Cucumber's Cucurbitacin B (CuB) Blocks the Skin Cancer Proliferation in Vitro

Skin cancer is a chronic and medical caused cell growth disorderly and uncontrollably due to the alternation of DNA.


Most cases of skin cancer begin in the cells on the surface of the inner lining, before proliferating to other tissues through cell cycle division.


Compared to normal cells with a limit of cycle division, the cancer cell can divide indefinitely. Some tumor can also stimulate the production of the new vessels to provide them with additional energy from the preexist vessel.


Most common types of skin cancer are

* Basal cell cancer
It is the most common type of skin cancer as a result of abnormal growth of the cells in the lowest layer of the epidermis, accounting more than 90% of all skin cancer in the U.S.


* Squamous cell cancer
Squamous cell cancer arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.


* Melanoma
Melanoma is a result of malignancy of melanocytes, which are the cell produced dark pigment for your skin.


Most common symptoms of skin cancer are abnormal skin patches, such as flat, scaly, brown or flesh-colored patches, a white, waxy scar-like sore, scaly red skin lesion, skin bump or lump, sore that won't heal, unintentional weight loss and non-healing ulcer, especially on lip or ears.


If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility.


The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound which processes anti-skin cancer property, researchers investigated cucurbitacin B (CuB) effect, a major compound found in cucumber on cutaneous squamous cell carcinoma (CSCC).

According to the tested analysis, CuB inhibited 50% growth (ED50) of the CSCC cell lines (SRB1, SRB12, SCC13, COLO16) in liquid culture at 4 x 10(-7)-10(-5) M.

At 10(-7) M, CuB inhibited nearly all of the CSCC clonogenic cells used in the study through cell cycle arrest.

Interestingly, injection of Cub exerted cancer cell morphologic changes within 60 min. Moreover, Cub (10(-8)-10(-6) M, 3-24 h) was effective in inhibiting the proteins associated with SRB1 and SRB12 cell lines proliferation by disrupting the cell cycle division.



The migration of SRB1 and SRB12 cells was also suppression by the injection of 10(-7) M CuB.


Most importantly, CuB exerted the synergistic potentiation of the anti-proliferative effect of cisplatin in CSCC.


In other words, CuB suppressed the cancer cell progression linearly in a dose-dependent manner through its G2/M cell cycle arrest


Based on the findings, researchers wrote, "CuB has a prominent anti-proliferative activity on CSCC cells".



Taken altogether, cucumber processed a high amount of CuB may be used for the treatment of skin cancer, pending to the confirmation of the larger sample size and multicenter human study.



Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines by Chen W1, Leiter A, Yin D, Meiring M, Louw VJ, Koeffler HP. (PubMed)