All About Vitamins: Vitamin B5 (Pantothenic acid) Promoted Integrity of Skin Tissue with Less Scar Formation

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

 Pantothenic acid  may have a profound effect in promotion of skin tissues including collagen in fibroblasts, a recent study by respectable institute suggested.

According to study by the Tohoku University, pantothenic acid topical administration showed a significant benefit in moisturization of the skin tissues. Deficiency of the vitamin may affect skin function in maintaining the structural integrity of the connective tissue.

In fact, the study also found that pantothenic acid depletion decreased the synthesis of keratinocyte growth factor in speedup wound healing and reduced skin tissue integration.

Noscarna, a reduced scar appearance commercial product, included vitamin B5 derivative, applied to hypertrophic scars in the rabbit ear model. showed a enormous improvements of scar healing and skin pigment in compared to non treatment group.

Truly, according to the study, the efficacy of the production in reduced scar forming is attributed to many mechanisms, including a significant reduction in scar elevation index, anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts.

Dr. Lee DW , the lead author said, "(The promotion of reduced scar forming of ) Noscarn showed more favorable effects on hypertrophic scars than a commercial product, Contractubex".

More interesting, in the support of the above analysis, Dr.Ebner F postulated , " The topical use of dexpanthenol, the stable alcoholic analog of pantothenic acid, is based on good skinpenetration and high local concentrations of dexpanthenol when administered in an adequate vehicle, such as water-in-oil emulsions. Topical dexpanthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with dexpanthenol".

According to the study, topical use of dexpanthenol in skin disorders, after 3 - 4 weeks, expressed considerably improvement of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures.

Taking altogether, there is no doubt that vitamin B5 may be considered as an topical ingredient used in cosmetic care for treatment of speedup skin healing with less scar formation.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts by Kobayashi D1, Kusama M, Onda M, Nakahata N.(PubMed)
(2) Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects by Lee DW1, Ku SK, Cho HJ, Kim JH, Hiep TT, Han SD, Kim BG, Kang MK, Do ES, Jun JH, Jang SW, Son MW, Sohn YT, Choi HG, Yong CS, Kim JO.(PubMed)
(3) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)

All About Vitamins: Pantothenic acid in Neuro Degenerative Risk

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Deprivation of pantothenic acid (PA; vitamin B5) may associate to the early onset of neurodegenerative disease, a study bu renowned university suggested.

In a study of Wild-type and Pank2 mutant mice fed pantothenic acid-deficient diets monitored for general health, fertility and movement and compared with animals on control diets over time, showed a significant effect in manifested azoospermia (a phenotype also seen in Pank2 mice) and exhibited movement disorder with a low-lying pelvis and slow steps.

Mice fed with vitamin B5 deficit diet also effect the physical movement of the limbs caused by muscular spasm and abnormal posture in both mice groups.

According to the University of California, the result of the testing indicated that vitamin B5 deficiency may express the similar expression in neuro degernerative effect as seen in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz syndrome). 

Further more, in the study of a mouse knock-out of the orthologous murine gene (Pank2) to enhance the understanding of the mechanisms of disease and serve as a testing ground for therapies, researchers found that overtime, murine mice manifest retinal degeneration,   progressive photoreceptor decline, decreased cell number and disruption of the outer segment and reduced pupillary constriction response.

More interestingly, in compared to wild type, experiment mice showed a significantly ameliorated fertility in displayed a condition of no sperm semen.

The reduced fertility and physical move and retinal degeneration caused by vitamin B5 deficiency 

demonstrated a similarity to in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz syndrome) cause ofvitamin B5 deficit, therefore, vitamin B5 may be considered as a therapeutic supplemnt in reduced risk neuro degenerative disease caused by acute vitamin B5 deficiency individuals.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration by Kuo YM1, Hayflick SJ, Gitschier J.(PubMed)
(2) Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia by Kuo YM1, Duncan JL, Westaway SK, Yang H, Nune G, Xu EY, Hayflick SJ, Gitschier J.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Pantothenic Acid in Hair Thickening

By Kyle J. Norton.
Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Vitamin B5 used combination with other ingredients may have a potential effect in protected against hair loss and treatment of hair thinning, a renowned institute study suggested.

