people who are overweight and obese.
In the study to compare the genetic preposition of patients with Chronic venous insufficiency (CVI) and those without, researchers at the Duke University School of Medicine, showed that
* Relative gene expression profiles analyzed by the study significantly differed between patients with CVI and patients unaffected by CVI.
* Regulatory genes of mediators of the inflammatory reaction and collagen production were up-regulated and down-regulated, respectively in CVI patients, compared to those without.
* Some unanalyzed relative gene expression of multiple genes were significantly different in CVI patients compared to those without, according to the DNA microarray analysis.
These results suggested that people who carry these genes are more likely associated with the substantial risk of varicose veins compared to people who do not.
Butcher's broom is a low evergreen shrub, a species of Ruscus aculeatus, belonging to the family Asparagaceae, native to Eurasia.
The medical plant has been used in herbal medicine to treat reduce inflammation, Peripheral vascular disease, Hemorrhoids Bronchial asthma, Varicose veins, Hypotension, Jaundice, functional disorders of the heart, kidney disorder, venotonic and anti-oedematous properties, etc..
The chemical ingredients of Butcher's broom include rutin, sitosterol, sparteine, spirostanol saponins, steroidal sapogenins, sterols, stigmasterol, sulfated steroidal saponins, sweet broom, tetracosanoic acid, triterpenes, triterpenes, tyramine, etc.
On finding, the natural ingredient or whole food for the treatment of varicose vein without inducing any side effects, researchers at the Thorne Research examine the effects of oral dietary supplementation and the traditional treatment of hemorrhoids and varicose veins.
Application of traditional medicine such as herbal Butcher's boom exerted a strong effect in the restoration of the loss of vascular integrity associated with the pathogenesis of both hemorrhoids and varicose veins.
Butcher's broom and other tested botanical plant extracts also improved microcirculation, capillary flow, and vascular tone, and to strengthen the connective tissue of the perivascular amorphous substrate.
These plant may be the alternative by preventing time-consuming, painful, and expensive complications of varicose veins and hemorrhoids induced by conventional surgery. suggested by Dr. MacKay D.
Additionally, the Mayo Clinic and Foundation experiments to evaluate the effect of an extract of Butcher's broon and to characterize pharmacologically adrenergic receptors in human varicose veins to the natural transmitter norepinephrine showed the application of Norepinephrine and Ruscus extract at the concentration-dependent inhibits the contractions in all veins.
Contractions to the extract were greater in varicose tributaries than in greater saphenous veins from varicose patients compared to the injection of Norepinephrine.
Interestingly, unlike Norepinephrine, contractions to Butcher's broom extract were not reduced by the alpha-adrenergic blocker, which is conventional medicine for the treatment of hypertension that relaxes certain muscles and helps small blood vessels remain open in control veins but were reduced by the alpha2-adrenergic blocker, an immobilizing an anesthetic drug in varicose veins.
These results strongly suggested that patients who used alpha-adrenergic blockers medicine for treatment of high blood pressure should switch to the alpha2-adrenergic blockade, before applying butcher's broom extract for the treatment of varicose veins.
Taken altogether, herbal Butcher's broom may be considered a functional herb for the treatment of varicose veins without inducing side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hemorrhoids and varicose veins: a review of treatment options by MacKay D.(PubMed)
(2) Pharmacological assessment of adrenergic receptors in human varicose veins by Miller VM, Rud KS, Gloviczki P.(PubMed)
(4) Genomics of varicose veins and chronic venous insufficiency by Markovic JN1, Shortell CK. (PubMed)
Thursday, February 21, 2019
Phytochemical Anacardic Acids, Kills Prostate Cancer Cells in Vivo and Vitro
Anacardic acids may process a significant effect in reducing the risk and treatment of prostate cancer, some scientists suggested.
Prostate cancer is a chronic medical condition characterized by cell growth disorderly and uncontrollably in the prostate tissue.
Most cases of prostate cancer start on the cell of the surface of the prostate inner lining due to unknown mechanisms that alter the prostate cells DNA.
Most prostate cancers and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Prostate cancer is very slowly cancer.
The exact causes of prostate cancer are debatable.
People who were infected by the prostate cell change may not feel any symptoms until they are the age of 50 or over.
Aging, ethnicity, family history and hereditary breast and ovarian cancer (HBOC) syndrome associated with DNA-repair mutations to the BRCA1 and/or BRCA2 genes, exposure to toxic chemicals are the most common risk factors associated to the onset of the diseases.
However, most men who have some of the above risk factors do not develop prostate cancer.
Some researchers in the comparison of prostate cancer risk in men who follow different diets and lifestyle suggested, the risk of prostate cancer increased substantially in men who follow the Western diet high saturated fat and trans fat, red meat, and processed foods and low in fruits and vegetable and whole grains.
On the other hand, the risk of prostate cancer decreases in men who have followed the traditional diet.
