All About Vitamins: Vitamin B6 in Reduced Risk of Depression in Women

By Kyle J. Norton.

Vitamin B6 may have a profound effect in reduced risk of depression, a respectably university study suggested

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens,Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate metabolism, brain health, and liver detoxification, etc.

In the study of evaluated 140 individuals, with symptoms of depression by the Major Depression Inventory, and biochemical markers of vitamin B deficiency, researchers filed the following results
1. 18 (13%) individuals were depressed. A low plasma level of PLP(v the phosphate derivative of vitamin B6 in plasma) was significantly associated with the depression score
2. Depression was not associated to other vitamin B such as plasma vitamin B12 (p=0.13), plasma methylmalonic acid (p=0.67), erythrocyte folate (p=0.77), and plasma total homocysteine (p=0.16).

The study highly suggested that a low level of plasma PLP is associated to depression and may also have elevated symptoms expression.of depression.

Additionally, in the study in comparison of  male mice weighing 25-30 g, in measured the immobility time and latency to immobility in the forced swimming test as a model of despair and the number of marbles buried (MB) in an open field used as the model of obsessive compulsive behavior in mice,
Injection of Vitamin B6 (100 mg/kg, i.p.) coadministred with clomipramine, fluoxetine, or venlafaxine. showed that
1. Vitamin B6 significantly reduced immobility when used conjunction with clomipramine (141 ± 15 s) or venlafaxine (116 ± 15 s) in compared with the drugs alone.
2. No beneficial response was seen in co-administration of vitamin B6 with fluoxetine compared to fluoxetine alone.
3. Fluoxetine also increased the latency to first immobility. Vitamin B6 + clomipramine or venlafaxine reduced the MB behaviour by 77 ± 12% and 83 ± 7% respectively

Other in the investigated participants in the Québec Longitudinal Study on Nutrition and Aging (NuAge), free of depression (that is, 30-item Geriatric Depression Scale (GDS) <11) at baseline (N=1368; 74 ± 4 years old; 50.5% women), screened annually for incidence of depression (GDS ⩾ 11) or antidepressant medication, researchers found that

1. Over 3 years, 170 participants were identified as depressed
2. Intake of the highest fertile of B6 from food is 43% less likely to become depressed after adjusting
for demographic and health factors, who experience relative odd risk ratio of 0.57 in compared to men
3. In deed, vitamin B6 intake has a non significant effect in risk of depression in men
4. Risk of depression of men increased in lower intake of vitamin B12, not B6

These findings suggested that vitamin B6 as a harmless agent may be used for treatment of depression in women, particularly in obsessive compulsive disorder as an adjuvant for better drug response.

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Sources
(1) Vitamin B6 level is associated with symptoms of depression by Hvas AM1, Juul S, Bech P, Nexø E.(PubMed)
(2) Effect of concomitant administration of three different antidepressants with vitamin B6 on depression and obsessive compulsive disorder in mice models by Mesripour A1, Hajhashemi V1, Kuchak A1.(PubMed)
(2) Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging by Gougeon L1,2, Payette H3,4, Morais JA5, Gaudreau P6,7, Shatenstein B8,9, Gray-Donald K2.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.