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Tuesday, October 17, 2017

All About Vitamins: Vitamin B5 on implication of Brain Acetylcholine

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid may have a profound effect in improved brain activities through influencing function of acetylcholine, neurotransmitter.

Acetylcholine as a neurotransmitter, is a chemical released by nerve cells to send signals to other cells.

In a study to measure brain acetylcholine (ACh) synthesis from precursor [14C]-pyruvate, pantothenic acid (PA) concentration in the brain of rats treated with either ethanol (5-6 g kg-1 body wt daily) alone or ethanol with PA supplementation (100-200 mg kg-1 body wt daily), researchers found that chronic ethanol exposure in rats showed a significant decreased ACh synthesis caused by depleting PA, in negated function of neurotransmitters induced by acetylcholine (ACh).

Other, in the compared 3 studies of rats fed Lieber-DeCarli formula diet with either 5% ethanol or maltose-dextrin (controls) for 19-36 d, researchers filed the following reports
1. The heart pantothenate levels of ethanol-fed rats were 51-78% in compared to control
2. The heart total CoA levels, the precursor of vitamin B5 of ethanol-fed rats were 78-90% in compared to  controls.
3. Liver total CoA and pantothenate levels were lower in ethanol-fed rats than in controls in one and two studies,
4. Rats fed with 0.5-2.5 g ethanol/kg body weight, showed an acute effect of ethanol on pantothenate conversion to CoA in liver.

The result implicated an important result of environment ethanol in reduced levels of brain acetylcholine (ACh) and Total coenzyme A (CoA), thus attenuating brain function in regulating in arousal, attention, memory and motivation.
Taking altogether, there is no doubt that exposure to environment ethanol may have a negative effect the function of motor neurons release  in order to activate muscles in nervous system

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(1) Effects of acute and chronic ethanol ingestion on pantothenate and CoA status of rats by Israel BC, Smith CM.(PubMed)
(2) Effects of ethanol and pantothenic acid on brain acetylcholine synthesis by Rivera-Calimlim L1, Hartley D, Osterhout D.(PubMed)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

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