Dr.Roberto Fabiani, the lead author at the University of Perugia, in the study "A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis" said, " The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".
Men who are at higher risk of prostate cancer due to family history and ethnicity may lower the risk by changing diet pattern with more fruits and vegetable and less red meat and processed foods.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc..
In the study to reaffirm the anti-prostate cancer effect of Anacardic acid (6-pentadecylsalicylic acid), a natural inhibitor of histone acetyltransferase from Amphipterygium adstringens, researchers at the East China Normal University conducted an investigation to examine whether this salicylic acid could block angiogenesis.
Application of Anacardic acid significantly suppressed the vascular endothelial growth factor (VEGF)in the induction of prostate cancer cell proliferation, migration, and adhesion and capillary-like structure formation of primary cultured human umbilical vascular endothelial cells (HUVECs) without detecting cellular toxicity.
Anacardic acid also effectively inhibited vascular development in chick embryo chorioallantoic membrane ex vivo (n = 10) and VEGF-triggered corneal neovascularization in vivo.
In mice bearing human prostate tumor xenografts (n = 6-7), application of anacardic acid (2 mg/kg per day) inhibited the volume and weight of solid tumors through apoptosis.
Furthermore, application of anacardic acid retarded the prostate tumor cell proliferation and microvessel density.
Additionally, Anacardic acid (AA) as a mixture of 2-hydroxy-6-alkylbenzoic acid homologs also inhibited LNCaP cell proliferation, induces G1/S cell cycle arrest and apoptosis of LNCaP cell.
After taking into account co and confounders, researchers discovered that AA-induced the LNCaP cells apoptosis may be due to the following aspects
* AA can regulate p300 transcription and protein level against the processes of cell proliferation and differentiation.in LNCaP cells.
* AA can activate p53 through its function as a regulator of the cell cycle and a tumor suppression against LNCaP cells.
* AA can down-regulates androgen receptor (AR) through suppressing p300 in the development and progression of prostate cancer.
The results suggested that AA process multiple anti-tumor activities in LNCaP cells.
Taken altogether, Anacardic acids may be considered a functional phytochemical for the prevention of prostate cancer and combined with the primary therapy for the treatment of prostate cancer, without inducing any side effects, depending on the large and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway by Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.(PubMed)
(2) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling by Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X.(PubMed)
(3) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PMC)
Wednesday, February 20, 2019
White Button Mushroom Which Processes A Potential to Cure Fatty Liver Disease
White button mushroom may have a protective effect against the onset and treatment of nonalcoholic liver disease, some scientists suggested.
Fatty liver or hepatic steatosis is a disease caused by the buildup of fat in the liver. If the fat in your liver is over 5 percent proportional to the liver cells, you are considered to have the early stage of the fatty liver disease.
According to the American liver foundation, the fatty liver is the most common disease in the US, affecting over affecting around 25 % of the population. The disease is most common in the age group between 40 and 60.
The common diseases associated with the onset of the nonalcoholic fatty liver disease include obesity hyperlipidemia, or high levels of fats in the blood, especially high triglycerides, diabetes, and genetic inheritance.
However, some researchers also found that long-term use of certain medication is the prevalent risk factors of the fatty liver such as rapid weight loss side effects of certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodarone (Pacerone), and valproic acid (Depakote).
Can the nonalcoholic fatty liver disease be prevented? Dr. William Nseir, the lead author in the study " Role of diet and lifestyle changes in nonalcoholic fatty liver disease", wrote, "there is no drug therapy that can be formulated for treating NAFLD. A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management" and
"NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
The result suggested that if you have followed a healthy diet high in fruits and vegetables, whole grain and low in saturated and trans fat, red meat and processed food and lifestyle accompanied by moderate exercise, you risk of nonalcoholic fatty liver disease is closed to zero.
If you are experiencing the symptoms of a persistently enlarged fluid-filled abdomen, jaundice of the skin and eyes, confusion and abnormal bleeding, please check with your doctor to rule out the possibility of fatty liver disease.
Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,
It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.
The chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.
In the concerns of low estrogen production in the risk of nonalcoholic fatty liver disease in the menopause women, researchers at the cellular team at the Beckman Research Institute of the City of Hope launched an investigation to examine the effects of white mushroom in the groups of ovariectomized mice (a model of postmenopausal women).
Selected OVX mice were fed a high-fat diet supplemented with WBM powder before injection of white button mushroom to induce fatty disease pattern.
Application of white button mushroom (WBM) exerted a significantly protective effect against liver steatosis in ovariectomized (OVX) mice.
As dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.
The pathological examination also suggested that WBM lowers fat accumulation in tissue in the livers of mice.
Furthermore, the glucose clearance ability of tested mice also improved substantially compared to untreated mice group.
According to the microarray analysis, genes associated to the fatty acid biosynthesis pathway, particularly the genes for fatty acid synthetase (Fas), a major determinant of the maximal hepatic capacity to generate fatty acids by de novo lipogenesis and fatty acid elongase 6 (Elovl6) which plays a key role in fat synthesis were down-regulated (reduced function).
