White Button Mushroom Which Processes A Potential to Cure Fatty Liver Disease

White button mushroom may have a protective effect against the onset and treatment of nonalcoholic liver disease, some scientists suggested.

Fatty liver or hepatic steatosis is a disease caused by the buildup of fat in the liver. If the fat in your liver is over 5 percent proportional to the liver cells, you are considered to have the early stage of the fatty liver disease.


According to the American liver foundation, the fatty liver is the most common disease in the US, affecting over affecting around 25 % of the population. The disease is most common in the age group between 40 and 60.


The common diseases associated with the onset of the nonalcoholic fatty liver disease include obesity hyperlipidemia, or high levels of fats in the blood, especially high triglycerides, diabetes, and genetic inheritance.


However, some researchers also found that long-term use of certain medication is the prevalent risk factors of the fatty liver such as rapid weight loss side effects of certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodarone (Pacerone), and valproic acid (Depakote).


Can the nonalcoholic fatty liver disease be prevented? Dr. William Nseir, the lead author in the study " Role of diet and lifestyle changes in nonalcoholic fatty liver disease", wrote, "there is no drug therapy that can be formulated for treating NAFLD. A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management" and


"NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".


The result suggested that if you have followed a healthy diet high in fruits and vegetables, whole grain and low in saturated and trans fat, red meat and processed food and lifestyle accompanied by moderate exercise, you risk of nonalcoholic fatty liver disease is closed to zero.


If you are experiencing the symptoms of a persistently enlarged fluid-filled abdomen, jaundice of the skin and eyes, confusion and abnormal bleeding, please check with your doctor to rule out the possibility of fatty liver disease.


Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,

It is a genus A. Muscaria and belong to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.

The chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.

In the concerns of low estrogen production in the risk of nonalcoholic fatty liver disease in the menopause women, researchers at the cellular team at the Beckman Research Institute of the City of Hope launched an investigation to examine the effects of white mushroom in the groups of ovariectomized mice (a model of postmenopausal women).

Selected OVX mice were fed a high-fat diet supplemented with WBM powder before injection of white button mushroom to induce fatty disease pattern.

Application of white button mushroom (WBM) exerted a significantly protective effect against liver steatosis in ovariectomized (OVX) mice.

As dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.

The pathological examination also suggested that WBM lowers fat accumulation in tissue in the livers of mice.

Furthermore, the glucose clearance ability of tested mice also improved substantially compared to untreated mice group.

According to the microarray analysis, genes associated to the fatty acid biosynthesis pathway, particularly the genes for fatty acid synthetase (Fas), a major determinant of the maximal hepatic capacity to generate fatty acids by de novo lipogenesis and fatty acid elongase 6 (Elovl6) which plays a key role in fat synthesis were down-regulated (reduced function).

Additionally, in vivo, the down-regulation of the expression of FAS and ELOVL6 in the HepG2 cell line by WBM extract was attributed to the inhibition of Liver X receptor (LXR) signaling and it's downstream transcriptional factor SREBP1c.


Where Liver X receptors (LXRs) are important regulators of cholesterol and fatty acid and SREBP-1c is associated with fatty liver and increased visceral fat mass.


The finding indicated that WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women.

The study was published on October 25 on the US National Library of Medicine and National Institutes of Health. You can view the publication by clicking the link in the resources,


Taken altogether, white button mushroom may be considered a functional food for the prevention and treatment of nonalcoholic fatty liver disease.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Role of diet and lifestyle changes in nonalcoholic fatty liver disease by William Nseir, Elias Hellou, and Nimer Assy. (PubMed)