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Tuesday, October 10, 2017

All About Vitamins: Vitamin B5 (Pantothenic acid) Promoted Integrity of Skin Tissue with Less Scar Formation

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

 Pantothenic acid  may have a profound effect in promotion of skin tissues including collagen in fibroblasts, a recent study by respectable institute suggested.

According to study by the Tohoku University, pantothenic acid topical administration showed a significant benefit in moisturization of the skin tissues. Deficiency of the vitamin may affect skin function in maintaining the structural integrity of the connective tissue.

In fact, the study also found that pantothenic acid depletion decreased the synthesis of keratinocyte growth factor in speedup wound healing and reduced skin tissue integration.

Noscarna, a reduced scar appearance commercial product, included vitamin B5 derivative, applied to hypertrophic scars in the rabbit ear model. showed a enormous improvements of scar healing and skin pigment in compared to non treatment group.

Truly, according to the study, the efficacy of the production in reduced scar forming is attributed to many mechanisms, including a significant reduction in scar elevation index, anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts.

Dr. Lee DW , the lead author said, "(The promotion of reduced scar forming of ) Noscarn showed more favorable effects on hypertrophic scars than a commercial product, Contractubex".

More interesting, in the support of the above analysis, Dr.Ebner F postulated , " The topical use of dexpanthenol, the stable alcoholic analog of pantothenic acid, is based on good skinpenetration and high local concentrations of dexpanthenol when administered in an adequate vehicle, such as water-in-oil emulsions. Topical dexpanthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with dexpanthenol".

According to the study, topical use of dexpanthenol in skin disorders, after 3 - 4 weeks, expressed considerably improvement of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures.

Taking altogether, there is no doubt that vitamin B5 may be considered as an topical ingredient used in cosmetic care for treatment of speedup skin healing with less scar formation.

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Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts by Kobayashi D1, Kusama M, Onda M, Nakahata N.(PubMed)
(2) Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects by Lee DW1, Ku SK, Cho HJ, Kim JH, Hiep TT, Han SD, Kim BG, Kang MK, Do ES, Jun JH, Jang SW, Son MW, Sohn YT, Choi HG, Yong CS, Kim JO.(PubMed)
(3) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)

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