Additionally, in vivo, the down-regulation of the expression of FAS and ELOVL6 in the HepG2 cell line by WBM extract was attributed to the inhibition of Liver X receptor (LXR) signaling and it's downstream transcriptional factor SREBP1c.
Where Liver X receptors (LXRs) are important regulators of cholesterol and fatty acid and SREBP-1c is associated with fatty liver and increased visceral fat mass.
The finding indicated that WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women.
The study was published on October 25 on the US National Library of Medicine and National Institutes of Health. You can view the publication by clicking the link in the resources,
Taken altogether, white button mushroom may be considered a functional food for the prevention and treatment of nonalcoholic fatty liver disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Role of diet and lifestyle changes in nonalcoholic fatty liver disease by William Nseir, Elias Hellou, and Nimer Assy. (PubMed)
Herbal Cayenne, the Best Antioxidant Functional Fruit
Herbal Cayenne may have a potential effect in stimulating the production of antioxidants from the host body to inhibit the overexpression of free radicals, some scientists suggested.
Free radicals are unstable molecules having an unpaired electron in the outer ring. in order for them to maintain stable, free radical must donate or steal an electron from another molecule, leading to a domino's chain reaction that cannot stop until inhibited by antioxidant or they are paired.
Antioxidants are stable molecules that inhibit the free radical oxidation and the unpaired electrons which are highly and chemically reactive in the human body.
Normally, the expression of free radicals is neutralized by antioxidants produced by the host body enzymes. However, if the host antioxidant enzymes are suppressed, free radical can overexpress, leading to oxidative stress.
Overexpression of free radicals in initiating oxidative stress to the human body can cause oxidative damage to the cells, proteins, and DNA, the underlying factors in many chronic diseases, including type 2 diabetes, and cardiovascular disease.
Most common free radicals have been found to cause significant damage to DNA, proteins, carbohydrates, and lipids of the cell nucleus, and membranes are hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.
The causes of the production of free radicals are associated either from normal essential metabolic processes in the human body inducing diet or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.
People who follow the Western diet high in saturated and trans fat, red meat and processed foods ( high oxidation) and low in fruits and vegetable (low antioxidants) are susceptible to the overexpression of free radical or oxidative stress.
Truly, Fats and oils not can be oxidized during storage as a result of exposure to light, air but also can become oxidized, creating free radicals, if they are heated in high temperature, the main cooking style found in the Western diet.
Saturated fats are less likely than unsaturated fats to become oxidized. When cooking fats are reused, they become more oxidized and produce even more free radicals.
Cayenne is also known as Cayenne pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.
The kitchen spice has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
The chemical constituents of Cayenne include capsaicin, capsaicin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
In the investigation of the antioxidant activity, DPPH radical-scavenging activity correlated with total bioactive compounds (capsaicinoids, carotenoids, flavonoids, and total phenolics) in pepper cultivars, researchers at the Universidad Complutense de Madrid launched a study on the individual carotenoid and phenolic content as well as the antioxidant properties of four red-hot dried cultivars (Capsicum annuum L.).
Hot dried peppers at ripe stage demonstrated the high content of bioactive compounds that exhibited significant antioxidant properties (26-80 micromol Trolox equivalents/g of dry matter), compared to polyphenols >2000 mg/100 g of dry matter and carotenoids ranging from 95-437 mg/100 g of dry matter.
The amount released from the food matrix by the action of digestive enzymes was about 75% for total polyphenols, up to 49% for both beta-carotene and zeaxanthin, and up to 41% for beta-cryptoxanthin.
And, 50 to 80% of these carotenoids could reach the colon to be potentially fermented or could remain unavailable.
Furthermore, the study of sweet red bell pepper, one of the best sources of ascorbic acid and carotenoids and phenolic compounds important in the human diet, researchers emphasized that organic growing increased the level of antioxidant compounds such as carotenoids, phenolic compounds and vitamin C in sweet bell pepper, compared to conventional cultivated.
However, the second significant factor affecting the antioxidant compound content of sweet bell pepper was totally depending on the varieties.
Geography, climate change environment factors and time of harvest may also affect the antioxidant contents of the bell pepper.
Taken altogether, herbal cayenne processed a high amount of bioactive antioxidants may be considered a functional food for reducing the risk of oxidative stress-related diseases.
Due to numbers of an unknown factor which may affect the quality of the fruits, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of herbal cayenne antioxidant possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bioactive compounds of four hot pepper varieties (Capsicum annuum L.), antioxidant capacity, and intestinal bioaccessibility by Hervert-Hernández D1, Sáyago-Ayerdi SG, Goñi I.(PubMed)
(2) Characterisation of antioxidant compounds in sweet bell pepper (Capsicum annuum L.) under organic and conventional growing systems by Hallmann E1, Rembiałkowska E.(PubMed)
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