In the study to examine the growth and quality of hair after treatment with Pantogar, another prescription (Verum-2) and placebo for four months in 60 patients with diffuse effluvium capillorum and agnogenic structural alternations of hair, group treated with Pantogar, a formula including vitamin B5 as a main ingredients, demonstrated not only improvement of quality of hair and but also reduced the retarded hair loss in compared to other groups.

More importantly, application of Pantogar were well tolerance and adverse effects could not be substantiate.

Other in the study of the ability of a novel leave-on technology combination of caffeine, niacinamide, panthenol, dimethicone and an acrylate polymer (CNPDA), showed a significant effect in thicken the hair growth in the applied area as well as increased suppleness/pliability (decreased shear modulus) and better ability to withstand force without breaking (increased break stress).

Dr, Davis MG, the lead author said, "significantly increased the diameter of individual, existing terminal scalp hair fibres by 2-5 μm, which yields an increase in the cross-sectional area of approximately 10%. Beyond the diameter increase"

The astonished result from the cosmetic treatments, may have a therapeutic effect in hair thinning individuals, but can not reverse the condition of hair loss.

Taking altogether, vitamin B5 may be considered as hair thicken ingredient used combination with with other agent for reduced risk of hair loss caused by hair thinning individuals. It is recommended that you consult your doctor before applying.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) A novel cosmetic approach to treat thinning hair by Davis MG1, Thomas JH, van de Velde S, Boissy Y, Dawson TL Jr, Iveson R, Sutton K.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B5 (Pantothenic acid) in Reduced Risk and Treatment of Acne

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid may have a profound effect in reduced risk and treatment in acne, according to the renowned institute study.

In a randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris randomized to application of pantothenic acid-based dietary supplement, or a placebo for 12 weeks (endpoint), group treated pantothenic acid-based dietary supplement with showed a significant mean reduction in total lesion count in compared to placebo at week 12.

According to the Global Assessment and Dermatology Life Quality Index (DLQI) scores, pantothenic acid-based dietary supplement group scored a higher expression in a reduced effect in facial skin inflammation as well.

In fact and more precisely, the application showed a significantly reduced area-specific with acne and inflammatory blemishes.

Dr. Yang M, the lead researchers said, "Administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration".

Other researchers also expressed  a concern of acne besides caused by hormone factors, it may also be induced in person with vitamin B5 deficiency.

Dr. Leung LH, said, "a radically different theory for its pathogenesis and relate its basic pathology to a deficiency in pantothenic acid, a vitamin hitherto not known to cause any deficiency syndrome in humans. Hence, the effect of hormonal factors in this disease entity becomes secondary to that of the availability of pantothenic acid".

Taking altogether, there is no doubt that vitamin B5 have a therapeutic effect in reduced risk and treatment of acne vulgaris, particular in patients with pantothenic acid deficiency.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne by Yang M1, Moclair B, Hatcher V, Kaminetsky J, Mekas M, Chapas A, Capodice J.(PubMed)
(2) Pantothenic acid deficiency as the pathogenesis of acne vulgaris by Leung LH1.(PubMed)

All About Vitamins: Vitamin B5 and Weight loss

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

The prevalence of extreme overweight and obesity has caused concerns of scientific community. According to the statistic, approximately, over 68% of US population are either overweight or obese. Intake of vitamin B5 supplement may have a potential effect in induced weight loss, according to the study by the Hong Kong Central Hospital.

Intake of vitamin b5 may relieve weigh watchers against sensation of hunger and temptation of fasting through providing sufficient amount of energy released from storage fat.

Dr Leung LH, the author of the study suggested, "Supplementation of this vitamin would facilitate complete catabolism of fatty acids and thus the formation of ketone bodies could be circumvented" and "using this method for weight reduction together with a careful observation of calorie intake, I have great success in treating overweight-to-obese patients to lose weight".

Other study in support above differentiation in different way, in a study of libitum or pair-feeding of 3- or 6-wk-old rats in compared to rats fed purified diets supplemented with 0 to 1600 mg pantothenate per kilogram of diet with blood sampling from 3 to 24 h after feeding, vitamin B5 deficiency mice displayed a insignificant of weight loss but elevated serum triglyceride and free fatty acid levels in compared to non deficiency groups.

But Wittwer CT, the lead author said, "Mild pantothenate deficiency appears to have observable in vivo effects on triglyceride metabolism before severe deficiency causes significant weight loss".

