Tocopherols Suppress the Onset of Metabolic Syndrome

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndrome, you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

Symptoms of signs of metabolic syndrome depending on the types of affected conditions and complications.


The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in a high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.

Most people with metabolic syndrome do not experience any symptoms until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.


Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of α- and γ-tocopherol levels on metabolic syndrome.

According to the analysis of the magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women),
* The α- tocopherol/cholesterol ratio was positively associated with VAT (β scaled by the interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR) Odds Ratio (OR): 1.83; 95% CI: 1.21-2.76 for 3rd vs. 1st tertile).


* The γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile).

* The γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), visceral (VAT) (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile).

* Finally, α- and γ-tocopherol levels were positively associated with high triglycerides and low high-density lipoprotein cholesterol levels (all Ptrend < 0.05).

After talking about other factors into account, researchers said, "Circulating vitamin E levels displayed strong associations with VAT and MetS".


Taken altogether, tocopherols used regularly may be considered adjunct therapies for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content by Waniek S1, di Giuseppe R2, Plachta-Danielzik S3, Ratjen I4, Jacobs G5,6, Koch M7,8, Borggrefe J9, Both M10, Müller HP11, Kassubek J12, Nöthlings U13, Esatbeyoglu T14, Schlesinger S15, Rimbach G16, Lieb W. (PubMed)