Common Fig or Fig (Ficus carica) Gobbles Up Triple-Negative Invasive Breast Cancer in Vitro

The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a women's breast is totally determined by the amount of fat.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. There are also rare cases that breast cancer starts in other areas of the breast.

At the advanced stage, after colonizing the entire breast the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.

The exact causes of breast cancer are unknown.


In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.


Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.

More importantly, triple-negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.

Particularly, according to the epidemiological study, younger women and in women of African ancestry are susceptible to a higher risk of basal-like triple-negative breast cancers.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive which can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancers, with decreased risk after 5 years, triple-negative breast cancers have a substantial higher recurrent rate within 5 years after treatment.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding a natural compound or whole food for the treatment of cancer, researchers investigated the effects of Ficus carica leaves on triple-negative breast cancer MDA-MB-231 cells.

According to the tested differentiation, the application of Ficus carica leaves promoted the gene expressions associated with apoptosis.

Furthermore, Ficus carica leaves also demonstrated significant activity in the induction of S phase cell cycle arrest by changing the expression of cyclin-dependent kinases involved in the cancer cell cycle division.

The cell mobility associated with metastasis. in the cells was also inhibited by the application.

Most importantly, 2 chemical compounds bergapten and psoralen found in the F. Carica leaves also had similar anticancer effects as F. Carica leaf extracts.

Based on the results, researchers wrote, "F. Carica leaves might be a good source to develop drugs for suppressing cancer-cell growth and migration to treat triple-negative breast cancers".

Taken altogether, common fig or fig (Ficus carica) may be considered a remedy for the prevention and treatment of triple-negative breast cancer, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells by Yu Zhang,1 Youzhong Wan,1,2 Bo Huo,1 Boyuan Li,1 Yue Jin,1 and Xin Hu. (PMC)