All About Vitamins: Vitamin B5(Pantothenic acid) in Reduced Risk Of Non Alcoholic Liver Disease?

By Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5

Vitamin B5 deficiency may have a significant effect in Risk Of Non Alcoholic Liver Disease, a respectable institute study suggested.

In the evaluated methionine-choline deficient (MCD) and Western diet mouse models of NASH, with MCD diet-fed mice treated with pantothenate and N-acetylcysteine or placebo, researcher at the joint study lead by the Duke University Medical Center, suggested that treatment with pantothenate and N-acetylcysteine did not inhibit caspase-2 activation, improve NASH, normalize PANK expression, or restore free CoA levels in MCD diet-fed mice evn though antothenic acid (PaA) is a vitamin fromed an integral part of coenzyme A (CoA).

The result indicated that Pantothenic acid have a insignificant effect in reduced risk and treatment of Nonalcoholic fatty liver disease (NAFLD).

Contrast to the above differentiation, the university of Shiga Prefecture study of PaA deficiency in increased risk of accumulation of tissue fats, with Weaning rats fed the PaA-free diet for 30 d. Rats, then divided into two groups. One group was continuously fed the PaA-free diet, and the other was fed the PaA-containing diet for an additional 13 d, reported the following results
1. Fat accumulated by consuming the PaA-free diet for 30 d was decreased by consuming the PaA-containing diet for an additional 13 d.
2. PaA-free diet feeding elicited much greater accumulation of liver, perinephric, and plasma fats.
3.. Administration of PaA expressed a strong effect in decreased accumulated fat.

Dr. Shibata K, the lead author said, "PaA deficiency causes fat accumulation, and re administration of PaA decreases the tissue fat in rats fed the pantothenic acid-free diet".

Furthermore, in the evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine the role of ketogenesis in preventing diet-induced steatohepatitis, researchers showd that intake of supplementation of the CoASH precursors pantothenic acid and cysteine normalized TCA intermediates and gluconeogenesis in the liver, resulting in ameliorately hepatocyte injury and inflammation, decreased glycemia,.......

In regard to the information collected, further cohost and large sample size studies are necessary to confirm either ways.

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Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model by Machado MV1,2, Kruger L1, Jewell ML1, Michelotti GA1, Pereira Tde A1, Xie G1, Moylan CA1, Diehl AM3.(PubMed)
(2) Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption by Shibata K1, Fukuwatari T, Higashiyama S, Sugita C, Azumano I, Onda M.(PubMed)
(3) Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia by Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA.(PubMed)