Taking together, there is no doubt that vitamin B5 deficiency is associated to weight loss involuntary. People who would like to use vitamin B5 supplement as a weight loss supplement should consult with their doctor before applying.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Pantothenic acid as a weight-reducing agent: fasting without hunger, weakness and ketosis by Leung LH1.(PubMed)
(2) Mild pantothenate deficiency in rats elevates serum triglyceride and free fatty acid levels by Wittwer CT1, Beck S, Peterson M, Davidson R, Wilson DE, Hansen RG.(PubMed)

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

All About Vitamins: Vitamin B5(Pantothenic acid) in Wound Healing Processes

By Kyle J. Norton.


Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Would healing is the natural process of the body in protection against infection, inflammation and further injure to the damage of the original site.

Intake of itamin B5(Pantothenic acid) may have a potential effect in speedup would healing after injure, a hospital study suggested.

According to the INSERM Unité 61-Service de Chirurgie B, Hôpital Civil, application of combined pantothenic acid (PA) and ascorbic acid (AA) exhibited speed of wound healing processes through stimulated the growth of fibroblasts, in human fetal skin or foreskin.

Dr. Lacroix B, the lead author said, "When cultures were incubated with PA and AA, the release of intracellular protein into the culture medium increased."

The expression of combination showed a significant would healing through increased production of protein in regulation intracellular differentiation.

Additionally, in the study of PA (40 micrograms/ml) added to the basal culture medium, vitamin B5 displayed a significant increase of cell proliferation by thymidine Incorporation Assay and involved in stimulated secretion of intracellular protein synthesis in production of fibroblast in cell cultures.

 without inducing a release of other proteins which is important as would healing have caused Therefore, in treating wounded patients in prevent substantial loss of protein during the process,  protein diet is most recommended.

Taking together, there is not doubt that vitamin B5 have a therapeutic effect in wound healing process in exhibited production of  fibroblast through stimulated secretion of intracellular protein. 

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Role of pantothenic and ascorbic acid in wound healing processes: in vitro study on fibroblasts by Lacroix B1, Didier E, Grenier JF.(PubMed)
(2) Effects of pantothenic acid on fibroblastic cell cultures by Lacroix B1, Didier E, Grenier JF.(PubMed)

All About Vitamins: Niacin in Inhibited Inflammatory Expression

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Inflammation is a natural response of immune system in protection of our body against foreign invasion and prevent further damage to injured or damage body's tissues and organs. Over expression of immunity in this case may cause complications if not under controlled.

Niacin is found to inhibit inflammatory expression through its anti-nociceptive activity, a renowned institutes joint study suggested.

According to the Universidade de São Paulo, nicotinic acid (Hnic) and its isomer isonicotinic acid (ina) activated ligands (L) from niacin displayed anti inflammatory effect in inhibition of mechanical hyperalgesia induced by prostaglandin E2, carrageenan, a common food additive and antigen-induced arthritis.

Furthermore, in animal study, mice induced inflammation by formalin.fed with nicotinic acid (250, 500 or 1000 mg/kg, -1 h) showed a significant effect in demonstrated anti the first and the second phases of the nociceptive response against pain expression.
At dose (250 or 500 mg/kg, -1 and 3 h) nicotinic acid also displayed a decreased mechanical allodynia in triggering pain response from stimuli which provoke pain induced by carrageenan, in rat model.

Additionally, besides reduced inflammatory activity against pain, nicotinic acid (250 or 500 mg/kg, p.o., -1 and 3 h) also expressed an ameliorated paw edema caused by carrageenan.

Dr. Godin AM, the lead author said, " our results represent the first demonstration of the activity of nicotinic acid in experimental models of nociceptive and inflammatory pain and also provide further support to its anti-inflammatory activity. It is unlikely that conversion to nicotinamide represents an important mechanism to explain the antinociceptive and anti-inflammatory activities of nicotinic acid".

Taking together, nicotinic acid, a drug that has already been approved for clinical use with a positive safety record to treat high cholesterol and heart disease , may be used as anti inflammatory agent in reduced complications caused over reaction of immunity.

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands by Freitas CS1, Roveda AC Jr2, Truzzi DR2, Garcia AC2, Cunha TM1, Cunha FQ1, Franco DW2.(PubMed)
(2) Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models by Godin AM1, Ferreira WC, Rocha LT, Ferreira RG, Paiva AL, Merlo LA, Nascimento EB Jr, Bastos LF, Coelho MM.(PubMed)